Identification of metabolic engineering targets for the enhancement of 1,4-butanediol production in recombinant E. coli using large-scale kinetic models

Metabolic Engineering

Volumn 35, Issue , 2016, Pages 148-159

  Andreozzi, Stefano ^a,b   Chakrabarti, Anirikh ^a,b   Soh, Keng Cher ^a,b   Burgard, Anthony ^c   Yang, Tae Hoon ^c   Van Dien, Stephen ^c   Miskovic, Ljubisa ^a,b   Hatzimanikatis, Vassily ^a,b  

^a EPFL   (Switzerland)

^b SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^c GENOMATICA INC   (United States)

Author keywords

1,4 butanediol; Flux balance analysis; Kinetic models; Metabolic control analysis; ORACLE; Thermodynamics; Uncertainty

Indexed keywords

BEVERAGES; CHEMICAL CONTAMINATION; ENZYMES; ESCHERICHIA COLI; KINETIC PARAMETERS; KINETIC THEORY; METABOLISM; POPULATION STATISTICS; RISK ANALYSIS; RISK ASSESSMENT; THERMODYNAMICS; UNCERTAINTY ANALYSIS;

1 ,4-BUTANEDIOL; FLUX BALANCE ANALYSIS; KINETIC MODELS; METABOLIC CONTROL ANALYSIS; ORACLE; UNCERTAINTY;

METABOLIC ENGINEERING;

1,4 BUTANEDIOL; ACETYL COENZYME A; ALCOHOL; ALDEHYDE DEHYDROGENASE; BACTERIAL ENZYME; CARBON; CITRATE SYNTHASE; ENOLASE; GAMMA BUTYROLACTONE; GLUCOSE; GLUCOSE 6 PHOSPHATE ISOMERASE; GLUTAMIC ACID; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE; LACTIC ACID; MALATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE; PHOSPHOENOLPYRUVATE CARBOXYLASE; PHOSPHOGLYCERATE KINASE; PHOSPHOGLYCERATE MUTASE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUCCINATE DEHYDROGENASE; SUCCINIC SEMIALDEHYDE; SUCCINYL COENZYME A; TRIOSEPHOSPHATE ISOMERASE; 1,4-BUTANEDIOL; BUTANEDIOL;

ACTIVE TRANSPORT; ARTICLE; BACTERIAL KINETICS; BACTERIAL STRAIN; BIOMASS; BYPRODUCT FORMATION; CELL GROWTH; CITRIC ACID CYCLE; CONCEPTUAL FRAMEWORK; CULTURE MEDIUM; ENZYME ACTIVITY; ESCHERICHIA COLI; FERMENTATION; GLUCOSE TRANSPORT; GLYCOLYSIS; METABOLIC ENGINEERING; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXIDATION REDUCTION STATE; OXYGEN CONSUMPTION; OXYGENATION; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; STEADY STATE; STRAIN IMPROVEMENT; THERMODYNAMICS; BIOLOGICAL MODEL; GENETICS; KINETICS; METABOLISM; PHYSIOLOGY; TRANSGENIC ORGANISM;

BUTYLENE GLYCOLS; CITRIC ACID CYCLE; ESCHERICHIA COLI; KINETICS; MODELS, BIOLOGICAL; ORGANISMS, GENETICALLY MODIFIED;

EID: 84969351865     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2016.01.009     Document Type: Article

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