Human Anti-Lipopolysaccharid (LPS) antibodies against Legionella with high species specificity

Human Antibodies

Volumn 26, Issue 1, 2017, Pages 29-38

  Kuhn, Philipp ^a,f   Thiem, Stefanie ^a,b   Steinert, Michael ^a,c   Purvis, Duncan ^d   Lugmayr, Veronika ^e   Treutlein, Ulrich ^e   Plobner, Lutz ^e   Leiser, Robert Matthias ^e   Hust, Michael ^a   Dübel, Stefan ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^d Vantix DIAGNOSTICS   (United States)

^e Agrobiogen GmbH   (Germany)

^f YUMAB GmbH   (Germany)

Author keywords

antibody engineering; antibody fragments; biosensor; diagnostics; Legionella; LPS; panning; Phage display

Indexed keywords

ANTI LIPOPOLYSACCHARIDE ANTIBODY; ANTIBODY; UNCLASSIFIED DRUG; BACTERIUM ANTIBODY; IMMUNOGLOBULIN FC FRAGMENT; LIPOPOLYSACCHARIDE; RECOMBINANT PROTEIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

AFFINITY CHROMATOGRAPHY; ANTIBODY SPECIFICITY; ARTICLE; CLOSTRIDIACEAE; DNA SEQUENCE; ENTEROBACTERIACEAE; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; IMMUNOSENSOR; LEGIONELLA PNEUMOPHILA; NONHUMAN; PHAGE DISPLAY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PSEUDOMONADACEAE; SENSITIVITY AND SPECIFICITY; WESTERN BLOTTING; ANIMAL; ANTIBODY AFFINITY; BIOSYNTHESIS; CHEMISTRY; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; LIMIT OF DETECTION; MICROBIOLOGY; MOUSE; PEPTIDE LIBRARY; POND; PROCEDURES; PROTEIN STABILITY;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; LEGIONELLA PNEUMOPHILA; LIMIT OF DETECTION; LIPOPOLYSACCHARIDES; MICE; PEPTIDE LIBRARY; PONDS; PROTEIN STABILITY; RECOMBINANT PROTEINS; SINGLE-CHAIN ANTIBODIES; WATER MICROBIOLOGY;

EID: 85025816520     PISSN: 10932607     EISSN: 1875869X     Source Type: Journal    
DOI: 10.3233/HAB-170318     Document Type: Article

References (49)

