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Volumn 28, Issue 13, 2017, Pages 1754-1767

Phosphorylation of NHE3-S719 regulates NHE3 activity through the formation of multiple signaling complexes

Author keywords

[No Author keywords available]

Indexed keywords

CARBACHOL; CASEIN KINASE II; FORSKOLIN; GLUTATHIONE; HYBRID PROTEIN; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR 5; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SNX27 PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG; CALCIUM; LYSOPHOSPHOLIPID; PHOSPHOPROTEIN; PROTEIN BINDING; SLC9A3 PROTEIN, HUMAN; SODIUM; SODIUM PROTON EXCHANGE PROTEIN; SODIUM-HYDROGEN EXCHANGER REGULATORY FACTOR;

EID: 85021666674     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E16-12-0862     Document Type: Article
Times cited : (11)

References (49)
  • 2
    • 33745743608 scopus 로고    scopus 로고
    • Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation
    • Ammar YB, Takeda S, Hisamitsu T, Mori H, Wakabayashi S (2006). Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation. EMBO J 25, 2315-2325.
    • (2006) EMBO J , vol.25 , pp. 2315-2325
    • Ammar, Y.B.1    Takeda, S.2    Hisamitsu, T.3    Mori, H.4    Wakabayashi, S.5
  • 3
    • 84903555061 scopus 로고    scopus 로고
    • Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLCPKC? Signaling
    • Cha B, Chen T, Sarker R, Yang J, Raben D, Tse CM, Kovbasnjuk O, Donowitz M (2014). Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLCPKC? signaling. Am J Physiol Cell Physiol 307, C55-C65.
    • (2014) Am J Physiol Cell Physiol , vol.307 , pp. C55-C65
    • Cha, B.1    Chen, T.2    Sarker, R.3    Yang, J.4    Raben, D.5    Tse, C.M.6    Kovbasnjuk, O.7    Donowitz, M.8
  • 4
    • 46749118449 scopus 로고    scopus 로고
    • The epithelial brush border Na+/H+ exchanger NHE3 associates with the actin cytoskeleton by binding to ezrin directly and via PDZ domain-containing Na+/H+ exchanger regulatory factor (NHERF) proteins
    • Cha B, Donowitz M (2008). The epithelial brush border Na+/H+ exchanger NHE3 associates with the actin cytoskeleton by binding to ezrin directly and via PDZ domain-containing Na+/H+ exchanger regulatory factor (NHERF) proteins. Clin Exp Pharmacol Physiol 35, 863-871.
    • (2008) Clin Exp Pharmacol Physiol , vol.35 , pp. 863-871
    • Cha, B.1    Donowitz, M.2
  • 5
    • 4344578072 scopus 로고    scopus 로고
    • The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2, but is dependent on an intact actin cytoskeleton as determined by FRAP
    • Cha B, Kenworthy A, Murtazina R, Donowitz M (2004). The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2, but is dependent on an intact actin cytoskeleton as determined by FRAP. J Cell Sci 117, 3353-3365.
    • (2004) J Cell Sci , vol.117 , pp. 3353-3365
    • Cha, B.1    Kenworthy, A.2    Murtazina, R.3    Donowitz, M.4
  • 6
    • 20444441935 scopus 로고    scopus 로고
    • CGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein
    • Cha B, Kim JH, Hut H, Hogema BM, Nadarja J, Zizak M, Cavet M, Lee-Kwon W, Lohmann SM, Smolenski A, et al. (2005). cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein. J Biol Chem 280, 16642-16650.
    • (2005) J Biol Chem , vol.280 , pp. 16642-16650
    • Cha, B.1    Kim, J.H.2    Hut, H.3    Hogema, B.M.4    Nadarja, J.5    Zizak, M.6    Cavet, M.7    Lee-Kwon, W.8    Lohmann, S.M.9    Smolenski, A.10
  • 7
    • 78650114041 scopus 로고    scopus 로고
    • Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP-and [Ca2+]-but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine
    • Chen M, Sultan A, Cinar A, Yeruva S, Riederer B, Singh AK, Li J, Bonhagen J, Chen G, Yun C, et al. (2010). Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP-and [Ca2+]-but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine. J Physiol 588, 5049-5063.
