-
1
-
-
0942288120
-
Bacteria engineered for fuel ethanol production: Current status
-
Dien, B. S., Cotta, M. A., and Jeffries, T. W. (2003) Bacteria engineered for fuel ethanol production: current status Appl. Microbiol. Biotechnol. 63, 258-266
-
(2003)
Appl. Microbiol. Biotechnol.
, vol.63
, pp. 258-266
-
-
Dien, B.S.1
Cotta, M.A.2
Jeffries, T.W.3
-
2
-
-
57049098094
-
Metabolic engineering of microorganisms for biofuels production: From bugs to synthetic biology to fuels
-
Lee, S. K., Chou, H., Ham, T. S., Lee, T. S., and Keasling, J. D. (2008) Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels Curr. Opin. Biotechnol. 19, 556-563
-
(2008)
Curr. Opin. Biotechnol.
, vol.19
, pp. 556-563
-
-
Lee, S.K.1
Chou, H.2
Ham, T.S.3
Lee, T.S.4
Keasling, J.D.5
-
3
-
-
58249098522
-
Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol
-
Steen, E. J., Chan, R., Prasad, N., Myers, S., Petzold, C. J., Redding, A., Ouellet, M., and Keasling, J. D. (2008) Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol Microb. Cell. Fact. 7, 36
-
(2008)
Microb. Cell. Fact.
, vol.7
, pp. 36
-
-
Steen, E.J.1
Chan, R.2
Prasad, N.3
Myers, S.4
Petzold, C.J.5
Redding, A.6
Ouellet, M.7
Keasling, J.D.8
-
4
-
-
0142027026
-
Metabolic engineering for the microbial production of 1,3-propanediol
-
Nakamura, C. E. and Whited, G. M. (2003) Metabolic engineering for the microbial production of 1,3-propanediol Curr. Opin. Biotechnol. 14, 454-459
-
(2003)
Curr. Opin. Biotechnol.
, vol.14
, pp. 454-459
-
-
Nakamura, C.E.1
Whited, G.M.2
-
5
-
-
33646575569
-
Isolation and characterization of acid-tolerant, thermophilic bacteria for effective fermentation of biomass-derived sugars to lactic acid
-
Patel, M. A., Ou, M. S., Harbrucker, R., Aldrich, H. C., Buszko, M. L., Ingram, L. O., and Shanmugam, K. T. (2006) Isolation and characterization of acid-tolerant, thermophilic bacteria for effective fermentation of biomass-derived sugars to lactic acid Appl. Environ. Microbiol. 72, 3228-3235
-
(2006)
Appl. Environ. Microbiol.
, vol.72
, pp. 3228-3235
-
-
Patel, M.A.1
Ou, M.S.2
Harbrucker, R.3
Aldrich, H.C.4
Buszko, M.L.5
Ingram, L.O.6
Shanmugam, K.T.7
-
6
-
-
33746913914
-
Metabolic engineering of Escherichia coli and Corynebacterium glutamicum for biotechnological production of organic acids and amino acids
-
Wendisch, V. F., Bott, M., and Eikmanns, B. J. (2006) Metabolic engineering of Escherichia coli and Corynebacterium glutamicum for biotechnological production of organic acids and amino acids Curr. Opin. Microbiol. 9, 268-274
-
(2006)
Curr. Opin. Microbiol.
, vol.9
, pp. 268-274
-
-
Wendisch, V.F.1
Bott, M.2
Eikmanns, B.J.3
-
7
-
-
33747280991
-
Production of succinic acid by bacterial fermentation
-
Song, H. and Lee, S. Y. (2006) Production of succinic acid by bacterial fermentation Enzyme Microb. Technol. 39, 352-361
-
(2006)
Enzyme Microb. Technol.
