NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

Journal of Experimental Medicine

Volumn 214, Issue 6, 2017, Pages 1725-1736

  Stutz, Andrea ^a,g   Kolbe, Carl Christian ^a   Stahl, Rainer ^a   Horvath, Gabor L ^a   Franklin, Bernardo S ^a   van Ray, Olivia ^a   Brinkschulte, Rebecca ^a,b   Geyer, Matthias ^a,b   Meissner, Felix ^c   Latz, Eicke ^a,d,e,f  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b CENTER OF ADVANCED EUROPEAN STUDIES AND RESEARCH CAESAR   (Germany)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^f NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^g IFM Therapeutics   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOPYRIN; PHOSPHOPROTEIN PHOSPHATASE 2A; SERINE; INFLAMMASOME; NLRP3 PROTEIN, MOUSE; PHOSPHOPROTEIN PHOSPHATASE 2; PHOSPHOSERINE; PROTEIN BINDING; PYRIN;

ARTICLE; CRYSTAL STRUCTURE; ENZYME INHIBITION; GENE SILENCING; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PYRIN DOMAIN; SEQUENCE ALIGNMENT; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; HEK293 CELL LINE; HUMAN; METABOLISM; MOUSE; PHOSPHORYLATION; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; HEK293 CELLS; HUMANS; INFLAMMASOMES; MICE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN DOMAINS; PROTEIN PHOSPHATASE 2; PYRIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85021854728     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20160933     Document Type: Article

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