-
1
-
-
80052967403
-
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study
-
Ross OA, Soto-Ortolaza AI, Heckman MG, Aasly JO, Abahuni N, et al. (2011) Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study. Lancet neurology 10: 898-908.
-
(2011)
Lancet Neurology
, vol.10
, pp. 898-908
-
-
Ross, O.A.1
Soto-Ortolaza, A.I.2
Heckman, M.G.3
Aasly, J.O.4
Abahuni, N.5
-
2
-
-
50049104725
-
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
-
Healy DG, Falchi M, O'Sullivan SS, Bonifati V, Durr A, et al. (2008) Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study. Lancet neurology 7: 583-590.
-
(2008)
Lancet Neurology
, vol.7
, pp. 583-590
-
-
Healy, D.G.1
Falchi, M.2
O'Sullivan, S.S.3
Bonifati, V.4
Durr, A.5
-
3
-
-
34547107314
-
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease
-
Melrose HL, Kent CB, Taylor JP, Dachsel JC, Hinkle KM, et al. (2007) A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease. Neuroscience 147: 1047-1058.
-
(2007)
Neuroscience
, vol.147
, pp. 1047-1058
-
-
Melrose, H.L.1
Kent, C.B.2
Taylor, J.P.3
Dachsel, J.C.4
Hinkle, K.M.5
-
4
-
-
79951811351
-
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies
-
Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, et al. (2011) Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet 377: 641-649.
-
(2011)
Lancet
, vol.377
, pp. 641-649
-
-
Nalls, M.A.1
Plagnol, V.2
Hernandez, D.G.3
Sharma, M.4
Sheerin, U.M.5
-
5
-
-
84856070973
-
LRRK2 and Human Disease: A Complicated Question or a Question of Complexes?
-
Lewis PA, Manzoni C, (2012) LRRK2 and Human Disease: A Complicated Question or a Question of Complexes? Sci Signal 5: pe2.
-
(2012)
Sci Signal
, vol.5
-
-
Lewis, P.A.1
Manzoni, C.2
-
6
-
-
74049127960
-
Genomewide association study of leprosy
-
Zhang FR, Huang W, Chen SM, Sun LD, Liu H, et al. (2009) Genomewide association study of leprosy. N Engl J Med 361: 2609-2618.
-
(2009)
N Engl J Med
, vol.361
, pp. 2609-2618
-
-
Zhang, F.R.1
Huang, W.2
Chen, S.M.3
Sun, L.D.4
Liu, H.5
-
7
-
-
78649489009
-
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
-
Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, et al. (2010) Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 42: 1118-1125.
-
(2010)
Nat Genet
, vol.42
, pp. 1118-1125
-
-
Franke, A.1
McGovern, D.P.2
Barrett, J.C.3
Wang, K.4
Radford-Smith, G.L.5
-
8
-
-
78649389313
-
The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
-
Cookson MR, (2010) The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease. Nat Rev Neurosci 11: 791-797.
-
(2010)
Nat Rev Neurosci
, vol.11
, pp. 791-797
-
-
Cookson, M.R.1
-
9
-
-
28044460070
-
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
-
West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, et al. (2005) Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci U S A 102: 16842-16847.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 16842-16847
-
-
West, A.B.1
Moore, D.J.2
Biskup, S.3
Bugayenko, A.4
Smith, W.W.5
-
10
-
-
34247468302
-
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
-
Lewis PA, Greggio E, Beilina A, Jain S, Baker A, et al. (2007) The R1441C mutation of LRRK2 disrupts GTP hydrolysis. Biochem Biophys Res Commun 357: 668-671.
-
(2007)
Biochem Biophys Res Commun
, vol.357
, pp. 668-671
-
-
Lewis, P.A.1
Greggio, E.2
Beilina, A.3
Jain, S.4
Baker, A.5
-
11
-
-
77953395313
-
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions
-
Greggio E, Cookson MR (2009) Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions. ASN Neuro 1.
