Smooth pursuit eye movement, prepulse inhibition, and auditory paired stimuli processing endophenotypes across the schizophrenia-bipolar disorder psychosis dimension

Schizophrenia Bulletin

Volumn 40, Issue 3, 2014, Pages 642-652

  Ivleva, Elena I ^a   Moates, Amanda F ^a   Hamm, Jordan P ^b   Bernstein, Ira H ^a   O'Neill, Hugh B ^c   Cole, Darwynn ^a   Clementz, Brett A ^b   Thaker, Gunvant K ^c   Tamminga, Carol A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

auditory ERP; bipolar disorder; prepulse inhibition; psychosis; schizophrenia; smooth pursuit eye movement

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; LITHIUM DERIVATIVE; MOOD STABILIZER; NEUROLEPTIC AGENT;

ADULT; ALPHA RHYTHM; ARTICLE; BETA RHYTHM; BIPOLAR I DISORDER; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ELECTRONEUROLOGY; ENDOPHENOTYPE; EVOKED AUDITORY RESPONSE; FEMALE; FREQUENCY DISCRIMINATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PREPULSE INHIBITION; PRIORITY JOURNAL; PSYCHIATRIC TREATMENT; SCHIZOPHRENIA; SMOOTH PURSUIT EYE MOVEMENT; THETA RHYTHM; TREND STUDY; ADOLESCENT; BIPOLAR DISORDER; CASE CONTROL STUDY; EYE MOVEMENT DISORDER; FAMILY; GENETICS; MIDDLE AGED; PATHOPHYSIOLOGY; PERCEPTION DEAFNESS; PHYSIOLOGY; PSYCHOLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; AUDITORY PERCEPTUAL DISORDERS; BIPOLAR DISORDER; CASE-CONTROL STUDIES; EVOKED POTENTIALS, AUDITORY; FAMILY; FEMALE; HUMANS; MALE; MIDDLE AGED; OCULAR MOTILITY DISORDERS; PREPULSE INHIBITION; PURSUIT, SMOOTH; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; YOUNG ADULT;

EID: 84899014092     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbt047     Document Type: Article

References (49)