    • (2010) J Physiol , vol.588 , pp. 5049-5063
    • Chen, M.1    Sultan, A.2    Cinar, A.3    Yeruva, S.4    Riederer, B.5    Singh, A.K.6    Li, J.7    Bonhagen, J.8    Chen, G.9    Yun, C.10
  • 8
    • 84921683215 scopus 로고    scopus 로고
    • Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: Identification of a multifunctional phosphorylation site
    • Chen T, Kocinsky HS, Cha B, Murtazina R, Yang J, Tse CM, Singh V, Cole R, Aronson PS, de Jonge H, et al. (2015). Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation site. J Biol Chem 290, 1952-1965.
    • (2015) J Biol Chem , vol.290 , pp. 1952-1965
    • Chen, T.1    Kocinsky, H.S.2    Cha, B.3    Murtazina, R.4    Yang, J.5    Tse, C.M.6    Singh, V.7    Cole, R.8    Aronson, P.S.9    De Jonge, H.10
  • 9
    • 34447629085 scopus 로고    scopus 로고
    • Regulatory binding partners and complexes of NHE3
    • Donowitz M, Li X (2007). Regulatory binding partners and complexes of NHE3. Physiol Rev 3, 825-872.
    • (2007) Physiol Rev , vol.3 , pp. 825-872
    • Donowitz, M.1    Li, X.2
  • 11
    • 84861887083 scopus 로고    scopus 로고
    • Deciphering the mechanisms of the Na+/H+ exchanger-3 regulation in organ dysfunction
    • Girardi AC, Sole , Di F (2012). Deciphering the mechanisms of the Na+/H+ exchanger-3 regulation in organ dysfunction. Am J Physiol Cell Physiol 302, C1569-C1587.
    • (2012) Am J Physiol Cell Physiol , vol.302 , pp. C1569-C1587
    • Girardi, A.C.1    Di, F.2
  • 12
    • 77954942429 scopus 로고    scopus 로고
    • Regulation of intracellular pH by p90Rsk-dependent activation of an Na(+)/H(+) exchanger in starfish oocytes
    • Harada K, Fukuda E, Hirohashi N, Chiba K (2010). Regulation of intracellular pH by p90Rsk-dependent activation of an Na(+)/H(+) exchanger in starfish oocytes. J Biol Chem 285, 24044-24054.
    • (2010) J Biol Chem , vol.285 , pp. 24044-24054
    • Harada, K.1    Fukuda, E.2    Hirohashi, N.3    Chiba, K.4
  • 13
    • 84898615008 scopus 로고    scopus 로고
    • Structural dynamics and regulation of the mammalian SLC9A family of Na+/H+ exchangers
    • Hendus-Altenburger R, Kragelund BB, Pedersen SF (2014). Structural dynamics and regulation of the mammalian SLC9A family of Na+/H+ exchangers. Curr Top Membr 73, 69-148.
    • (2014) Curr Top Membr , vol.73 , pp. 69-148
    • Hendus-Altenburger, R.1    Kragelund, B.B.2    Pedersen, S.F.3
  • 14
    • 0032502358 scopus 로고    scopus 로고
    • Subcellular redistribution is involved in acute regulation of the brush border Na/H exchanger isoform 3 in human colon adenocarcinoma cell line Caco-2 Protein kinase C-mediated inhibition of the exchanger
    • Janecki A J, Montrose MH, Zimniak P, Zweibaum A, Tse C M, Khurana S, Donowitz M (1998). Subcellular redistribution is involved in acute regulation of the brush border Na/H exchanger isoform 3 in human colon adenocarcinoma cell line Caco-2. Protein kinase C-mediated inhibition of the exchanger. J Biol Chem 273, 8790-8798.
    • (1998) J Biol Chem , vol.273 , pp. 8790-8798
    • Janecki, A.J.1    Montrose, M.H.2    Zimniak, P.3    Zweibaum, A.4    Tse, C.M.5    Khurana, S.6    Donowitz, M.7
  • 15
    • 0034677953 scopus 로고    scopus 로고
    • Basic fibroblast growth factor stimulates surface expression and activity of Na(+)/H(+) exchanger NHE3 via mechanism involving phosphatidylinositol 3-kinase
    • Janecki AJ, Janecki M, Akhter S, Donowitz M (2000). Basic fibroblast growth factor stimulates surface expression and activity of Na(+)/H(+) exchanger NHE3 via mechanism involving phosphatidylinositol 3-kinase. J Biol Chem 275, 8133-8142.
