메뉴 건너뛰기




Volumn 4, Issue 2, 2014, Pages 200-210

The role of the renin-angiotensin-aldosterone system in the pathobiology of pulmonary arterial hypertension (2013 Grover Conference series)

Author keywords

Aldosterone; Angiotensin II; Mineralocorticoid receptor; Pulmonary arterial hypertension; Spironolactone

Indexed keywords


EID: 85026336684     PISSN: 20458932     EISSN: 20458940     Source Type: Journal    
DOI: 10.1086/675984     Document Type: Review
Times cited : (96)

References (88)
  • 1
    • 84867599718 scopus 로고    scopus 로고
    • Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: Results from the pulmonary hypertension registry of the United Kingdom and Ireland
    • Ling Y, Johnson MK, Kiely DG, et al. Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: results from the pulmonary hypertension registry of the United Kingdom and Ireland. Am J Respir Crit Care Med 2012;186:790-796.
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 790-796
    • Ling, Y.1    Johnson, M.K.2    Kiely, D.G.3
  • 2
    • 77954758530 scopus 로고    scopus 로고
    • Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era
    • Humbert M, Sitbon O, Chaouat A, et al. Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation 2010;122:156-163.
    • (2010) Circulation , vol.122 , pp. 156-163
    • Humbert, M.1    Sitbon, O.2    Chaouat, A.3
  • 3
    • 4143081514 scopus 로고    scopus 로고
    • Pathology of pulmonary hypertension
    • Voelkel NF, Cool C. Pathology of pulmonary hypertension. Cardiol Clin 2004;22:343-351, v.
    • (2004) Cardiol Clin , vol.22 , pp. 343-351
    • Voelkel, N.F.1    Cool, C.2
  • 4
    • 82555195583 scopus 로고    scopus 로고
    • Looking to the future: A new decade of pulmonary arterial hypertension therapy
    • McLaughlin VV. Looking to the future: a new decade of pulmonary arterial hypertension therapy. Eur Respir Rev 2011; 20:262-269.
    • (2011) Eur Respir Rev , vol.20 , pp. 262-269
    • McLaughlin, V.V.1
  • 5
    • 57349188499 scopus 로고    scopus 로고
    • Molecular mechanisms of pulmonary arterial hypertension: Role of mutations in the bone morpho-genetic protein type II receptor
    • Davies RJ, Morrell NW. Molecular mechanisms of pulmonary arterial hypertension: role of mutations in the bone morpho-genetic protein type II receptor. Chest 2008;134:1271-1277.
    • (2008) Chest , vol.134 , pp. 1271-1277
    • Davies, R.J.1    Morrell, N.W.2
  • 6
    • 84865718686 scopus 로고    scopus 로고
    • The study of risk in pulmonary arterial hypertension
    • Rubin LJ, Simonneau G, Badesch D, et al. The study of risk in pulmonary arterial hypertension. Eur Respir Rev 2012; 21:234-238.
    • (2012) Eur Respir Rev , vol.21 , pp. 234-238
    • Rubin, L.J.1    Simonneau, G.2    Badesch, D.3
  • 7
    • 84878682776 scopus 로고    scopus 로고
    • Regulation of aldosterone secretion: From physiology to disease
    • Beuschlein F. Regulation of aldosterone secretion: from physiology to disease. Eur J Endocrinol 2013;168:R85-R93.
    • (2013) Eur J Endocrinol , vol.168 , pp. R85-R93
    • Beuschlein, F.1
  • 8
    • 37049043764 scopus 로고
    • Uptake of triti-ated aldosterone by rat tissues
    • Sulya LL, McCaa CS, Read VH, Bomer D. Uptake of triti-ated aldosterone by rat tissues. Nature 1963;200:788-789.
    • (1963) Nature , vol.200 , pp. 788-789
    • Sulya, L.L.1    McCaa, C.S.2    Read, V.H.3    Bomer, D.4
  • 9
    • 3042731163 scopus 로고    scopus 로고
    • Serum aldosterone and the incidence of hypertension in nonhypertensive persons
    • Vasan RS, Evans JC, Larson MG, et al. Serum aldosterone and the incidence of hypertension in nonhypertensive persons. N Engl J Med 2004;351:33-41.
    • (2004) N Engl J Med , vol.351 , pp. 33-41
    • Vasan, R.S.1    Evans, J.C.2    Larson, M.G.3
  • 10
    • 67649519778 scopus 로고    scopus 로고
    • Longitudinal tracking of left ventricular mass over the adult life course: Clinical correlates of short-and long-term change in the framingham offspring study
    • Lieb W, Xanthakis V, Sullivan LM, et al. Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short-and long-term change in the framingham offspring study. Circulation 2009; 119: 3085-3092.
