Intestinal dysbiosis, barrier dysfunction, and bacterial translocation account for CKD-related systemic inflammation

Journal of the American Society of Nephrology

Volumn 28, Issue 1, 2017, Pages 76-83

  Andersen, Kirstin ^a   Kesper, Marie Sophie ^a   Marschner, Julian A ^a   Konrad, Lukas ^a   Ryu, Mi ^a   Kumar, Santhosh V R ^a   Kulkarni, Onkar P ^a   Mulay, Shrikant R ^a   Romoli, Simone ^a   Demleitner, Jana ^b   Schiller, Patrick ^b   Dietrich, Alexander ^b   Müller, Susanna ^b   Gross, Oliver ^c   Ruscheweyh, Hans Joachim ^d   Huson, Daniel H ^d   Stecher, Bárbel ^b   Anders, Hans Joachim ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CASPASE 11; CD14 ANTIGEN; CD69 ANTIGEN; COLLAGEN TYPE 4; COLLAGEN TYPE 4 ALPHA 3; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; PENTRAXIN; PENTRAXIN 2; SECRETORY IMMUNOGLOBULIN; SERUM AMYLOID P; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ALCALIGENACEAE; ALPORT SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; BACTERIAL COUNT; BACTERIAL TRANSLOCATION; BACTEROIDACEAE; BACTEROIDETES; BETAPROTEOBACTERIA; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHRONIC KIDNEY FAILURE; COMMENSAL ESCHERICHIA COLI; CONTROLLED STUDY; CYTOKINE PRODUCTION; DYSBIOSIS; INFLAMMATION; INTESTINE FLORA; MOUSE; NONHUMAN; POPULATION ABUNDANCE; PORPHYROMONADACEAE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SYSTEMIC DISEASE; T LYMPHOCYTE ACTIVATION; TH17 CELL; VERRUCOMICROBIUM; ANIMAL; COMPLICATION; INTESTINE; MICROBIOLOGY;

ANIMALS; BACTERIAL TRANSLOCATION; DYSBIOSIS; INFLAMMATION; INTESTINES; MICE; RENAL INSUFFICIENCY, CHRONIC;

EID: 85021850620     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2015111285     Document Type: Article

References (35)

