Genome-wide pleiotropy between Parkinson disease and autoimmune diseases

JAMA Neurology

Volumn 74, Issue 7, 2017, Pages 780-792

  Witoelar, Aree ^a,b   Jansen, Iris E ^c,d   Wang, Yunpeng ^a,e   Desikan, Rahul S ^e,f   Gibbs, J Raphael ^g,s   Blauwendraat, Cornelis ^d   Thompson, Wesley K ^e,h   Hernandez, Dena G ^d,g,s   Djurovic, Srdjan ^a,b   Schork, Andrew J ^e   Bettella, Francesco ^a,az   Ellinghaus, David ⁱ   Franke, Andre ⁱ   Lie, Benedicte A ^a,b,j,k   McEvoy, Linda K ^e,j   Karlsen, Tom H ^j,k,l,m   Lesage, Suzanne ^n,o,p,q   Morris, Huw R ^r   Brice, Alexis ^n,o,p,q   Wood, Nicholas W ^r,s   Heutink, Peter ^c,d,t   Hardy, John ^r,s   Singleton, Andrew B ^g   Dale, Anders M ^e   Gasser, Thomas ^d,t   Andreassen, Ole A ^a   Sharma, Manu ^d,t,u   Nalls, Mike A ^g   Plagnol, Vincent ^r   Sheerin, Una Marie ^s   Saad, Mohamad ^o,v   Simon Sanchez, Javier ^d,t   Schulte, Claudia ^t   Sveinbjornsdottir, Sigurlaug ^w,x,y   Arepalli, Sampath ^g   Barker, Roger ^z   Ben Shlomo, Yoav ^aa   Berendse, Henk W ^ab   Berg, Daniela ^d,t   Bhatia, Kailash ^s   De Bie, Rob M A ^ac   Biffi, Alessandro ^ad,ae   Bloem, Bas ^af   Bochdanovits, Zoltan ^c   Bonin, Michael ^u   Bras, Jose M ^s   Brockmann, Kathrin ^d,t   Brooks, Janet ^g   Burn, David J ^ag   Majounie, Elisa ^g   Charlesworth, Gavin ^s   Lungu, Codrin ^ah   Chen, Honglei ^ai   Chinnery, Patrick F ^aj   Chong, Sean ^g   Clarke, Carl E ^ak,al   Cookson, Mark R ^g   Cooper, J Mark ^s   Corvol, Jean Christophe ^o,p,q   Counsell, Carl ^am   Damier, Philippe ^an   Dartigues, Jean Francois ^o   Deloukas, Panos ^ao   Deuschl, Gunther ^ap   Dexter, David T ^aq   Van Dijk, Karin D ^ab   Dillman, Allissa ^g   Durif, Frank ^ar   Durr, Alexandra ^o,p,q   Edkins, Sarah ^ao   Evans, Jonathan R ^as   Foltynie, Thomas ^s   Dong, Jing ^ai   Gardner, Michelle ^s   Goate, Alison ^at   Gray, Emma ^ao   Guerreiro, Rita ^s   Harris, Clare ^am   Van Hilten, Jacobus J ^au   Hofman, Albert ^av   Hollenbeck, Albert ^aw   Holton, Janice ^s   Hu, Michele ^ax   Huang, Xuemei ^ay   Wurster, Isabel ^d,t   Matzler, Walter ^d,t   Hudson, Gavin ^aj   Hunt, Sarah E ^ao   Huttenlocher, Johanna ^az   Illig, Thomas ^ba   Jonsson, Palmi V ^w   Lambert, Jean Charles ^o,bb   Langford, Cordelia ^as   Lees, Andrew ^s   Lichtner, Peter ^ba   Limousin, Patricia ^s   Lopez, Grisel ^bc   Lorenz, Delia ^ap   McNeill, Alisdair ^s   Moorby, Catriona ^ak   Moore, Matthew ^g   Morrison, Karen E ^ak,bd   Escott Price, Valentina ^be   Mudanohwo, Ese ^r,s   O'Sullivan, Sean S ^s   Pearson, Justin ^be   Perlmutter, Joel S ^bf   Petursson, Hjorvar ^u,az   Pollak, Pierre ^bg   Post, Bart ^af   Potter, Simon ^ao   Ravina, Bernard ^bh   Revesz, Tamas ^s   Riess, Olaf ^u   Rivadeneira, Fernando ^av   Rizzu, Patrizia ^c   Ryten, Mina ^s   Sawcer, Stephen ^bi   Schapira, Anthony ^s   Scheffer, Hans ^af   Shaw, Karen ^s   Shoulson, Ira ^bj   Shulman, Joshua ^bk   Sidransky, Ellen ^bc   Smith, Colin ^bl   Spencer, Chris C A ^bm   Stefansson, Hreinn ^az   Stockton, Joanna D ^ak   Strange, Amy ^bm   Talbot, Kevin ^ax   Tanner, Carlie M ^bn   Tashakkori Ghanbaria, Avazeh ^ao   Tison, Francois ^bo   Trabzuni, Daniah ^o,s   Traynor, Bryan J ^g   Uitterlinden, Andre G ^av   Velseboer, Daan ^ac   Vidailhet, Marie ^o   Walker, Robert ^bl   Van De Warrenburg, Bart ^af   Wickremaratchi, Mirdhu ^bp   Williams, Nigel ^be   Williams Gray, Caroline H ^z   Winder Rhodes, Sophie ^bq   Stefansson, Kari ^az   Martinez, Maria ^v   Ferrucci, Luigi ^g   Johnson, Robert ^br   Longo, Dan L ^g   Nalls, Michael A ^g   O'Brien, Richard ^bs   Troncoso, Juan ^bs   Van Der Brug, Marcel ^g,bt   Zielke, H Ronald ^br   Zonderman, Alan ^g   Weale, Mike ^bu   more..