1. Ivleva EI, Morris DW, Moates AF, Suppes T, Thaker GK, Tamminga CA. Genetics and intermediate phenotypes of the schizophrenia-bipolar disorder boundary. Neurosci Biobehav Rev. 2010;34:897-921.
2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), 4th ed. Washington, DC: American Psychiatric Association; 1994.
3. Gottesman II, Shields J. Genetic theorizing and schizophrenia. Br J Psychiatry. 1973;122:15-30.
4. Thaker GK. Neurophysiological endophenotypes across bipolar and schizophrenia psychosis. Schizophr Bull. 2008;34:760-773.
5. Gooding DC, Iacono WG, Katsanis J, Beiser M, Grove WM. The association between lithium carbonate and smooth pursuit eye tracking among first-episode patients with psychotic affective disorders. Psychophysiology. 1993;30:3-9.
6. Braff DL, Geyer MA, Swerdlow NR. Human studies of prepulse inhibition of startle: Normal subjects, patient groups, and pharmacological studies. Psychopharmacology (Berl). 2001;156:234-258.
7. Kumari V, Das M, Zachariah E, Ettinger U, Sharma T. Reduced prepulse inhibition in unaffected siblings of schizophrenia patients. Psychophysiology. 2005;42:588-594.
8. Wynn JK, Dawson ME, Schell AM, McGee M, Salveson D, Green MF. Prepulse facilitation and prepulse inhibition in schizophrenia patients and their unaffected siblings. Biol Psychiatry. 2004;55:518-523.
9. Perry W, Minassian A, Feifel D, Braff DL. Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania. Biol Psychiatry. 2001;50:418-424.
10. Barrett SL, Kelly C, Watson DR, Bell R, King DJ. Normal levels of prepulse inhibition in the euthymic phase of bipolar disorder. Psychol Med. 2005;35:1737-1746.
11. Brockhaus-Dumke A, Schultze-Lutter F, Mueller R, et al. Sensory gating in schizophrenia: P50 and N100 gating in antipsychotic-free subjects at risk, first-episode, and chronic patients. Biol Psychiatry. 2008;64:376-384.
12. Hamm JP, Ethridge LE, Shapiro JR, et al. Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis. Psychophysiology. 2012;49:522-530.
13. Clementz BA, Geyer MA, Braff DL. Poor P50 suppression among schizophrenia patients and their first-degree biological relatives. Am J Psychiatry. 1998;155:1691-1694.
14. Schulze KK, Hall MH, McDonald C, et al. P50 auditory evoked potential suppression in bipolar disorder patients with psychotic features and their unaffected relatives. Biol Psychiatry. 2007;62:121-128.
15. Clementz BA, Blumenfeld LD. Multichannel electroencephalographic assessment of auditory evoked response suppression in schizophrenia. Exp Brain Res. 2001;139:377-390.
16. Chang WP, Arfken CL, Sangal MP, Boutros NN. Probing the relative contribution of the first and second responses to sensory gating indices: A meta-Analysis. Psychophysiology. 2011;48:980-992.
17. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured clinical interview for DSM-IV Axis I Disorders/Patient Edition (SCID-I/P). New York: New York State Psychiatric Institute, Biometrics Research Department; 1996.
18. Zanarini MC, Frankenburg FR, Sickel AE, Yong L. The Diagnostic Interview for DSM-IV Personality Disorders (DIP DIV). Belmont: McLean Hospital; 1996.
19. Overall JE, Gorham DR. The Brief Psychiatric Rating Scale. Psychological Reports. 1962;10:799-812.
20. Thaker GK, Avila MT, Hong EL, Medoff DR, Ross DE, Adami HM. A model of smooth pursuit eye movement deficit associated with the schizophrenia phenotype. Psychophysiology. 2003;40:277-284.
21. Thaker GK, Ross DE, Cassady SL, et al. Smooth pursuit eye movements to extraretinal motion signals: Deficits in relatives of patients with schizophrenia. Arch Gen Psychiatry. 1998;55:830-836.
22. Hong LE, Summerfelt A, Wonodi I, Adami H, Buchanan RW, Thaker GK. Independent domains of inhibitory gating in schizophrenia and the effect of stimulus interval. Am J Psychiatry. 2007;164:61-65.
23. Hamm AO, Weike AI, Schupp HT. The effect of neuroleptic medication on prepulse inhibition in schizophrenia patients: Current status and future issues. Psychopharmacology (Berl). 2001;156:259-265.
24. Delorme A, Makeig S. EEGLAB: An open source toolbox for analysis of single-Trial EEG dynamics including independent component analysis. J Neurosci Methods. 2004;134:9-21.
25. Ethridge LE, Hamm JP, Shapiro JR, et al. Neural activations during auditory oddball processing discriminating schizophrenia and psychotic bipolar disorder. Biol Psychiatry. 2012;72:766-774.
26. O'Driscoll GA, Callahan BL. Smooth pursuit in schizophrenia: A meta-Analytic review of research since 1993. Brain Cogn. 2008;68:359-370.