    • (2000) J Biol Chem , vol.275 , pp. 8133-8142
    • Janecki, A.J.1    Janecki, M.2    Akhter, S.3    Donowitz, M.4
  • 16
    • 0037189512 scopus 로고    scopus 로고
    • Ca2+-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis
    • Kim JH, Lee-Kwon W, Park JB, Ryu SH, Yun CH, Donowitz M (2002). Ca2+-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis. J Biol Chem 277, 23714-23724.
    • (2002) J Biol Chem , vol.277 , pp. 23714-23724
    • Kim, J.H.1    Lee-Kwon, W.2    Park, J.B.3    Ryu, S.H.4    Yun, C.H.5    Donowitz, M.6
  • 17
    • 0035903178 scopus 로고    scopus 로고
    • Constitutively active phosphatidylinositol 3-kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3
    • Lee-Kwon W, Johns DC, Cha B, Cavet M, Park J, Tsichlis P, Donowitz M (2001). Constitutively active phosphatidylinositol 3-kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3. J Biol Chem 276, 31296-31304.
    • (2001) J Biol Chem , vol.276 , pp. 31296-31304
    • Lee-Kwon, W.1    Johns, D.C.2    Cha, B.3    Cavet, M.4    Park, J.5    Tsichlis, P.6    Donowitz, M.7
  • 18
    • 0029031096 scopus 로고
    • Separate C-terminal domains of the epithelial specific brush border Na+/H+ exchanger isoform NHE3 are involved in stimulation and inhibition by protein kinases/growth factors
    • Levine SA, Nath SK, Yun CH, Yip JW, Montrose M, Donowitz M, Tse CM (1995). Separate C-terminal domains of the epithelial specific brush border Na+/H+ exchanger isoform NHE3 are involved in stimulation and inhibition by protein kinases/growth factors. J Biol Chem 270, 13716-13725.
    • (1995) J Biol Chem , vol.270 , pp. 13716-13725
    • Levine, S.A.1    Nath, S.K.2    Yun, C.H.3    Yip, J.W.4    Montrose, M.5    Donowitz, M.6    Tse, C.M.7
  • 19
    • 84922549163 scopus 로고    scopus 로고
    • Fractionation of subcellular membrane vesicles of epithelial and non-epithelial cells by OptiPrep™ density gradient ultracentrifugation
    • Li X, Donowitz M (2014). Fractionation of subcellular membrane vesicles of epithelial and non-epithelial cells by OptiPrep™ density gradient ultracentrifugation. Methods Mol Biol 174, 85-99.
    • (2014) Methods Mol Biol , vol.174 , pp. 85-99
    • Li, X.1    Donowitz, M.2
  • 20
    • 0035576776 scopus 로고    scopus 로고
    • Na+/H+ exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: A role for rafts in trafficking and rapid stimulation of NHE3
    • Li X, Galli T, Leu S, Wade J B, Weinman E J, Leung G, Cheong A, Louvard D, Donowitz M (2001). Na+/H+ exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: a role for rafts in trafficking and rapid stimulation of NHE3. J Physiol 537, 537-552.
    • (2001) J Physiol , vol.537 , pp. 537-552
    • Li, X.1    Galli, T.2    Leu, S.3    Wade, J.B.4    Weinman, E.J.5    Leung, G.6    Cheong, A.7    Louvard, D.8    Donowitz, M.9
  • 21
    • 0347991871 scopus 로고    scopus 로고
    • Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: Role in absorption and differentiation
    • Li X, Leu S, Cheong A, Zhang H, Baibakov B, Shih C, Birnbaum MJ, Donowitz M (2004). Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation. Gastroenterology 126, 122-135.
    • (2004) Gastroenterology , vol.126 , pp. 122-135
    • Li, X.1    Leu, S.2    Cheong, A.3    Zhang, H.4    Baibakov, B.5    Shih, C.6    Birnbaum, M.J.7    Donowitz, M.8
  • 22
    • 79251561246 scopus 로고    scopus 로고
    • D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2-dependent process
    • Lin R, Murtazina R, Cha B, Chakraborty M, Sarker R, Chen TE, Lin Z, Hogema BM, de Jonge HR, Seidler U, et al. (2011). D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2-dependent process. Gastroenterology 140, 560-571.