, vol.39
, pp. 352-361
-
-
Song, H.1
Lee, S.Y.2
-
8
-
-
84856074574
-
An engineered microbial platform for direct biofuel production from brown macroalgae
-
Wargacki, A. J., Leonard, E., Win, M. N., Regitsky, D. D., Santos, C. N. S., Kim, P. B., Cooper, S. R., Raisner, R. M., Herman, A., Sivitz, A. B., Lakshmanaswamy, A., Kashiyama, Y., Baker, D., and Yoshikuni, Y. (2012) An engineered microbial platform for direct biofuel production from brown macroalgae Science 335, 308-313
-
(2012)
Science
, vol.335
, pp. 308-313
-
-
Wargacki, A.J.1
Leonard, E.2
Win, M.N.3
Regitsky, D.D.4
Santos, C.N.S.5
Kim, P.B.6
Cooper, S.R.7
Raisner, R.M.8
Herman, A.9
Sivitz, A.B.10
Lakshmanaswamy, A.11
Kashiyama, Y.12
Baker, D.13
Yoshikuni, Y.14
-
9
-
-
34247109045
-
Natural products as sources of new drugs over the last 25 years
-
Newman, D. J. and Cragg, G. M. (2007) Natural products as sources of new drugs over the last 25 years J. Nat. Prod. 70, 461-477
-
(2007)
J. Nat. Prod.
, vol.70
, pp. 461-477
-
-
Newman, D.J.1
Cragg, G.M.2
-
10
-
-
0032082930
-
Phenylpropanoid biosynthesis and its regulation
-
Weisshaar, B. and Jenkins, G. I. (1998) Phenylpropanoid biosynthesis and its regulation Curr. Opin. Plant Biol. 1, 251-257
-
(1998)
Curr. Opin. Plant Biol.
, vol.1
, pp. 251-257
-
-
Weisshaar, B.1
Jenkins, G.I.2
-
12
-
-
34250785114
-
The function of terpene natural products in the natural world
-
Gershenzon, J. and Dudareva, N. (2007) The function of terpene natural products in the natural world Nat. Chem. Biol. 3, 408-414
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 408-414
-
-
Gershenzon, J.1
Dudareva, N.2
-
13
-
-
73849152200
-
Medicinally important secondary metabolites in recombinant microorganisms or plants: Progress in alkaloid biosynthesis
-
Schäfer, H. and Wink, M. (2009) Medicinally important secondary metabolites in recombinant microorganisms or plants: progress in alkaloid biosynthesis Biotechnol. J. 4, 1684-1703
-
(2009)
Biotechnol. J.
, vol.4
, pp. 1684-1703
-
-
Schäfer, H.1
Wink, M.2
-
14
-
-
1342311388
-
Merging the potential of microbial genetics with biological and chemical diversity: An even brighter future for marine natural product drug discovery
-
Salomon, C. E., Magarvey, N. A., and Sherman, D. H. (2004) Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery Nat. Prod. Rep. 21, 105-121
-
(2004)
Nat. Prod. Rep.
, vol.21
, pp. 105-121
-
-
Salomon, C.E.1
Magarvey, N.A.2
Sherman, D.H.3
-
15
-
-
56249130054
-
Developing an industrial artemisinic acid fermentation process to support the cost-effective production of antimalarial artemisinin-based combination therapies
-
Lenihan, J. R., Tsuruta, H., Diola, D., Renninger, N. S., and Regentin, R. (2008) Developing an industrial artemisinic acid fermentation process to support the cost-effective production of antimalarial artemisinin-based combination therapies Biotechnol. Prog. 24, 1026-1032
-
(2008)
Biotechnol. Prog.
, vol.24
, pp. 1026-1032
-
-
Lenihan, J.R.1
Tsuruta, H.2
Diola, D.3
Renninger, N.S.4
Regentin, R.5
-
16
-
-
79958232375
-
Biosynthesis of isoprene in Escherichia coli via methylerythritol phosphate (MEP) pathway
-
Zhao, Y., Yang, J., Qin, B., Li, Y., Sun, Y., Su, S., and Xian, M. (2011) Biosynthesis of isoprene in Escherichia coli via methylerythritol phosphate (MEP) pathway Appl. Microbiol. Biotechnol. 90, 1915-1922
-
(2011)
Appl. Microbiol. Biotechnol.
, vol.90
, pp. 1915-1922
-
-
Zhao, Y.1
Yang, J.2
Qin, B.3
Li, Y.4
Sun, Y.5
Su, S.6
Xian, M.7
-
17
-
-
78649716727
-
Manufacturing molecules through metabolic engineering
-
Keasling, J. D. (2010) Manufacturing molecules through metabolic engineering Science 330, 1355-1358
-
(2010)
Science
, vol.330
, pp. 1355-1358
-
-
Keasling, J.D.1
-
18
-
-
77954860039
-
Debottlenecking the 1,3-propanediol pathway by metabolic engineering
-
Celińska, E. (2010) Debottlenecking the 1,3-propanediol pathway by metabolic engineering Biotechnol. Adv. 28, 519-530
-
(2010)
Biotechnol. Adv.
