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Volumn 6, Issue 3, 2017, Pages

Silencing of NRF2 reduces the expression of ALDH1A1 and ALDH3A1 and sensitizes to 5-FU in pancreatic cancer cells

Author keywords

5 FU; ALDH1A1; ALDH3A1; NRF2; Pancreatic cancer

Indexed keywords


EID: 85021946967     PISSN: None     EISSN: 20763921     Source Type: Journal    
DOI: 10.3390/antiox6030052     Document Type: Article
Times cited : (60)

References (47)
  • 2
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Hidalgo, M. Pancreatic cancer. N. Engl. J. Med. 2010, 362, 1605–1617.
    • (2010) N. Engl. J. Med , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 4
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann, P.C.; Huber, S.L.; Herrler, T.; Aicher, A.; Ellwart, J.W.; Guba, M.; Bruns, C.J.; Heeschen, C. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 2007, 1, 313–323.
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3    Aicher, A.4    Ellwart, J.W.5    Guba, M.6    Bruns, C.J.7    Heeschen, C.8
  • 6
    • 84890612101 scopus 로고    scopus 로고
    • New insights into the cell lineage of pancreatic ductal adenocarcinoma: Evidence for tumor stem cells in premalignant lesions?
    • Kopp, J.L.; Sander, M. New insights into the cell lineage of pancreatic ductal adenocarcinoma: Evidence for tumor stem cells in premalignant lesions? Gastroenterology 2014, 146, 24–26.
    • (2014) Gastroenterology , vol.146 , pp. 24-26
    • Kopp, J.L.1    Sander, M.2
  • 9
    • 84877057303 scopus 로고    scopus 로고
    • Mechanisms of chemoresistance in cancer stem cells
    • Abdullah, L.N.; Chow, E.K. Mechanisms of chemoresistance in cancer stem cells. Clin. Transl. Med. 2013, 2, 3.
    • (2013) Clin. Transl. Med , vol.2 , pp. 3
    • Abdullah, L.N.1    Chow, E.K.2
  • 10
    • 84865004801 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 1A1 confers intrinsic and acquired resistance to gemcitabine in human pancreatic adenocarcinoma MIA PaCa-2 cells
    • Duong, H.Q.; Hwang, J.S.; Kim, H.J.; Kang, H.J.; Seong, Y.S.; Bae, I. Aldehyde dehydrogenase 1A1 confers intrinsic and acquired resistance to gemcitabine in human pancreatic adenocarcinoma MIA PaCa-2 cells. Int. J. Oncol. 2012, 41, 855–861.
    • (2012) Int. J. Oncol , vol.41 , pp. 855-861
    • Duong, H.Q.1    Hwang, J.S.2    Kim, H.J.3    Kang, H.J.4    Seong, Y.S.5    Bae, I.6
  • 11
    • 79955593909 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase: Its role as a cancer stem cell marker comes down to the specific isoform
    • Marcato, P.; Dean, C.A.; Giacomantonio, C.A.; Lee, P.W. Aldehyde dehydrogenase: Its role as a cancer stem cell marker comes down to the specific isoform. Cell Cycle 2011, 10, 1378–1384.
    • (2011) Cell Cycle , vol.10 , pp. 1378-1384
    • Marcato, P.1    Dean, C.A.2    Giacomantonio, C.A.3    Lee, P.W.4
  • 12
    • 84919346697 scopus 로고    scopus 로고
    • Aldehyde dehydrogenases in cancer: An opportunity for biomarker and drug development?
    • Pors, K.; Moreb, J.S. Aldehyde dehydrogenases in cancer: An opportunity for biomarker and drug development? Drug Discov. Today 2014, 19, 1953–1963.
    • (2014) Drug Discov. Today , vol.19 , pp. 1953-1963
    • Pors, K.1    Moreb, J.S.2
  • 14
    • 0030024868 scopus 로고    scopus 로고
    • Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer
    • Magni, M.; Shammah, S.; Schiro, R.; Mellado, W.; Dalla-Favera, R.; Gianni, A.M. Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer. Blood 1996, 87, 1097–1103.
    • (1996) Blood , vol.87 , pp. 1097-1103
    • Magni, M.1    Shammah, S.2    Schiro, R.3    Mellado, W.4    Dalla-Favera, R.5    Gianni, A.M.6