1. Carrero JJ, Stenvinkel P: Inflammation in end-stage renal disease-what have we learned in 10 years? Semin Dial 23: 498-509, 2010
2. McIntyre CW, Harrison LE, Eldehni MT, Jefferies HJ, Szeto CC, John SG, Sigrist MK, Burton JO, Hothi D, Korsheed S, Owen PJ, Lai KB, Li PK: Circulating endotoxemia: A novel factor in systemic inflammation and cardiovascular disease in chronic kidney disease. Clin J Am Soc Nephrol 6: 133-141, 2011
3. Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R: Diversity, stability and resilience of the human gut microbiota. Nature 489: 220-230, 2012
4. Buffie CG, Pamer EG: Microbiota-mediated colonization resistance against intestinal pathogens. Nat Rev Immunol 13: 790-801, 2013
5. O'Hara AM, Shanahan F: The gut flora as a forgotten organ. EMBO Rep 7: 688-693, 2006
6. Maynard CL, Elson CO, Hatton RD, Weaver CT: Reciprocal interactions of the intestinal microbiota and immune system. Nature 489: 231-241, 2012
7. Lutz P, Nischalke HD, Strassburg CP, Spengler U: Spontaneous bacterial peritonitis: The clinical challenge of a leaky gut and a cirrhotic liver. World J Hepatol 7: 304-314, 2015
8. Sertaridou E, Papaioannou V, Kolios G, Pneumatikos I: Gut failure in critical care:Old school versus new school. AnnGastroenterol 28: 309-322, 2015
9. Maloy KJ, Powrie F: Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 474: 298-306, 2011
10. Verbrugge FH, Dupont M, Steels P, Grieten L, Malbrain M, Tang WH, Mullens W: Abdominal contributions to cardiorenal dysfunction in congestive heart failure.JAmColl Cardiol 62: 485-495, 2013
11. Cosgrove D, Meehan DT, Grunkemeyer JA, Kornak JM, Sayers R, Hunter WJ, Samuelson GC: Collagen COL4A3 knockout: A mouse model for autosomal Alport syndrome. Genes Dev 10: 2981-2992, 1996
12. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi- Castagnoli P, Layton B, Beutler B: Defective LPS signaling in C3H/HeJ and C57BL/10ScCrmice:Mutations in Tlr4 gene. Science 282: 2085-2088, 1998
13. Kayagaki N, WongMT, Stowe IB, Ramani SR, Gonzalez LC, Akashi-Takamura S, Miyake K, Zhang J, Lee WP, Muszynski A, Forsberg LS, Carlson RW, Dixit VM: Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science 341: 1246-1249, 2013
14. Gupta J, Mitra N, Kanetsky PA, Devaney J, Wing MR, ReillyM, Shah VO, Balakrishnan VS, Guzman NJ, Girndt M, Periera BG, Feldman HI, Kusek JW, Joffe MM, Raj DS; CRIC Study Investigators: Association between albuminuria, kidney function, and inflammatory biomarker profile in CKD in CRIC. Clin J Am Soc Nephrol 7: 1938-1946, 2012
15. Poesen R, Ramezani A, Claes K, Augustijns P, Kuypers D, Barrows IR, Muralidharan J, Evenepoel P, Meijers B, Raj DS: Associations of soluble CD14 and endotoxin with mortality, cardiovascular disease, and progression of kidney disease among patients with CKD. Clin J Am Soc Nephrol 10: 1525-1533, 2015
16. Vaziri ND, Wong J, Pahl M, Piceno YM, Yuan J, DeSantis TZ, Ni Z, Nguyen TH, Andersen GL: Chronic kidney disease alters intestinal microbial flora. Kidney Int 83: 308-315, 2013
17. Wong J, Piceno YM, Desantis TZ, Pahl M, Andersen GL, Vaziri ND: Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of shortchain fatty acid-producing intestinal microbiota in ESRD. Am J Nephrol 39: 230-237, 2014
18. Vaziri ND, Goshtasbi N, Yuan J, Jellbauer S, Moradi H, Raffatellu M, Kalantar-Zadeh K: Uremic plasma impairs barrier function and depletes the tight junction protein constituents of intestinal epithelium. Am J Nephrol 36: 438-443, 2012
19. VaziriND, Yuan J, KhazaeliM, Masuda Y, Ichii H, Liu S: Oral activated charcoal adsorbent (AST-120) ameliorates chronic kidney disease- induced intestinal epithelial barrier disruption. Am J Nephrol 37: 518-525, 2013
20. Vaziri ND, Yuan J, Rahimi A, Ni Z, Said H, Subramanian VS: Disintegration of colonic epithelial tight junction in uremia: A likely cause of CKD-associated inflammation. Nephrol Dial Transplant 27: 2686-2693, 2012
21. Mulay SR, Desai J, Kumar SV, Eberhard JN, Thomasova D, Romoli S, Grigorescu M, Kulkarni OP, Popper B, Vielhauer V, Zuchtriegel G, Reichel C, Brásen JH, Romagnani P, Bilyy R, Munoz LE, Herrmann M, Liapis H, Krautwald S, Linkermann A, Anders HJ: Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis. Nat Commun 7: 10274, 2016
22. Winter SE, Báumler AJ:Why related bacterial species bloom simultaneously in the gut: Principles underlying the 'Like will to like' concept. Cell Microbiol 16: 179-184, 2014
23. Mishima E, Fukuda S, Shima H, Hirayama A, Akiyama Y, Takeuchi Y, FukudaNN, Suzuki T, Suzuki C, Yuri A, Kikuchi K, Tomioka Y, Ito S, Soga T, Abe T: Alteration of the intestinal environment by lubiprostone is associated with amelioration of adenine-induced CKD. J Am Soc Nephrol 26: 1787-1794, 2015
24. Amery-Gale J, Vaz PK, Whiteley P, Tatarczuch L, Taggart DA, Charles JA, Schultz D, Ficorilli NP, Devlin JM, Wilks CR: Detection and identification of a gammaherpesvirus in Antechinus spp. in Australia.JWildlDis 50: 334-339, 2014
25. Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SL: Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med 368: 1575-1584, 2013
26. Anders HJ, Andersen K, Stecher B: The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease. Kidney Int 83: 1010-1016, 2013
27. Ramezani A, Raj DS: The gut microbiome, kidney disease, and targeted interventions. J Am Soc Nephrol 25: 657-670, 2014
28. Koppe L, Mafra D, Fouque D: Probiotics and chronic kidney disease. Kidney Int 88: 958-966, 2015
29. Ryu M, Kulkarni OP, Radomska E, Miosge N, Gross O, Anders HJ: Bacterial CpG-DNA accelerates Alport glomerulosclerosis by inducing an M1 macrophage phenotype and tumor necrosis factor-a-mediated podocyte loss. Kidney Int 79: 189-198, 2011
30. Stecher B, Hapfelmeier S, Müller C, Kremer M, Stallmach T, Hardt WD: Flagella and chemotaxis are required for efficient induction of Salmonella enterica serovar Typhimurium colitis in streptomycin-pretreated mice. Infect Immun 72: 4138-4150, 2004
31. Schreiber A, Shulhevich Y, Geraci S, Hesser J, Stsepankou D, Neudecker S, Koenig S, Heinrich R, Hoecklin F, Pill J, Friedemann J, Schweda F, Gretz N, Schock-Kusch D: Transcutaneous measurement of renal function in conscious mice. Am J Physiol Renal Physiol 303: F783-F788, 2012
32. Gronbach K, Flade I, Holst O, Lindner B, Ruscheweyh HJ, Wittmann A, Menz S, Schwiertz A, Adam P, Stecher B, Josenhans C, SuerbaumS, GruberAD, Kulik A, HusonD, Autenrieth IB, Frick JS: Endotoxicity of lipopolysaccharide as a determinant of T-cell-mediated colitis induction in mice. Gastroenterology 146: 765-775, 2014
33. Lozupone C, Lladser ME, Knights D, Stombaugh J, Knight R: UniFrac: An effective distance metric for microbial community comparison. ISME J 5: 169-172, 2011
34. McArdle B: Fitting multivariate models to community data: A comment on distancebased redundancy analysis. Ecology 82: 290-297, 2001
35. Darisipudi MN, Thomasova D, Mulay SR, Brech D, Noessner E, Liapis H, Anders HJ: Uromodulin triggers IL-1b-dependent innate immunity via the NLRP3 inflammasome. J Am Soc Nephrol 23: 1783-1789, 2012