, vol.28
, pp. 519-530
-
-
Celińska, E.1
-
19
-
-
43049136820
-
Combinatorial engineering of microbes for optimizing cellular phenotype
-
Santos, C. N. S. and Stephanopoulos, G. (2008) Combinatorial engineering of microbes for optimizing cellular phenotype Curr. Opin. Chem. Biol. 12, 168-176
-
(2008)
Curr. Opin. Chem. Biol.
, vol.12
, pp. 168-176
-
-
Santos, C.N.S.1
Stephanopoulos, G.2
-
20
-
-
79952910616
-
Enzyme mechanism as a kinetic control element for designing synthetic biofuel pathways
-
Bond-Watts, B. B., Bellerose, R. J., and Chang, M. C. Y. (2011) Enzyme mechanism as a kinetic control element for designing synthetic biofuel pathways Nat. Chem. Biol. 7, 222-227
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 222-227
-
-
Bond-Watts, B.B.1
Bellerose, R.J.2
Chang, M.C.Y.3
-
21
-
-
77950858901
-
Analysis of polyhydroxybutyrate flux limitations by systematic genetic and metabolic perturbations
-
Tyo, K. E. J., Fischer, C. R., Simeon, F., and Stephanopoulos, G. (2010) Analysis of polyhydroxybutyrate flux limitations by systematic genetic and metabolic perturbations Metab. Eng. 12, 187-195
-
(2010)
Metab. Eng.
, vol.12
, pp. 187-195
-
-
Tyo, K.E.J.1
Fischer, C.R.2
Simeon, F.3
Stephanopoulos, G.4
-
22
-
-
33645870422
-
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
-
Ro, D.-K., Paradise, E. M., Ouellet, M., Fisher, K. J., Newman, K. L., Ndungu, J. M., Ho, K. A., Eachus, R. A., Ham, T. S., Kirby, J., Chang, M. C. Y., Withers, S. T., Shiba, Y., Sarpong, R., and Keasling, J. D. (2006) Production of the antimalarial drug precursor artemisinic acid in engineered yeast Nature 440, 940-943
-
(2006)
Nature
, vol.440
, pp. 940-943
-
-
Ro, D.-K.1
Paradise, E.M.2
Ouellet, M.3
Fisher, K.J.4
Newman, K.L.5
Ndungu, J.M.6
Ho, K.A.7
Eachus, R.A.8
Ham, T.S.9
Kirby, J.10
Chang, M.C.Y.11
Withers, S.T.12
Shiba, Y.13
Sarpong, R.14
Keasling, J.D.15
-
23
-
-
79959374585
-
Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol
-
Yim, H., Haselbeck, R., Niu, W., Pujol-Baxley, C., Burgard, A., Boldt, J., Khandurina, J., Trawick, J. D., Osterhout, R. E., Stephen, R., Estadilla, J., Teisan, S., Schreyer, H. B., Andrae, S., Yang, T. H., Lee, S. Y., Burk, M. J., and Dien, S. V. (2011) Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol Nat. Chem. Biol. 7, 445-452
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 445-452
-
-
Yim, H.1
Haselbeck, R.2
Niu, W.3
Pujol-Baxley, C.4
Burgard, A.5
Boldt, J.6
Khandurina, J.7
Trawick, J.D.8
Osterhout, R.E.9
Stephen, R.10
Estadilla, J.11
Teisan, S.12
Schreyer, H.B.13
Andrae, S.14
Yang, T.H.15
Lee, S.Y.16
Burk, M.J.17
Dien, S.V.18
-
24
-
-
33744509927
-
Engineering life: Building a fab for biology
-
Bio FAB, Baker, D., Church, G., Collins, J., Endy, D., Jacobson, J., Keasling, J., Modrich, P., Smolke, C., and Weiss, R. (2006) Engineering life: building a fab for biology Sci. Am. 294, 44-51
-
(2006)
Sci. Am.
