Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid

Nature Communications

Volumn 8, Issue , 2017, Pages

  Walther, Thomas ^a,b,d   Topham, Christopher M ^a   Irague, Romain ^a   Auriol, Clément ^a,b   Baylac, Audrey ^a   Cordier, Hélène ^b   Dressaire, Clémentine ^a,b   Lozano Huguet, Luce ^a   Tarrat, Nathalie ^a,e   Martineau, Nelly ^a,c   Stodel, Marion ^a   Malbert, Yannick ^a,b   Maestracci, Marc ^c   Huet, Robert ^c   André, Isabelle ^a,b   Remaud Siméon, Magali ^a,b   François, Jean Marie ^a,b  

^a INSA   (France)

^b l Alimentation et l Environnement   (France)

^c Adisseo France SAS   (France)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^e CEMES CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIHYDROXYBUTYRIC ACID; BUTYRIC ACID DERIVATIVE; MALATE KINASE; MALATE SEMIALDEHYDE DEHYDROGENASE; MALATE SEMIALDEHYDE REDUCTASE; MALIC ACID; METHIONINE DERIVATIVE; OXIDOREDUCTASE; PROTEIN KINASE; UNCLASSIFIED DRUG; 2,4-DIHYDROXYBUTYRATE; ALDEHYDE DEHYDROGENASE; BUTANEDIOL; GLUCOSE; MALATE DEHYDROGENASE; MALATE DEHYDROGENASE (DECARBOXYLATING); METHIONINE; PHOSPHOTRANSFERASE;

AMINO ACID; BIOACTIVITY; CHEMICAL COMPOUND; COLIFORM BACTERIUM; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ENGINEERING; METABOLISM; METABOLITE;

ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; METABOLIC ENGINEERING; METABOLISM; METABOLITE; MOLECULAR MODEL; NONHUMAN; STEREOSPECIFICITY; GENETICS; SITE DIRECTED MUTAGENESIS; SYNTHETIC BIOLOGY; THERMODYNAMICS;

ANIMALIA; ESCHERICHIA COLI;

ALDEHYDE OXIDOREDUCTASES; BUTYLENE GLYCOLS; BUTYRATES; ESCHERICHIA COLI; GLUCOSE; MALATE DEHYDROGENASE; METABOLIC ENGINEERING; METABOLIC NETWORKS AND PATHWAYS; METHIONINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHOSPHOTRANSFERASES; SYNTHETIC BIOLOGY; THERMODYNAMICS;

EID: 85021069824     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms15828     Document Type: Article

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