Myocardial steatosis and left ventricular contractile dysfunction in patients with severe aortic stenosis

Circulation: Cardiovascular Imaging

Volumn 6, Issue 5, 2013, Pages 808-816

  Mahmod, Masliza ^a   Bull, Sacha ^a   Suttie, Joseph J ^a   Pal, Nikhil ^a   Holloway, Cameron ^a   Dass, Sairia ^a   Myerson, Saul G ^a   Schneider, Jurgen E ^a   De Silva, Ravi ^b   Petrou, Mario ^b   Sayeed, Rana ^b   Westaby, Stephen ^b   Clelland, Colin ^b   Francis, Jane M ^a   Ashrafian, Houman ^a   Karamitsos, Theodoros D ^a   Neubauer, Stefan ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Aortic valve stenosis; Cardiac MRI; Myocardial steatosis; Spectroscopy; Strain

Indexed keywords

TRIACYLGLYCEROL;

ADULT; AGED; AORTA STENOSIS; AORTA VALVE REPLACEMENT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE MASS; HUMAN; MALE; MYOCARDIAL DISEASE; MYOCARDIAL STEATOSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEATOSIS;

AORTIC VALVE STENOSIS; CARDIAC MRI; MYOCARDIAL STEATOSIS; SPECTROSCOPY; STRAIN;

AGED; AORTIC VALVE STENOSIS; BIOPSY; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; ECHOCARDIOGRAPHY; FEMALE; HEART VALVE PROSTHESIS IMPLANTATION; HUMANS; LINEAR MODELS; MAGNETIC RESONANCE IMAGING, CINE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MYOCARDIAL CONTRACTION; MYOCARDIUM; PREDICTIVE VALUE OF TESTS; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; TRIGLYCERIDES; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT;

EID: 84884494206     PISSN: 19419651     EISSN: 19420080     Source Type: Journal    
DOI: 10.1161/CIRCIMAGING.113.000559     Document Type: Article

References (37)

