Cardiovascular magnetic resonance imaging to assess myocardial fibrosis in valvular heart disease

International Journal of Cardiovascular Imaging

Volumn 34, Issue 1, 2018, Pages 97-112

  Podlesnikar, Tomaz ^a   Delgado, Victoria ^a   Bax, Jeroen J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Aortic regurgitation; Aortic stenosis; Cardiovascular magnetic resonance; Feature tracking; Late gadolinium enhancement; Mitral regurgitation; T1 mapping; Tagging; Valvular heart disease

Indexed keywords

GADOLINIUM; CONTRAST MEDIUM;

AORTIC REGURGITATION; AORTIC STENOSIS; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CONTRAST ENHANCEMENT; DISEASE ASSOCIATION; DISEASE SEVERITY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE FIBROSIS; HEART VALVE SURGERY; HEART VENTRICLE REMODELING; HUMAN; MITRAL VALVE REGURGITATION; MOLECULAR IMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; RISK ASSESSMENT; VALVULAR HEART DISEASE; AORTIC VALVE; AORTIC VALVE STENOSIS; CARDIAC MUSCLE; CARDIOMYOPATHY; DIAGNOSTIC IMAGING; FIBROSIS; HEART STROKE VOLUME; MITRAL VALVE; PATHOLOGY; PATHOPHYSIOLOGY; PREDICTIVE VALUE; PROGNOSIS; SEVERITY OF ILLNESS INDEX;

AORTIC VALVE; AORTIC VALVE INSUFFICIENCY; AORTIC VALVE STENOSIS; CARDIOMYOPATHIES; CONTRAST MEDIA; FIBROSIS; HUMANS; MAGNETIC RESONANCE IMAGING; MITRAL VALVE; MITRAL VALVE INSUFFICIENCY; MYOCARDIUM; PREDICTIVE VALUE OF TESTS; PROGNOSIS; SEVERITY OF ILLNESS INDEX; STROKE VOLUME; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 85021101253     PISSN: 15695794     EISSN: 15730743     Source Type: Journal    
DOI: 10.1007/s10554-017-1195-y     Document Type: Article

References (74)

1. Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology, European Association for Cardio-Thoracic Surgery, Vahanian A et al. (2012) Guidelines on the management of valvular heart disease (version 2012). Eur Heart J 33:2451–2496. doi:10.1093/eurheartj/ehs109
2. Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M (2006) Burden of valvular heart diseases: a population-based study. Lancet 368:1005–1011. doi:10.1016/S0140-6736(06)69208-8
3. Nishimura RA, Otto CM, Bonow RO et al (2014) 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 63:e57–e185. doi:10.1016/j.jacc.2014.02.536
4. Enriquez-Sarano M, Sundt TM, 3rd (2010) Early surgery is recommended for mitral regurgitation. Circulation 121:804–811. doi:10.1161/CIRCULATIONAHA.109.868083 (discussion 812)
5. Villari B, Campbell SE, Hess OM, Mall G, Vassalli G, Weber KT, Krayenbuehl HP (1993) Influence of collagen network on left ventricular systolic and diastolic function in aortic valve disease. J Am Coll Cardiol 22:1477–1484
6. Mewton N, Liu CY, Croisille P, Bluemke D, Lima JA (2011) Assessment of myocardial fibrosis with cardiovascular magnetic resonance. J Am Coll Cardiol 57:891–903. doi:10.1016/j.jacc.2010.11.013
7. Taylor AJ, Salerno M, Dharmakumar R, Jerosch-Herold M (2016) T1 mapping: basic techniques and clinical applications. JACC Cardiovasc Imaging 9:67–81. doi:10.1016/j.jcmg.2015.11.005
8. Flett AS, Hayward MP, Ashworth MT et al (2010) Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans. Circulation 122:138–144. doi:10.1161/circulationaha.109.930636
9. Miller CA, Naish JH, Bishop P et al (2013) Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume. Circ Cardiovasc Imaging 6:373–383. doi:10.1161/circimaging.112.000192
10. Fontana M, White SK, Banypersad SM et al (2012) Comparison of T1 mapping techniques for ECV quantification. Histological validation and reproducibility of ShMOLLI versus multibreath-hold T1 quantification equilibrium contrast CMR. J Cardiovasc Magn Reson 14:88. doi:10.1186/1532-429x-14-88
11. Bulluck H, Maestrini V, Rosmini S et al (2015) Myocardial T1 mapping. Circ J 79:487–494. doi:10.1253/circj.CJ-15-0054
12. Moon JC, Messroghli DR, Kellman P et al (2013) Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement. J Cardiovasc Magn Reson 15:92. doi:10.1186/1532-429x-15-92
13. Croisille P, Revel D, Saeed M (2006) Contrast agents and cardiac MR imaging of myocardial ischemia: from bench to bedside. Eur Radiol 16:1951–1963. doi:10.1007/s00330-006-0244-z
14. Kim RJ, Wu E, Rafael A et al (2000) The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N Engl J Med 343:1445–1453. doi:10.1056/nejm200011163432003
15. Wu E, Ortiz JT, Tejedor P et al (2008) Infarct size by contrast enhanced cardiac magnetic resonance is a stronger predictor of outcomes than left ventricular ejection fraction or end-systolic volume index: prospective cohort study. Heart 94:730–736. doi:10.1136/hrt.2007.122622
16. Kwong RY, Chan AK, Brown KA, Chan CW, Reynolds HG, Tsang S, Davis RB (2006) Impact of unrecognized myocardial scar detected by cardiac magnetic resonance imaging on event-free survival in patients presenting with signs or symptoms of coronary artery disease. Circulation 113:2733–2743. doi:10.1161/CIRCULATIONAHA.105.570648
17. Assomull RG, Prasad SK, Lyne J et al (2006) Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy. J Am Coll Cardiol 48:1977–1985. doi:10.1016/j.jacc.2006.07.049
18. O’Hanlon R, Grasso A, Roughton M et al (2010) Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy. J Am Coll Cardiol 56:867–874. doi:10.1016/j.jacc.2010.05.010
19. Dweck MR, Joshi S, Murigu T et al (2011) Midwall fibrosis is an independent predictor of mortality in patients with aortic stenosis. J Am Coll Cardiol 58:1271–1279. doi:10.1016/j.jacc.2011.03.064
20. Helm PA, Caravan P, French BA et al (2008) Postinfarction myocardial scarring in mice: molecular MR imaging with use of a collagen-targeting contrast agent. Radiology 247:788–796. doi:10.1148/radiol.2473070975
21. Spuentrup E, Ruhl KM, Botnar RM et al (2009) Molecular magnetic resonance imaging of myocardial perfusion with EP-3600, a collagen-specific contrast agent: initial feasibility study in a swine model. Circulation 119:1768–1775. doi:10.1161/circulationaha.108.826388
