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Volumn 309, Issue 1, 2015, Pages C14-C21

Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2

Author keywords

Lysophosphatidic acid; Na+ H+ exchanger 3; Phosphorylation; Ribosomal S6 kinase

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; FOCAL ADHESION KINASE 2; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR 5; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN RSK1; PROTEIN RSK2; PROTEIN SERINE THREONINE KINASE; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG; 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; EGFR PROTEIN, HUMAN; LPAR5 PROTEIN, HUMAN; LYSOPHOSPHOLIPID; PDPK1 PROTEIN, HUMAN; PTK2B PROTEIN, HUMAN; RIBOSOMAL PROTEIN S6 KINASE, 90KDA, POLYPEPTIDE 3; S6 KINASE; SODIUM PROTON EXCHANGE PROTEIN; SODIUM-HYDROGEN EXCHANGER 3;

EID: 84930679505     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00067.2015     Document Type: Article
Times cited : (28)

References (50)
  • 1
    • 52449095361 scopus 로고    scopus 로고
    • The RSK family of kinases: Emerging roles in cellular signalling
    • Anjum R, Blenis J. The RSK family of kinases: emerging roles in cellular signalling. Nat Rev Mol Cell Biol 9: 747-758, 2008.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 747-758
    • Anjum, R.1    Blenis, J.2
  • 2
    • 49949098676 scopus 로고    scopus 로고
    • Two pathways for lysophosphatidic acid production
    • Aoki J, Inoue A, Okudaira S. Two pathways for lysophosphatidic acid production. Biochim Biophys Acta 1781: 513-518, 2008.
    • (2008) Biochim Biophys Acta , vol.1781 , pp. 513-518
    • Aoki, J.1    Inoue, A.2    Okudaira, S.3
  • 3
    • 0033199841 scopus 로고    scopus 로고
    • Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: Identification of five sites of phosphorylation in vivo
    • Casamayor A, Morrice NA, Alessi DR. Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo. Biochem J 342: 287-292, 1999.
    • (1999) Biochem J , vol.342 , pp. 287-292
    • Casamayor, A.1    Morrice, N.A.2    Alessi, D.R.3
  • 5
    • 33744779069 scopus 로고    scopus 로고
    • The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: Dual role in NHE3 trafficking and mobility in the brush border
    • Cha B, Tse M, Yun C, Kovbasnjuk O, Mohan S, Hubbard A, Arpin M, Donowitz M. The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: dual role in NHE3 trafficking and mobility in the brush border. Mol Biol Cell 17: 2661-2673, 2006.
    • (2006) Mol Biol Cell , vol.17 , pp. 2661-2673
    • Cha, B.1    Tse, M.2    Yun, C.3    Kovbasnjuk, O.4    Mohan, S.5    Hubbard, A.6    Arpin, M.7    Donowitz, M.8
  • 8
    • 84935439562 scopus 로고    scopus 로고
    • Pyk and ERK your way to the hub by taking a RSK 2. Focus on “Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2.
    • Domingue JC, Rao MC. Pyk and ERK your way to the hub by taking a RSK 2. Focus on “Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2.” Am J Physiol Cell Physiol (May 13, 2015). doi:10.1152/ajpcell.00128.2015.
    • (2015) Am J Physiol Cell Physiol (May , pp. 13
    • Domingue, J.C.1    Rao, M.C.2
  • 10
    • 80054700545 scopus 로고    scopus 로고
    • Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids
    • He P, Lee SJ, Lin S, Seidler U, Lang F, Fejes-Toth G, Naray-Fejes-Toth A, Yun CC. Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids. Mol Biol Cell 22: 3812-3825, 2011.
    • (2011) Mol Biol Cell , vol.22 , pp. 3812-3825
    • He, P.1    Lee, S.J.2    Lin, S.3    Seidler, U.4    Lang, F.5    Fejes-Toth, G.6    Naray-Fejes-Toth, A.7    Yun, C.C.8
  • 11
    • 57749112095 scopus 로고    scopus 로고
    • IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calcium
    • He P, Zhang H, Yun CC. IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calcium. J Biol Chem 283: 33544-33553, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 33544-33553
    • He, P.1    Zhang, H.2    Yun, C.C.3
  • 13
    • 0028880396 scopus 로고
    • Plasma membrane Na+/H+ exchanger isoforms (NHE-1, -2, and -3) are differentially responsive to second messenger agonists of the protein kinase A and C pathways