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g NATIONAL INSTITUTE ON AGING   (United States)

^h UNIVERSITY OF COPENHAGEN   (Denmark)

ⁱ UNIVERSITY OF KIEL   (Germany)

^j OSLO UNIVERSITY HOSPITAL   (Norway)

^k OSLO UNIVERSITY HOSPITAL   (Norway)

^l UNIVERSITY OF BERGEN   (Norway)

^m Division of Cancer   (Norway)

ⁿ SORBONNE UNIVERSITÉ   (France)

^o INSERM   (France)

^p CNRS   (France)

^q PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^r UNIVERSITY COLLEGE LONDON   (United Kingdom)

^s UNIVERSITY COLLEGE LONDON   (United Kingdom)

^t UNIVERSITY OF TÜBINGEN   (Germany)

^u UNIVERSITY OF TÜBINGEN   (Germany)

^v University of Toulouse III   (France)

^w LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^x BROOMFIELD HOSPITAL   (United Kingdom)

^y QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^z UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^aa UNIVERSITY OF BRISTOL   (United Kingdom)

^ab VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^ac UNIVERSITY OF AMSTERDAM   (Netherlands)

^ad MASSACHUSETTS GENERAL HOSPITAL   (United States)

^ae BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^af RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^ag NEWCASTLE UNIVERSITY   (United Kingdom)

^ah NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^ai NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^aj NEWCASTLE UNIVERSITY   (United Kingdom)

^ak UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^al CITY HOSPITAL   (United Kingdom)

^am UNIVERSITY OF ABERDEEN   (United Kingdom)

^an NANTES UNIVERSITY HOSPITAL   (France)

^ao WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^ap UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^aq IMPERIAL COLLEGE LONDON   (United Kingdom)

^ar SERVICE DE RHUMATOLOGIE   (France)

^as UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^at WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^au LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^av ERASMUS MEDICAL CENTER   (Netherlands)

^aw AARP   (United States)

^ax UNIVERSITY OF OXFORD   (United Kingdom)

^ay PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^az DECODE GENETICS   (Iceland)

^ba INSTITUTE OF EPIDEMIOLOGY   (Germany)

^bb UNIV LILLE   (France)

^bc NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^bd QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^be CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^bf WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bg GRENOBLE UNIVERSITY HOSPITAL   (France)