    • (2009) Circulation , vol.119 , pp. 3085-3092
    • Lieb, W.1    Xanthakis, V.2    Sullivan, L.M.3
  • 11
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spi-ronolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
    • Pitt B, Zannad F, Remme WJ, et al. The effect of spi-ronolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341:709-717.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 12
    • 42649115768 scopus 로고    scopus 로고
    • Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis
    • Santos RA, Ferreira AJ, Simoes ESAC. Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis. Exp Physiol 2008;93:519-527.
    • (2008) Exp Physiol , vol.93 , pp. 519-527
    • Santos, R.A.1    Ferreira, A.J.2    Simoes, E.S.A.C.3
  • 13
    • 77951879058 scopus 로고    scopus 로고
    • Aldosterone: Effects on the kidney and cardiovascular system
    • Briet M, Schiffrin EL. Aldosterone: effects on the kidney and cardiovascular system. Nat Rev Nephrol 2010;6:261-273.
    • (2010) Nat Rev Nephrol , vol.6 , pp. 261-273
    • Briet, M.1    Schiffrin, E.L.2
  • 15
    • 84871708442 scopus 로고    scopus 로고
    • Angiotensin II and III metabolism and effects on steroid production in the HAC15 human adrenocortical cell line
    • Oki K, Kopf PG, Campbell WB, et al. Angiotensin II and III metabolism and effects on steroid production in the HAC15 human adrenocortical cell line. Endocrinology 2013;154: 214-221.
    • (2013) Endocrinology , vol.154 , pp. 214-221
    • Oki, K.1    Kopf, P.G.2    Campbell, W.B.3
  • 16
    • 0033635110 scopus 로고    scopus 로고
    • Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells
    • Touyz RM, Schiffrin EL. Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol Rev 2000;52:639-672.
    • (2000) Pharmacol Rev , vol.52 , pp. 639-672
    • Touyz, R.M.1    Schiffrin, E.L.2
  • 17
    • 77957881110 scopus 로고    scopus 로고
    • Different effects of angiotensin II and angiotensin-(1-7) on vascular smooth muscle cell proliferation and migration
    • Zhang F, Hu Y, Xu Q, Ye S. Different effects of angiotensin II and angiotensin-(1-7) on vascular smooth muscle cell proliferation and migration. PLoS One 2013;5:e12323.
    • (2013) Plos One , vol.5
    • Zhang, F.1    Hu, Y.2    Xu, Q.3    Ye, S.4
  • 18
    • 0028820617 scopus 로고
    • Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension
    • Morrell NW, Atochina EN, Morris KG, Danilov SM, Stenmark KR. Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. J Clin Invest 1995; 96: 1823-1833.
    • (1995) J Clin Invest , vol.96 , pp. 1823-1833
    • Morrell, N.W.1    Atochina, E.N.2    Morris, K.G.3    Danilov, S.M.4    Stenmark, K.R.5
  • 19
    • 84867589328 scopus 로고    scopus 로고
    • Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension
    • de Man FS, Tu L, Handoko ML, et al. Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension. Am J Respir Crit Care Med 2012;186: 780-789.
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 780-789
    • De Man, F.S.1    Tu, L.2    Handoko, M.L.3
  • 20
    • 84880778204 scopus 로고    scopus 로고
    • ACE2 activation confers endothe-lial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats
    • Li G, Liu Y, Zhu Y, et al. ACE2 activation confers endothe-lial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats. Lung 2013;191:327-336.
    • (2013) Lung , vol.191 , pp. 327-336
    • Li, G.1    Liu, Y.2    Zhu, Y.3
  • 22
    • 0032886630 scopus 로고    scopus 로고
    • Angiotensin II activates MAPK and stimulates growth of human pulmonary artery smooth muscle via AT1 receptors
    • Morrell NW, Upton PD, Kotecha S, et al. Angiotensin II activates MAPK and stimulates growth of human pulmonary artery smooth muscle via AT1 receptors. Am J Physiol 1999;277:L440-L448.
    • (1999) Am J Physiol , vol.277 , pp. L440-L448
    • Morrell, N.W.1    Upton, P.D.2    Kotecha, S.3
  • 23
    • 0033645470 scopus 로고    scopus 로고
    • Expression of pulmonary vascular angiotensin-converting enzyme in primary and secondary plexiform pulmonary hypertension
    • Orte C, Polak JM, Haworth SG, Yacoub MH, Morrell NW. Expression of pulmonary vascular angiotensin-converting enzyme in primary and secondary plexiform pulmonary hypertension. J Pathol 2000;192:379-384.