    • Kandasamy RA, Yu FH, Harris R, Boucher A, Hanrahan JW, Or-lowski J. Plasma membrane Na+/H+ exchanger isoforms (NHE-1, -2, and -3) are differentially responsive to second messenger agonists of the protein kinase A and C pathways. J Biol Chem 270: 29209-29216, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 29209-29216
    • Kandasamy, R.A.1    Yu, F.H.2    Harris, R.3    Boucher, A.4    Hanrahan, J.W.5    Or-Lowski, J.6
  • 14
    • 34548030449 scopus 로고    scopus 로고
    • NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity
    • Kocinsky HS, Dynia DW, Wang T, Aronson PS. NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity. Am J Physiol Renal Physiol 293: F212-F218, 2007.
    • (2007) Am J Physiol Renal Physiol , vol.293 , pp. F212-F218
    • Kocinsky, H.S.1    Dynia, D.W.2    Wang, T.3    Aronson, P.S.4
  • 15
    • 0030695944 scopus 로고    scopus 로고
    • Identification of sites required for down-regulation of Na/H exchanger NHE3 activity by cAMP-dependent protein kinase
    • Kurashima K, Yu FH, Cabado AG, Szabo EZ, Grinstein S, Orlowski J. Identification of sites required for down-regulation of Na/H exchanger NHE3 activity by cAMP-dependent protein kinase. J Biol Chem 272: 28672-28679, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 28672-28679
    • Kurashima, K.1    Yu, F.H.2    Cabado, A.G.3    Szabo, E.Z.4    Grinstein, S.5    Orlowski, J.6
  • 16
    • 0032491428 scopus 로고    scopus 로고
    • The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3
    • Lamprecht G, Weinman EJ, Yun CC. The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3. J Biol Chem 273: 29972-29978, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 29972-29978
    • Lamprecht, G.1    Weinman, E.J.2    Yun, C.C.3
  • 17
    • 33747685338 scopus 로고    scopus 로고
    • GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5
    • Lee CW, Rivera R, Gardell S, Dubin AE, Chun J. GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. J Biol Chem 281: 23589-23597, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 23589-23597
    • Lee, C.W.1    Rivera, R.2    Gardell, S.3    Dubin, A.E.4    Chun, J.5
  • 18
    • 84878971521 scopus 로고    scopus 로고
    • Distinct phospholipase C-fj isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure
    • Lee SJ, Leoni G, Neumann PA, Chun J, Nusrat A, Yun CC. Distinct phospholipase C-fj isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure. Mol Cell Biol 33: 2016-2028, 2013.
    • (2013) Mol Cell Biol , vol.33 , pp. 2016-2028
    • Lee, S.J.1    Leoni, G.2    Neumann, P.A.3    Chun, J.4    Nusrat, A.5    Yun, C.C.6
  • 20
    • 38349096466 scopus 로고    scopus 로고
    • Critical role for Rsk2 in T-lymphocyte activation
    • Lin JX, Spolski R, Leonard WJ. Critical role for Rsk2 in T-lymphocyte activation. Blood 111: 525-533, 2008.
    • (2008) Blood , vol.111 , pp. 525-533
    • Lin, J.X.1    Spolski, R.2    Leonard, W.J.3
  • 21
    • 78149481269 scopus 로고    scopus 로고
    • The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine
    • Lin S, Lee SJ, Shim H, Chun J, Yun CC. The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine. Am J Physiol Gastrointest Liver Physiol 299: G1128-G1138, 2010.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.299 , pp. G1128-G1138
    • Lin, S.1    Lee, S.J.2    Shim, H.3    Chun, J.4    Yun, C.C.5
  • 22
    • 65249173527 scopus 로고    scopus 로고
    • The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer
    • Lin S, Wang D, Iyer S, Ghaleb AM, Shim H, Yang VW, Chun J, Yun CC. The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer. Gastroenterology 136: 1711-1720, 2009.
    • (2009) Gastroenterology , vol.136 , pp. 1711-1720
    • Lin, S.1    Wang, D.2    Iyer, S.3    Ghaleb, A.M.4    Shim, H.5    Yang, V.W.6    Chun, J.7    Yun, C.C.8
  • 24
    • 34948831682 scopus 로고    scopus 로고
    • ERK1/2-p90RSK-mediated phosphorylation of Na+/H+ exchanger isoform 1