^bh BIOGEN   (United States)

^bi UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^bj UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^bk BAYLOR COLLEGE OF MEDICINE   (United States)

^bl UNIVERSITY OF EDINBURGH   (United Kingdom)

^bm UNIVERSITY OF OXFORD   (United Kingdom)

^bn PARKINSON S INSTITUTE   (United States)

^bo HAUT LÉVÊQUE HOSPITAL   (France)

^bp CARDIFF UNIVERSITY   (United Kingdom)

^bq UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^br UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^bs JOHNS HOPKINS UNIVERSITY   (United States)

^bt GENENTECH INC   (United States)

^bu KING'S COLLEGE LONDON   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUTOIMMUNE DISEASE; BOLA2 GENE; CELIAC DISEASE; CRHR1 GENE; CROHN DISEASE; GAK GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; GUCY1A3 GENE; HLA DRB5 GENE; HLA GENE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; KANSL1 GENE; LRRK2 GENE; MAJOR CLINICAL STUDY; MAPT GENE; METHYLATION; MULTIPLE SCLEROSIS; OUTCOME ASSESSMENT; PARKINSON DISEASE; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PSORIASIS; RHEUMATOID ARTHRITIS; SETD1A GENE; TRIM10 GENE; ULCERATIVE COLITIS; WNT3 GENE; GENETIC PREDISPOSITION; GENETICS; RISK FACTOR;

ARTHRITIS, RHEUMATOID; AUTOIMMUNE DISEASES; CELIAC DISEASE; COLITIS, ULCERATIVE; CROHN DISEASE; DIABETES MELLITUS, TYPE 1; GENETIC LOCI; GENETIC PLEIOTROPY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MULTIPLE SCLEROSIS; PARKINSON DISEASE; PSORIASIS; RISK FACTORS;

EID: 85024384526     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2017.0469     Document Type: Article

References (76)