    • (2000) J Pathol , vol.192 , pp. 379-384
    • Orte, C.1    Polak, J.M.2    Haworth, S.G.3    Yacoub, M.H.4    Morrell, N.W.5
  • 24
    • 0031005005 scopus 로고    scopus 로고
    • Right ventricular angiotensin converting enzyme activity and expression is increased during hypoxic pulmonary hypertension
    • Morrell NW, Danilov SM, Satyan KB, Morris KG, Stenmark KR. Right ventricular angiotensin converting enzyme activity and expression is increased during hypoxic pulmonary hypertension. Cardiovasc Res 1997;34:393-403.
    • (1997) Cardiovasc Res , vol.34 , pp. 393-403
    • Morrell, N.W.1    Danilov, S.M.2    Satyan, K.B.3    Morris, K.G.4    Stenmark, K.R.5
  • 25
    • 0028850404 scopus 로고
    • Role of angiotensin-converting enzyme and angiotensin II in development of hypoxic pulmonary hypertension
    • Morrell NW, Morris KG, Stenmark KR. Role of angiotensin-converting enzyme and angiotensin II in development of hypoxic pulmonary hypertension. Am J Physiol 1995;269: H1186-H1194.
    • (1995) Am J Physiol , vol.269
    • Morrell, N.W.1    Morris, K.G.2    Stenmark, K.R.3
  • 26
    • 79958734872 scopus 로고    scopus 로고
    • ACE2 improves right ventricular function in a pressure overload model
    • Johnson JA, West J, Maynard KB, Hemnes AR. ACE2 improves right ventricular function in a pressure overload model. PLoS One 2011;6:e20828.
    • (2011) Plos One , vol.6
    • Johnson, J.A.1    West, J.2    Maynard, K.B.3    Hemnes, A.R.4
  • 27
    • 78049352553 scopus 로고    scopus 로고
    • The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension
    • Shenoy V, Ferreira AJ, Qi Y, et al. The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension. Am J Respir Crit Care Med 2010;182: 1065-1072.
    • (2010) Am J Respir Crit Care Med , vol.182 , pp. 1065-1072
    • Shenoy, V.1    Ferreira, A.J.2    Qi, Y.3
  • 28
    • 33645834948 scopus 로고    scopus 로고
    • Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II
    • Yamamoto K, Ohishi M, Katsuya T, et al. Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II. Hypertension 2006;47:718-726.
    • (2006) Hypertension , vol.47 , pp. 718-726
    • Yamamoto, K.1    Ohishi, M.2    Katsuya, T.3
  • 29
    • 66249133083 scopus 로고    scopus 로고
    • Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension
    • Ferreira AJ, Shenoy V, Yamazato Y, et al. Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension. Am J Respir Crit Care Med 2009;179:1048-1054.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 1048-1054
    • Ferreira, A.J.1    Shenoy, V.2    Yamazato, Y.3
  • 30
    • 62549141438 scopus 로고    scopus 로고
    • Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia
    • Dempsey EC, Wick MJ, Karoor V, et al. Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia. Am J Pathol 2009;174:782-796.
    • (2009) Am J Pathol , vol.174 , pp. 782-796
    • Dempsey, E.C.1    Wick, M.J.2    Karoor, V.3
  • 31
    • 0037361583 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme DD genotype in patients with primary pulmonary hypertension: Increased frequency and association with preserved haemodynamics
    • Abraham WT, Raynolds MV, Badesch DB, et al. Angiotensin-converting enzyme DD genotype in patients with primary pulmonary hypertension: increased frequency and association with preserved haemodynamics. J Renin Angiotensin Aldosterone Syst 2003;4:27-30.
    • (2003) J Renin Angiotensin Aldosterone Syst , vol.4 , pp. 27-30
    • Abraham, W.T.1    Raynolds, M.V.2    Badesch, D.B.3
  • 32
    • 0019934990 scopus 로고
    • Captopril as treatment for patients with pulmonary hypertension: Problem of variability in assessing chronic drug treatment
    • Rich S, Martinez J, Lam W, Rosen KM. Captopril as treatment for patients with pulmonary hypertension: problem of variability in assessing chronic drug treatment. Br Heart J 1982;48:272-277.
    • (1982) Br Heart J , vol.48 , pp. 272-277
    • Rich, S.1    Martinez, J.2    Lam, W.3    Rosen, K.M.4
  • 33
    • 0020684116 scopus 로고
    • Captopril in primary pulmonary hypertension
    • Leier CV, Bambach D, Nelson S, et al. Captopril in primary pulmonary hypertension. Circulation 1983;67:155-161.
    • (1983) Circulation , vol.67 , pp. 155-161
    • Leier, C.V.1    Bambach, D.2    Nelson, S.3
  • 34
    • 0020459780 scopus 로고
    • Haemodynamic and hormonal effects ofcaptopril in primary pulmonary hypertension
    • Ikram H, Maslowski AH, Nicholls MG, Espiner EA, Hull FT. Haemodynamic and hormonal effects ofcaptopril in primary pulmonary hypertension. Br Heart J 1982;48:541-545.