, vol.294
, pp. 44-51
-
-
Bio, F.A.B.1
Baker, D.2
Church, G.3
Collins, J.4
Endy, D.5
Jacobson, J.6
Keasling, J.7
Modrich, P.8
Smolke, C.9
Weiss, R.10
-
25
-
-
84859768457
-
Parts plus pipes: Synthetic biology approaches to metabolic engineering
-
Boyle, P. M. and Silver, P. A. (2012) Parts plus pipes: Synthetic biology approaches to metabolic engineering Metab. Eng 14, 223-232
-
(2012)
Metab. Eng
, vol.14
, pp. 223-232
-
-
Boyle, P.M.1
Silver, P.A.2
-
26
-
-
65649123015
-
A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3)
-
Dietrich, J. A., Yoshikuni, Y., Fisher, K. J., Woolard, F. X., Ockey, D., McPhee, D. J., Renninger, N. S., Chang, M. C. Y., Baker, D., and Keasling, J. D. (2009) A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3) ACS Chem. Biol. 4, 261-267
-
(2009)
ACS Chem. Biol.
, vol.4
, pp. 261-267
-
-
Dietrich, J.A.1
Yoshikuni, Y.2
Fisher, K.J.3
Woolard, F.X.4
Ockey, D.5
McPhee, D.J.6
Renninger, N.S.7
Chang, M.C.Y.8
Baker, D.9
Keasling, J.D.10
-
27
-
-
78149425711
-
Novel activity of Rhodobacter sphaeroides spheroidene monooxygenase CrtA expressed in Escherichia coli
-
Lee, P. C., Holtzapple, E., and Schmidt-Dannert, C. (2010) Novel activity of Rhodobacter sphaeroides spheroidene monooxygenase CrtA expressed in Escherichia coli Appl. Environ. Microbiol. 76, 7328-7331
-
(2010)
Appl. Environ. Microbiol.
, vol.76
, pp. 7328-7331
-
-
Lee, P.C.1
Holtzapple, E.2
Schmidt-Dannert, C.3
-
28
-
-
70350518093
-
A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds
-
Sawayama, A. M., Chen, M. M. Y., Kulanthaivel, P., Kuo, M.-S., Hemmerle, H., and Arnold, F. H. (2009) A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds Chem.-Eur. J. 15, 11723-11729
-
(2009)
Chem. - Eur. J.
, vol.15
, pp. 11723-11729
-
-
Sawayama, A.M.1
Chen, M.M.Y.2
Kulanthaivel, P.3
Kuo, M.-S.4
Hemmerle, H.5
Arnold, F.H.6
-
29
-
-
0042975166
-
Natural products-A simple model to explain chemical diversity
-
Firn, R. D. and Jones, C. G. (2003) Natural products-A simple model to explain chemical diversity Nat. Prod. Rep. 20, 382-391
-
(2003)
Nat. Prod. Rep.
, vol.20
, pp. 382-391
-
-
Firn, R.D.1
Jones, C.G.2
-
30
-
-
79958097953
-
The moderately efficient enzyme: Evolutionary and physicochemical trends shaping enzyme parameters
-
Bar-Even, A., Noor, E., Savir, Y., Liebermeister, W., Davidi, D., Tawfik, D. S., and Milo, R. (2011) The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters Biochemistry 50, 4402-4410
-
(2011)
Biochemistry
, vol.50
, pp. 4402-4410
-
-
Bar-Even, A.1
Noor, E.2
Savir, Y.3
Liebermeister, W.4
Davidi, D.5
Tawfik, D.S.6
Milo, R.7
-
31
-
-
77956371200
-
Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control
-
Leonard, E., Ajikumar, P. K., Thayer, K., Xiao, W.-H., Mo, J. D., Tidor, B., Stephanopoulos, G., and Prather, K. L. J. (2010) Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control Proc. Natl. Acad. Sci. U.S.A. 107, 13654-13659
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 13654-13659
-
-
Leonard, E.1
Ajikumar, P.K.2
Thayer, K.3
Xiao, W.-H.4
Mo, J.D.5
Tidor, B.6
Stephanopoulos, G.7
Prather, K.L.J.8
-
32
-
-
84857503105
-
The imminent role of protein engineering in synthetic biology
-
Foo, J. L., Ching, C. B., Chang, M. W., and Leong, S. S. J. (2012) The imminent role of protein engineering in synthetic biology Biotechnol. Adv. 30, 541-549
-
(2012)
Biotechnol. Adv.