1. Simon-Sanchez J, Schulte C, Bras JM, et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet. 2009; 41(12):1308-1312.
2. Keller MF, Saad M, Bras J, et al; International Parkinson's Disease Genomics Consortium (IPDGC); Wellcome Trust Case Control Consortium 2 (WTCCC2). Using genome-wide complex trait analysis to quantify "missing heritability" in Parkinson's disease. Hum Mol Genet. 2012;21(22): 4996-5009.
3. Nalls MA, Pankratz N, Lill CM, et al; International Parkinson's Disease Genomics Consortium (IPDGC); Parkinson's Study Group (PSG) Parkinson's Research: The Organized Genetics Initiative (PROGENI); 23andMe; GenePD; NeuroGenetics Research Consortium (NGRC); Hussman Institute of Human Genomics (HIHG); Ashkenazi Jewish Dataset Investigator; Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE); North American Brain Expression Consortium (NABEC); United Kingdom Brain Expression Consortium (UKBEC); Greek Parkinson's Disease Consortium; Alzheimer Genetic Analysis Group. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet. 2014;46(9):989-993.
4. Nalls MA, Plagnol V, Hernandez DG, et al; International Parkinson Disease Genomics Consortium. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: ameta-analysis of genome-wide association studies. Lancet. 2011;377(9766):641-649.
5. Holmans P, Moskvina V, Jones L, et al. A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease. Hum Mol Genet. 2012.
6. McCarthy MI, Abecasis GR, Cardon LR, et al. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet. 2008;9(5):356-369.
7. Khandelwal PJ, Herman AM, Moussa CE. Inflammation in the early stages of neurodegenerative pathology. J Neuroimmunol. 2011;238(1-2):1-11.
8. Akiyama H, Barger S, Barnum S, et al. Inflammation and Alzheimer's disease. Neurobiol Aging. 2000;21(3):383-421.
9. Phani S, Loike JD, Przedborski S. Neurodegeneration and inflammation in Parkinson's disease. Parkinsonism Relat Disord. 2012;18(suppl 1):S207-S209.
10. McGeer PL,McGeer EG. Inflammation and neurodegeneration in Parkinson's disease. Parkinsonism Relat Disord. 2004;10(suppl 1):S3-S7.
11. Arai H, Furuya T, Mizuno Y, Mochizuki H. Inflammation and infection in Parkinson's disease. Histol Histopathol. 2006;21(6):673-678.
12. Li X, Sundquist J, Sundquist K. Subsequent risks of Parkinson disease in patients with autoimmune and related disorders: a nationwide epidemiological study from Sweden. Neurodegener Dis. 2012;10(1-4):277-284.
13. Rugbjerg K, Friis S, Ritz B, Schernhammer ES, Korbo L, Olsen JH. Autoimmune disease and risk for Parkinson disease: a population-based case-control study. Neurology. 2009;73(18):1462-1468.
14. Pedemonte E, Trabucco E, Cella M, Solaro C. Parkinsonism in multiple sclerosis patients: a casual or causal association? Parkinsonism Relat Disord. 2013;19(4):492-493.
15. Vieregge P, KlostermannW, Bruckmann H. Parkinsonism in multiple sclerosis. Mov Disord. 1992;7(4):380-382.
16. Nielsen NM, Pasternak B, Stenager E, Koch-Henriksen N, Frisch M. Multiple sclerosis and risk of Parkinson's disease: a Danish nationwide cohort study. Eur J Neurol. 2014;21(1):107-111. Medline:24053187
17. Chen H, Jacobs E, Schwarzschild MA, et al. Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease. Ann Neurol. 2005;58 (6):963-967.
18. Chen H, Zhang SM, Hernan MA, et al. Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease. Arch Neurol. 2003;60(8): 1059-1064.
19. Mosley RL, Hutter-Saunders JA, Stone DK, Gendelman HE. Inflammation and adaptive immunity in Parkinson's disease. Cold Spring Harb Perspect Med. 2012;2(1):a009381.
20. Zimprich A, Biskup S, Leitner P, et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron. 2004;44 (4):601-607.
21. Barrett JC, Hansoul S, Nicolae DL, et al; NIDDK IBD Genetics Consortium; Belgian-French IBD Consortium;Wellcome Trust Case Control Consortium. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet. 2008;40(8):955-962.
22. Nalls MA, Saad M, Noyce AJ, et al; International Parkinson's Disease Genomics Consortium (IPDGC); Wellcome Trust Case Control Consortium 2 (WTCCC2); North American Brain Expression Consortium (NABEC); United Kingdom Brain Expression Consortium (UKBEC). Genetic comorbidities in Parkinson's disease. Hum Mol Genet. 2014;23(3):831-841.
23. Yokoyama JS,Wang Y, Schork AJ, et al; Alzheimer's Disease Neuroimaging Initiative. Association between genetic traits for immune-mediated diseases and Alzheimer disease. JAMA Neurol. 2016;73(6):691-697.