    • Luo J, Kintner DB, Shull GE, Sun D. ERK1/2-p90RSK-mediated phosphorylation of Na+/H+ exchanger isoform 1. J Biol Chem 282: 28274-28284, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 28274-28284
    • Luo, J.1    Kintner, D.B.2    Shull, G.E.3    Sun, D.4
  • 25
    • 0041831246 scopus 로고    scopus 로고
    • Does membrane trafficking play a role in regulating the sodium/hydrogen exchanger isoform 3 in the proximal tubule?
    • McDonough AA, Biemesderfer D. Does membrane trafficking play a role in regulating the sodium/hydrogen exchanger isoform 3 in the proximal tubule? Curr Opin Nephrol Hypertens 12: 533-541, 2003.
    • (2003) Curr Opin Nephrol Hypertens , vol.12 , pp. 533-541
    • McDonough, A.A.1    Biemesderfer, D.2
  • 27
    • 0037337159 scopus 로고    scopus 로고
    • Regulation of the ABC kinases by phosphorylation: Protein kinase C as a paradigm
    • Newton AC. Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J 370: 361-371, 2003.
    • (2003) Biochem J , vol.370 , pp. 361-371
    • Newton, A.C.1
  • 28
    • 0035813230 scopus 로고    scopus 로고
    • Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity
    • Park J, Hill MM, Hess D, Brazil DP, Hofsteenge J, Hemmings BA. Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity. J Biol Chem 276: 37459-37471, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 37459-37471
    • Park, J.1    Hill, M.M.2    Hess, D.3    Brazil, D.P.4    Hofsteenge, J.5    Hemmings, B.A.6
  • 31
    • 0034785929 scopus 로고    scopus 로고
    • Characterization of regulatory events associated with membrane targeting of p90 ribosomal S6 kinase 1
    • Richards SA, Dreisbach VC, Murphy LO, Blenis J. Characterization of regulatory events associated with membrane targeting of p90 ribosomal S6 kinase 1. Mol Cell Biol 21: 7470-7480, 2001.
    • (2001) Mol Cell Biol , vol.21 , pp. 7470-7480
    • Richards, S.A.1    Dreisbach, V.C.2    Murphy, L.O.3    Blenis, J.4
  • 33
    • 84555189440 scopus 로고    scopus 로고
    • Regulation and function of the RSK family of protein kinases
    • Romeo Y, Zhang X, Roux PP. Regulation and function of the RSK family of protein kinases. Biochem J 441: 553-569, 2012.
    • (2012) Biochem J , vol.441 , pp. 553-569
    • Romeo, Y.1    Zhang, X.2    Roux, P.P.3
  • 35
    • 55549139194 scopus 로고    scopus 로고
    • Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3
    • Sarker R, Gronborg M, Cha B, Mohan S, Chen Y, Pandey A, Litchfield D, Donowitz M, Li X. Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3. Mol Biol Cell 19: 3859-3870, 2008.
    • (2008) Mol Biol Cell , vol.19 , pp. 3859-3870
    • Sarker, R.1    Gronborg, M.2    Cha, B.3    Mohan, S.4    Chen, Y.5    Pandey, A.6    Litchfield, D.7    Donowitz, M.8    Li, X.9
  • 36
    • 77956528144 scopus 로고    scopus 로고
    • PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like growth factor-I-stimulated AKT activation and vascular smooth muscle cell survival
    • Shen X, Xi G, Radhakrishnan Y, Clemmons DR. PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like growth factor-I-stimulated AKT activation and vascular smooth muscle cell survival. J Biol Chem 285: 29416-29424, 2010.
    • (2010) J Biol Chem , vol.285 , pp. 29416-29424
    • Shen, X.1    Xi, G.2    Radhakrishnan, Y.3    Clemmons, D.R.4
  • 37
    • 10044281770 scopus 로고    scopus 로고
    • Activation of p90 Rsk1 is sufficient for differentiation of PC12 cells
    • Silverman E, Frodin M, Gammeltoft S, Maller JL. Activation of p90 Rsk1 is sufficient for differentiation of PC12 cells. Mol Cell Biol 24: 10573-10583, 2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 10573-10583
    • Silverman, E.1    Frodin, M.2    Gammeltoft, S.3    Maller, J.L.4
  • 39
    • 0033575236 scopus 로고    scopus 로고
    • P90RSK is a serum-stimulated Na+/H+ exchanger isoform-1 kinase: Regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1
    • Takahashi E, Abe J, Gallis B, Aebersold R, Spring DJ, Krebs EG, Berk BC. p90RSK is a serum-stimulated Na+/H+ exchanger isoform-1 kinase: regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1. J Biol Chem 274: 20206-20214, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 20206-20214
