The RIT2 and STX1B polymorphisms are associated with Parkinson's disease

Parkinsonism and Related Disorders

Volumn 21, Issue 3, 2015, Pages 300-302

  Wang, Jian Yong ^a   Gong, Mei Ying ^a   Ye, Yang Lie ^a   Ye, Jin Min ^a   Lin, Guo Liang ^a   Zhuang, Qing Qing ^a   Zhang, Xiong ^a   Zhu, Jian Hong ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Association; Parkinson's disease; Polymorphism; RIT2; STX1B

Indexed keywords

ADENINE; GUANINE; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; RIT2 PROTEIN, HUMAN; SYNTAXIN 1;

ADULT; AGED; ALLELE; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HAN CHINESE; HUMAN; MAJOR CLINICAL STUDY; MALE; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; RIT2 GENE; STX1B GENE; ASIAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; COHORT STUDIES; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MONOMERIC GTP-BINDING PROTEINS; PARKINSON DISEASE; POLYMORPHISM, SINGLE NUCLEOTIDE; SYNTAXIN 1;

EID: 84923228506     PISSN: 13538020     EISSN: 18735126     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2014.12.006     Document Type: Article

References (12)

1. Bekris L.M., Mata I.F., Zabetian C.P. The genetics of Parkinson disease. JGeriatr Psychiatry Neurol 2010, 23:228-242.
2. International Parkinson's Disease Genomics C, Wellcome Trust Case Control C Atwo-stage meta-analysis identifies several new loci for Parkinson's disease. PLoS Genet 2011, 7:e1002142.
3. Pankratz N., Beecham G.W., DeStefano A.L., Dawson T.M., Doheny K.F., Factor S.A., et al. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. Ann Neurol 2012, 71:370-384.
4. Lee C.H., Della N.G., Chew C.E., Zack D.J. Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. JNeurosci 1996, 16:6784-6794.
5. Lee D., Lee S.Y., Lee E.N., Chang C.S., Paik S.R. alpha-Synuclein exhibits competitive interaction between calmodulin and synthetic membranes. JNeurochem 2002, 82:1007-1017.
6. Padilla R., Maccioni R.B., Avila J. Calmodulin binds to a tubulin binding site of the microtubule-associated protein tau. Mol Cell Biochem 1990, 97:35-41.
7. Zhou Q., Li J., Wang H., Yin Y., Zhou J. Identification of nigral dopaminergic neuron-enriched genes in adult rats. Neurobiol Aging 2011, 32:313-326.
8. Bossers K., Meerhoff G., Balesar R., van Dongen J.W., Kruse C.G., Swaab D.F., et al. Analysis of gene expression in Parkinson's disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death. Brain Pathol 2009, 19:91-107.
9. Lin C.H., Chen M.L., Yu C.Y., Wu R.M. RIT2 variant is not associated with Parkinson's disease in a Taiwanese population. Neurobiol Aging 2013, 34. 2236 e1-3.
10. Pihlstrom L., Axelsson G., Bjornara K.A., Dizdar N., Fardell C., Forsgren L., et al. Supportive evidence for 11 loci from genome-wide association studies in Parkinson's disease. Neurobiol Aging 2013, 34. 1708 e7-13.
11. Smirnova T., Stinnakre J., Mallet J. Characterization of a presynaptic glutamate receptor. Science 1993, 262:430-433.
12. De Jager P.L., Srivastava G., Lunnon K., Burgess J., Schalkwyk L.C., Yu L., et al. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci 2014, 17:1156-1163.