27. Avila MT, McMahon RP, Elliott AR, Thaker GK. Neurophysiological markers of vulnerability to schizophrenia: Sensitivity and specificity of specific quantitative eye movement measures. J Abnorm Psychol. 2002;111:259-267.
28. Kathmann N, Hochrein A, Uwer R, Bondy B. Deficits in gain of smooth pursuit eye movements in schizophrenia and affective disorder patients and their unaffected relatives. Am J Psychiatry. 2003;160:696-702.
29. Hong LE, Avila MT, Adami H, Elliot A, Thaker GK. Components of the smooth pursuit function in deficit and nondeficit schizophrenia. Schizophr Res. 2003;63:39-48.
30. Moates AF, Ivleva EI, O'Neill HB, et al. Predictive pursuit association with deficits in working memory in psychosis. Biol Psychiatry. 2012;72:752-757.
31. Lencer R, Reilly JL, Harris MS, Sprenger A, Keshavan MS, Sweeney JA. Sensorimotor transformation deficits for smooth pursuit in first-episode affective psychoses and schizophrenia. Biol Psychiatry. 2010;67:217-223.
32. Calkins ME, Iacono WG, Ones DS. Eye movement dysfunction in first-degree relatives of patients with schizophrenia: A meta-Analytic evaluation of candidate endophenotypes. Brain Cogn. 2008;68:436-461.
33. Brenner CA, Kieffaber PD, Clementz BA, et al. Event-related potential abnormalities in schizophrenia: A failure to 'gate in' salient information? Schizophr Res. 2009;113:332-338.
34. Hong LE, Summerfelt A, McMahon RP, Thaker GK, Buchanan RW. Gamma/beta oscillation and sensory gating deficit in schizophrenia. Neuroreport. 2004;15:155-159.
35. Hong LE, Summerfelt A, Mitchell BD, et al. Sensory gating endophenotype based on its neural oscillatory pattern and heritability estimate. Arch Gen Psychiatry. 2008;65:1008-1016.
36. Ford JM, Roth WT, Menon V, Pfefferbaum A. Failures of automatic and strategic processing in schizophrenia: Comparisons of event-related brain potential and startle blink modification. Schizophr Res. 1999;37:149-163.
37. Mackeprang T, Kristiansen KT, Glenthoj BY. Effects of antipsychotics on prepulse inhibition of the startle response in drug-naïve schizophrenic patients. Biol Psychiatry. 2002;52:863-873.
38. Kumari V, Ettinger U, Crawford TJ, Zachariah E, Sharma T. Lack of association between prepulse inhibition and antisaccadic deficits in chronic schizophrenia: Implications for identification of schizophrenia endophenotypes. J Psychiatr Res. 2005;39:227-240.
39. Ettinger U, Hejda S, Flak V, Corr PJ. Prepulse inhibition of the acoustic startle reflex and oculomotor control. Psychophysiology. 2005;42:473-482.
40. Price GW, Michie PT, Johnston J, et al. A multivariate electrophysiological endophenotype, from a unitary cohort, shows greater research utility than any single feature in the Western Australian family study of schizophrenia. Biol Psychiatry. 2006;60:1-10.
41. Grunwald T, Boutros NN, Pezer N, et al. Neuronal substrates of sensory gating within the human brain. Biol Psychiatry. 2003;53:511-519.
42. Swerdlow NR, Geyer MA, Braff DL. Neural circuit regulation of prepulse inhibition of startle in the rat: Current knowledge and future challenges. Psychopharmacology (Berl). 2001;156:194-215.
43. Arolt V, Lencer R, Purmann S, et al. Testing for linkage of eye tracking dysfunction and schizophrenia to markers on chromosomes 6, 8, 9, 20, and 22 in families multiply affected with schizophrenia. Am J Med Genet. 1999;88:603-606.
44. Matthysse S, Holzman PS, Gusella JF, et al. Linkage of eye movement dysfunction to chromosome 6p in schizophrenia: Additional evidence. Am J Med Genet B Neuropsychiatr Genet. 2004;128B:30-36.
45. Hong LE, Wonodi I, Stine OC, Mitchell BD, Thaker GK. Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibition. Biol Psychiatry. 2008;63:17-23.
46. Roussos P, Giakoumaki SG, Rogdaki M, Pavlakis S, Frangou S, Bitsios P. Prepulse inhibition of the startle reflex depends on the catechol O-methyltransferase Val158Met gene polymorphism. Psychol Med. 2008;38:1651-1658.
47. Roussos P, Giakoumaki SG, Bitsios P. A risk PRODH haplotype affects sensorimotor gating, memory, schizotypy, and anxiety in healthy male subjects. Biol Psychiatry. 2009;65:1063-1070.
48. Leonard S, Gault J, Hopkins J, et al. Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. Arch Gen Psychiatry. 2002;59:1085-1096.
49. Myles-Worsley M, Coon H, McDowell J, et al. Linkage of a composite inhibitory phenotype to a chromosome 22q locus in eight Utah families. Am J Med Genet. 1999;88:544-550.