Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: Identification of a multifunctional phosphorylation site

Journal of Biological Chemistry

Volumn 290, Issue 4, 2015, Pages 1952-1965

  Chen, Tiane ^a   Kocinsky, Hetal S ^b,d   Cha, Boyoung ^a   Murtazina, Rakhilya ^a   Yang, Jianbo ^a   Tse, C Ming ^a   Singh, Varsha ^a   Cole, Robert ^a   Aronson, Peter S ^b   De Jonge, Hugo ^c   Sarker, Rafiquel ^a   Donowitz, Mark ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d Achillion Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; MAMMALS; SIGNAL TRANSDUCTION; TITANIUM DIOXIDE;

CARBOXYFLUORESCEIN; CELL SURFACE BIOTINYLATION; CGMP INHIBITION; DEXAMETHASONES; IMMUNOBLOTTING; MEMBRANE TRAFFICKING; PHOSPHORYLATION SITES; SURFACE EXPRESSION;

PHOSPHORYLATION;

CYCLIC AMP; CYCLIC GMP KINASE II; DEXAMETHASONE; GUANYLATE KINASE; SERINE; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG; CYCLIC GMP DEPENDENT PROTEIN KINASE 2; SODIUM PROTON EXCHANGE PROTEIN; SODIUM-HYDROGEN EXCHANGER 3;

ANIMAL TISSUE; ARTICLE; CACO 2 CELL LINE; CELL MIGRATION; CONTROLLED STUDY; ENZYME INHIBITION; FLUOROMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INHIBITION KINETICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; SURFACE PROPERTY; ANIMAL; BINDING SITE; CELL MEMBRANE; CHEMISTRY; GENETIC TRANSFECTION; INTESTINE; METABOLISM; MICROVILLUS; MUTAGENESIS; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT;

ORYCTOLAGUS CUNICULUS;

ANIMALS; BINDING SITES; CACO-2 CELLS; CELL MEMBRANE; CYCLIC GMP-DEPENDENT PROTEIN KINASE TYPE II; DEXAMETHASONE; HUMANS; INTESTINES; MASS SPECTROMETRY; MICE; MICROVILLI; MUTAGENESIS; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SERINE; SODIUM-HYDROGEN ANTIPORTER; SURFACE PROPERTIES; TRANSFECTION;

EID: 84921683215     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.590174     Document Type: Article

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