1. Allard MF. Energy substrate metabolism in cardiac hypertrophy. Curr Hypertens Rep. 2004; 6: 430-435. (Pubitemid 39600098)
2. Schaffer JE. Lipotoxicity: when tissues overeat. Curr Opin Lipidol. 2003; 14: 281-287. (Pubitemid 36688207)
3. Chiu HC, Kovacs A, Ford DA, Hsu FF, Garcia R, Herrero P, Saffitz JE, Schaffer JE. A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest. 2001; 107: 813-822. (Pubitemid 32274034)
4. Bilet L, van de Weijer T, Hesselink MK, Glatz JF, Lamb HJ, Wildberger J, Kooi ME, Schrauwen P, Schrauwen-Hinderling VB. Exercise-induced modulation of cardiac lipid content in healthy lean young men. Basic Res Cardiol. 2011; 106: 307-315.
5. McGavock JM, Victor RG, Unger RH, Szczepaniak LS; American College of Physicians and the American Physiological Society. Adiposity of the heart, revisited. Ann Intern Med. 2006; 144: 517-524.
6. McGavock JM, Lingvay I, Zib I, Tillery T, Salas N, Unger R, Levine BD, Raskin P, Victor RG, Szczepaniak LS. Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study. Circulation. 2007; 116: 1170-1175. (Pubitemid 47360218)
7. Ng AC, Delgado V, Bertini M, van der Meer RW, Rijzewijk LJ, Hooi Ewe S, Siebelink HM, Smit JW, Diamant M, Romijn JA, de Roos A, Leung DY, Lamb HJ, Bax JJ. Myocardial steatosis and biventricular strain and strain rate imaging in patients with type 2 diabetes mellitus. Circulation. 2010; 122: 2538-2544.
8. Szczepaniak LS, Dobbins RL, Metzger GJ, Sartoni-D'Ambrosia G, Arbique D, Vongpatanasin W, Unger R, Victor RG. Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging. Magn Reson Med. 2003; 49: 417-423. (Pubitemid 36262808)
9. Reingold JS, McGavock JM, Kaka S, Tillery T, Victor RG, Szczepaniak LS. Determination of triglyceride in the human myocardium by magnetic resonance spectroscopy: reproducibility and sensitivity of the method. Am J Physiol Endocrinol Metab. 2005; 289: E935-E939. (Pubitemid 41504396)
10. Shehata ML, Cheng S, Osman NF, Bluemke DA, Lima JA. Myocardial tissue tagging with cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2009; 11: 55.
11. Ozkan A, Kapadia S, Tuzcu M, Marwick TH. Assessment of left ventricular function in aortic stenosis. Nat Rev Cardiol. 2011; 8: 494-501.
12. Hudsmith LE, Petersen SE, Francis JM, Robson MD, Neubauer S. Normal human left and right ventricular and left atrial dimensions using steady state free precession magnetic resonance imaging. J Cardiovasc Magn Reson. 2005; 7: 775-782. (Pubitemid 41770055)
13. Stuber M, Spiegel MA, Fischer SE, Scheidegger MB, Danias PG, Pedersen EM, Boesiger P. Single breath-hold slice-following CSPAMM myocardial tagging. MAGMA. 1999; 9: 85-91. (Pubitemid 29510660)
14. Rial B, Robson MD, Neubauer S, Schneider JE. Rapid quantification of myocardial lipid content in humans using single breath-hold 1H MRS at 3 Tesla. Magn Reson Med. 2011; 66: 619-624.
15. Baumgartner H, Hung J, Bermejo J, Chambers JB, Evangelista A, Griffin BP, Iung B, Otto CM, Pellikka PA, Quiñones M; American Society of Echocardiography; European Association of Echocardiography. Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice. J Am Soc Echocardiogr. 2009; 22: 1-23; quiz 101.
16. Sharma S, Adrogue JV, Golfman L, Uray I, Lemm J, Youker K, Noon GP, Frazier OH, Taegtmeyer H. Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart. FASEB J. 2004; 18: 1692-1700. (Pubitemid 39463708)
17. McCann GP, Gan CT, Beek AM, Niessen HW, Vonk Noordegraaf A, van Rossum AC. Extent of MRI delayed enhancement of myocardial mass is related to right ventricular dysfunction in pulmonary artery hypertension. AJR Am J Roentgenol. 2007; 188: 349-355. (Pubitemid 46167734)
18. Szczepaniak LS, Babcock EE, Schick F, Dobbins RL, Garg A, Burns DK, McGarry JD, Stein DT. Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol. 1999; 276(5 pt 1): E977-E989. (Pubitemid 29249618)
19. Zhang Y, Ren J. Role of cardiac steatosis and lipotoxicity in obesity cardiomyopathy. Hypertension. 2011; 57: 148-150.
20. Neubauer S. The failing heart-an engine out of fuel. N Engl J Med. 2007; 356: 1140-1151. (Pubitemid 46425598)