    • (2011) Gastroenterology , vol.140 , pp. 560-571
    • Lin, R.1    Murtazina, R.2    Cha, B.3    Chakraborty, M.4    Sarker, R.5    Chen, T.E.6    Lin, Z.7    Hogema, B.M.8    De Jonge, H.R.9    Seidler, U.10
  • 24
    • 0032736233 scopus 로고    scopus 로고
    • Acute regulation of proximal tubule apical membrane Na/H exchanger NHE-3, role of phosphorylation, protein trafficking, and regulatory factors
    • Moe OW (1999). Acute regulation of proximal tubule apical membrane Na/H exchanger NHE-3, role of phosphorylation, protein trafficking, and regulatory factors. J Am Soc Nephrol 10, 2412-2425.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 2412-2425
    • Moe, O.W.1
  • 27
    • 33745857631 scopus 로고    scopus 로고
    • Na+/H+ exchanger NHE3 activity and trafficking are lipid raft-dependent
    • Murtazina R, Kovbasnjuk O, Donowit M, Li X (2006). Na+/H+ exchanger NHE3 activity and trafficking are lipid raft-dependent. J Biol Chem 281, 17845-17855.
    • (2006) J Biol Chem , vol.281 , pp. 17845-17855
    • Murtazina, R.1    Kovbasnjuk, O.2    Donowit, M.3    Li, X.4
  • 28
    • 0029963333 scopus 로고    scopus 로고
    • Hyperosmolarity inhibits the Na+/H+ exchanger isoforms NHE2 and NHE3: An effect opposite to that on NHE1
    • Nath SK, Hang CY, Levine SA, Yun CH, Montrose MH, Donowitz M, Tse CM (1996). Hyperosmolarity inhibits the Na+/H+ exchanger isoforms NHE2 and NHE3: an effect opposite to that on NHE1. Am J Physiol 270, G431-G441.
    • (1996) Am J Physiol , vol.270 , pp. G431-G441
    • Nath, S.K.1    Hang, C.Y.2    Levine, S.A.3    Yun, C.H.4    Montrose, M.H.5    Donowitz, M.6    Tse, C.M.7
  • 29
    • 84930679505 scopus 로고    scopus 로고
    • Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2
    • No YR, He P, Yoo BK, Yun CC (2015). Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2. Am J Physiol Cell Physiol 309, C14-C21.
    • (2015) Am J Physiol Cell Physiol , vol.309 , pp. C14-C21
    • No, Y.R.1    He, P.2    Yoo, B.K.3    Yun, C.C.4
  • 30
    • 79955365244 scopus 로고    scopus 로고
    • The intracellular distal tail of the Na+/H+ exchanger NHE1 is intrinsically disordered: Implications for NHE1 trafficking
    • Nørholm AB, Hendus-Altenburger R, Bjerre G, Kjaergaard M, Pedersen SF, Kragelund BB (2011). The intracellular distal tail of the Na+/H+ exchanger NHE1 is intrinsically disordered: implications for NHE1 trafficking. Biochemistry 50, 3469-3480.
    • (2011) Biochemistry , vol.50 , pp. 3469-3480
    • Nørholm, A.B.1    Hendus-Altenburger, R.2    Bjerre, G.3    Kjaergaard, M.4    Pedersen, S.F.5    Kragelund, B.B.6
  • 31
    • 0035907278 scopus 로고    scopus 로고
    • Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers
    • Pang T, Su X, Wakabayashi S, Shigekawa M (2001). Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers. J Biol Chem 276, 17367-17372.
    • (2001) J Biol Chem , vol.276 , pp. 17367-17372
    • Pang, T.1    Su, X.2    Wakabayashi, S.3    Shigekawa, M.4
  • 32
    • 84948184410 scopus 로고    scopus 로고
    • Mechanisms underlying dysregulation of electrolyte absorption in inflammatory bowel disease-associated diarrhea
    • Priyamvada S, Gomes R, Gill RK, Saksena S, Alrefai WA, Dudeja PK (2015). Mechanisms underlying dysregulation of electrolyte absorption in inflammatory bowel disease-associated diarrhea. Inflamm Bowel Dis 21, 2926-2935.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 2926-2935
    • Priyamvada, S.1    Gomes, R.2    Gill, R.K.3    Saksena, S.4    Alrefai, W.A.5    Dudeja, P.K.6
  • 33
    • 55549139194 scopus 로고    scopus 로고
    • Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3
    • Sarker R, Grønborg M, Cha B, Mohan S, Chen Y, Pandey A, Litchfield D, Donowitz M, Li X (2008). Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3. Mol Biol Cell 19, 3859-3870.
