The function and regulation of mesenchymal-to-epithelial transition in somatic cell reprogramming

Current Opinion in Genetics and Development

Volumn 28, Issue , 2014, Pages 32-37

  Shu, Xiaodong ^a   Pei, Duanqing ^a  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION; CELL FATE; CELL PROLIFERATION; DOWN REGULATION; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; FIBROBLAST; GENE EXPRESSION; HUMAN; KERATINOCYTE; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROCEDURES CONCERNING CELLS; REGULATORY MECHANISM; REVIEW; SENESCENCE; SIGNAL TRANSDUCTION; SOMATIC CELL; SOMATIC CELL REPROGRAMMING; UPREGULATION; ANIMAL; CELL DIFFERENTIATION; CELL LINEAGE; CYTOLOGY; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CELLULAR REPROGRAMMING; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; PLURIPOTENT STEM CELLS; SIGNAL TRANSDUCTION;

EID: 84906770124     PISSN: 0959437X     EISSN: 18790380     Source Type: Journal    
DOI: 10.1016/j.gde.2014.08.005     Document Type: Review

References (36)

1. Thiery J.P., Acloque H., Huang R.Y., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
2. Polyak K., Weinberg R.A. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 2009, 9:265-273.
3. Lamouille S., Subramanyam D., Blelloch R., Derynck R. Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Curr Opin Cell Biol 2013, 25:200-207.
4. Lamouille S., Xu J., Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol 2014, 15:178-196.
5. Samavarchi-Tehrani P., Golipour A., David L., Sung H.K., Beyer T.A., Datti A., Woltjen K., Nagy A., Wrana J.L. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell 2010, 7:64-77.
6. Li R., Liang J., Ni S., Zhou T., Qing X., Li H., He W., Chen J., Li F., Zhuang Q., et al. A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 2010, 7:51-63.
7. Polo J.M., Anderssen E., Walsh R.M., Schwarz B.A., Nefzger C.M., Lim S.M., Borkent M., Apostolou E., Alaei S., Cloutier J., et al. A molecular roadmap of reprogramming somatic cells into iPS cells. Cell 2012, 151:1617-1632.
8. Hansson J., Rafiee M.R., Reiland S., Polo J.M., Gehring J., Okawa S., Huber W., Hochedlinger K., Krijgsveld J. Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency. Cell Rep 2012, 2:1579-1592.
9. Sakurai K., Talukdar I., Patil V.S., Dang J., Li Z., Chang K.Y., Lu C.C., Delorme-Walker V., Dermardirossian C., Anderson K., et al. Kinome-wide Functional analysis highlights the role of cytoskeletal remodeling in somatic cell reprogramming. Cell Stem Cell 2014, 14:523-534.
10. Chen T., Yuan D., Wei B., Jiang J., Kang J., Ling K., Gu Y., Li J., Xiao L., Pei G. E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation. Stem Cells 2010, 28:1315-1325.
11. Bedzhov I., Alotaibi H., Basilicata M.F., Ahlborn K., Liszewska E., Brabletz T., Stemmler M.P. Adhesion, but not a specific cadherin code, is indispensable for ES cell and induced pluripotency. Stem Cell Res 2013, 11:1250-1263.
12. Bao X., Zhu X., Liao B., Benda C., Zhuang Q., Pei D., Qin B., Esteban M.A. MicroRNAs in somatic cell reprogramming. Curr Opin Cell Biol 2013, 25:208-214.
13. Liao B., Bao X., Liu L., Feng S., Zovoilis A., Liu W., Xue Y., Cai J., Guo X., Qin B., et al. MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition. J Biol Chem 2011, 286:17359-17364.
14. Subramanyam D., Lamouille S., Judson R.L., Liu J.Y., Bucay N., Derynck R., Blelloch R. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol 2011, 29:443-448.
15. Wang G., Guo X., Hong W., Liu Q., Wei T., Lu C., Gao L., Ye D., Zhou Y., Chen J., et al. Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation. Proc Natl Acad Sci U S A 2013, 110:2858-2863.
16. Judson R.L., Greve T.S., Parchem R.J., Blelloch R. MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells. Nat Struct Mol Biol 2013, 20:1227-1235.