    • (1982) Br Heart J , vol.48 , pp. 541-545
    • Ikram, H.1    Maslowski, A.H.2    Nicholls, M.G.3    Espiner, E.A.4    Hull, F.T.5
  • 35
    • 33744956091 scopus 로고    scopus 로고
    • Aldosterone breakthrough during RAS blockade: A role for endothelins and their antagonists?
    • Rossi GP. Aldosterone breakthrough during RAS blockade: a role for endothelins and their antagonists? Curr Hypertens Rep 2006;8:262-268.
    • (2006) Curr Hypertens Rep , vol.8 , pp. 262-268
    • Rossi, G.P.1
  • 36
    • 0037183651 scopus 로고    scopus 로고
    • Elevated plasma aldosterone levels despite complete inhibition ofthe vascular angiotensin-converting enzyme in chronic heart failure
    • Jorde UP, Vittorio T, Katz SD, Colombo PC, Latif F, Le Jemtel TH. Elevated plasma aldosterone levels despite complete inhibition ofthe vascular angiotensin-converting enzyme in chronic heart failure. Circulation 2002; 106:1055-1057.
    • (2002) Circulation , vol.106 , pp. 1055-1057
    • Jorde, U.P.1    Vittorio, T.2    Katz, S.D.3    Colombo, P.C.4    Latif, F.5    Le Jemtel, T.H.6
  • 37
    • 84865214267 scopus 로고    scopus 로고
    • Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension
    • Maron BA, Zhang YY, White K, et al. Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension. Circulation 2012;126:963-974.
    • (2012) Circulation , vol.126 , pp. 963-974
    • Maron, B.A.1    Zhang, Y.Y.2    White, K.3
  • 38
    • 84874473854 scopus 로고    scopus 로고
    • Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: A pilot study
    • Maron BA, Opotowsky AR, Landzberg MJ, Loscalzo J, Waxman AB, Leopold JA. Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: a pilot study. Eur J Heart Fail 2013;15:277-283.
    • (2013) Eur J Heart Fail , vol.15 , pp. 277-283
    • Maron, B.A.1    Opotowsky, A.R.2    Landzberg, M.J.3    Loscalzo, J.4    Waxman, A.B.5    Leopold, J.A.6
  • 39
    • 84881617288 scopus 로고    scopus 로고
    • Effectiveness of spironolactone plus ambrisentan for treatment of pulmonary arterial hypertension (From the [ARIES] study 1 and 2 trials)
    • Maron BA, Waxman AB, Opotowsky AR, et al. Effectiveness of spironolactone plus ambrisentan for treatment of pulmonary arterial hypertension (from the [ARIES] study 1 and 2 trials). Am J Cardiol 2013;112:720-725.
    • (2013) Am J Cardiol , vol.112 , pp. 720-725
    • Maron, B.A.1    Waxman, A.B.2    Opotowsky, A.R.3
  • 40
    • 9244235982 scopus 로고    scopus 로고
    • Cardiac synthesis of aldosterone: Going, going, gone..?
    • Funder JW. Cardiac synthesis of aldosterone: going, going, gone..? Endocrinology 2004;145:4793-4795.
    • (2004) Endocrinology , vol.145 , pp. 4793-4795
    • Funder, J.W.1
  • 42
    • 27844503497 scopus 로고    scopus 로고
    • The aldosterone syn-thase (CYP11B2) and 11beta-hydroxylase (CYP11B1) genes are not expressed in the rat heart
    • Ye P, Kenyon CJ, MacKenzie SM, et al. The aldosterone syn-thase (CYP11B2) and 11beta-hydroxylase (CYP11B1) genes are not expressed in the rat heart. Endocrinology 2005;146: 5287-5293.
    • (2005) Endocrinology , vol.146 , pp. 5287-5293
    • Ye, P.1    Kenyon, C.J.2    Mackenzie, S.M.3
  • 43
    • 0029788193 scopus 로고    scopus 로고
    • Regulation of aldo-sterone synthase in human vascular endothelial cells by angiotensin II and adrenocorticotropin
    • Takeda Y, Miyamori I, Yoneda T, et al. Regulation of aldo-sterone synthase in human vascular endothelial cells by angiotensin II and adrenocorticotropin. J Clin Endocrinol Metab 1996;81:2797-2800.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 2797-2800
    • Takeda, Y.1    Miyamori, I.2    Yoneda, T.3
  • 45
    • 0028923221 scopus 로고
    • Aldosterone biosynthesis and action in vascular cells
    • Takeda R, Hatakeyama H, Takeda Y, et al. Aldosterone biosynthesis and action in vascular cells. Steroids 1995;60:120-124.
