Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension

Circulation

Volumn 126, Issue 8, 2012, Pages 963-974

  Maron, Bradley A ^a,b   Zhang, Ying Yi ^a   White, Kevin ^a   Chan, Stephen Y ^a   Handy, Diane E ^a   Mahoney, Christopher E ^a   Loscalzo, Joseph ^a   Leopold, Jane A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b VA BOSTON HEALTHCARE SYSTEM   (United States)

Author keywords

aldosterone; endothelin; nitric oxide; pulmonary heart disease; redox biochemistry

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; CYSTEINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; ENDOTHELIN B RECEPTOR; EPLERENONE; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; SPIRONOLACTONE; THIOL GROUP;

ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LUNG ENDOTHELIUM; MALE; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PULMONARY HYPERTENSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ALDOSTERONE; ANIMALS; CELLS, CULTURED; CYSTEINE; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; ENDOTHELIN-1; HUMANS; HYPERTENSION, PULMONARY; MALE; MINERALOCORTICOID RECEPTOR ANTAGONISTS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATION-REDUCTION; OXIDATIVE STRESS; PULMONARY ARTERY; PULMONARY WEDGE PRESSURE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN B; SPIRONOLACTONE; SULFHYDRYL COMPOUNDS;

EID: 84865214267     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.094722     Document Type: Article

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