    • (2008) Mol Biol Cell , vol.19 , pp. 3859-3870
    • Sarker, R.1    Grønborg, M.2    Cha, B.3    Mohan, S.4    Chen, Y.5    Pandey, A.6    Litchfield, D.7    Donowitz, M.8    Li, X.9
  • 35
    • 84896804088 scopus 로고    scopus 로고
    • AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: Role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking
    • Singh V, Lin R, Yang J, Cha B, Sarker R, Tse CM, Donowitz M (2014). AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking. J Biol Chem 289, 5449-5461.
    • (2014) J Biol Chem , vol.289 , pp. 5449-5461
    • Singh, V.1    Lin, R.2    Yang, J.3    Cha, B.4    Sarker, R.5    Tse, C.M.6    Donowitz, M.7
  • 37
    • 84890633880 scopus 로고    scopus 로고
    • Differential association of the Na+/H+ exchanger regulatory factor (NHERF) family of adaptor proteins with the raft-and the non-raft brush border membrane fractions of NHE3
    • Sultan A, Luo M, Yu Q, Riederer B, Xia W, Chen M, Lissner S, Gessner JE, Donowitz M, Yun CC, et al. (2013). Differential association of the Na+/H+ exchanger regulatory factor (NHERF) family of adaptor proteins with the raft-and the non-raft brush border membrane fractions of NHE3. Cell Physiol Biochem 32, 1386-1402.
    • (2013) Cell Physiol Biochem , vol.32 , pp. 1386-1402
    • Sultan, A.1    Luo, M.2    Yu, Q.3    Riederer, B.4    Xia, W.5    Chen, M.6    Lissner, S.7    Gessner, J.E.8    Donowitz, M.9    Yun, C.C.10
  • 38
    • 25444434666 scopus 로고    scopus 로고
    • Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1
    • Wang D, Sun H, Lang F, Yun CC (2005). Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1. Am J Physiol Cell Physiol 289, C802-C810.
    • (2005) Am J Physiol Cell Physiol , vol.289 , pp. C802-C810
    • Wang, D.1    Sun, H.2    Lang, F.3    Yun, C.C.4
  • 39
    • 0033021073 scopus 로고    scopus 로고
    • Acute regulation of Na/H exchanger NHE3 activity by protein kinase C: Role of NHE3 phosphorylation
    • Wiederkehr MR, Zhao H, Moe OW (1999). Acute regulation of Na/H exchanger NHE3 activity by protein kinase C: role of NHE3 phosphorylation. Am J Physiol 276, C1205-C1217.
    • (1999) Am J Physiol , vol.276 , pp. C1205-C1217
    • Wiederkehr, M.R.1    Zhao, H.2    Moe, O.W.3
  • 40
    • 67349266694 scopus 로고    scopus 로고
    • Universal sample preparation method for proteome analysis
    • Wisniewski JR, Zougman A, Nagaraj N, Mann M (2009). Universal sample preparation method for proteome analysis. Nat Methods 6, 359-362.
    • (2009) Nat Methods , vol.6 , pp. 359-362
    • Wisniewski, J.R.1    Zougman, A.2    Nagaraj, N.3    Mann, M.4
  • 41
    • 84878749405 scopus 로고    scopus 로고
    • NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells
    • Yang J, Singh V, Cha B, Chen TE, Sarker R, Murtazina R, Jin S, Zachos NC, Patterson GH, Tse CM, et al. (2013). NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells. J Biol Chem 288, 16960-16974.
    • (2013) J Biol Chem , vol.288 , pp. 16960-16974
    • Yang, J.1    Singh, V.2    Cha, B.3    Chen, T.E.4    Sarker, R.5    Murtazina, R.6    Jin, S.7    Zachos, N.C.8    Patterson, G.H.9    Tse, C.M.10
  • 42
    • 84904497991 scopus 로고    scopus 로고
    • NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol
    • Yang J, Singh V, Chen TE, Sarker R, Xiong L, Cha B, Jin S, Li X, Tse CM, Zachos NC, Donowitz M (2014). NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol. J Biol Chem 289, 20039-20053.