    • (1995) Steroids , vol.60 , pp. 120-124
    • Takeda, R.1    Hatakeyama, H.2    Takeda, Y.3
  • 46
    • 0029988733 scopus 로고    scopus 로고
    • Endothelin adre-nocortical secretagogue effect is mediated by the B receptor in rats
    • Belloni AS, Rossi GP, Andreis PG, et al. Endothelin adre-nocortical secretagogue effect is mediated by the B receptor in rats. Hypertension 1996;27:1153-1159.
    • (1996) Hypertension , vol.27 , pp. 1153-1159
    • Belloni, A.S.1    Rossi, G.P.2    Reis, P.G.3
  • 48
    • 46449124591 scopus 로고    scopus 로고
    • Ambrisentan for the treatment of pulmonary arterial hypertension: Results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2
    • Galie N, Olschewski H, Oudiz RJ, et al. Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2. Circulation 2008;117:3010-3019.
    • (2008) Circulation , vol.117 , pp. 3010-3019
    • Galie, N.1    Olschewski, H.2    Oudiz, R.J.3
  • 49
    • 84867396866 scopus 로고    scopus 로고
    • Frequency ofedema in patients with pulmonary arterial hypertension receiving ambrisentan
    • Shapiro S, Pollock DM, Gillies H, et al. Frequency ofedema in patients with pulmonary arterial hypertension receiving ambrisentan. Am J Cardiol 2012;110:1373-1377.
    • (2012) Am J Cardiol , vol.110 , pp. 1373-1377
    • Shapiro, S.1    Pollock, D.M.2    Gillies, H.3
  • 50
    • 84874229170 scopus 로고    scopus 로고
    • Vascular actions ofaldosterone
    • Briet M, Schiffrin EL. Vascular actions ofaldosterone. J Vasc Res 2013;50:89-99.
    • (2013) J Vasc Res , vol.50 , pp. 89-99
    • Briet, M.1    Schiffrin, E.L.2
  • 52
    • 50249143541 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonists and endothelial function
    • Maron BA, Leopold JA. Mineralocorticoid receptor antagonists and endothelial function. Curr Opin Investig Drugs 2008;9:963-969.
    • (2008) Curr Opin Investig Drugs , vol.9 , pp. 963-969
    • Maron, B.A.1    Leopold, J.A.2
  • 53
    • 77649106201 scopus 로고    scopus 로고
    • Aldosterone receptor antagonists: Effective but often forgotten
    • Maron BA, Leopold JA. Aldosterone receptor antagonists: effective but often forgotten. Circulation 2010;121:934-939.
    • (2010) Circulation , vol.121 , pp. 934-939
    • Maron, B.A.1    Leopold, J.A.2
  • 54
    • 0036796624 scopus 로고    scopus 로고
    • Aldosterone induces acute endothelial dysfunction in vivo in humans: Evidence for an aldosterone-induced vasculopathy
    • Farquharson CA, Struthers AD. Aldosterone induces acute endothelial dysfunction in vivo in humans: evidence for an aldosterone-induced vasculopathy. Clin Sci (Lond) 2002; 103:425-431.
    • (2002) Clin Sci (Lond) , vol.103 , pp. 425-431
    • Farquharson, C.A.1    Struthers, A.D.2
  • 55
    • 2942685646 scopus 로고    scopus 로고
    • Impaired endothelium-dependent flow-mediated vasodilation in hypertensive subjects with hyperaldosteron-ism
    • Nishizaka MK, Zaman MA, Green SA, Renfroe KY, Cal-houn DA. Impaired endothelium-dependent flow-mediated vasodilation in hypertensive subjects with hyperaldosteron-ism. Circulation 2004;109:2857-2861.
    • (2004) Circulation , vol.109 , pp. 2857-2861
    • Nishizaka, M.K.1    Zaman, M.A.2    Green, S.A.3    Renfroe, K.Y.4    Cal-Houn, D.A.5
  • 56
    • 33745974852 scopus 로고    scopus 로고
    • Molecular mechanism of the inhibitory effect of aldosterone on endothelial NO synthase activity
    • Nagata D, Takahashi M, Sawai K, et al. Molecular mechanism of the inhibitory effect of aldosterone on endothelial NO synthase activity. Hypertension 2006;48:165-171.
    • (2006) Hypertension , vol.48 , pp. 165-171
    • Nagata, D.1    Takahashi, M.2    Sawai, K.3
  • 57
    • 79551487567 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/salt
    • Griol-Charhbili V, Fassot C, Messaoudi S, Perret C, Agra-part V, Jaisser F. Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/salt. Hypertension 2011;57:238-244.
    • (2011) Hypertension , vol.57 , pp. 238-244
    • Griol-Charhbili, V.1    Fassot, C.2    Messaoudi, S.3    Perret, C.4    Agra-Part, V.5    Jaisser, F.6
  • 58
    • 33846963787 scopus 로고    scopus 로고
    • Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehy-drogenase activity
    • Leopold JA, Dam A, Maron BA, et al. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehy-drogenase activity. Nat Med 2007;13:189-197.
