The role of LRRK2 in inflammatory bowel disease

Cell Research

Volumn 22, Issue 7, 2012, Pages 1092-1094

  Liu, Zhihua ^a   Lenardo, Michael J ^b  

^a INSTITUTE OF BIOPHYSICS   (China)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LRRK2 PROTEIN, HUMAN; LRRK2 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE;

ANIMAL; ARTICLE; COLITIS; ENTERITIS; GENETICS; HUMAN; METABOLISM;

ANIMALS; COLITIS; HUMANS; INFLAMMATORY BOWEL DISEASES; PROTEIN-SERINE-THREONINE KINASES;

MUS;

EID: 84863430895     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2012.42     Document Type: Article

References (15)

1. Anderson CA, Boucher G, Lees CW, et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 2011; 43:246-252.
2. Franke A, McGovern DP, Barrett JC, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010; 42:1118-1125.
3. Barrett JC, Hansoul S, Nicolae DL, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008; 40:955-962.
4. Lin CH, Tsai PI, Wu RM, Chien CT. LRRK2 Parkinson's disease: from animal models to cellular mechanisms. Rev Neurosci 2011; 22:411-418.
5. Hakimi M, Selvanantham T, Swinton E, et al. Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. J Neural Transm 2011; 118:795-808.
6. Gardet A, Benita Y, Li C, et al. LRRK2 is involved in the IFN-gamma response and host response to pathogens. J Immunol 2010; 185:5577-5585.
7. Gwack Y, Sharma S, Nardone J, et al. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature 2006; 441:646-650. (Pubitemid 43927297)
8. Hogan PG, Chen L, Nardone J, Rao A. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 2003; 17:2205-2232. (Pubitemid 37128637)
9. Willingham AT, Orth AP, Batalov S, et al. A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. Science 2005; 309:1570-1573. (Pubitemid 41266484)
10. Weigmann B, Lehr HA, Yancopoulos G, et al. The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis. J Exp Med 2008; 205:2099-2110.
11. Shih TC, Hsieh SY, Hsieh YY, et al. Aberrant activation of nuclear factor of activated T cell 2 in lamina propria mononuclear cells in ulcerative colitis. World J Gastroenterol 2008; 14:1759-1767.
12. Sharma S, Findlay GM, Bandukwala HS, et al. Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc Natl Acad Sci USA 2011; 108:11381-11386.
13. Liu Z, Lee J, Krummey S, Lu W, Cai H, Lenardo MJ. The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat Immunol 2011; 12:1063-1070.
14. Brest P, Lapaquette P, Souidi M, et al. A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nat Genet 2011; 43:242-245.
15. Strober W, Kitani A, Fuss I, Asano N, Watanabe T. The molecular basis of NOD2 susceptibility mutations in Crohn's disease. Mucosal Immunol 2008; 1 Suppl 1:S5-9.