1. Y.A. Kwaik, L.Y. Gao, B.J. Stone, C. Venkataraman and O.S. Harb, Invasion of protozoa by Legionella pneumophila and its role in bacterial ecology and pathogenesis, Appl Environ Microbiol 64 (1998), 3127-3133.
2. D.G. Addiss, J.P. Davis, M. LaVenture, P.J. Wand, M.A. Hutchinson and R.M. McKinney, Community-acquired Legionnaires' disease associated with a cooling tower: Evidence for longer-distance transport of Legionella pneumophila, Am J Epidemiol 130 (1989), 557-568.
3. H. Aurell, P. Catala, P. Farge, F.Wallet, M. Le Brun, J.H. Helbig, S. Jarraud and P. Lebaron, Rapid detection and enumeration of Legionella pneumophila in hot water systems by solidphase cytometry, Appl Environ Microbiol 70 (2004), 1651-1657.
4. C. Barthe, J.R. Joly, D. Ramsay, M. Boissinot and N. Benhamou, Common epitope on the lipopolysaccharide of Legionella pneumophila recognized by a monoclonal antibody, J Clin Microbiol 26 (1988), 1016-1023.
5. A. Borges, M. Simões, A. Martínez-Murcia and M. Saavedra, Detection of Legionella SPP in natural and man-made water systems using standard guidelines, Journal of Microbiology Research 2 (2012), 95-102.
6. J.A. Bozue and W. Johnson, Interaction of Legionella pneumophila with Acanthamoeba castellanii: Uptake by coiling phagocytosis and inhibition of phagosome-lysosome fusion, Infect Immun 64 (1996), 668-673.
7. D.J. Brenner, A.G. Steigerwalt and J.E. McDade, Classification of the Legionnaires' disease bacterium: Legionella pneumophila, genus novum, species nova, of the family Legionellaceae, familia nova, Ann Intern Med 90 (1979), 656-658.
8. S. Buchbinder, K. Trebesius and J. Heesemann, Evaluation of detection of Legionella SPP in water samples by fluorescence in itu hybridization, PCR amplification and bacterial culture, Int J Med Microbiol 292 (2002), 241-245.
9. L. Cai, Y. Yang, N. Jiao and R. Zhang, Evaluation of tangential flow filtration for the concentration and separation of bacteria and viruses in contrasting marine environments, PLoS One 10 (2015), e0136741.
10. C.A. Ciesielski, M.J. Blaser andW.L.Wang, Serogroup specificity of Legionella pneumophila is related to lipopolysaccharide characteristics, Infect Immun 51 (1986), 397-404.
11. N. Coetzee, H. Duggal, J. Hawker, S. Ibbotson, T.G. Harrison, N. Phin, V. Laza-Stanca, R. Johnston, Z. Iqbal, Y. Rehman, E. Knapper, S. Robinson and N. Aigbogun, An outbreak of Legionnaires' disease associated with a display spa pool in retail premises, Stoke-on-Trent, United Kingdom, July 2012, Euro Surveill 17 (2012).
12. M.R. Davis, Jr. and J.B. Goldberg, Purification and visualization of lipopolysaccharide from Gram-negative bacteria by hot aqueous-phenol extraction, J Vis Exp (2012).
13. R.B. Fitzgeorge, A. Baskerville, M. Broster, P. Hambleton and P.J. Dennis, Aerosol infection of animals with strains of Legionella pneumophila of different virulence: Comparison with intraperitoneal and intranasal routes of infection, J Hyg (Lond) 90 (1983), 81-89.
14. C.B. Fliermans, W.B. Cherry, L.H. Orrison, S.J. Smith, D.L. Tison and D.H. Pope, Ecological distribution of Legionella pneumophila, Appl Environ Microbiol 41 (1981), 9-16.
15. D.W. Fraser, T.R. Tsai, W. Orenstein, W.E. Parkin, H.J. Beecham, R.G. Sharrar, J. Harris, G.F. Mallison, S.M. Martin, J.E. McDade, C.C. Shepard and P.S. Brachman, Legionnaires' disease: Description of an epidemic of pneumonia, N Engl J Med 297 (1977), 1189-1197.
16. A. Frenzel, J. Kügler, S. Wilke, T. Schirrmann and M. Hust, Construction of human antibody gene libraries and selection of antibodies by phage display, Methods Mol Biol 1060 (2014), 215-243.
17. L.Y. Gao, O.S. Harb and Y.A. Kwaik, Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant host cells, mammalian macrophages and protozoa, Infect Immun 65 (1997), 4738-4746.
18. R.A. Griep, C. van Twisk, J.R. van Beckhoven, J.M. van der Wolf and A. Schots, Development of specific recombinant monoclonal antibodies against the lipopolysaccharide of ralstonia solanacearum race 3, Phytopathology 88 (1998), 795-803.
19. J.G. Guillet, J. Hoebeke, C. Tram, S. Marullo and A.D. Strosberg, Characterization, serological specificity, and diagnostic possibilities of monoclonal antibodies against Legionella pneumophila, J Clin Microbiol 18 (1983), 793-797.
20. D. Harper, Minimising the spread of Legionnaires' disease-a programme designed to prevent incubation of LP in hospital water and air conditioning systems, Hosp Eng 38 (1984), 5-9.
21. J.H. Helbig, J.B. Kurtz, M.C. Pastoris, C. Pelaz and P.C. Luck, Antigenic lipopolysaccharide components of Legionella pneumophila recognized by monoclonal antibodies: Possibilities and limitations for division of the species into serogroups, J Clin Microbiol 35 (1997), 2841-2845.
22. J.H. Helbig, P.C. Luck, Y.A. Knirel, W. Witzleb and U. Zahringer, Molecular characterization of a virulenceassociated epitope on the lipopolysaccharide of Legionella pneumophila serogroup 1, Epidemiol Infect 115 (1995), 71-78.
23. V. Jager, K. Bussow, A. Wagner, S. Weber, M. Hust, A. Frenzel and T. Schirrmann, High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells, BMC Biotechnol 13 (2013), 52.
24. R.I. Jepras, R.B. Fitzgeorge and A. Baskerville, A comparison of virulence of two strains of Legionella pneumophila based on experimental aerosol infection of guinea-pigs, J Hyg (Lond) 95 (1985), 29-38.