-
(2009)
ASN Neuro
, vol.1
-
-
Greggio, E.1
Cookson, M.R.2
-
12
-
-
8844266996
-
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
-
Paisan-Ruiz C, Jain S, Evans EW, Gilks WP, Simon J, et al. (2004) Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 44: 595-600.
-
(2004)
Neuron
, vol.44
, pp. 595-600
-
-
Paisan-Ruiz, C.1
Jain, S.2
Evans, E.W.3
Gilks, W.P.4
Simon, J.5
-
13
-
-
8844233579
-
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
-
Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, et al. (2004) Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44: 601-607.
-
(2004)
Neuron
, vol.44
, pp. 601-607
-
-
Zimprich, A.1
Biskup, S.2
Leitner, P.3
Lichtner, P.4
Farrer, M.5
-
14
-
-
33645790701
-
LRRK2 expression linked to dopamine-innervated areas
-
Galter D, Westerlund M, Carmine A, Lindqvist E, Sydow O, et al. (2006) LRRK2 expression linked to dopamine-innervated areas. Annals of neurology 59: 714-719.
-
(2006)
Annals of Neurology
, vol.59
, pp. 714-719
-
-
Galter, D.1
Westerlund, M.2
Carmine, A.3
Lindqvist, E.4
Sydow, O.5
-
15
-
-
34250199013
-
Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain
-
Higashi S, Biskup S, West AB, Trinkaus D, Dawson VL, et al. (2007) Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain. Brain Res 1155: 208-219.
-
(2007)
Brain Res
, vol.1155
, pp. 208-219
-
-
Higashi, S.1
Biskup, S.2
West, A.B.3
Trinkaus, D.4
Dawson, V.L.5
-
16
-
-
79960661378
-
LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative study
-
Sharma S, Bandopadhyay R, Lashley T, Renton AE, Kingsbury AE, et al. (2011) LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative study. Neuropathology and Applied Neurobiology 37: 777-790.
-
(2011)
Neuropathology and Applied Neurobiology
, vol.37
, pp. 777-790
-
-
Sharma, S.1
Bandopadhyay, R.2
Lashley, T.3
Renton, A.E.4
Kingsbury, A.E.5
-
17
-
-
77957283003
-
Leucine-rich repeat kinase 2 is associated with the endoplasmic reticulum in dopaminergic neurons and accumulates in the core of Lewy bodies in Parkinson disease
-
Vitte J, Traver S, Maues De Paula A, Lesage S, Rovelli G, et al. (2010) Leucine-rich repeat kinase 2 is associated with the endoplasmic reticulum in dopaminergic neurons and accumulates in the core of Lewy bodies in Parkinson disease. J Neuropathol Exp Neurol 69: 959-972.
-
(2010)
J Neuropathol Exp Neurol
, vol.69
, pp. 959-972
-
-
Vitte, J.1
Traver, S.2
Maues De Paula, A.3
Lesage, S.4
Rovelli, G.5
-
18
-
-
48349136889
-
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
-
Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, et al. (2008) Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 40: 955-962.
-
(2008)
Nat Genet
, vol.40
, pp. 955-962
-
-
Barrett, J.C.1
Hansoul, S.2
Nicolae, D.L.3
Cho, J.H.4
Duerr, R.H.5
-
19
-
-
61449229760
-
Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13
-
Plagnol V, Smyth DJ, Todd JA, Clayton DG, (2009) Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13. Biostatistics 10: 327-334.
-
(2009)
Biostatistics
, vol.10
, pp. 327-334
-
-
Plagnol, V.1
Smyth, D.J.2
Todd, J.A.3
Clayton, D.G.4
-
20
-
-
84864417548
-
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing
-
Howie B, Fuchsberger C, Stephens M, Marchini J, Abecasis G, (2012) Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nature Genetics 44: 955-959.