21. Marfella R, Di Filippo C, Portoghese M, Barbieri M, Ferraraccio F, Siniscalchi M, Cacciapuoti F, Rossi F, D'Amico M, Paolisso G. Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome[s]. J Lipid Res. 2009; 50: 2314-2323.
22. Unger RH. Lipotoxic diseases. Annu Rev Med. 2002; 53: 319-336. (Pubitemid 34177884)
23. Goldberg IJ, Trent CM, Schulze PC. Lipid metabolism and toxicity in the heart. Cell Metab. 2012; 15: 805-812.
24. Borisov AB, Ushakov AV, Zagorulko AK, Novikov N Y, Selivanova KF, Edwards CA, Russell MW. Intracardiac lipid accumulation, lipoatrophy of muscle cells and expansion of myocardial infarction in type 2 diabetic patients. Micron. 2008; 39: 944-951.
25. Golia G, Milano AD, Dodonov M, Bergamini C, Faggian G, Tomezzoli A, Vassanelli C. Influence of myocardial fibrosis on left ventricular hypertrophy in patients with symptomatic severe aortic stenosis. Cardiology. 2011; 120: 139-145.
26. Motoyasu M, Kurita T, Onishi K, Uemura S, Tanigawa T, Okinaka T, Takeda K, Nakano T, Ito M, Sakuma H. Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomyopathy assessed by magnetic resonance imaging. Circ J. 2008; 72: 378-383. (Pubitemid 351600629)
27. Rijzewijk LJ, van der Meer RW, Smit JW, Diamant M, Bax JJ, Hammer S, Romijn JA, de Roos A, Lamb HJ. Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus. J Am Coll Cardiol. 2008; 52: 1793-1799.
28. Beyerbacht HP, Lamb HJ, van Der Laarse A, Vliegen HW, Leujes F, Hazekamp MG, de Roos A, van Der Wall EE. Aortic valve replacement in patients with aortic valve stenosis improves myocardial metabolism and diastolic function. Radiology. 2001; 219: 637-643. (Pubitemid 32476250)
29. Mannacio V, Di Tommaso L, Stassano P, De Amicis V, Vosa C. Myocardial metabolism and diastolic function after aortic valve replacement for aortic stenosis: influence of patient-prosthesis mismatch. Eur J Cardiothorac Surg. 2012; 41: 316-321.
30. Rajappan K, Rimoldi OE, Camici PG, Bellenger NG, Pennell DJ, Sheridan DJ. Functional changes in coronary microcirculation after valve replacement in patients with aortic stenosis. Circulation. 2003; 107: 3170-3175. (Pubitemid 36793087)
31. Biederman RW, Doyle M, Yamrozik J, Williams RB, Rathi VK, Vido D, Caruppannan K, Osman N, Bress V, Rayarao G, Biederman CM, Mankad S, Magovern JA, Reichek N. Physiologic compensation is supranormal in compensated aortic stenosis: does it return to normal after aortic valve replacement or is it blunted by coexistent coronary artery disease? An intramyocardial magnetic resonance imaging study. Circulation. 2005; 112(9 suppl): I429-I436. (Pubitemid 41266710)
32. Delgado V, Tops LF, van Bommel RJ, van der Kley F, Marsan NA, Klautz RJ, Versteegh MI, Holman ER, Schalij MJ, Bax JJ. Strain analysis in patients with severe aortic stenosis and preserved left ventricular ejection fraction undergoing surgical valve replacement. Eur Heart J. 2009; 30: 3037-3047.
33. Algahim MF, Sen S, Taegtmeyer H. Bariatric surgery to unload the stressed heart: a metabolic hypothesis. Am J Physiol Heart Circ Physiol. 2012; 302: H1539-H1545.
34. Dahl JS, Videbæk L, Poulsen MK, Rudbæk TR, Pellikka PA, Møller JE. Global strain in severe aortic valve stenosis: relation to clinical outcome after aortic valve replacement. Circ Cardiovasc Imaging. 2012; 5: 613-620.
35. Szczepaniak LS, Dobbins RL, Stein DT, McGarry JD. Bulk magnetic susceptibility effects on the assessment of intra- and extramyocellular lipids in vivo. Magn Reson Med. 2002; 47: 607-610. (Pubitemid 34194017)
36. Boesch C, Slotboom J, Hoppeler H, Kreis R. in vivo determination of intra-myocellular lipids in human muscle by means of localized 1H-MR-spectroscopy. Magn Reson Med. 1997; 37: 484-493. (Pubitemid 27146825)
37. Nagarajan V, Gopalan V, Kaneko M, Angeli V, Gluckman P, Richards AM, Kuchel PW, Velan SS. Cardiac function and lipid distribution in rats fed a high-fat diet: in vivo magnetic resonance imaging and spectroscopy. Am J Physiol Heart Circ Physiol. 2013; 304: H1495-H1504.