25. D. Jurgens and F.J. Fehrenbach, Cross-reacting lipopolysaccharide antigens in Legionella pneumophila serogroups 1 to 14, Infect Immun 63 (1995), 2180-2184.
26. Y.A. Knirel, E.T. Rietschel, R. Marre and U. Zahringer, The structure of the O-specific chain of Legionella pneumophila serogroup 1 lipopolysaccharide, Eur J Biochem 221 (1994), 239-245.
27. N. Kobayashi, H. Oyama, Y. Kato, J. Goto, E. Soderlind and C.A. Borrebaeck, Two-step in vitro antibody affinity maturation enables estradiol-17beta assays with more than 10-fold higher sensitivity, Anal Chem 82 (2010), 1027-1038.
28. O. Kooistra, E. Luneberg, B. Lindner, Y.A. Knirel, M. Frosch and U. Zahringer, Complex O-acetylation in Legionella pneumophila serogroup 1 lipopolysaccharide, evidence for two genes involved in 8-O-acetylation of legionaminic acid, Biochemistry 40 (2001), 7630-7640.
29. L.H. Krojgaard, K.A. Krogfelt, H.J. Albrechtsen and S.A. Uldum, Detection of Legionella by quantitative-polymerase chain reaction (qPCR) for monitoring and risk assessment, BMC Microbiol 11 (2011), 254.
30. J. Kügler, S. Wilke, D. Meier, F. Tomszak, A. Frenzel, T. Schirrmann, S. Dubel, H. Garritsen, B. Hock, L. Toleikis, M. Schuttend M. Hust, Generation and analysis of the improved human HAL9/10 antibody phage display libraries, BMC Biotechnol 15 (2015), 10.
31. P. Kuhn, V. Fuhner, T. Unkauf, G.M. Moreira, A. Frenzel, S. Miethe and M. Hust, Recombinant antibodies for diagnostics and therapy against pathogens and toxins generated by phage display, Proteomics Clin Appl (2016).
32. X. Li, D. Lu, Z. Sheng, K. Chen, X. Guo, M. Jin and H. Han, A fast and sensitive immunoassay of avian influenza virus based on label-free quantum dot probe and lateral flow test strip, Talanta 100 (2012), 1-6.
33. C.E. Lucas, T.H. Taylor, Jr. and B.S. Fields, Accuracy and precision of Legionella isolation by US laboratories in the ELITE program pilot study, Water Res 45 (2011), 4428-4436.
34. P.O. Magalhaes, A.M. Lopes, P.G. Mazzola, C. Rangel-Yagui, T.C. Penna and A. Pessoa, Jr., Methods of endotoxin removal from biological preparations: a review, J Pharm Pharm Sci 10 (2007), 388-404.
35. E. Mauriz, A. Calle, J.J. Manclus, A. Montoya, A. Hildebrandt, D. Barcelo and L.M. Lechuga, Optical immunosensor for fast and sensitive detection of DDT and related compounds in river water samples, Biosens Bioelectron 22 (2007), 1410-1418.
36. B.J. McCarthy and A.S. Hill, Altering the fine specificity of an anti-Legionella single chain antibody by a single amino acid insertion, J Immunol Methods 251 (2001), 137-149.
37. G.K. Morris, C.M. Patton, J.C. Feeley, S.E. Johnson, G. Gorman, W.T. Martin, P. Skaliy, G.F. Mallison, B.D. Politi and D.C. Mackel, Isolation of the Legionnaires' disease bacterium from environmental samples, Ann Intern Med 90 (1979), 664-666.
38. H. Nikaido, Outer membrane, Escherichia Coli and Salmonella (1996), 29-47.
39. F.S. Nolte, C.A. Conlin and M.A. Motley, Electrophoretic and serological characterization of the lipopolysaccharides of Legionella pneumophila, Infect Immun 52 (1986), 676-681.
40. M. Palusinska-Szysz and M. Cendrowska-Pinkosz, Pathogenicity of the family Legionellaceae, Arch Immunol Ther Exp (Warsz) 57 (2009), 279-290.
41. L. Pei, M. Rieger, S. Lengger, S. Ott, C. Zawadsky, N.M. Hartmann, H.C. Selinka, A. Tiehm, R. Niessner and M. Seidel, Combination of crossflow ultrafiltration, monolithic affinity filtration, and quantitative reverse transcriptase PCR for rapid concentration and quantification of model viruses in water, Environ Sci Technol 46 (2012), 10073-10080.
42. F. Petitjean, J.G. Guillet, B. Vray, J. Hoebeke, C. Tram and A.D. Strosberg, Standardization for diagnostic purposes of a monoclonal antibody against Legionella pneumophila, Dev Biol Stand 57 (1984), 99-105.
43. U. Reidt, B. Geisberger, C. Heller and A. Friedberger, Automated immunomagnetic processing and separation of Legionella pneumophila with manual detection by sandwich ELISA and PCR amplification of the ompS gene, J Lab Autom 16 (2011), 157-164.
44. Robert-Koch-Institut, Legionãrskrankheit in Deutschland (2001 bis 2013), in: Epidemiologisches Bulletin, Nr 13, 2015.
45. T.J. Rowbotham, Preliminary report on the pathogenicity of Legionella pneumophila for freshwater and soil amoebae, J Clin Pathol 33 (1980), 1179-1183.
46. J.O. Tobin, J. Beare, M.S. Dunnill, S. Fisher-Hoch, M. French, R.G. Mitchell, P.J. Morris and M.F. Muers, Legionnaires' disease in a transplant unit: Isolation of the causative agent from shower baths, Lancet 2 (1980), 118-121.
47. H. von Baum, S. Ewig, R. Marre, N. Suttorp, S. Gonschior, T. Welte, C. Luck and G. Competence, Network for community acquired pneumonia study, community-acquired legionella pneumonia: New insights from the German competence network for community acquired pneumonia, Clin Infect Dis 46 (2008), 1356-1364.
48. A. Wunderlich, C. Torggler, D. Elsasser, C. Luck, R. Niessner and M. Seidel, Rapid quantification method for Legionella pneumophila in surface water, Anal Bioanal Chem 408 (2016), 2203-2213.
49. V.L. Yu, J.F. Plouffe, M.C. Pastoris, J.E. Stout, M. Schousboe, A.Widmer, J. Summersgill, T. File, C.M. Heath, D.L. Paterson and A. Chereshsky, Distribution of Legionella species and serogroups isolated by culture in patients with sporadic community-acquired legionellosis: An international collaborative survey, J Infect Dis 186 (2002), 127-128.