Multilevel engineering of the upstream module of aromatic amino acid biosynthesis in Saccharomyces cerevisiae for high production of polymer and drug precursors

Metabolic Engineering

Volumn 42, Issue , 2017, Pages 134-144

  Suástegui, Miguel ^a,c   Yu Ng, Chiam ^b,c   Chowdhury, Anupam ^b,c   Sun, Wan ^c   Cao, Mingfeng ^a,c   House, Emma ^c   Maranas, Costas D ^b,c   Shao, Zengyi ^a,c,d  

^a Iowa State University of Science and Technology   (United States)

^b The Pennsylvania State University   (United States)

^c IOWA STATE UNIVERSITY   (United States)

^d IOWA STATE UNIVERSITY   (United States)

Author keywords

Aromatic amino acid pathway; Computational strain design; Muconic acid; Multilevel metabolic engineering; Shikimic acid; Transcriptional regulation

Indexed keywords

AMINO ACIDS; AROMATIC COMPOUNDS; AROMATIZATION; BIOCHEMISTRY; BIOSYNTHESIS; CARBOXYLIC ACIDS; METABOLISM; METABOLITES; PLASTIC DEFORMATION; PRODUCTION PLATFORMS; YEAST;

AROMATIC AMINO ACID; BIOSYNTHESIS PATHWAYS; MUCONIC ACID; PENTOSE PHOSPHATE PATHWAY; SHIKIMIC ACIDS; TRANSCRIPTIONAL REGULATION; TRANSCRIPTIONAL REPRESSION; TRANSCRIPTIONAL REPRESSORS;

METABOLIC ENGINEERING;

3 DEHYDROQUINATE SYNTHASE; 3 DEOXY 7 PHOSPHOHEPTULONATE SYNTHASE; 3 PHOPHOGLYCERATE KINASE; 6 PHOSPHOFRUCTOKINASE; ALDEHYDE DEHYDROGENASE; ARO1 PROTEIN; ARO2 PROTEIN; ARO3 PROTEIN; ARO4 PROTEIN; AROMATIC AMINO ACID; BASE; CARBON; CATECHOL 1,2 DIOXYGENASE; FUNGAL ENZYME; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; KETOL ISOMERASE; MUCONIC ACID; PHO13 ENZYME; PHOSPHOENOLPYRUVATE; POLYMER; PREPHENATE DEHYDROGENASE; PROTOCATECHUIC ACID; PYRUVATE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIBOSE 5 PHOSPHATE; SHIKIMIC ACID; TRANSALDOLASE; TRANSCRIPTION FACTOR; TRANSKETOLASE; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; FUNGAL STRAIN; METABOLIC ENGINEERING; NONHUMAN; OXIDATION; PENTOSE PHOSPHATE CYCLE; POLYMERIZATION; PRIORITY JOURNAL; PROMOTER REGION; REPRESSOR GENE; SACCHAROMYCES CEREVISIAE; TRANS GOLGI NETWORK; TRANSCRIPTION REGULATION; UPREGULATION; BIOSYNTHESIS; GENETICS; METABOLISM;

AMINO ACIDS, AROMATIC; METABOLIC ENGINEERING; SACCHAROMYCES CEREVISIAE;

EID: 85021308127     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2017.06.008     Document Type: Article

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