, vol.30
, pp. 541-549
-
-
Foo, J.L.1
Ching, C.B.2
Chang, M.W.3
Leong, S.S.J.4
-
33
-
-
80053393229
-
Protein design in metabolic engineering and synthetic biology
-
Pleiss, J. (2011) Protein design in metabolic engineering and synthetic biology Curr. Opin. Biotechnol. 22, 611-617
-
(2011)
Curr. Opin. Biotechnol.
, vol.22
, pp. 611-617
-
-
Pleiss, J.1
-
34
-
-
84857633496
-
Protein engineering towards natural product synthesis and diversification
-
Zabala, A. O., Cacho, R. A., and Tang, Y. (2012) Protein engineering towards natural product synthesis and diversification J. Ind. Microbiol. Biotechnol. 39, 227-241
-
(2012)
J. Ind. Microbiol. Biotechnol.
, vol.39
, pp. 227-241
-
-
Zabala, A.O.1
Cacho, R.A.2
Tang, Y.3
-
36
-
-
51449121245
-
Scopoletin is biosynthesized via ortho-hydroxylation of feruloyl CoA by a 2-oxoglutarate-dependent dioxygenase in Arabidopsis thaliana
-
Kai, K., Mizutani, M., Kawamura, N., Yamamoto, R., Tamai, M., Yamaguchi, H., Sakata, K., and Shimizu, B. (2008) Scopoletin is biosynthesized via ortho-hydroxylation of feruloyl CoA by a 2-oxoglutarate-dependent dioxygenase in Arabidopsis thaliana Plant J. 55, 989-999
-
(2008)
Plant J.
, vol.55
, pp. 989-999
-
-
Kai, K.1
Mizutani, M.2
Kawamura, N.3
Yamamoto, R.4
Tamai, M.5
Yamaguchi, H.6
Sakata, K.7
Shimizu, B.8
-
37
-
-
76549093442
-
Phenylpropanoid Biosynthesis
-
Vogt, T. (2010) Phenylpropanoid Biosynthesis Mol. Plant 3, 2-20
-
(2010)
Mol. Plant
, vol.3
, pp. 2-20
-
-
Vogt, T.1
-
38
-
-
0033009718
-
Hyperproduction of tryptophan by Corynebacterium glutamicum with the modified pentose phosphate pathway
-
Ikeda, M. and Katsumata, R. (1999) Hyperproduction of tryptophan by Corynebacterium glutamicum with the modified pentose phosphate pathway Appl. Environ. Microbiol. 65, 2497-2502
-
(1999)
Appl. Environ. Microbiol.
, vol.65
, pp. 2497-2502
-
-
Ikeda, M.1
Katsumata, R.2
-
39
-
-
34247593085
-
L-tyrosine production by deregulated strains of Escherichia coli
-
Lütke-Eversloh, T. and Stephanopoulos, G. (2007) L-tyrosine production by deregulated strains of Escherichia coli Appl. Microbiol. Biotechnol. 75, 103-110
-
(2007)
Appl. Microbiol. Biotechnol.
, vol.75
, pp. 103-110
-
-
Lütke-Eversloh, T.1
Stephanopoulos, G.2
-
40
-
-
42549093749
-
Terpenoids: Opportunities for biosynthesis of natural product drugs using engineered microorganisms
-
Ajikumar, P. K., Tyo, K., Carlsen, S., Mucha, O., Phon, T. H., and Stephanopoulos, G. (2008) Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms Mol. Pharm. 5, 167-190
-
(2008)
Mol. Pharm.
, vol.5
, pp. 167-190
-
-
Ajikumar, P.K.1
Tyo, K.2
Carlsen, S.3
Mucha, O.4
Phon, T.H.5
Stephanopoulos, G.6
-
41
-
-
79953251042
-
The family of terpene synthases in plants: A mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom
-
Chen, F., Tholl, D., Bohlmann, J., and Pichersky, E. (2011) The family of terpene synthases in plants: a mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom Plant J. 66, 212-229
-
(2011)
Plant J.
, vol.66
, pp. 212-229
-
-
Chen, F.1
Tholl, D.2
Bohlmann, J.3
Pichersky, E.4
-
42
-
-
77951133659
-
Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates
-
Noel, J. P., Dellas, N., Faraldos, J. A., Zhao, M., Hess, B. A., Jr, Smentek, L., Coates, R. M., and O'Maille, P. E. (2010) Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates ACS Chem. Biol. 5, 377-392
-
(2010)
ACS Chem. Biol.
