Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke

Stroke

Volumn 44, Issue 5, 2013, Pages 1426-1432

  Van Velthoven, Cindy T J ^a   Sheldon, R Ann ^b   Kavelaars, Annemieke ^c   Derugin, Nikita ^b   Vexler, Zinaida S ^b   Willemen, Hanneke L D M ^a   Maas, Mirjam ^a   Heijnen, Cobi J ^a,c   Ferriero, Donna M ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

cell transplantation; cerebral ischemia; mesenchymal stem cells; neonatal stroke; postnatal

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN DAMAGE; BRAIN INFARCTION SIZE; BRAIN INJURY; CELL PROLIFERATION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DIFFUSION WEIGHTED IMAGING; GRAY MATTER; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELL TRANSPLANTATION; MIDDLE CEREBRAL ARTERY OCCLUSION; NEONATAL STROKE; NEWBORN; NEWBORN DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION; SENSORIMOTOR FUNCTION; WHITE MATTER;

ANIMALS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; INFARCTION, MIDDLE CEREBRAL ARTERY; MESENCHYMAL STEM CELL TRANSPLANTATION; NERVE FIBERS, MYELINATED; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; STROKE;

EID: 84876875233     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.000326     Document Type: Article

References (27)

1. Ferriero DM. Neonatal brain injury. N Engl J Med. 2004;351:1985-1995.
2. Kirton A, deVeber G. Advances in perinatal ischemic stroke. Pediatr Neurol. 2009;40:205-214.
3. Chen J, Li Y, Wang L, Lu M, Zhang X, Chopp M. Therapeutic beneft of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats. J Neurol Sci. 2001;189:49-57.
4. van Velthoven CT, Kavelaars A, van Bel F, Heijnen CJ. Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration. Brain Behav Immun. 2010;24:387-393.
5. van Velthoven CT, Kavelaars A, van Bel F, Heijnen CJ. Mesenchymal stem cell transplantation changes the gene expression profile of the neonatal ischemic brain. Brain Behav Immun. 2011;25:1342-1348.
6. Qu R, Li Y, Gao Q, Shen L, Zhang J, Liu Z, et al. Neurotrophic and growth factor gene expression profling of mouse bone marrow stro-mal cells induced by ischemic brain extracts. Neuropathology. 2007;27:355-363.
7. van Velthoven CT, Kavelaars A, van Bel F, Heijnen CJ. Repeated mesen-chymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendro-cytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function. J Neurosci. 2010;30:9603-9611.
8. Mizuguchi H, Sasaki T, Kawabata K, Sakurai F, Hayakawa T. Fiber-modifed adenovirus vectors mediate effcient gene transfer into undif-ferentiated and adipogenic-differentiated human mesenchymal stem cells. Biochem Biophys Res Commun. 2005;332:1101-1106.
9. Derugin N, Ferriero DM, Vexler ZS. Neonatal reversible focal cerebral ischemia: a new model. Neurosci Res. 1998;32:349-353.
10. van Velthoven CT, Kavelaars A, van Bel F, Heijnen CJ. Nasal administration of stem cells: a promising novel route to treat neonatal ischemic brain damage. Pediatr Res. 2010;68:419-422.
11. Nijboer CH, van der Kooij MA, van Bel F, Ohl F, Heijnen CJ, Kavelaars A. Inhibition of the JNK/AP-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic-ischemic brain injury. Brain Behav Immun. 2010;24:812-821.
12. Faustino JV, Wang X, Johnson CE, Klibanov A, Derugin N, Wendland MF, et al. Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke. J Neurosci. 2011;31:12992-13001.
13. Zhang ZG, Chopp M. Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol. 2009;8:491-500.
14. Torrente Y, Polli E. Mesenchymal stem cell transplantation for neurode-generative diseases. Cell Transplant. 2008;17:1103-1113.
15. Kim ES, Ahn SY, Im GH, Sung DK, Park YR, Choi SH, et al. Human umbilical cord blood-derived mesenchymal stem cell transplantation attenuates severe brain injury by permanent middle cerebral artery occlusion in newborn rats. Pediatr Res. 2012;72:277-284.
16. Ohtaki H, Ylostalo JH, Foraker JE, Robinson AP, Reger RL, Shioda S, et al. Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of infammatory/immune responses. Proc Natl Acad Sci USA. 2008;105:14638-14643.
17. Geddes R, Vannucci RC, Vannucci SJ. Delayed cerebral atrophy following moderate hypoxia-ischemia in the immature rat. Dev Neurosci. 2001;23:180-185.
18. Levison SW, Goldman JE. Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain. Neuron. 1993;10:201-212.
19. Yang Z, Covey MV, Bitel CL, Ni L, Jonakait GM, Levison SW. Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury. Ann Neurol. 2007;61:199-208.
20. Donega V, van Velthoven CT, Nijboer CH, van Bel F, Kas MJ, Kavelaars A, et al. Intranasal mesenchymal stem cell treatment for neonatal brain damage: long-term cognitive and sensorimotor improvement. PLoS ONE. 2013;8:e51253.
21. Gonzalez FF, Abel R, Almli CR, Mu D, Wendland M, Ferriero DM. Erythropoietin sustains cognitive function and brain volume after neonatal stroke. Dev Neurosci. 2009;31:403-411.
22. Jiang Y, Wei N, Lu T, Zhu J, Xu G, Liu X. Intranasal brain-derived neu-rotrophic factor protects brain from ischemic insult via modulating local infammation in rats. Neuroscience. 2011;172:398-405.
23. Schäbitz WR, Steigleder T, Cooper-Kuhn CM, Schwab S, Sommer C, Schneider A, et al. Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis. Stroke. 2007;38:2165-2172.
24. Ploughman M, Windle V, MacLellan CL, White N, Doré JJ, Corbett D. Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats. Stroke. 2009;40:1490-1495.
25. Park H, Poo MM. Neurotrophin regulation of neural circuit development and function. Nat Rev Neurosci. 2013;14:7-23.
26. Borlongan CV, Weiss MD. Baby STEPS: a giant leap for cell therapy in neonatal brain injury. Pediatr Res. 2011;70:3-9.
27. Ming GL, Song H. Adult neurogenesis in the mammalian brain: signif-cant answers and signifcant questions. Neuron. 2011;70:687-702.