Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting

PLoS Pathogens

Volumn 7, Issue 7, 2011, Pages

  Hagbom, Marie ^a   Istrate, Claudia ^a,b   Engblom, David ^a   Karlsson, Thommie ^a   Rodriguez Diaz, Jesus ^c,f   Buesa, Javier ^c   Taylor, John A ^d   Loitto, Vesa Matti ^a   Magnusson, Karl Eric ^a   Ahlman, Håkan ^e   Lundgren, Ove ^e   Svensson, Lennart ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

^c UNIVERSITY OF VALENCIA   (Spain)

^d UNIVERSITY OF AUCKLAND   (New Zealand)

^e UNIVERSITY OF GOTHENBURG   (Sweden)

^f INSTITUTO DE AGROQUÍMICA Y TECNOLOGÍA DE ALIMENTOS CSIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CYCLIC AMP; INOSITOL 1,4,5 TRISPHOSPHATASE; PROTEIN FOS; ROTAVIRUS NONSTRUCTURAL PROTEIN 4; SEROTONIN; CALCIUM; GLYCOPROTEIN; NS28 PROTEIN, ROTAVIRUS; PROTEIN C FOS; SEROTONIN ANTAGONIST; TOXIN; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA POSTREMA; ARTICLE; BRAIN STEM; CALCIUM CELL LEVEL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIARRHEA; ENTEROCHROMAFFIN CELL; HUMAN; HUMAN CELL; INTESTINE CELL; INTESTINE INNERVATION; MIDGUT; MOUSE; NAUSEA AND VOMITING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; ROTAVIRUS; ROTAVIRUS INFECTION; SEROTONIN RELEASE; SOLITARY TRACT NUCLEUS; TUMOR CELL; VIRUS PARTICLE; VIRUS REPLICATION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; BRAIN; CHILD; DRUG EFFECT; GENE EXPRESSION REGULATION; JEJUNUM; METABOLISM; NAUSEA; PATHOLOGY; PRESCHOOL CHILD; SECRETION; TUMOR CELL LINE; VAGUS NERVE; VIROLOGY; VOMITING;

ANIMALIA; MUS; ROTAVIRUS;

ANIMALS; BRAIN; CALCIUM; CELL LINE, TUMOR; CHILD; CHILD, PRESCHOOL; ENTEROCHROMAFFIN CELLS; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HUMANS; JEJUNUM; MICE; MICE, INBRED BALB C; NAUSEA; PROTO-ONCOGENE PROTEINS C-FOS; ROTAVIRUS; ROTAVIRUS INFECTIONS; SEROTONIN; SEROTONIN ANTAGONISTS; TOXINS, BIOLOGICAL; VAGUS NERVE; VIRAL NONSTRUCTURAL PROTEINS; VOMITING;

EID: 79960947500     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002115     Document Type: Article

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