22. Protti A, Lavin B, Dong X et al (2015) Assessment of myocardial remodeling using an elastin/tropoelastin specific agent with high field magnetic resonance imaging (MRI). J Am Heart Assoc 4:e001851. doi:10.1161/jaha.115.001851
23. Jivraj N, Phinikaridou A, Shah AM, Botnar RM (2014) Molecular imaging of myocardial infarction. Basic Res Cardiol 109:397. doi:10.1007/s00395-013-0397-2
24. Marciniak A, Claus P, Sutherland GR et al (2007) Changes in systolic left ventricular function in isolated mitral regurgitation. A strain rate imaging study. Eur Heart J 28:2627–2636. doi:10.1093/eurheartj/ehm072
25. Delgado V, Tops LF, van Bommel RJ et al (2009) Strain analysis in patients with severe aortic stenosis and preserved left ventricular ejection fraction undergoing surgical valve replacement. Eur Heart J 30:3037–3047. doi:10.1093/eurheartj/ehp351
26. Ibrahim el SH (2011) Myocardial tagging by cardiovascular magnetic resonance: evolution of techniques–pulse sequences, analysis algorithms, and applications. J Cardiovasc Magn Reson 13:36. doi:10.1186/1532-429x-13-36
27. Pedrizzetti G, Claus P, Kilner PJ, Nagel E (2016) Principles of cardiovascular magnetic resonance feature tracking and echocardiographic speckle tracking for informed clinical use. J Cardiovasc Magn Reson 18:51. doi:10.1186/s12968-016-0269-7
28. Schuster A, Hor KN, Kowallick JT, Beerbaum P, Kutty S (2016) Cardiovascular magnetic resonance myocardial feature tracking: concepts and clinical applications. Circ Cardiovasc Imaging 9:e004077. doi:10.1161/circimaging.115.004077
29. Padiyath A, Gribben P, Abraham JR et al (2013) Echocardiography and cardiac magnetic resonance-based feature tracking in the assessment of myocardial mechanics in tetralogy of Fallot: an intermodality comparison. Echocardiography 30:203–210. doi:10.1111/echo.12016
30. Morton G, Schuster A, Jogiya R, Kutty S, Beerbaum P, Nagel E (2012) Inter-study reproducibility of cardiovascular magnetic resonance myocardial feature tracking. J Cardiovasc Magn Reson 14:43. doi:10.1186/1532-429x-14-43
31. Augustine D, Lewandowski AJ, Lazdam M et al (2013) Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers: comparison with tagging and relevance of gender. J Cardiovasc Magn Reson 15:8. doi:10.1186/1532-429x-15-8
32. Barone-Rochette G, Pierard S, De Meester de Ravenstein C et al (2014) Prognostic significance of LGE by CMR in aortic stenosis patients undergoing valve replacement. J Am Coll Cardiol 64:144–154. doi:10.1016/j.jacc.2014.02.612
33. Azevedo CF, Nigri M, Higuchi ML et al (2010) Prognostic significance of myocardial fibrosis quantification by histopathology and magnetic resonance imaging in patients with severe aortic valve disease. J Am Coll Cardiol 56:278–287. doi:10.1016/j.jacc.2009.12.074
34. Chin CW, Everett RJ, Kwiecinski J et al (2016) Myocardial fibrosis and cardiac decompensation in aortic stenosis. JACC Cardiovasc Imaging. doi:10.1016/j.jcmg.2016.10.007
35. Chaikriangkrai K, Lopez-Mattei JC, Lawrie G et al (2014) Prognostic value of delayed enhancement cardiac magnetic resonance imaging in mitral valve repair. Ann Thorac Surg 98:1557–1563. doi:10.1016/j.athoracsur.2014.06.049
36. Musa TA, Uddin A, Swoboda PP et al (2017) Cardiovascular magnetic resonance evaluation of symptomatic severe aortic stenosis: association of circumferential myocardial strain and mortality. J Cardiovasc Magn Reson 19:13. doi:10.1186/s12968-017-0329-7
37. Krayenbuehl HP, Hess OM, Monrad ES, Schneider J, Mall G, Turina M (1989) Left ventricular myocardial structure in aortic valve disease before, intermediate, and late after aortic valve replacement. Circulation 79:744–755
38. Hein S, Arnon E, Kostin S et al (2003) Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation 107:984–991
39. Rakusan K, Flanagan MF, Geva T, Southern J, Van Praagh R (1992) Morphometry of human coronary capillaries during normal growth and the effect of age in left ventricular pressure-overload hypertrophy. Circulation 86:38–46