, vol.5
, pp. 377-392
-
-
Noel, J.P.1
Dellas, N.2
Faraldos, J.A.3
Zhao, M.4
Hess III, B.A.5
Smentek, L.6
Coates, R.M.7
O'Maille, P.E.8
-
43
-
-
82755189689
-
Cytochrome P450: Taming a wild type enzyme
-
Jung, S. T., Lauchli, R., and Arnold, F. H. (2011) Cytochrome P450: taming a wild type enzyme Curr. Opin. Biotechnol. 22, 809-817
-
(2011)
Curr. Opin. Biotechnol.
, vol.22
, pp. 809-817
-
-
Jung, S.T.1
Lauchli, R.2
Arnold, F.H.3
-
44
-
-
29344470062
-
Significance of flavonoids in plant resistance and enhancement of their biosynthesis
-
Treutter, D. (2005) Significance of flavonoids in plant resistance and enhancement of their biosynthesis Plant Biol. (Stuttgart) 7, 581-591
-
(2005)
Plant Biol. (Stuttgart)
, vol.7
, pp. 581-591
-
-
Treutter, D.1
-
45
-
-
35748966709
-
Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part I: Chemical diversity, impacts on plant biology and human health
-
Ververidis, F., Trantas, E., Douglas, C., Vollmer, G., Kretzschmar, G., and Panopoulos, N. (2007) Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part I: Chemical diversity, impacts on plant biology and human health Biotechnol. J. 2, 1214-1234
-
(2007)
Biotechnol. J.
, vol.2
, pp. 1214-1234
-
-
Ververidis, F.1
Trantas, E.2
Douglas, C.3
Vollmer, G.4
Kretzschmar, G.5
Panopoulos, N.6
-
46
-
-
79960981915
-
Plant phenylpropanoids as emerging anti-inflammatory agents
-
Korkina, L., Kostyuk, V., De Luca, C., and Pastore, S. (2011) Plant phenylpropanoids as emerging anti-inflammatory agents Mini-Rev. Med. Chem. 11, 823-835
-
(2011)
Mini-Rev. Med. Chem.
, vol.11
, pp. 823-835
-
-
Korkina, L.1
Kostyuk, V.2
De Luca, C.3
Pastore, S.4
-
47
-
-
44949125522
-
Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1
-
Jang, S., Kelley, K. W., and Johnson, R. W. (2008) Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1 Proc. Natl. Acad. Sci. U.S.A. 105, 7534-7539
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 7534-7539
-
-
Jang, S.1
Kelley, K.W.2
Johnson, R.W.3
-
48
-
-
51349127271
-
Multitargeted cancer prevention by quercetin
-
Murakami, A., Ashida, H., and Terao, J. (2008) Multitargeted cancer prevention by quercetin Cancer Lett. 269, 315-325
-
(2008)
Cancer Lett.
, vol.269
, pp. 315-325
-
-
Murakami, A.1
Ashida, H.2
Terao, J.3
-
49
-
-
40849116488
-
Structure and function of enzymes involved in the biosynthesis of phenylpropanoids
-
Ferrer, J.-L., Austin, M. B., Stewart, C., and Noel, J. P. (2008) Structure and function of enzymes involved in the biosynthesis of phenylpropanoids Plant Physiol. Biochem. 46, 356-370
-
(2008)
Plant Physiol. Biochem.
, vol.46
, pp. 356-370
-
-
Ferrer, J.-L.1
Austin, M.B.2
Stewart, C.3
Noel, J.P.4
-
50
-
-
67650685038
-
Biosynthesis and biotechnological production of flavanones: Current state and perspectives
-
Fowler, Z. L. and Koffas, M. A. G. (2009) Biosynthesis and biotechnological production of flavanones: current state and perspectives Appl. Microbiol. Biotechnol. 83, 799-808
-
(2009)
Appl. Microbiol. Biotechnol.
, vol.83
, pp. 799-808
-
-
Fowler, Z.L.1
Koffas, M.A.G.2
-
51
-
-
33644816925
-
Functional expression of a P450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in Escherichia coli
-
Leonard, E., Yan, Y., and Koffas, M. A. G. (2006) Functional expression of a P450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in Escherichia coli Metab. Eng. 8, 172-181
-
(2006)
Metab. Eng.