24. Andreassen OA, Djurovic S, Thompson WK, et al; International Consortium for Blood Pressure GWAS; Diabetes Genetics Replication and Meta-analysis Consortium; Psychiatric Genomics Consortium SchizophreniaWorking Group. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am J Hum Genet. 2013;92(2):197-209.
25. Andreassen OA, Thompson WK, Schork AJ, et al; Psychiatric Genomics Consortium (PGC); Bipolar Disorder and SchizophreniaWorking Groups. Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genet. 2013;9(4):e1003455.
26. Andreassen OA, Harbo HF,Wang Y, et al; Psychiatric Genomics Consortium (PGC) Bipolar Disorder and SchizophreniaWork Groups; International Multiple Sclerosis Genetics Consortium (IMSGC). Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci. Mol Psychiatry. 2015;20 (2):207-214.
27. Franke A,McGovern DP, Barrett JC, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet. 2010;42(12):1118-1125.
28. Anderson CA, Boucher G, Lees CW, et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet. 2011;43(3):246-252.
29. Stahl EA, Raychaudhuri S, Remmers EF, et al; BIRAC Consortium; YEAR Consortium. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet. 2010;42(6):508-514.
30. Barrett JC, Clayton DG, Concannon P, et al; Type 1 Diabetes Genetics Consortium. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet. 2009;41(6):703-707.
31. Dubois PC, Trynka G, Franke L, et al. Multiple common variants for celiac disease influencing immune gene expression. Nat Genet. 2010;42(4): 295-302.
32. Ellinghaus D, Ellinghaus E, Nair RP, et al. Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. Am J Hum Genet. 2012;90(4):636-647.
33. Sawcer S, Hellenthal G, Pirinen M, et al; International Multiple Sclerosis Genetics Consortium;Wellcome Trust Case Control Consortium 2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 2011;476(7359):214-219.
34. Efron B. Large-Scale Inference: Empirical Bayes Methods for Estimation, Testing and Prediction. New York, NY: Cambridge University Press; 2010.
35. Schweder T, Spjotvoll E. Plots of P-values to evaluate many tests simultaneously. Biometrika. 1982;69(3):493-502.
36. Liu JZ, Hov JR, Folseraas T, et al; UK-PSCSC Consortium; International PSC Study Group; International IBD Genetics Consortium. Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis. Nat Genet. 2013;45(6):670-675.
37. Desikan RS, Schork AJ,Wang Y, et al; ADNI, ADGC, GERAD, CHARGE and IPDGC Investigators. Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus. Mol Psychiatry. 2015;20(12):1588-1595.
38. Nalls MA, Bras J, Hernandez DG, et al. NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases. Neurobiol Aging. 2014.
39. Gibbs JR, van der Brug MP, Hernandez DG, et al. Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet. 2010;6(5):e1000952.
40. Ramasamy A, Trabzuni D, Guelfi S, et al; UK Brain Expression Consortium; North American Brain Expression Consortium. Genetic variability in the regulation of gene expression in ten regions of the human brain. Nat Neurosci. 2014;17(10):1418-1428.
41. Blauwendraat C, Francescatto M, Gibbs JR, et al. Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe. Genome Med. 2016;8(1):65.
42. Szklarczyk D, Franceschini A,Wyder S, et al. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2015;43(database issue):D447-D452.
43. Wider C, Vilarino-Guell C, Jasinska-Myga B, et al. Association of the MAPT locus with Parkinson's disease. Eur J Neurol. 2010;17(3):483-486.
44. WissemannWT, Hill-Burns EM, Zabetian CP, et al. Association of Parkinson disease with structural and regulatory variants in the HLA region. Am J Hum Genet. 2013;93(5):984-993.
45. Ahmed I, Tamouza R, Delord M, et al. Association between Parkinson's disease and the HLA-DRB1 locus. Mov Disord. 2012;27(9):1104-1110.
46. Peters JE, Lyons PA, Lee JC, et al. Insight into genotype-phenotype associations through eQTL mapping in multiple cell types in health and immune-mediated disease. PLoS Genet. 2016;12(3): e1005908.
47. Teslovich TM, Musunuru K, Smith AV, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010;466(7307):707-713.
48. Liu Z, Lenardo MJ. The role of LRRK2 in inflammatory bowel disease. Cell Res. 2012;22(7): 1092-1094.