40. Bull S, White SK, Piechnik SK et al (2013) Human non-contrast T1 values and correlation with histology in diffuse fibrosis. Heart 99:932–937. doi:10.1136/heartjnl-2012-303052
41. Lee SP, Lee W, Lee JM, Park EA, Kim HK, Kim YJ, Sohn DW (2015) Assessment of diffuse myocardial fibrosis by using MR imaging in asymptomatic patients with aortic stenosis. Radiology 274:359–369. doi:10.1148/radiol.14141120
42. Chin CW, Semple S, Malley T et al (2014) Optimization and comparison of myocardial T1 techniques at 3T in patients with aortic stenosis. Eur Heart J Cardiovasc Imaging 15:556–565. doi:10.1093/ehjci/jet245
43. Flett AS, Sado DM, Quarta G et al (2012) Diffuse myocardial fibrosis in severe aortic stenosis: an equilibrium contrast cardiovascular magnetic resonance study. Eur Heart J Cardiovasc Imaging 13:819–826. doi:10.1093/ehjci/jes102
44. Dusenbery SM, Jerosch-Herold M, Rickers C, Colan SD, Geva T, Newburger JW, Powell AJ (2014) Myocardial extracellular remodeling is associated with ventricular diastolic dysfunction in children and young adults with congenital aortic stenosis. J Am Coll Cardiol 63:1778–1785. doi:10.1016/j.jacc.2013.11.066
45. Chin CW, Shah AS, McAllister DA et al (2014) High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis. Eur Heart J 35:2312–2321. doi:10.1093/eurheartj/ehu189
46. Shah AS, Chin CW, Vassiliou V et al (2014) Left ventricular hypertrophy with strain and aortic stenosis. Circulation 130:1607–1616. doi:10.1161/circulationaha.114.011085
47. Debl K, Djavidani B, Buchner S et al (2006) Delayed hyperenhancement in magnetic resonance imaging of left ventricular hypertrophy caused by aortic stenosis and hypertrophic cardiomyopathy: visualisation of focal fibrosis. Heart 92:1447–1451. doi:10.1136/hrt.2005.079392
48. Rudolph A, Abdel-Aty H, Bohl S, Boye P, Zagrosek A, Dietz R, Schulz-Menger J (2009) Noninvasive detection of fibrosis applying contrast-enhanced cardiac magnetic resonance in different forms of left ventricular hypertrophy relation to remodeling. J Am Coll Cardiol 53:284–291. doi:10.1016/j.jacc.2008.08.064
49. Weidemann F, Herrmann S, Stork S et al (2009) Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosis. Circulation 120:577–584. doi:10.1161/circulationaha.108.847772
50. Dweck MR, Boon NA, Newby DE (2012) Calcific aortic stenosis: a disease of the valve and the myocardium. J Am Coll Cardiol 60:1854–1863. doi:10.1016/j.jacc.2012.02.093
51. Singh A, Greenwood JP, Berry C et al (2017) Comparison of exercise testing and CMR measured myocardial perfusion reserve for predicting outcome in asymptomatic aortic stenosis: the prognostic importance of microvascular dysfunction in aortic stenosis (PRIMID AS) Study. Eur Heart J. doi:10.1093/eurheartj/ehx001
52. Kim YJ, Choi BW, Hur J et al (2008) Delayed enhancement in hypertrophic cardiomyopathy: comparison with myocardial tagging MRI. J Magn Reson Imaging 27:1054–1060. doi:10.1002/jmri.21366
53. Bogarapu S, Puchalski MD, Everitt MD, Williams RV, Weng HY, Menon SC (2016) Novel cardiac magnetic resonance feature tracking (CMR-FT) analysis for detection of myocardial fibrosis in pediatric hypertrophic cardiomyopathy. Pediatr Cardiol 37:663–673. doi:10.1007/s00246-015-1329-8
54. Schneeweis C, Lapinskas T, Schnackenburg B et al (2014) Comparison of myocardial tagging and feature tracking in patients with severe aortic stenosis. J Heart Valve Dis 23:432–440
55. Singh A, Steadman CD, Khan JN et al (2015) Intertechnique agreement and interstudy reproducibility of strain and diastolic strain rate at 1.5 and 3 tesla: a comparison of feature-tracking and tagging in patients with aortic stenosis. J Magn Reson Imaging 41:1129–1137. doi:10.1002/jmri.24625
56. Al Musa T, Uddin A, Swoboda PP et al (2017) Myocardial strain and symptom severity in severe aortic stenosis: insights from cardiovascular magnetic resonance. Quant Imaging Med Surg 7:38–47. doi:10.21037/qims.2017.02.05
57. Mahmod M, Bull S, Suttie JJ et al (2013) Myocardial steatosis and left ventricular contractile dysfunction in patients with severe aortic stenosis. Circ Cardiovasc Imaging 6:808–816. doi:10.1161/circimaging.113.000559