-
(2012)
Nature Genetics
, vol.44
, pp. 955-959
-
-
Howie, B.1
Fuchsberger, C.2
Stephens, M.3
Marchini, J.4
Abecasis, G.5
-
21
-
-
79959851714
-
A two-stage meta-analysis identifies several new loci for Parkinson's disease
-
Plagnol V, Nalls MA, Bras JM, Hernandez DG, Sharma M, et al. (2011) A two-stage meta-analysis identifies several new loci for Parkinson's disease. PLoS Genet 7: e1002142.
-
(2011)
PLoS Genet
, vol.7
-
-
Plagnol, V.1
Nalls, M.A.2
Bras, J.M.3
Hernandez, D.G.4
Sharma, M.5
-
22
-
-
80053572217
-
Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies
-
Trabzuni D, Ryten M, Walker R, Smith C, Imran S, et al. (2011) Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies. Journal of neurochemistry 119: 275-282.
-
(2011)
Journal of Neurochemistry
, vol.119
, pp. 275-282
-
-
Trabzuni, D.1
Ryten, M.2
Walker, R.3
Smith, C.4
Imran, S.5
-
23
-
-
45149108420
-
Mapping the genetic architecture of gene expression in human liver
-
Schadt EE, Molony C, Chudin E, Hao K, Yang X, et al. (2008) Mapping the genetic architecture of gene expression in human liver. PLoS biology 6: e107.
-
(2008)
PLoS Biology
, vol.6
-
-
Schadt, E.E.1
Molony, C.2
Chudin, E.3
Hao, K.4
Yang, X.5
-
24
-
-
77956637896
-
Genetics and beyond-the transcriptome of human monocytes and disease susceptibility
-
Zeller T, Wild P, Szymczak S, Rotival M, Schillert A, et al. (2010) Genetics and beyond-the transcriptome of human monocytes and disease susceptibility. PloS one 5: e10693.
-
(2010)
PloS One
, vol.5
-
-
Zeller, T.1
Wild, P.2
Szymczak, S.3
Rotival, M.4
Schillert, A.5
-
25
-
-
84871809302
-
STAR: ultrafast universal RNA-seq aligner
-
Dobin A, Davis C, Schlesinger F, Drenkow J, Zaleski C, et al. (2013) STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29: 15-21.
-
(2013)
Bioinformatics
, vol.29
, pp. 15-21
-
-
Dobin, A.1
Davis, C.2
Schlesinger, F.3
Drenkow, J.4
Zaleski, C.5
-
26
-
-
80054933395
-
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
-
Liu Z, Lee J, Krummey S, Lu W, Cai H, et al. (2011) The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat Immunol 12: 1063-1070.
-
(2011)
Nat Immunol
, vol.12
, pp. 1063-1070
-
-
Liu, Z.1
Lee, J.2
Krummey, S.3
Lu, W.4
Cai, H.5
-
27
-
-
84865791125
-
MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies
-
Trabzuni D, Wray S, Vandrovcova J, Ramasamy A, Walker R, et al. (2012) MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies. Human molecular genetics 18: 4094-4103.
-
(2012)
Human Molecular Genetics
, vol.18
, pp. 4094-4103
-
-
Trabzuni, D.1
Wray, S.2
Vandrovcova, J.3
Ramasamy, A.4
Walker, R.5
-
28
-
-
34548292504
-
PLINK: a tool set for whole-genome association and population-based linkage analyses
-
Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. American journal of human genetics 81: 559-575.
-
(2007)
American Journal of Human Genetics
, vol.81
, pp. 559-575
-
-
Purcell, S.1
Neale, B.2
Todd-Brown, K.3
Thomas, L.4
Ferreira, M.A.5
-
29
-
-
78649508578
-
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes
-
Li Y, Willer CJ, Ding J, Scheet P, Abecasis GR, (2010) MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol 34: 816-834.
