A design-build-test cycle using modeling and experiments reveals interdependencies between upper glycolysis and xylose uptake in recombinant S. cerevisiae and improves predictive capabilities of large-scale kinetic models

Biotechnology for Biofuels

Volumn 10, Issue 1, 2017, Pages

  Miskovic, Ljubisa ^a   Alff Tuomala, Susanne ^b   Soh, Keng Cher ^a   Barth, Dorothee ^b   Salusjärvi, Laura ^b   Pitkänen, Juha Pekka ^b   Ruohonen, Laura ^b   Penttilä, Merja ^b   Hatzimanikatis, Vassily ^a  

^a EPFL   (Switzerland)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

Author keywords

Bioethanol; Hexokinase; HXK2 deletion; Large scale kinetic models; Metabolic control analysis; S. cerevisiae; Xylose utilization

Indexed keywords

BIOETHANOL; BIOREACTORS; COMPLEX NETWORKS; ENZYMES; FERMENTATION; GLUCOSE; KINETIC PARAMETERS; KINETICS; METABOLIC ENGINEERING; METABOLISM; MODEL BUILDINGS; PATHOLOGY; PHYSIOLOGY; POPULATION STATISTICS; RISK ANALYSIS; RISK ASSESSMENT; YEAST;

HEXOKINASES; HXK2 DELETION; KINETIC MODELS; METABOLIC CONTROL ANALYSIS; S.CEREVISIAE; XYLOSE UTILIZATIONS;

KINETIC THEORY;

BIOFUEL; BIOTECHNOLOGY; DESIGN; ETHANOL; EXPERIMENTAL STUDY; NUMERICAL MODEL; REACTION KINETICS; SUGAR;

SACCHAROMYCES CEREVISIAE;

EID: 85021642215     PISSN: 17546834     EISSN: None     Source Type: Journal    
DOI: 10.1186/s13068-017-0838-5     Document Type: Article

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