    • (2007) Nat Med , vol.13 , pp. 189-197
    • Leopold, J.A.1    Dam, A.2    Maron, B.A.3
  • 59
    • 59649118170 scopus 로고    scopus 로고
    • Identification of a retinal aldosterone system and the protective effects of mineralocorticoid receptor antagonism on retinal vascular pathology
    • Wilkinson-Berka JL, Tan G, Jaworski K, Miller AG. Identification of a retinal aldosterone system and the protective effects of mineralocorticoid receptor antagonism on retinal vascular pathology. Circ Res 2009;104:124-133.
    • (2009) Circ Res , vol.104 , pp. 124-133
    • Wilkinson-Berka, J.L.1    Tan, G.2    Jaworski, K.3    Miller, A.G.4
  • 60
    • 84859962403 scopus 로고    scopus 로고
    • Spironolactone improves nephropa-thy by enhancing glucose-6-phosphate dehydrogenase activity and reducing oxidative stress in diabetic hypertensive rat
    • Pessoa BS, Peixoto EB, Papadimitriou A, Lopes de Faria JM, Lopes de Faria JB. Spironolactone improves nephropa-thy by enhancing glucose-6-phosphate dehydrogenase activity and reducing oxidative stress in diabetic hypertensive rat. J Renin Angiotensin Aldosterone Syst 2012;13:56-66.
    • (2012) J Renin Angiotensin Aldosterone Syst , vol.13 , pp. 56-66
    • Pessoa, B.S.1    Peixoto, E.B.2    Papadimitriou, A.3    Lopes De Faria, J.M.4    Lopes De Faria, J.B.5
  • 61
    • 1542511743 scopus 로고    scopus 로고
    • Oxidative stress in severe pulmonary hypertension
    • Bowers R, Cool C, Murphy RC, et al. Oxidative stress in severe pulmonary hypertension. Am J Respir Crit Care Med 2004;169:764-769.
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 764-769
    • Bowers, R.1    Cool, C.2    Murphy, R.C.3
  • 62
    • 65549123191 scopus 로고    scopus 로고
    • Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells
    • Maron BA, Zhang YY, Handy DE, et al. Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells. J Biol Chem 2009;284:7665-7672.
    • (2009) J Biol Chem , vol.284 , pp. 7665-7672
    • Maron, B.A.1    Zhang, Y.Y.2    Handy, D.E.3
  • 63
    • 79960012285 scopus 로고    scopus 로고
    • Activation ofSrc-ATF1 pathway is involved in upregulation of Nox1, a catalytic subunit of NADPH oxidase, by aldosterone
    • Shi G, Fu Y, Jiang W, et al. Activation ofSrc-ATF1 pathway is involved in upregulation of Nox1, a catalytic subunit of NADPH oxidase, by aldosterone. Endocr J 2011;58:491-499.
    • (2011) Endocr J , vol.58 , pp. 491-499
    • Shi, G.1    Fu, Y.2    Jiang, W.3
  • 64
    • 47849127408 scopus 로고    scopus 로고
    • Synergy of aldosterone and high salt induces vascular smooth muscle hypertrophy through up-regulation of NOX1
    • Fan C, Kawai Y, Inaba S, et al. Synergy of aldosterone and high salt induces vascular smooth muscle hypertrophy through up-regulation of NOX1. J Steroid Biochem Mol Biol 2008;111:29-36.
    • (2008) J Steroid Biochem Mol Biol , vol.111 , pp. 29-36
    • Fan, C.1    Kawai, Y.2    Inaba, S.3
  • 65
    • 78649888159 scopus 로고    scopus 로고
    • Aldosterone enhances IGF-I-mediated signaling and biological function in vascular smooth muscle cells
    • Cascella T, Radhakrishnan Y, Maile LA, et al. Aldosterone enhances IGF-I-mediated signaling and biological function in vascular smooth muscle cells. Endocrinology 2010;151: 5851-5864.
    • (2010) Endocrinology , vol.151 , pp. 5851-5864
    • Cascella, T.1    Radhakrishnan, Y.2    Maile, L.A.3
  • 66
    • 84856120511 scopus 로고    scopus 로고
    • T regulatory lymphocytes prevent aldosterone-induced vascular injury
    • Kasal DA, Barhoumi T, Li MW, et al. T regulatory lymphocytes prevent aldosterone-induced vascular injury. Hypertension 2012;59:324-330.
    • (2012) Hypertension , vol.59 , pp. 324-330
    • Kasal, D.A.1    Barhoumi, T.2    Li, M.W.3
  • 67
    • 44949169677 scopus 로고    scopus 로고
    • Functional mineral-ocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion
    • Caprio M, Newfell BG, la Sala A, et al. Functional mineral-ocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion. Circ Res 2008;102:1359-1367.