, vol.8
, pp. 172-181
-
-
Leonard, E.1
Yan, Y.2
Koffas, M.A.G.3
-
52
-
-
33744491283
-
Flavonoid diversity and biosynthesis in seed of Arabidopsis thaliana
-
Routaboul, J.-M., Kerhoas, L., Debeaujon, I., Pourcel, L., Caboche, M., Einhorn, J., and Lepiniec, L. (2006) Flavonoid diversity and biosynthesis in seed of Arabidopsis thaliana Planta 224, 96-107
-
(2006)
Planta
, vol.224
, pp. 96-107
-
-
Routaboul, J.-M.1
Kerhoas, L.2
Debeaujon, I.3
Pourcel, L.4
Caboche, M.5
Einhorn, J.6
Lepiniec, L.7
-
53
-
-
44949201614
-
Redesigning enzymes based on adaptive evolution for optimal function in synthetic metabolic pathways
-
Yoshikuni, Y., Dietrich, J. A., Nowroozi, F. F., Babbitt, P. C., and Keasling, J. D. (2008) Redesigning enzymes based on adaptive evolution for optimal function in synthetic metabolic pathways Chem. Biol. 15, 607-618
-
(2008)
Chem. Biol.
, vol.15
, pp. 607-618
-
-
Yoshikuni, Y.1
Dietrich, J.A.2
Nowroozi, F.F.3
Babbitt, P.C.4
Keasling, J.D.5
-
54
-
-
77957329119
-
Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli
-
Ajikumar, P. K., Xiao, W.-H., Tyo, K. E. J., Wang, Y., Simeon, F., Leonard, E., Mucha, O., Phon, T. H., Pfeifer, B., and Stephanopoulos, G. (2010) Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli Science 330, 70-74
-
(2010)
Science
, vol.330
, pp. 70-74
-
-
Ajikumar, P.K.1
Xiao, W.-H.2
Tyo, K.E.J.3
Wang, Y.4
Simeon, F.5
Leonard, E.6
Mucha, O.7
Phon, T.H.8
Pfeifer, B.9
Stephanopoulos, G.10
-
55
-
-
79551478567
-
Diversion of flux toward sesquiterpene production in Saccharomyces cerevisiae by fusion of host and heterologous enzymes
-
Albertsen, L., Chen, Y., Bach, L. S., Rattleff, S., Maury, J., Brix, S., Nielsen, J., and Mortensen, U. H. (2011) Diversion of flux toward sesquiterpene production in Saccharomyces cerevisiae by fusion of host and heterologous enzymes Appl. Environ. Microbiol. 77, 1033-1040
-
(2011)
Appl. Environ. Microbiol.
, vol.77
, pp. 1033-1040
-
-
Albertsen, L.1
Chen, Y.2
Bach, L.S.3
Rattleff, S.4
Maury, J.5
Brix, S.6
Nielsen, J.7
Mortensen, U.H.8
-
56
-
-
68449088806
-
Synthetic protein scaffolds provide modular control over metabolic flux
-
Dueber, J. E., Wu, G. C., Malmirchegini, G. R., Moon, T. S., Petzold, C. J., Ullal, A. V., Prather, K. L. J., and Keasling, J. D. (2009) Synthetic protein scaffolds provide modular control over metabolic flux Nat. Biotechnol. 27, 753-759
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 753-759
-
-
Dueber, J.E.1
Wu, G.C.2
Malmirchegini, G.R.3
Moon, T.S.4
Petzold, C.J.5
Ullal, A.V.6
Prather, K.L.J.7
Keasling, J.D.8
-
57
-
-
79955164750
-
Engineered ketol-Acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli
-
Bastian, S., Liu, X., Meyerowitz, J. T., Snow, C. D., Chen, M. M. Y., and Arnold, F. H. (2011) Engineered ketol-Acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli Metab. Eng. 13, 345-352
-
(2011)
Metab. Eng.
, vol.13
, pp. 345-352
-
-
Bastian, S.1
Liu, X.2
Meyerowitz, J.T.3
Snow, C.D.4
Chen, M.M.Y.5
Arnold, F.H.6
-
58
-
-
78751476638
-
Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli
-
Fasan, R., Crook, N. C., Peters, M. W., Meinhold, P., Buelter, T., Landwehr, M., Cirino, P. C., and Arnold, F. H. (2011) Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli Biotechnol. Bioeng. 108, 500-510
-
(2011)
Biotechnol. Bioeng.
