Combining rational metabolic engineering and flux optimization strategies for efficient production of fumaric acid

Applied Microbiology and Biotechnology

Volumn 99, Issue 20, 2015, Pages 8455-8464

  Song, Chan Woo ^a   Lee, Sang Yup ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Escherichia coli; Flux optimization; Fumaric acid; Metabolic engineering

Indexed keywords

AMINO ACIDS; BATCH CELL CULTURE; CARBON; ESCHERICHIA COLI; GENE ENCODING; GLUCOSE; METABOLISM;

ENGINEERED STRAINS; EXPRESSION VECTORS; FED-BATCH CULTURES; FLUX OPTIMIZATION; FUMARIC ACIDS; PHARMACEUTICAL INDUSTRY; PHOSPHOENOLPYRUVATE CARBOXYLASE; SUCCINATE DEHYDROGENASE;

METABOLIC ENGINEERING;

ASPARTATE AMMONIA LYASE; FUMARIC ACID; GLUCOSE; SUCCINATE DEHYDROGENASE; FUMARIC ACID DERIVATIVE;

BIOENGINEERING; CHEMICAL INDUSTRY; COLIFORM BACTERIUM; DRUG; FOOD INDUSTRY; GENE EXPRESSION; METABOLISM; OPTIMIZATION; ORGANIC ACID;

ARTICLE; BACTERIAL STRAIN; BACTERIUM MUTANT; CONTROLLED STUDY; ESCHERICHIA COLI; EXPRESSION VECTOR; METABOLIC ENGINEERING; NONHUMAN; PROTEIN EXPRESSION; GENE DELETION; GENE EXPRESSION; GENE VECTOR; GENETICS; METABOLISM; PROCEDURES;

ESCHERICHIA COLI;

ESCHERICHIA COLI; FUMARATES; GENE DELETION; GENE EXPRESSION; GENETIC VECTORS; GLUCOSE; METABOLIC ENGINEERING; METABOLIC NETWORKS AND PATHWAYS;

EID: 84941992427     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-015-6816-6     Document Type: Article

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