Neuroprotective effect of ginkgolide K against H2O 2-induced PC12 cell cytotoxicity by ameliorating mitochondrial dysfunction and oxidative stress

Biological and Pharmaceutical Bulletin

Volumn 37, Issue 2, 2014, Pages 217-225

  Ma, Shuwei ^a   Liu, Xingyan ^b   Xun, Qingrui ^c   Zhang, Xiantao ^d  

^a QIQIHAR UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c Heilongjiang Academy of Traditional Chinese Medicine   (China)

^d GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE   (China)

Author keywords

Caspase 3 activity; Caspase 9 activity; Cytochrome c; Ginkgolide k; PC12 cell; Reactive oxygen species (ros) level

Indexed keywords

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BRAIN ISCHEMIA; CASPASES; CELL SURVIVAL; CYTOCHROMES C; GINKGO BILOBA; GINKGOLIDES; HYDROGEN PEROXIDE; L-LACTATE DEHYDROGENASE; LACTONES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PC12 CELLS; PHYTOTHERAPY; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; REACTIVE OXYGEN SPECIES;

EID: 84893247152     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b13-00378     Document Type: Article

References (38)

1. Mahadevan S, Park Y. Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses. J. Food Sci., 73, R14-R19 (2008).
2. Chan PC, Xia Q, Fu PP. Ginkgo biloba leave extract: biological, medicinal, and toxicological effects. J. Environ. Sci. Health. C. Environ. Carcinog. Ecotoxicol. Rev., 25, 211-244 (2007).
3. Vitolo O, Gong B, Cao Z, Ishii H, Jaracz S, Nakanishi K, Arancio O, Dzyuba SV, Lefort R, Shelanski M. Protection against β-amyloid induced abnormal synaptic function and cell death by ginkgolide. J. Neurobiol. Aging, 30, 257-265 (2009).
4. Ma S, Yin H, Chen L, Liu H, Zhao M, Zhang X. Neuroprotective effect of ginkgolide K against acute ischemic stroke on middle cerebral ischemia occlusion in rats. J. Nat. Med., 66, 25-31 (2012).
5. Belayev L, Khoutorova L, Atkins K, Gordon WC, Alvarez-Builla J, Bazan NG. LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia. Exp. Neurol., 214, 253-258 (2008).
6. Magliaro BC, Saldanha CJ. Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation. Brain Res., 1283, 14-24 (2009).
7. Ochiai T, Takenaka Y, Kuramoto Y, Kasuya M, Fukuda K, Kimura M, Shimeno H, Misasi R, Hiraiwa M, Soeda S. Molecular mechanism for neuro-protective effect of prosaposin against oxidative stress: Its regulation of dimeric transcription factor formation. Biochimica et Biophysica Acta (BBA)-General Subjects, 1780, 1441-1447 (2008).
8. 2, a newer thyrotropin releasing hormone analog in in vitro and in vivo models of cerebral ischemia. Peptides, 32, 1225-1231 (2011).
9. Simerabet M, Robin E, Aristi I, Adamczyk S, Tavernier B, Vallet B, Bordet R, Lebuffe G. Preconditioning by an in situ administration of hydrogen peroxide: involvement of reactive oxygen species and mitochondrial ATP-dependent potassium channel in a cerebral ischemia-reperfusion model. Brain Res., 1240, 177-184 (2008).
10. Cassarino DS, Bennett JP Jr. An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration. Brain Res. Brain Res. Rev., 29, 1-25 (1999).
11. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature, 408, 239-247 (2000).
12. Atif F, Yousuf S, Agrawal SK. S-Allyl L-cysteine diminishes cerebral ischemia-induced mitochondrial dysfunctions in hippocampus. Brain Res., 1265, 128-137 (2009).
13. Lu B. Mitochondrial dynamics and neurodegeneration. Curr. Neurol. Neurosci. Rep., 9, 212-219 (2009).
14. Liu X, Xu KD, Yan M, Wang YP, Zheng XX. Protective effects of galantamine against Aβ-induced PC12 cell apoptosis by preventing mitochondrial dysfunction and endoplasmic reticulum stress. Neurochem. Int., 57, 588-599 (2010).
15. Yin WL, He JQ, Hu B, Jiang ZS, Tang XQ. Hydrogen sulfide inhibits MPP+-induced apoptosis in PC12 cells. Life Sci., 85, 269-275 (2009).
16. 2-induced apoptosis of PC-12 cells. Phytomedicine, 18, 843-847 (2011).
17. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63 (1983).