    • (2014) J Biol Chem , vol.289 , pp. 20039-20053
    • Yang, J.1    Singh, V.2    Chen, T.E.3    Sarker, R.4    Xiong, L.5    Cha, B.6    Jin, S.7    Li, X.8    Tse, C.M.9    Zachos, N.C.10    Donowitz, M.11
  • 43
    • 0037235374 scopus 로고    scopus 로고
    • Concerted roles of SGK1 and the Na+/H+ exchanger regulatory factor 2 (NHERF2) in regulation of NHE3
    • Yun CC (2003). Concerted roles of SGK1 and the Na+/H+ exchanger regulatory factor 2 (NHERF2) in regulation of NHE3. Cell Physiol Biochem 13, 29-40.
    • (2003) Cell Physiol Biochem , vol.13 , pp. 29-40
    • Yun, C.C.1
  • 44
    • 84898028932 scopus 로고    scopus 로고
    • Carbachol-mediated endocytosis of NHE3 involves a clathrin-independent mechanism requiring lipid rafts and Cdc42
    • Zachos NC, Alamelumangpuram B, Lee LJ, Wang P, Kovbasnjuk O (2014). Carbachol-mediated endocytosis of NHE3 involves a clathrin-independent mechanism requiring lipid rafts and Cdc42. Cell Physiol Biochem 33, 869-881.
    • (2014) Cell Physiol Biochem , vol.33 , pp. 869-881
    • Zachos, N.C.1    Alamelumangpuram, B.2    Lee, L.J.3    Wang, P.4    Kovbasnjuk, O.5
  • 45
    • 67249086093 scopus 로고    scopus 로고
    • Regulation of intestinal electroneutral sodium absorption and the brush border Na+/H+ exchanger by intracellular calcium
    • Zachos NC, Kovbasnjuk O, Donowitz M (2009). Regulation of intestinal electroneutral sodium absorption and the brush border Na+/H+ exchanger by intracellular calcium. Ann NY Acad Sci 1165, 240-248.
    • (2009) Ann NY Acad Sci , vol.1165 , pp. 240-248
    • Zachos, N.C.1    Kovbasnjuk, O.2    Donowitz, M.3
  • 46
    • 15744368985 scopus 로고    scopus 로고
    • Molecular physiology of intestinal Na+/H+ exchange
    • Zachos NC, Tse M, Donowitz M (2005). Molecular physiology of intestinal Na+/H+ exchange. Annu Rev Physiol 67, 411-443.
    • (2005) Annu Rev Physiol , vol.67 , pp. 411-443
    • Zachos, N.C.1    Tse, M.2    Donowitz, M.3
  • 47
    • 45549104272 scopus 로고    scopus 로고
    • Calcineurin B homologous protein 3 promotes the biosynthetic maturation, cell surface stability, and optimal transport of the Na+/H+ exchanger NHE1 isoform
    • Zaun HC, Shrier A, Orlowski A (2008). Calcineurin B homologous protein 3 promotes the biosynthetic maturation, cell surface stability, and optimal transport of the Na+/H+ exchanger NHE1 isoform. J Biol Chem 218, 12456-12467.
    • (2008) J Biol Chem , vol.218 , pp. 12456-12467
    • Zaun, H.C.1    Shrier, A.2    Orlowski, A.3
  • 48
    • 80053411891 scopus 로고    scopus 로고
    • Elevated calcium acutely regulates dynamic interactions of NHERF2 and NHE3 proteins in opossum kidney (OK) cell microvilli
    • Zhu X, Cha B, Zachos NC, Sarker R, Chakraborty M, Chen TE, Kovbasnjuk O, Donowitz M (2011). Elevated calcium acutely regulates dynamic interactions of NHERF2 and NHE3 proteins in opossum kidney (OK) cell microvilli. J Biol Chem 286, 34486-34496.
    • (2011) J Biol Chem , vol.286 , pp. 34486-34496
    • Zhu, X.1    Cha, B.2    Zachos, N.C.3    Sarker, R.4    Chakraborty, M.5    Chen, T.E.6    Kovbasnjuk, O.7    Donowitz, M.8
  • 49
    • 84859735370 scopus 로고    scopus 로고
    • Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process
    • Zizak M, Chen T, Bartonicek D, Sarker R, Zachos NC, Cha B, Kovbasnjuk O, Korac J, Mohan S, Cole R, et al. (2012). Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process. J Biol Chem 287, 13442-13456.
    • (2012) J Biol Chem , vol.287 , pp. 13442-13456
    • Zizak, M.1    Chen, T.2    Bartonicek, D.3    Sarker, R.4    Zachos, N.C.5    Cha, B.6    Kovbasnjuk, O.7    Korac, J.8    Mohan, S.9    Cole, R.10


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