58. Meyer CG, Frick M, Lotfi S et al (2014) Regional left ventricular function after transapical vs. transfemoral transcatheter aortic valve implantation analysed by cardiac magnetic resonance feature tracking. Eur Heart J Cardiovasc Imaging 15:1168–1176. doi:10.1093/ehjci/jeu103
59. Borer JS, Truter S, Herrold EM et al (2002) Myocardial fibrosis in chronic aortic regurgitation: molecular and cellular responses to volume overload. Circulation 105:1837–1842
60. Piper C, Schultheiss HP, Akdemir D, Rudolf J, Horstkotte D, Pauschinger M (2003) Remodeling of the cardiac extracellular matrix differs between volume- and pressure-overloaded ventricles and is specific for each heart valve lesion. J Heart Valve Dis 12:592–600
61. Mannacio V, Guadagno E, Mannacio L et al (2015) Comparison of left ventricular myocardial structure and function in patients with aortic stenosis and those with pure aortic regurgitation. Cardiology 132:111–118. doi:10.1159/000431283
62. Sparrow P, Messroghli DR, Reid S, Ridgway JP, Bainbridge G, Sivananthan MU (2006) Myocardial T1 mapping for detection of left ventricular myocardial fibrosis in chronic aortic regurgitation: pilot study. AJR Am J Roentgenol 187:W630–W635. doi:10.2214/ajr.05.1264
63. de Meester de Ravenstein C, Bouzin C, Lazam S et al (2015) Histological Validation of measurement of diffuse interstitial myocardial fibrosis by myocardial extravascular volume fraction from modified look-locker imaging (MOLLI) T1 mapping at 3 T. J Cardiovasc Magn Reson 17:48. doi:10.1186/s12968-015-0150-0
64. Pomerantz BJ, Wollmuth JR, Krock MD et al (2005) Myocardial systolic strain is decreased after aortic valve replacement in patients with aortic insufficiency. Ann Thorac Surg 80:2186–2192. doi:10.1016/j.athoracsur.2005.05.095
65. Ungacta FF, Davila-Roman VG, Moulton MJ et al (1998) MRI-radiofrequency tissue tagging in patients with aortic insufficiency before and after operation. Ann Thorac Surg 65:943–950
66. Lancellotti P, Moura L, Pierard LA et al (2010) European association of echocardiography recommendations for the assessment of valvular regurgitation. Part 2: mitral and tricuspid regurgitation (native valve disease). Eur J Echocardiogr 11:307–332. doi:10.1093/ejechocard/jeq031
67. Fuster V, Danielson MA, Robb RA, Broadbent JC, Brown AL Jr, Elveback LR (1977) Quantitation of left ventricular myocardial fiber hypertrophy and interstitial tissue in human hearts with chronically increased volume and pressure overload. Circulation 55:504–508
68. Edwards NC, Moody WE, Yuan M, Weale P, Neal D, Townend JN, Steeds RP (2014) Quantification of left ventricular interstitial fibrosis in asymptomatic chronic primary degenerative mitral regurgitation. Circ Cardiovasc Imaging 7:946–953. doi:10.1161/CIRCIMAGING.114.002397
69. Han Y, Peters DC, Salton CJ et al (2008) Cardiovascular magnetic resonance characterization of mitral valve prolapse. JACC Cardiovasc Imaging 1:294–303. doi:10.1016/j.jcmg.2008.01.013
70. Maniar HS, Brady BD, Lee U, Cupps BP, Kar J, Wallace KM, Pasque MK (2014) Early left ventricular regional contractile impairment in chronic mitral regurgitation occurs in a consistent, heterogeneous pattern. J Thorac Cardiovasc Surg 148:1694–1699. doi:10.1016/j.jtcvs.2014.05.088
71. Mankad R, McCreery CJ, Rogers WJ Jr, Weichmann RJ, Savage EB, Reichek N, Kramer CM (2001) Regional myocardial strain before and after mitral valve repair for severe mitral regurgitation. J Cardiovasc Magn Reson 3:257–266
72. Ahmed MI, Gladden JD, Litovsky SH et al (2010) Increased oxidative stress and cardiomyocyte myofibrillar degeneration in patients with chronic isolated mitral regurgitation and ejection fraction > 60%. J Am Coll Cardiol 55:671–679. doi:10.1016/j.jacc.2009.08.074
73. Schiros CG, Dell’Italia LJ, Gladden JD et al (2012) Magnetic resonance imaging with 3-dimensional analysis of left ventricular remodeling in isolated mitral regurgitation: implications beyond dimensions. Circulation 125:2334–2342. doi:10.1161/circulationaha.111.073239
74. Ahmed MI, Guichard JL, Rajasekaran NS et al (2016) Disruption of desmin-mitochondrial architecture in patients with regurgitant mitral valves and preserved ventricular function. J Thorac Cardiovasc Surg 152(1059–1070):e1052. doi:10.1016/j.jtcvs.2016.06.017