    • (2008) Circ Res , vol.102 , pp. 1359-1367
    • Caprio, M.1    Newfell, B.G.2    La Sala, A.3
  • 68
    • 79957503877 scopus 로고    scopus 로고
    • Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans
    • Thum T, Schmitter K, Fleissner F, et al. Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans. Eur Heart J 2011; 32:1275-1286.
    • (2011) Eur Heart J , vol.32 , pp. 1275-1286
    • Thum, T.1    Schmitter, K.2    Fleissner, F.3
  • 71
    • 77954242394 scopus 로고    scopus 로고
    • The epithelial sodium channel (ENaC): Mediator of the aldoste-rone response in the vascular endothelium?
    • Kusche-Vihrog K, Callies C, Fels J, Oberleithner H. The epithelial sodium channel (ENaC): mediator of the aldoste-rone response in the vascular endothelium? Steroids 2010; 75:544-549.
    • (2010) Steroids , vol.75 , pp. 544-549
    • Kusche-Vihrog, K.1    Callies, C.2    Fels, J.3    Oberleithner, H.4
  • 72
    • 37249005847 scopus 로고    scopus 로고
    • Aldosterone and amiloride alter ENaC abundance in vascular endothe-lium
    • Kusche-Vihrog K, Sobczak K, Bangel N, et al. Aldosterone and amiloride alter ENaC abundance in vascular endothe-lium. Pfluegers Arch 2008;455:849-857.
    • (2008) Pfluegers Arch , vol.455 , pp. 849-857
    • Kusche-Vihrog, K.1    Sobczak, K.2    Bangel, N.3
  • 73
    • 77957894160 scopus 로고    scopus 로고
    • Menage a trois: Aldosterone, sodium and nitric oxide in vascular endothe-lium
    • Fels J, Oberleithner H, Kusche-Vihrog K. Menage a trois: aldosterone, sodium and nitric oxide in vascular endothe-lium. Biochim Biophys Acta 2010;1802:1193-1202.
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 1193-1202
    • Fels, J.1    Oberleithner, H.2    Kusche-Vihrog, K.3
  • 74
    • 84861531444 scopus 로고    scopus 로고
    • Aldosterone inhibits antifibrotic factors in mouse hypertensive heart
    • Azibani F, Benard L, Schlossarek S, et al. Aldosterone inhibits antifibrotic factors in mouse hypertensive heart. Hypertension 2012;59:1179-1187.
    • (2012) Hypertension , vol.59 , pp. 1179-1187
    • Azibani, F.1    Benard, L.2    Schlossarek, S.3
  • 75
    • 31744433843 scopus 로고    scopus 로고
    • Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD (P)H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats
    • Nakano S, Kobayashi N, Yoshida K, Ohno T, Matsuoka H. Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD (P)H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats. Hypertens Res 2005;28:925-936.
    • (2005) Hypertens Res , vol.28 , pp. 925-936
    • Nakano, S.1    Kobayashi, N.2    Yoshida, K.3    Ohno, T.4    Matsuoka, H.5
  • 76
    • 79958030363 scopus 로고    scopus 로고
    • Coronary endothelial dysfunction after cardiomyocyte-specific mineralocorticoid receptor overexpression
    • Favre J, Gao J, Zhang AD, et al. Coronary endothelial dysfunction after cardiomyocyte-specific mineralocorticoid receptor overexpression. Am J Physiol Heart Circ Physiol 2011; 300:H2035-H2043.
    • (2011) Am J Physiol Heart Circ Physiol , vol.300 , pp. H2035-H2043
    • Favre, J.1    Gao, J.2    Zhang, A.D.3
  • 77
    • 20544464438 scopus 로고    scopus 로고
    • Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias
    • Ouvrard-Pascaud A, Sainte-Marie Y, Benitah JP, et al. Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias. Circulation 2005;111: 3025-3033.
    • (2005) Circulation , vol.111 , pp. 3025-3033
    • Ouvrard-Pascaud, A.1    Sainte-Marie, Y.2    Benitah, J.P.3
  • 78
    • 28244450903 scopus 로고    scopus 로고
    • A direct relationship between plasma aldosterone and cardiac L-type Ca2+ current in mice
    • Perrier R, Richard S, Sainte-Marie Y, et al. A direct relationship between plasma aldosterone and cardiac L-type Ca2+ current in mice. J Physiol 2005;569:153-162.
    • (2005) J Physiol , vol.569 , pp. 153-162
    • Perrier, R.1    Richard, S.2    Sainte-Marie, Y.3
  • 79
    • 66549118329 scopus 로고    scopus 로고
    • Mineralocorti-coid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins
    • Gomez AM, Rueda A, Sainte-Marie Y, et al. Mineralocorti-coid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins. Circulation 2009;119:2179-2187.
