Rational design of human metapneumovirus live attenuated vaccine candidates by inhibiting viral mRNA cap methyltransferase

Journal of Virology

Volumn 88, Issue 19, 2014, Pages 11411-11429

  Zhang, Yu ^a,b   Wei, Yongwei ^a   Zhang, Xiaodong ^a   Cai, Hui ^a   Niewiesk, Stefan ^a   Li, Jianrong ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONSERVED REGION VI OF THE LARGE POLYMERASE PROTEIN; DNA POLYMERASE; GUANINE 7 OXIDE; LIVE VACCINE; METHYLTRANSFERASE; RIBOSE; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA; NEUTRALIZING ANTIBODY; RECOMBINANT PROTEIN; VIRUS ANTIBODY; VIRUS VACCINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; COTTON RAT; DRUG DESIGN; ENZYME ACTIVITY; FEMALE; GENE MUTATION; GENETIC STABILITY; HUMAN METAPNEUMOVIRUS INFECTION; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; LOWER RESPIRATORY TRACT; METHYLATION; MOLECULAR CLONING; NONHUMAN; PLASMID; POLYMERASE CHAIN REACTION; PROTEIN MOTIF; RADIOIMMUNOPRECIPITATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; STRUCTURAL HOMOLOGY; ULTRACENTRIFUGATION; UPPER RESPIRATORY TRACT; VIRUS NEUTRALIZATION; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TITRATION; ACTIVE IMMUNIZATION; ANIMAL; BIOSYNTHESIS; CHEMISTRY; ENZYMOLOGY; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; METAPNEUMOVIRUS; PARAMYXOVIRUS INFECTION; PROTEIN BINDING; SIGMODONTINAE; VACCINATION;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; BINDING SITES; FEMALE; GENE EXPRESSION; HUMANS; IMMUNITY, ACTIVE; METAPNEUMOVIRUS; METHYLTRANSFERASES; PARAMYXOVIRIDAE INFECTIONS; PROTEIN BINDING; RECOMBINANT PROTEINS; S-ADENOSYLMETHIONINE; SIGMODONTINAE; VACCINATION; VACCINES, ATTENUATED; VIRAL PROTEINS; VIRAL VACCINES;

EID: 84906972010     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00876-14     Document Type: Article

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