  • 15
    • 0036202207 scopus 로고    scopus 로고
    • Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: A retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens
    • Sladek, N.E.; Kollander, R.; Sreerama, L.; Kiang, D.T. Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: A retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens. Cancer Chemother. Pharmacol. 2002, 49, 309–321.
    • (2002) Cancer Chemother. Pharmacol , vol.49 , pp. 309-321
    • Sladek, N.E.1    Kollander, R.2    Sreerama, L.3    Kiang, D.T.4
  • 16
    • 84900538153 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis
    • Yan, J.; De Melo, J.; Cutz, J.C.; Aziz, T.; Tang, D. Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis. Br. J. Cancer 2014, 110, 2593–2603.
    • (2014) Br. J. Cancer , vol.110 , pp. 2593-2603
    • Yan, J.1    De Melo, J.2    Cutz, J.C.3    Aziz, T.4    Tang, D.5
  • 17
    • 84899579623 scopus 로고    scopus 로고
    • Combination of dasatinib and gemcitabine reduces the ALDH1A1 expression and the proliferation of gemcitabine-resistant pancreatic cancer MIA PaCa-2 cells
    • Duong, H.Q.; Yi, Y.W.; Kang, H.J.; Bae, I.; Jang, Y.J.; Kwak, S.J.; Seong, Y.S. Combination of dasatinib and gemcitabine reduces the ALDH1A1 expression and the proliferation of gemcitabine-resistant pancreatic cancer MIA PaCa-2 cells. Int. J. Oncol. 2014, 44, 2132–2138.
    • (2014) Int. J. Oncol , vol.44 , pp. 2132-2138
    • Duong, H.Q.1    Yi, Y.W.2    Kang, H.J.3    Bae, I.4    Jang, Y.J.5    Kwak, S.J.6    Seong, Y.S.7
  • 18
    • 63549121490 scopus 로고    scopus 로고
    • Nrf2 and keap1 mutations: Permanent activation of an adaptive response in cancer
    • Hayes, J.D.; McMahon, M. Nrf2 and keap1 mutations: Permanent activation of an adaptive response in cancer. Trends Biochem. Sci. 2009, 34, 176–188.
    • (2009) Trends Biochem. Sci , vol.34 , pp. 176-188
    • Hayes, J.D.1    McMahon, M.2
  • 20
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the keap1-Nrf2-are pathway
    • Kensler, T.W.; Wakabayashi, N.; Biswal, S. Cell survival responses to environmental stresses via the keap1-Nrf2-are pathway. Annu. Rev. Pharmacol. Toxicol. 2007, 47, 89–116.
    • (2007) Annu. Rev. Pharmacol. Toxicol , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 22
    • 79955921373 scopus 로고    scopus 로고
    • Differentiation-dependent expression of NADP(H):Quinone oxidoreductase-1 via NF-E2 related factor-2 activation in human epidermal keratinocytes
    • Piao, M.S.; Choi, J.Y.; Lee, D.H.; Yun, S.J.; Lee, J.B.; Lee, S.C. Differentiation-dependent expression of NADP(H):Quinone oxidoreductase-1 via NF-E2 related factor-2 activation in human epidermal keratinocytes. J. Dermatol. Sci. 2011, 62, 147–153.
    • (2011) J. Dermatol. Sci , vol.62 , pp. 147-153
    • Piao, M.S.1    Choi, J.Y.2    Lee, D.H.3    Yun, S.J.4    Lee, J.B.5    Lee, S.C.6
  • 27
    • 84956934807 scopus 로고    scopus 로고
    • Downregulation of Nrf2 promotes radiation-induced apoptosis through Nrf2 mediated notch signaling in non-small cell lung cancer cells
    • Zhao, Q.; Mao, A.; Yan, J.; Sun, C.; Di, C.; Zhou, X.; Li, H.; Guo, R.; Zhang, H. Downregulation of Nrf2 promotes radiation-induced apoptosis through Nrf2 mediated notch signaling in non-small cell lung cancer cells. Int. J. Oncol. 2016, 48, 765–773.
    • (2016) Int. J. Oncol , vol.48 , pp. 765-773
    • Zhao, Q.1    Mao, A.2    Yan, J.3    Sun, C.4    Di, C.5    Zhou, X.6    Li, H.7    Guo, R.8    Zhang, H.9
  • 29
    • 84923068541 scopus 로고    scopus 로고
    • Knockdown of nuclear factor erythroid 2-related factor 2 by lentivirus induces differentiation of glioma stem-like cells