-
(2010)
Genet Epidemiol
, vol.34
, pp. 816-834
-
-
Li, Y.1
Willer, C.J.2
Ding, J.3
Scheet, P.4
Abecasis, G.R.5
-
30
-
-
70350231628
-
Genotype imputation
-
Li Y, Willer C, Sanna S, Abecasis G, (2009) Genotype imputation. Annu Rev Genomics Hum Genet 10: 387-406.
-
(2009)
Annu Rev Genomics Hum Genet
, vol.10
, pp. 387-406
-
-
Li, Y.1
Willer, C.2
Sanna, S.3
Abecasis, G.4
-
31
-
-
36749042713
-
Tissue and organ donation for research in forensic pathology: the MRC Sudden Death Brain and Tissue Bank
-
Millar T, Walker R, Arango JC, Ironside JW, Harrison DJ, et al. (2007) Tissue and organ donation for research in forensic pathology: the MRC Sudden Death Brain and Tissue Bank. J Pathol 213: 369-375.
-
(2007)
J Pathol
, vol.213
, pp. 369-375
-
-
Millar, T.1
Walker, R.2
Arango, J.C.3
Ironside, J.W.4
Harrison, D.J.5
-
32
-
-
48449088739
-
The Sun Health Research Institute Brain Donation Program: description and experience, 1987-2007
-
Beach TG, Sue LI, Walker DG, Roher AE, Lue L, et al. (2008) The Sun Health Research Institute Brain Donation Program: description and experience, 1987-2007. Cell Tissue Bank 9: 229-245.
-
(2008)
Cell Tissue Bank
, vol.9
, pp. 229-245
-
-
Beach, T.G.1
Sue, L.I.2
Walker, D.G.3
Roher, A.E.4
Lue, L.5
-
33
-
-
0023277545
-
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
-
Chomczynski P, Sacchi N, (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159.
-
(1987)
Anal Biochem
, vol.162
, pp. 156-159
-
-
Chomczynski, P.1
Sacchi, N.2
-
34
-
-
0142121516
-
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
-
Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, et al. (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4: 249-264.
-
(2003)
Biostatistics
, vol.4
, pp. 249-264
-
-
Irizarry, R.A.1
Hobbs, B.2
Collin, F.3
Beazer-Barclay, Y.D.4
Antonellis, K.J.5
-
35
-
-
41149171125
-
Evidence based selection of housekeeping genes
-
de Jonge HJ, Fehrmann RS, de Bont ES, Hofstra RM, Gerbens F, et al. (2007) Evidence based selection of housekeeping genes. PLoS One 2: e898.
-
(2007)
PLoS One
, vol.2
-
-
de Jonge, H.J.1
Fehrmann, R.S.2
de Bont, E.S.3
Hofstra, R.M.4
Gerbens, F.5
-
36
-
-
44449126570
-
Identification of valid reference genes for the normalization of RT qPCR gene expression data in human brain tissue
-
Coulson DT, Brockbank S, Quinn JG, Murphy S, Ravid R, et al. (2008) Identification of valid reference genes for the normalization of RT qPCR gene expression data in human brain tissue. BMC Mol Biol 9: 46.
-
(2008)
BMC Mol Biol
, vol.9
, pp. 46
-
-
Coulson, D.T.1
Brockbank, S.2
Quinn, J.G.3
Murphy, S.4
Ravid, R.5
-
37
-
-
77952074665
-
Selection of optimal reference genes for normalization in quantitative RT-PCR
-
Chervoneva I, Li Y, Schulz S, Croker S, Wilson C, et al. (2010) Selection of optimal reference genes for normalization in quantitative RT-PCR. BMC Bioinformatics 11: 253.
-
(2010)
BMC Bioinformatics
, vol.11
, pp. 253
-
-
Chervoneva, I.1
Li, Y.2
Schulz, S.3
Croker, S.4
Wilson, C.5
|