    • (2009) Circulation , vol.119 , pp. 2179-2187
    • Gomez, A.M.1    Rueda, A.2    Sainte-Marie, Y.3
  • 80
    • 85047680324 scopus 로고
    • Myocardial fibrosis: Functional significance and regulatory factors
    • Weber KT, Brilla CG, Janicki JS. Myocardial fibrosis: functional significance and regulatory factors. Cardiovasc Res 1993;27:341-348.
    • (1993) Cardiovasc Res , vol.27 , pp. 341-348
    • Weber, K.T.1    Brilla, C.G.2    Janicki, J.S.3
  • 81
    • 84856100794 scopus 로고    scopus 로고
    • Oxidation of Ca MKII determines the cardiotoxic effects of aldosterone
    • He BJ, Joiner ML, Singh MV, et al. Oxidation of Ca MKII determines the cardiotoxic effects of aldosterone. Nat Med 2011;17:1610-1618.
    • (2011) Nat Med , vol.17 , pp. 1610-1618
    • He, B.J.1    Joiner, M.L.2    Singh, M.V.3
  • 82
    • 66549127501 scopus 로고    scopus 로고
    • ACCF/AHA 2009 expert consensus document on pulmonary hypertension: A report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association: Developed in collaboration with the American College of Chest Physicians, American Thoracic Society, Inc., and the Pulmonary Hypertension Association
    • McLaughlin VV, Archer SL, Badesch DB, et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association: developed in collaboration with the American College of Chest Physicians, American Thoracic Society, Inc., and the Pulmonary Hypertension Association. Circulation 2009; 119:2250-2294.
    • (2009) Circulation , vol.119 , pp. 2250-2294
    • McLaughlin, V.V.1    Archer, S.L.2    Badesch, D.B.3
  • 83
    • 70349634397 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of pulmonary hypertension
    • Galie N, Hoeper MM, Humbert M, et al. Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J 2009;34:1219-1263.
    • (2009) Eur Respir J , vol.34 , pp. 1219-1263
    • Galie, N.1    Hoeper, M.M.2    Humbert, M.3
  • 84
    • 84882329821 scopus 로고    scopus 로고
    • Cardiorenal protection by BAY 94-8862, a novel non-steroidal miner-alocorticoid receptor antagonist in a preclinical model of hypertension and diastolic heart failure
    • Delbeck M, Kretschmer A, Kast R, et al. Cardiorenal protection by BAY 94-8862, a novel non-steroidal miner-alocorticoid receptor antagonist in a preclinical model of hypertension and diastolic heart failure. Eur Heart J 2012; 33:772-773.
    • (2012) Eur Heart J , vol.33 , pp. 772-773
    • Delbeck, M.1    Kretschmer, A.2    Kast, R.3
  • 85
    • 84861554853 scopus 로고    scopus 로고
    • Discovery of BAY 94-8862: A nonsteroidal antagonist of the mineralocorti-coid receptor for the treatment of cardiorenal diseases
    • Barfacker L, Kuhl A, Hillisch A, et al. Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorti-coid receptor for the treatment of cardiorenal diseases. ChemMedChem 2012;7:1385-1403.
    • (2012) Chemmedchem , vol.7 , pp. 1385-1403
    • Barfacker, L.1    Kuhl, A.2    Hillisch, A.3
  • 86
    • 84882415231 scopus 로고    scopus 로고
    • Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: A randomized, double-blind trial
    • Pitt B, Kober L, Ponikowski P, et al. Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial. Eur Heart J 2013;34:2453-2463.
    • (2013) Eur Heart J , vol.34 , pp. 2453-2463
    • Pitt, B.1    Kober, L.2    Ponikowski, P.3
  • 87
    • 84875548405 scopus 로고    scopus 로고
    • A pilot study of the effect of spironolactone therapy on exercise capacity and en-dothelial dysfunction in pulmonary arterial hypertension: Study protocol for a randomized controlled trial
    • Elinoff JM, Rame JE, Forfia PR, et al. A pilot study of the effect of spironolactone therapy on exercise capacity and en-dothelial dysfunction in pulmonary arterial hypertension: study protocol for a randomized controlled trial. Trials 2013; 14:91.
    • (2013) Trials , vol.14 , pp. 91
    • Elinoff, J.M.1    Rame, J.E.2    Forfia, P.R.3
  • 88
    • 84881105043 scopus 로고    scopus 로고
    • Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension
    • Hadri L, Kratlian RG, Benard L, et al. Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension. Circulation 2013;128:512-523.
    • (2013) Circulation , vol.128 , pp. 512-523
    • Hadri, L.1    Kratlian, R.G.2    Benard, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.