Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia

Cell Stem Cell

Volumn 21, Issue 2, 2017, Pages 195-208.e6

  Windrem, Martha S ^a   Osipovitch, Mikhail ^b   Liu, Zhengshan ^a   Bates, Janna ^a   Chandler Militello, Devin ^a   Zou, Lisa ^a   Munir, Jared ^a   Schanz, Steven ^a   McCoy, Katherine ^a   Miller, Robert H ^d   Wang, Su ^a   Nedergaard, Maiken ^a,b   Findling, Robert L ^e   Tesar, Paul J ^f   Goldman, Steven A ^a,b,c  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c University of Copenhagen   (Denmark)

^d GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

astrocyte; childhood onset schizophrenia; dysmyelination; glia; glial differentiation; induced pluripotent stem cell; iPSC; mouse models; myelin; schizophrenia

Indexed keywords

CELL NUCLEUS ANTIGEN; ELAV LIKE PROTEIN 4; FIBROBLAST GROWTH FACTOR 14; GABA TRANSPORTER 1; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN 19; HERMES ANTIGEN; HOMEOBOX PROTEIN NKX-2.5; KRUPPEL LIKE FACTOR 4; MESSENGER RNA; MYC PROTEIN; MYELIN; MYELIN BASIC PROTEIN; NEUREXIN 1; NEUROLIGIN 1; OCTAMER TRANSCRIPTION FACTOR 4; OLIGODENDROCYTE MYELIN GLYCOPROTEIN; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; POTASSIUM CHANNEL KV1.3; RNA BINDING PROTEIN; SIRTUIN 2; STAGE SPECIFIC EMBRYO ANTIGEN 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 7 LIKE 2; TRANSCRIPTION FACTOR NKX2.2; TRANSCRIPTION FACTOR SOX10; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG; WNT7B PROTEIN;

ABNORMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTISOCIAL BEHAVIOR; ANXIETY; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CHIMERA; CONTROLLED STUDY; DNA FINGERPRINTING; FIBROBLAST; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GLIA CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; INDUCED PLURIPOTENT STEM CELL; MORPHOLOGY; MOUSE; MYELINATION; NONHUMAN; PATHOGENESIS; PATHOLOGY; PRIORITY JOURNAL; RNA SEQUENCE; SCHIZOPHRENIA; SHIVERER MOUSE; SHORT TANDEM REPEAT; SLEEP DISORDER; ANIMAL; ASTROCYTE; BEHAVIOR; GENE EXPRESSION REGULATION; GENETICS; GLIA; METABOLISM; MYELIN SHEATH; PHENOTYPE;

ANIMALS; ASTROCYTES; BEHAVIOR; CELL DIFFERENTIATION; CHIMERA; GENE EXPRESSION REGULATION; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; MYELIN SHEATH; NEUROGLIA; PHENOTYPE; SCHIZOPHRENIA;

EID: 85025471352     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2017.06.012     Document Type: Article

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