    • Zhu, J.; Wang, H.; Fan, Y.; Hu, Y.; Ji, X.; Sun, Q.; Liu, H. Knockdown of nuclear factor erythroid 2-related factor 2 by lentivirus induces differentiation of glioma stem-like cells. Oncol. Rep. 2014, 32, 1170–1178.
    • (2014) Oncol. Rep , vol.32 , pp. 1170-1178
    • Zhu, J.1    Wang, H.2    Fan, Y.3    Hu, Y.4    Ji, X.5    Sun, Q.6    Liu, H.7
  • 30
    • 79951818699 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis
    • Marcato, P.; Dean, C.A.; Pan, D.; Araslanova, R.; Gillis, M.; Joshi, M.; Helyer, L.; Pan, L.; Leidal, A.; Gujar, S.; et al. Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis. Stem Cells 2011, 29, 32–45.
    • (2011) Stem Cells , vol.29 , pp. 32-45
    • Marcato, P.1    Dean, C.A.2    Pan, D.3    Araslanova, R.4    Gillis, M.5    Joshi, M.6    Helyer, L.7    Pan, L.8    Leidal, A.9    Gujar, S.10
  • 31
    • 84896716558 scopus 로고    scopus 로고
    • Inhibition of Nrf2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine
    • Duong, H.Q.; Yi, Y.W.; Kang, H.J.; Hong, Y.B.; Tang, W.; Wang, A.; Seong, Y.S.; Bae, I. Inhibition of Nrf2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine. Int. J. Oncol. 2014, 44, 959–969.
    • (2014) Int. J. Oncol , vol.44 , pp. 959-969
    • Duong, H.Q.1    Yi, Y.W.2    Kang, H.J.3    Hong, Y.B.4    Tang, W.5    Wang, A.6    Seong, Y.S.7    Bae, I.8
  • 32
    • 0024357244 scopus 로고
    • Effects of type I and II interferons on cultured human breast cells: Interaction with estrogen receptors and with tamoxifen
    • Goldstein, D.; Bushmeyer, S.M.; Witt, P.L.; Jordan, V.C.; Borden, E.C. Effects of type I and II interferons on cultured human breast cells: Interaction with estrogen receptors and with tamoxifen. Cancer Res. 1989, 49, 2698–2702.
    • (1989) Cancer Res , vol.49 , pp. 2698-2702
    • Goldstein, D.1    Bushmeyer, S.M.2    Witt, P.L.3    Jordan, V.C.4    Borden, E.C.5
  • 33
    • 34249049000 scopus 로고    scopus 로고
    • Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib
    • Morgillo, F.; Kim, W.Y.; Kim, E.S.; Ciardiello, F.; Hong, W.K.; Lee, H.Y. Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin. Cancer Res. 2007, 13, 2795–2803.
    • (2007) Clin. Cancer Res , vol.13 , pp. 2795-2803
    • Morgillo, F.1    Kim, W.Y.2    Kim, E.S.3    Ciardiello, F.4    Hong, W.K.5    Lee, H.Y.6
  • 34
    • 84919481195 scopus 로고    scopus 로고
    • Comparative analysis of Nrf2-responsive gene expression in AcPC-1 pancreatic cancer cell line
    • Yi, Y.W.; Oh, S. Comparative analysis of Nrf2-responsive gene expression in AcPC-1 pancreatic cancer cell line. Genes Genom. 2015, 37, 97–109.
    • (2015) Genes Genom , vol.37 , pp. 97-109
    • Yi, Y.W.1    Oh, S.2
  • 35
    • 79958716191 scopus 로고    scopus 로고
    • ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma
    • Kim, M.P.; Fleming, J.B.; Wang, H.; Abbruzzese, J.L.; Choi, W.; Kopetz, S.; McConkey, D.J.; Evans, D.B.; Gallick, G.E. ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma. PLoS ONE 2011, 6, e20636.
    • (2011) Plos ONE , vol.6
    • Kim, M.P.1    Fleming, J.B.2    Wang, H.3    Abbruzzese, J.L.4    Choi, W.5    Kopetz, S.6    McConkey, D.J.7    Evans, D.B.8    Gallick, G.E.9
  • 36
    • 84889575198 scopus 로고    scopus 로고
    • Modulation of oxidative stress as an anticancer strategy
    • Gorrini, C.; Harris, I.S.; Mak, T.W. Modulation of oxidative stress as an anticancer strategy. Nat. Rev. Drug Discov. 2013, 12, 931–947.
    • (2013) Nat. Rev. Drug Discov , vol.12 , pp. 931-947
    • Gorrini, C.1    Harris, I.S.2    Mak, T.W.3
  • 37
    • 84991107767 scopus 로고    scopus 로고
    • Emerging role of Nrf2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters
    • Bai, X.; Chen, Y.; Hou, X.; Huang, M.; Jin, J. Emerging role of Nrf2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters. Drug Metab. Rev. 2016, 48, 541–567.
    • (2016) Drug Metab. Rev , vol.48 , pp. 541-567
    • Bai, X.1    Chen, Y.2    Hou, X.3    Huang, M.4    Jin, J.5
  • 39
    • 84055177613 scopus 로고    scopus 로고
    • The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ros levels
    • Merchant, A.A.; Singh, A.; Matsui, W.; Biswal, S. The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ros levels. Blood 2011, 118, 6572–6579.
    • (2011) Blood , vol.118 , pp. 6572-6579
    • Merchant, A.A.1    Singh, A.2    Matsui, W.3    Biswal, S.4
  • 40
    • 0022400840 scopus 로고
    • Enzymes of uracil catabolism in normal and neoplastic human tissues
    • Naguib, F.N.; el Kouni, M.H.; Cha, S. Enzymes of uracil catabolism in normal and neoplastic human tissues. Cancer Res. 1985, 45, 5405–5412.
    • (1985) Cancer Res , vol.45 , pp. 5405-5412
    • Naguib, F.N.1    El Kouni, M.H.2    Cha, S.3
  • 41
    • 84891756020 scopus 로고    scopus 로고
    • Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating src-dependent caspase-7 phosphorylation
    • Fu, Y.; Yang, G.; Zhu, F.; Peng, C.; Li, W.; Li, H.; Kim, H.G.; Bode, A.M.; Dong, Z.; Dong, Z. Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating src-dependent caspase-7 phosphorylation. Cell. Death Dis. 2014, 5, e983.
    • (2014) Cell. Death Dis , vol.5
    • Fu, Y.1    Yang, G.2    Zhu, F.3    Peng, C.4    Li, W.5    Li, H.6    Kim, H.G.7    Bode, A.M.8    Dong, Z.9    Dong, Z.10
  • 42
    • 84888342168 scopus 로고    scopus 로고
    • Inhibition of checkpoint kinase 2 (CHK2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabine
    • Duong, H.Q.; Hong, Y.B.; Kim, J.S.; Lee, H.S.; Yi, Y.W.; Kim, Y.J.; Wang, A.; Zhao, W.; Cho, C.H.; Seong, Y.S.; et al. Inhibition of checkpoint kinase 2 (CHK2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabine. J. Cell. Mol. Med. 2013, 17, 1261–1270.
    • (2013) J. Cell. Mol. Med , vol.17 , pp. 1261-1270
    • Duong, H.Q.1    Hong, Y.B.2    Kim, J.S.3    Lee, H.S.4    Yi, Y.W.5    Kim, Y.J.6    Wang, A.7    Zhao, W.8    Cho, C.H.9    Seong, Y.S.10
  • 43
    • 84949266511 scopus 로고    scopus 로고
    • Redox modulating Nrf2: A potential mediator of cancer stem cell resistance
    • Ryoo, I.G.; Lee, S.H.; Kwak, M.K. Redox modulating Nrf2: A potential mediator of cancer stem cell resistance. Oxid. Med. Cell. Longev. 2016, 2016, 2428153.
    • (2016) Oxid. Med. Cell. Longev , vol.2016 , pp. 2428153
    • Ryoo, I.G.1    Lee, S.H.2    Kwak, M.K.3
  • 44
    • 85010303365 scopus 로고    scopus 로고
    • Aldehyde dehydrogenases in cancer stem cells: Potential as therapeutic targets
    • Clark, D.W.; Palle, K. Aldehyde dehydrogenases in cancer stem cells: Potential as therapeutic targets. Ann. Transl. Med. 2016, 4, 518.
    • (2016) Ann. Transl. Med , vol.4 , pp. 518
    • Clark, D.W.1    Palle, K.2
  • 47
    • 84877608636 scopus 로고    scopus 로고
    • ALDH7A1 expression is associated with recurrence in patients with surgically resected non-small-cell lung carcinoma
    • Giacalone, N.J.; Den, R.B.; Eisenberg, R.; Chen, H.; Olson, S.J.; Massion, P.P.; Carbone, D.P.; Lu, B. ALDH7A1 expression is associated with recurrence in patients with surgically resected non-small-cell lung carcinoma. Future Oncol. 2013, 9, 737–745.
    • (2013) Future Oncol , vol.9 , pp. 737-745
    • Giacalone, N.J.1    Den, R.B.2    Eisenberg, R.3    Chen, H.4    Olson, S.J.5    Massion, P.P.6    Carbone, D.P.7    Lu, B.8


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