Pharmacokinetic studies of ginkgolide K in rat plasma and tissues after intravenous administration using ultra-high performance liquid chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 988, Issue , 2015, Pages 1-7

  Fan, Zhi Ying ^a   Liu, Xin Guang ^a   Guo, Ru Zhou ^a   Dong, Xin ^a   Gao, Wen ^a   Li, Ping ^a   Yang, Hua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Ginkgo; Ginkgolide K; Pharmacokinetics; Tissue distribution; UHPLC MS MS

Indexed keywords

BODY FLUIDS; CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; LIQUIDS; MASS SPECTROMETRY; PHARMACOKINETICS; RATS; SPECTROMETRY; TISSUE;

CHROMATOGRAPHIC SEPARATIONS; GINKGO; MULTIPLE-REACTION MONITORING MODES; PHARMACOKINETIC PARAMETERS; POSITIVE ELECTROSPRAY IONIZATION; TISSUE DISTRIBUTIONS; U-HPLC-MS; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHIES;

LIQUID CHROMATOGRAPHY;

ACETIC ACID ETHYL ESTER; DIAZEPAM; FORMIC ACID; GINKGOLIDE B; GINKGOLIDE DERIVATIVE; GINKGOLIDE K; ION; METHANOL; UNCLASSIFIED DRUG; GINKGOLIDE; LACTONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG HALF LIFE; DRUG TISSUE LEVEL; IONIC STRENGTH; KIDNEY PARENCHYMA; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; LIVER; MEAN RESIDENCE TIME; NONHUMAN; PLASMA CLEARANCE; PLASMA CONCENTRATION-TIME CURVE; POSITIVE ION ELECTROSPRAY; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; RAT; SINGLE DRUG DOSE; STANDARD; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION STUDY; ANIMAL; BLOOD; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; STATISTICAL MODEL;

GINKGO BILOBA; RATTUS;

ADMINISTRATION, INTRAVENOUS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; GINKGOLIDES; LACTONES; LINEAR MODELS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 84923349587     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2015.02.015     Document Type: Article

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