    • Takahashi, E.1    Abe, J.2    Gallis, B.3    Aebersold, R.4    Spring, D.J.5    Krebs, E.G.6    Berk, B.C.7
  • 42
    • 27244433306 scopus 로고    scopus 로고
    • Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission
    • Thomas GM, Rumbaugh GR, Harrar DB, Huganir RL. Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission. Proc Natl Acad Sci USA 102: 15006-15011, 2005.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15006-15011
    • Thomas, G.M.1    Rumbaugh, G.R.2    Harrar, D.B.3    Huganir, R.L.4
  • 43
    • 25444434666 scopus 로고    scopus 로고
    • Activation of NHE3 by dexameth-asone requires phosphorylation of NHE3 at Ser663 by SGK1
    • Wang D, Sun H, Lang F, Yun CC. Activation of NHE3 by dexameth-asone requires phosphorylation of NHE3 at Ser663 by SGK1. Am J Physiol Cell Physiol 289: C802-C810, 2005.
    • (2005) Am J Physiol Cell Physiol , vol.289 , pp. C802-C810
    • Wang, D.1    Sun, H.2    Lang, F.3    Yun, C.C.4
  • 44
    • 0033021073 scopus 로고    scopus 로고
    • Acute regulation of Na/H exchanger NHE3 activity by protein kinase C: Role of NHE3 phosphorylation
    • Wiederkehr MR, Zhao H, Moe OW. Acute regulation of Na/H exchanger NHE3 activity by protein kinase C: role of NHE3 phosphorylation. Am J Physiol Cell Physiol 276: C1205-C1217, 1999.
    • (1999) Am J Physiol Cell Physiol , vol.276 , pp. C1205-C1217
    • Wiederkehr, M.R.1    Zhao, H.2    Moe, O.W.3
  • 45
    • 0030738872 scopus 로고    scopus 로고
    • Regulation of the epithelial brush border Na+/H+ exchanger isoform 3 stably expressed in fibroblasts by fibroblast growth factor and phorbol esters is not through changes in phosphorylation of the exchanger
    • Yip JW, Ko WH, Viberti G, Huganir RL, Donowitz M, Tse CM. Regulation of the epithelial brush border Na+/H+ exchanger isoform 3 stably expressed in fibroblasts by fibroblast growth factor and phorbol esters is not through changes in phosphorylation of the exchanger. J Biol Chem 272: 18473-18480, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 18473-18480
    • Yip, J.W.1    Ko, W.H.2    Viberti, G.3    Huganir, R.L.4    Donowitz, M.5    Tse, C.M.6
  • 46
    • 80054878106 scopus 로고    scopus 로고
    • Lysophosphatidic acid 5 receptor induces activation of Na+/H+ exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells
    • Yoo BK, He P, Lee SJ, Yun CC. Lysophosphatidic acid 5 receptor induces activation of Na+/H+ exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells. Am J Physiol Cell Physiol 301: C1008-C1016, 2011.
    • (2011) Am J Physiol Cell Physiol , vol.301 , pp. C1008-C1016
    • Yoo, B.K.1    He, P.2    Lee, S.J.3    Yun, C.C.4
  • 47
    • 0037040897 scopus 로고    scopus 로고
    • Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2
    • Yun CC, Chen Y, Lang F. Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2. J Biol Chem 277: 7676-7683, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 7676-7683
    • Yun, C.C.1    Chen, Y.2    Lang, F.3
  • 48
    • 0032476006 scopus 로고    scopus 로고
    • NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin
    • Yun CHC, Lamprecht G, Forster DV, Sidor A. NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin. J Biol Chem 273: 25856-25863, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 25856-25863
    • Yun, C.1    Lamprecht, G.2    Forster, D.V.3    Sidor, A.4
  • 49
    • 0033548156 scopus 로고    scopus 로고
    • Acute inhibition of Na/H exchanger NHE-3 by cAMP. Role of protein kinase a and NHE-3 phosphoserines 552 and 605
    • Zhao H, Wiederkehr MR, Fan L, Collazo RL, Crowder LA, Moe OW. Acute inhibition of Na/H exchanger NHE-3 by cAMP. Role of protein kinase a and NHE-3 phosphoserines 552 and 605. J Biol Chem 274: 3978-3987, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 3978-3987
    • Zhao, H.1    Wiederkehr, M.R.2    Fan, L.3    Collazo, R.L.4    Crowder, L.A.5    Moe, O.W.6


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