18. Ji BS, Gao Y. Protective effect of trihexyphenidyl on hydrogen peroxide-induced oxidative damage in PC12 cells. Neurosci. Lett., 437, 50-54 (2008).
19. Chen X, Deng A, Zhou H, Gu J. Neuroprotective effect of 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-D-pyranoside against sodium nitroprusside-induced neurotoxicity in HT22 cells. Mol. Cell. Biochem., 383, 149-159 (2013).
20. LeBel CP, Ali SF, McKee M, Bondy SC. Organometal-induced increases in oxygen reactive species: the potential of 20,70-dichlorofluorescin diacetate as an index of neurotoxic damage. Toxicol. Appl. Pharmacol., 104, 17-24 (1990).
21. Satoh T, Enokido Y, Aoshima H, Uchiyama Y, Hatanaka H. Changes in mitochondrial membrane potential during oxidative stressinduced apoptosis in PC12 cells. J. Neurosci. Res., 50, 413-420 (1997).
22. Kedi X, Ming Y, Yongping W, Yi Y, Xiaoxiang Z. Free cholesterol overloading induced smooth muscle cells death and activated both ER- and mitochondrial-dependent death pathway. Atherosclerosis, 207, 123-130 (2009).
23. Keyster M, Klein A, Ludidi N. Caspase-like enzymatic activity and the ascorbate-glutathione cycle participate in salt stress tolerance of maize conferred by exogenously applied nitric oxide. Plant Signal. Behav., 7, 349-360 (2012).
24. Zhou J, Tang XC. Huperzine A attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons. FEBS Lett., 526, 21-25 (2002).
25. Grammatopoulos TN, Morris K, Bachar C, Moore S, Andres R, Weyhenmeyer JA. Angiotensin II attenuates chemical hypoxiainduced caspase-3 activation in primary cortical neuronal cultures. Brain Res. Bull., 62, 297-303 (2004).
26. Wang Z, Lu W, Li Y, Tang B. Alpinetin promotes Bax translocation, induces apoptosis through the mitochondrial pathway and arrests human gastric cancer cells at the G2/M phase. Mol. Med. Rep., 7, 915-920 (2013).
27. Jang JH, Surh YJ. Bcl-2 protects against Abeta(25-35)-induced oxidative PC12 cell death by potentiation of antioxidant capacity. Biochem. Biophys. Res. Commun., 320, 880-886 (2004).
28. Adibhatla RM, Hatcher JF. Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid. Redox. Signal., 12, 125-169 (2010).
29. Saeed SA, Shad KF, Saleem T, Javed F, Khan MU. Some new prospects in the understanding of the molecular basis of the pathogenesis of stroke. Exp. Brain Res., 182, 1-10 (2007).
30. Wang X, Michaelis EK. Selective neuronal vulnerability to oxidative stress in the brain. Front. Aging Neurosci., 2, 12-25 (2010).
31. Petit PX, Susin SA, Zamzami N, Mignotte B, Kroemer G. Mitochondria and programmed cell death: back to the future. FEBS Lett., 396, 7-13 (1996).
32. Chornyy S, Parkhomenko J, Chorna N. Thiamine deficiency caused by thiamine antagonists triggers upregulation of apoptosis inducing factor gene expression and leads to caspase 3-mediated apoptosis in neuronally differentiated rat PC-12 cells. Acta Biochim. Pol., 54, 315-322 (2007).
33. Sharifi AM, Eslami H, Larijani B, Davoodi J. Involvement of cas-pase- 8, -9, and -3 in high glucose-induced apoptosis in PC12 cells. Neurosci. Lett., 459, 47-51 (2009).
34. Wang DM, Li SQ, Zhu XY, Wang Y, Wu WL, Zhang XJ. Protective effects of Hesperidin against amyloid-β (Aβ) induced neurotoxicity through the voltage dependent anion channel 1 (VDAC1)-mediated mitochondrial apoptotic pathway in PC12 cells. Neurochem. Res., 38, 1034-1044 (2013).
35. Tibbetts MD, Zheng L, Lenardo MJ. The death effector domain protein family: regulators of cellular homeostasis. Nat. Immunol., 4, 404-409 (2003).
36. Inman GJ, Allday MJ. Apoptosis induced by TGF-beta 1 in Burkitt's lymphoma cells is caspase 8 dependent but is death receptor independent. J. Immunol., 165, 2500-2510 (2000).
37. von Haefen C, Wieder T, Essmann F, Schulze-Osthoff K, Dörken B, Daniel PT. Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop. Oncogene, 22, 2236-2247 (2003).
38. Maheshwari A, Badgujar L, Phukan B, Bodhankar SL, Thakurdesai P. Protective effect of Etoricoxib against middle cerebral artery occlusion induced transient focal cerebral ischemia in rats. Eur. J. Pharmacol., 667, 230-237 (2011).