17. Onder T.T., Kara N., Cherry A., Sinha A.U., Zhu N., Bernt K.M., Cahan P., Marcarci B.O., Unternaehrer J., Gupta P.B., et al. Chromatin-modifying enzymes as modulators of reprogramming. Nature 2012, 483:598-602.
18. Kidder B.L., Hu G., Yu Z.X., Liu C., Zhao K. Extended self-renewal and accelerated reprogramming in the absence of Kdm5b. Mol Cell Biol 2013, 33:4793-4810.
19. Brosh R., Assia-Alroy Y., Molchadsky A., Bornstein C., Dekel E., Madar S., Shetzer Y., Rivlin N., Goldfinger N., Sarig R., et al. p53 counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition. Cell Death Differ 2013, 20:312-320.
20. Downing T.L., Soto J., Morez C., Houssin T., Fritz A., Yuan F., Chu J., Patel S., Schaffer D.V., Li S. Biophysical regulation of epigenetic state and cell reprogramming. Nat Mater 2013, 12:1154-1162.
21. Yoo J., Kim J., Baek S., Park Y., Im H. Cell reprogramming into the pluripotent state using graphene based substrates. Biomaterials 2014, 35:8321-8329.
22. Hou P., Li Y., Zhang X., Liu C., Guan J., Li H., Zhao T., Ye J., Yang W., Liu K., et al. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 2013, 341:651-654.
23. Shu J., Wu C., Wu Y., Li Z., Shao S., Zhao W., Tang X., Yang H., Shen L., Zuo X., et al. Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell 2013, 153:963-975.
24. Montserrat N., Nivet E., Sancho-Martinez I., Hishida T., Kumar S., Miquel L., Cortina C., Hishida Y., Xia Y., Esteban C.R., et al. Reprogramming of human fibroblasts to pluripotency with lineage specifiers. Cell Stem Cell 2013, 13:341-350.
25. Bagci H., Fisher A.G. DNA demethylation in pluripotency and reprogramming: the role of tet proteins and cell division. Cell Stem Cell 2013, 13:265-269.
26. Doege C.A., Inoue K., Yamashita T., Rhee D.B., Travis S., Fujita R., Guarnieri P., Bhagat G., Vanti W.B., Shih A., et al. Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2. Nature 2012, 488:652-655.
27. Costa Y., Ding J., Theunissen T.W., Faiola F., Hore T.A., Shliaha P.V., Fidalgo M., Saunders A., Lawrence M., Dietmann S., et al. NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature 2013, 495:370-374.
28. Gao Y., Chen J., Li K., Wu T., Huang B., Liu W., Kou X., Zhang Y., Huang H., Jiang Y., et al. Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell 2013, 12:453-469.
29. Hu X., Zhang L., Mao S.Q., Li Z., Chen J., Zhang R.R., Wu H.P., Gao J., Guo F., Liu W., et al. Tet and TDG mediate DNA demethylation essential for mesenchymal-to-epithelial transition in somatic cell reprogramming. Cell Stem Cell 2014, 14:512-522.
30. Esteban M.A., Wang T., Qin B., Yang J., Qin D., Cai J., Li W., Weng Z., Chen J., Ni S., et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 2010, 6:71-79.
31. Wang T., Chen K., Zeng X., Yang J., Wu Y., Shi X., Qin B., Zeng L., Esteban M.A., Pan G., et al. The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell 2011, 9:575-587.
32. Chen J., Liu H., Liu J., Qi J., Wei B., Yang J., Liang H., Chen Y., Wu Y., Guo L., et al. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet 2013, 45:34-42.
33. Blaschke K., Ebata K.T., Karimi M.M., Zepeda-Martinez J.A., Goyal P., Mahapatra S., Tam A., Laird D.J., Hirst M., Rao A., et al. Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature 2013, 500:222-226.
34. Chen J., Guo L., Zhang L., Wu H., Yang J., Liu H., Wang X., Hu X., Gu T., Zhou Z., et al. Vitamin C modulates TET1 function during somatic cell reprogramming. Nat Genet 2013, 45:1504-1509.
35. Liu X., Sun H., Qi J., Wang L., He S., Liu J., Feng C., Chen C., Li W., Guo Y., et al. Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nat Cell Biol 2013, 15:829-838.
36. Di Stefano B., Sardina J.L., van Oevelen C., Collombet S., Kallin E.M., Vicent G.P., Lu J., Thieffry D., Beato M., Graf T. C/EBPalpha poises B cells for rapid reprogramming into induced pluripotent stem cells. Nature 2014, 506:235-239.