메뉴 건너뛰기




Volumn 8, Issue , 2017, Pages

A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; ACTIVIN; GATA6 PROTEIN, HUMAN; NANOG PROTEIN, HUMAN; OCTAMER TRANSCRIPTION FACTOR 4; POU5F1 PROTEIN, HUMAN; SNAI1 PROTEIN, HUMAN; SOX17 PROTEIN, HUMAN; TGFB1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR GATA 6; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SOX; TRANSFORMING GROWTH FACTOR BETA1;

EID: 85021782477     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms15166     Document Type: Article
Times cited : (110)

References (29)
  • 1
    • 84871586080 scopus 로고    scopus 로고
    • A molecular roadmap of reprogramming somatic cells into iPS cells
    • Polo, J. M. et al. A molecular roadmap of reprogramming somatic cells into iPS cells. Cell 151, 1617–1632 (2012).
    • (2012) Cell , vol.151 , pp. 1617-1632
    • Polo, J.M.1
  • 2
    • 84920720484 scopus 로고    scopus 로고
    • Genome-wide characterization of the routes to pluripotency
    • Hussein, S. M. et al. Genome-wide characterization of the routes to pluripotency. Nature 516, 198–206 (2014).
    • (2014) Nature , vol.516 , pp. 198-206
    • Hussein, S.M.1
  • 3
    • 84871683601 scopus 로고    scopus 로고
    • Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency
    • Hansson, J. et al. Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency. Cell Rep. 2, 1579–1592 (2012).
    • (2012) Cell Rep. , vol.2 , pp. 1579-1592
    • Hansson, J.1
  • 4
    • 84906770124 scopus 로고    scopus 로고
    • The function and regulation of mesenchymal-to-epithelial transition in somatic cell reprogramming
    • Shu, X. & Pei, D. The function and regulation of mesenchymal-to-epithelial transition in somatic cell reprogramming. Curr. Opin. Genet. Dev. 28, 32–37 (2014).
    • (2014) Curr. Opin. Genet. Dev. , vol.28 , pp. 32-37
    • Shu, X.1    Pei, D.2
  • 5
    • 77957551870 scopus 로고    scopus 로고
    • A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
    • Li, R. et al. A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 7, 51–63 (2010).
    • (2010) Cell Stem Cell , vol.7 , pp. 51-63
    • Li, R.1
  • 6
    • 77956320116 scopus 로고    scopus 로고
    • Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming
    • Samavarchi-Tehrani, P. et al. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell 7, 64–77 (2010).
    • (2010) Cell Stem Cell , vol.7 , pp. 64-77
    • Samavarchi-Tehrani, P.1
  • 7
    • 84880330190 scopus 로고    scopus 로고
    • Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming
    • Liu, X. et al. Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nat. Cell Biol. 15, 829–838 (2013).
    • (2013) Nat. Cell Biol. , vol.15 , pp. 829-838
    • Liu, X.1
  • 8
    • 70449534874 scopus 로고    scopus 로고
    • Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells
    • Song, Z. et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res. 19, 1233–1242 (2009).
    • (2009) Cell Res. , vol.19 , pp. 1233-1242
    • Song, Z.1
  • 9
    • 73449100783 scopus 로고    scopus 로고
    • Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells
    • Si-Tayeb, K. et al. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology 51, 297–305 (2010).
    • (2010) Hepatology , vol.51 , pp. 297-305
    • Si-Tayeb, K.1
  • 10
    • 84907188829 scopus 로고    scopus 로고
    • Genome-wide binding and transcriptome analysis of human farnesoid X receptor in primary human hepatocytes
    • Zhan, L. et al. Genome-wide binding and transcriptome analysis of human farnesoid X receptor in primary human hepatocytes. PLoS ONE 9, e105930 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e105930
    • Zhan, L.1
  • 11
    • 84891897900 scopus 로고    scopus 로고
    • Human liver sinusoidal endothelial cells but not hepatocytes contain factor VIII
    • Shahani, T. et al. Human liver sinusoidal endothelial cells but not hepatocytes contain factor VIII. J. Thromb. Haemost. 12, 36–42 (2014).
    • (2014) J. Thromb. Haemost. , vol.12 , pp. 36-42
    • Shahani, T.1
  • 12
    • 56749098074 scopus 로고    scopus 로고
    • Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
    • Pan, Q., Shai, O., Lee, L. J., Frey, B. J. & Blencowe, B. J. Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat. Genet. 40, 1413–1415 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 1413-1415
    • Pan, Q.1    Shai, O.2    Lee, L.J.3    Frey, B.J.4    Blencowe, B.J.5
  • 13
    • 28644448149 scopus 로고    scopus 로고
    • Efficient differentiation of human embryonic stem cells to definitive endoderm
    • D’Amour, K. A. et al. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat. Biotechnol. 23, 1534–1541 (2005).
    • (2005) Nat. Biotechnol. , vol.23 , pp. 1534-1541
    • D’Amour, K.A.1
  • 14
    • 70350536767 scopus 로고    scopus 로고
    • A small-molecule inhibitor of Tgf-b signaling replaces Sox2 in reprogramming by inducing Nanog