49. International Parkinson's Disease Genomics Consortium (IPDGC);Wellcome Trust Case Control Consortium 2 (WTCCC2). A two-stage meta-analysis identifies several new loci for Parkinson's disease. PLoS Genet. 2011;7(6):e1002142.
50. Wang JY, GongMY, Ye YL, et al. The RIT2 and STX1B polymorphisms are associated with Parkinson's disease. Parkinsonism Relat Disord. 2015;21(3):300-302.
51. Cotsapas C, Voight BF, Rossin E, et al; FOCiS Network of Consortia. Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet. 2011;7 (8):e1002254.
52. Gao X, Simon KC, Han J, Schwarzschild MA, Ascherio A. Genetic determinants of hair color and Parkinson's disease risk. Ann Neurol. 2009;65(1): 76-82.
53. Maaser C, Kannengiesser K, Specht C, et al. Crucial role of the melanocortin receptor MC1R in experimental colitis. Gut. 2006;55(10):1415-1422.
54. Webster EL, Torpy DJ, Elenkov IJ, Chrousos GP. Corticotropin-releasing hormone and inflammation. Ann N Y Acad Sci. 1998;840:21-32.
55. McEwan DG, Richter B, Claudi B, et al. PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection. Cell Host Microbe. 2015;17 (1):58-71.
56. Stow JL, Manderson AP, Murray RZ. SNAREing immunity: the role of SNAREs in the immune system. Nat Rev Immunol. 2006;6(12):919-929.
57. Nisole S, Stoye JP, Saib A. TRIM family proteins: retroviral restriction and antiviral defence. Nat Rev Microbiol. 2005;3(10):799-808.
58. Kawai T, Akira S. Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins. EMBO Mol Med. 2011;3(9):513-527.
59. Indik ZK, Park JG, Hunter S, Schreiber AD. The molecular dissection of Fc gamma receptor mediated phagocytosis. Blood. 1995;86(12):4389-4399.
60. Dijstelbloem HM, van de Winkel JG, Kallenberg CG. Inflammation in autoimmunity: receptors for IgG revisited. Trends Immunol. 2001;22(9):510-516.
61. Gessner JE, Heiken H, Tamm A, Schmidt RE. The IgG Fc receptor family. Ann Hematol. 1998;76 (6):231-248.
62. Weersma RK, Crusius JB, Roberts RL, et al. Association of FcgR2a, but not FcgR3a, with inflammatory bowel diseases across three Caucasian populations. Inflamm Bowel Dis. 2010;16 (12):2080-2089.
63. Franke L, el Bannoudi H, Jansen DT, et al. Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes. Eur J Hum Genet. 2016;24(2):263-270.
64. Grozdanov V, Bliederhaeuser C, RufWP, et al. Inflammatory dysregulation of blood monocytes in Parkinson's disease patients. Acta Neuropathol. 2014;128(5):651-663.
65. Cho DH, Tapscott SJ. Myotonic dystrophy: emerging mechanisms for DM1 and DM2. Biochim Biophys Acta. 2007;1772(2):195-204.
66. Kaliman P, Llagostera E.Myotonic dystrophy protein kinase (DMPK) and its role in the pathogenesis ofmyotonic dystrophy 1. Cell Signal. 2008;20(11):1935-1941.
67. Trembley JH, Tatsumi S, Sakashita E, et al. Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation. Mol Cell Biol. 2005;25(4):1446-1457.
68. Trabzuni D, Ryten M, EmmettW, et al; International Parkinson Disease Genomics Consortium (IPDGC). Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus. PLoS One. 2013;8(8):e70724.
69. Zhang Q, Pan Y, Yan R, et al. Commensal bacteria direct selective cargo sorting to promote symbiosis. Nat Immunol. 2015;16(9):918-926.
70. Rao M, Gershon MD. The bowel and beyond: the enteric nervous system in neurological disorders. Nat Rev Gastroenterol Hepatol. 2016;13 (9):517-528.
71. Pellegrini C, Colucci R, Antonioli L, et al. Intestinal dysfunction in Parkinson's disease: lessons learned from translational studies and experimental models. Neurogastroenterol Motil. 2016;28(12):1781-1791.
72. Ransohoff RM, Perry VH. Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol. 2009;27:119-145.
73. Stone DK, Reynolds AD, Mosley RL, Gendelman HE. Innate and adaptive immunity for the pathobiology of Parkinson's disease. Antioxid Redox Signal. 2009;11(9):2151-2166.
74. Daniele SG, Beraud D, Davenport C, Cheng K, Yin H,Maguire-Zeiss KA. Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders. Sci Signal. 2015;8(376):ra45.
75. Monahan AJ,Warren M, Carvey PM. Neuroinflammation and peripheral immune infiltration in Parkinson's disease: an autoimmune hypothesis. Cell Transplant. 2008;17(4):363-372.
76. American Diabetes Association; American Psychiatric Association; American Association of Clinical Endocrinologists; North American Association for the Study of Obesity. Consensus development conference on antipsychotic drugs and obesity and diabetes. Diabetes Care. 2004;27 (2):596-601.