Ginkgolide K attenuates neuronal injury after ischemic stroke by inhibiting mitochondrial fission and GSK-3β-dependent increases in mitochondrial membrane permeability

Oncotarget

Volumn 8, Issue 27, 2017, Pages 44682-44693

  Zhou, Xu ^a   Wang, Hui Ying ^a   Wu, Bin ^a   Cheng, Cai Yi ^a   Xiao, Wei ^b   Wang, Zhen Zhong ^b   Yang, Yu Yu ^a   Li, Ping ^a   Yang, Hua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b JIANGSU KANION PHARMACEUTICAL CO   (China)

Author keywords

Ginkgolide K; Ischemic stroke; Mitochondrial fission; Mitochondrial permeability transition pore; Neuron apoptosis

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; CYCLOPHILIN D; DYNAMIN; DYNAMIN RELATED PROTEIN 1; GINKGOLIDE DERIVATIVE; GINKGOLIDE K; GLYCOGEN SYNTHASE KINASE 3BETA; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NEUROPROTECTIVE AGENT; NORPHENAZONE; UNCLASSIFIED DRUG; CARRIER PROTEIN; CYTOCHROME C; DNM1L PROTEIN, MOUSE; GINKGOLIDE; GLUCOSE; LACTONE; OXYGEN; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN SIZE; CONTROLLED STUDY; ENZYME INHIBITION; LIMIT OF QUANTITATION; MALE; MITOCHONDRIAL FISSION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NEUROPROTECTION; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; ANIMAL; APOPTOSIS; CELL LINE; CEREBROVASCULAR ACCIDENT; CHANNEL GATING; CHEMISTRY; COMPLICATION; DRUG EFFECT; METABOLISM; MITOCHONDRIAL DYNAMICS; NERVE CELL; PATHOLOGY; PROTEIN TRANSPORT; REPERFUSION INJURY;

ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; CELL LINE; CYTOCHROMES C; DYNAMINS; GINKGOLIDES; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3 BETA; ION CHANNEL GATING; LACTONES; MALE; MICE; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NEURONS; NEUROPROTECTIVE AGENTS; OXYGEN; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; STROKE;

EID: 85021817221     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.17967     Document Type: Article

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