    • Ichida, J. K. et al. A small-molecule inhibitor of Tgf-b signaling replaces Sox2 in reprogramming by inducing Nanog. Cell Stem Cell 5, 491–503 (2009).
    • (2009) Cell Stem Cell , vol.5 , pp. 491-503
    • Ichida, J.K.1
  • 15
    • 84887273608 scopus 로고    scopus 로고
    • Epithelial plasticity: A common theme in embryonic and cancer cells
    • Nieto, M. A. Epithelial plasticity: a common theme in embryonic and cancer cells. Science 342, 1234850 (2013).
    • (2013) Science , vol.342 , pp. 1234850
    • Nieto, M.A.1
  • 16
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery, J. P., Acloque, H., Huang, R. Y. & Nieto, M. A. Epithelial-mesenchymal transitions in development and disease. Cell 139, 871–890 (2009).
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 17
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak, K. & Weinberg, R. A. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat. Rev. Cancer 9, 265–273 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 18
    • 0038757830 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis
    • Parviz, F. et al. Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nat. Genet. 34, 292–296 (2003).
    • (2003) Nat. Genet. , vol.34 , pp. 292-296
    • Parviz, F.1
  • 19
    • 84856974289 scopus 로고    scopus 로고
    • Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4alpha transduction
    • Takayama, K. et al. Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4alpha transduction. Mol. Ther. 20, 127–137 (2012).
    • (2012) Mol. Ther. , vol.20 , pp. 127-137
    • Takayama, K.1
  • 20
    • 79960649307 scopus 로고    scopus 로고
    • Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors
    • Sekiya, S. & Suzuki, A. Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature 475, 390–393 (2011).
    • (2011) Nature , vol.475 , pp. 390-393
    • Sekiya, S.1    Suzuki, A.2
  • 21
    • 84896142695 scopus 로고    scopus 로고
    • Direct reprogramming of human fibroblasts to functional and expandable hepatocytes
    • Huang, P. et al. Direct reprogramming of human fibroblasts to functional and expandable hepatocytes. Cell Stem Cell 14, 370–384 (2014).
    • (2014) Cell Stem Cell , vol.14 , pp. 370-384
    • Huang, P.1
  • 22
    • 0035167812 scopus 로고    scopus 로고
    • The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition
    • Carver, E. A., Jiang, R., Lan, Y., Oram, K. F. & Gridley, T. The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol. Cell. Biol. 21, 8184–8188 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 8184-8188
    • Carver, E.A.1    Jiang, R.2    Lan, Y.3    Oram, K.F.4    Gridley, T.5
  • 23
    • 84892151082 scopus 로고    scopus 로고
    • Snail1-dependent control of embryonic stem cell pluripotency and lineage commitment
    • Lin, Y. et al. Snail1-dependent control of embryonic stem cell pluripotency and lineage commitment. Nat. Commun. 5, 3070 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 3070
    • Lin, Y.1
  • 24
    • 79955419817 scopus 로고    scopus 로고
    • Snail and the microRNA-200 family act in opposition to regulate epithelial-to-mesenchymal transition and germ layer fate restriction in differentiating ESCs
    • Gill, J. G. et al. Snail and the microRNA-200 family act in opposition to regulate epithelial-to-mesenchymal transition and germ layer fate restriction in differentiating ESCs. Stem Cells 29, 764–776 (2011).
    • (2011) Stem Cells , vol.29 , pp. 764-776
    • Gill, J.G.1
  • 25
    • 84859210032 scopus 로고    scopus 로고
    • Fast gapped-read alignment with Bowtie 2
    • Langmead, B. & Salzberg, S. L. Fast gapped-read alignment with Bowtie 2. Nat. Methods 9, 357–359 (2012).
    • (2012) Nat. Methods , vol.9 , pp. 357-359
    • Langmead, B.1    Salzberg, S.L.2
  • 26
    • 79961123152 scopus 로고    scopus 로고
    • RSEM: Accurate transcript quantification from RNA-Seq data with or without a reference genome
    • Li, B. & Dewey, C. N. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics 12, 323 (2011).
    • (2011) BMC Bioinformatics , vol.12 , pp. 323
    • Li, B.1    Dewey, C.N.2
  • 28
    • 84988231210 scopus 로고    scopus 로고
    • Glbase: A framework for combining, analyzing and displaying heterogeneous genomic and high-throughput sequencing data
    • Hutchins, A. P., Jauch, R., Dyla, M. & Miranda-Saavedra, D. glbase: a framework for combining, analyzing and displaying heterogeneous genomic and high-throughput sequencing data. Cell Regen. 3, 1 (2014).
    • (2014) Cell Regen. , vol.3 , pp. 1
    • Hutchins, A.P.1    Jauch, R.2    Dyla, M.3    Miranda-Saavedra, D.4
  • 29
    • 84866369892 scopus 로고    scopus 로고
    • Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase
    • Buganim, Y. et al. Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell 150, 1209–1222 (2012).
    • (2012) Cell , vol.150 , pp. 1209-1222
    • Buganim, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.