, vol.108
, pp. 500-510
-
-
Fasan, R.1
Crook, N.C.2
Peters, M.W.3
Meinhold, P.4
Buelter, T.5
Landwehr, M.6
Cirino, P.C.7
Arnold, F.H.8
-
60
-
-
78349313517
-
Beyond directed evolution - Semi-rational protein engineering and design
-
Stefan, L. (2010) Beyond directed evolution-semi-rational protein engineering and design Curr. Opin. Biotechnol. 21, 734-743
-
(2010)
Curr. Opin. Biotechnol.
, vol.21
, pp. 734-743
-
-
Stefan, L.1
-
61
-
-
50649095790
-
Macromolecular modeling with rosetta
-
Das, R. and Baker, D. (2008) Macromolecular modeling with rosetta Annu. Rev. Biochem. 77, 363-382
-
(2008)
Annu. Rev. Biochem.
, vol.77
, pp. 363-382
-
-
Das, R.1
Baker, D.2
-
62
-
-
58149193233
-
The SWISS-MODEL Repository and associated resources
-
Kiefer, F., Arnold, K., Künzli, M., Bordoli, L., and Schwede, T. (2009) The SWISS-MODEL Repository and associated resources Nucleic Acids Res. 37, D387-392
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. 387-392
-
-
Kiefer, F.1
Arnold, K.2
Künzli, M.3
Bordoli, L.4
Schwede, T.5
-
63
-
-
69849109596
-
All-Atom chain-building by optimizing MODELLER energy function using conformational space annealing
-
Joo, K., Lee, J., Seo, J., Lee, K., Kim, B., and Lee, J. (2009) All-Atom chain-building by optimizing MODELLER energy function using conformational space annealing Proteins: Struct., Funct., Bioinf. 75, 1010-1023
-
(2009)
Proteins: Struct., Funct., Bioinf.
, vol.75
, pp. 1010-1023
-
-
Joo, K.1
Lee, J.2
Seo, J.3
Lee, K.4
Kim, B.5
Lee, J.6
-
64
-
-
0347383758
-
Modeller: Generation and Refinement of Homology-Based Protein Structure Models
-
Academic Press, New York
-
Fiser, A. and Šali, A. (2003) Modeller: Generation and Refinement of Homology-Based Protein Structure Models. In Macromolecular Crystallography, Part D, pp 461-491, Academic Press, New York.
-
(2003)
Macromolecular Crystallography, Part D
, pp. 461-491
-
-
Fiser, A.1
Šali, A.2
-
65
-
-
27344436659
-
Scalable molecular dynamics with NAMD
-
Phillips, J. C., Braun, R., Wang, W., Gumbart, J., Tajkhorshid, E., Villa, E., Chipot, C., Skeel, R. D., Kalé, L., and Schulten, K. (2005) Scalable molecular dynamics with NAMD J. Comput. Chem. 26, 1781-1802
-
(2005)
J. Comput. Chem.
, vol.26
, pp. 1781-1802
-
-
Phillips, J.C.1
Braun, R.2
Wang, W.3
Gumbart, J.4
Tajkhorshid, E.5
Villa, E.6
Chipot, C.7
Skeel, R.D.8
Kalé, L.9
Schulten, K.10
-
66
-
-
73149111493
-
Simultaneous prediction of protein folding and docking at high resolution
-
Das, R., André, I., Shen, Y., Wu, Y., Lemak, A., Bansal, S., Arrowsmith, C. H., Szyperski, T., and Baker, D. (2009) Simultaneous prediction of protein folding and docking at high resolution Proc. Natl. Acad. Sci. U.S.A. 106, 18978-18983
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 18978-18983
-
-
Das, R.1
André, I.2
Shen, Y.3
Wu, Y.4
Lemak, A.5
Bansal, S.6
Arrowsmith, C.H.7
Szyperski, T.8
Baker, D.9
-
67
-
-
0037093644
-
Increasing the precision of comparative models with YASARA NOVA-A self-parameterizing force field
-
Krieger, E., Koraimann, G., and Vriend, G. (2002) Increasing the precision of comparative models with YASARA NOVA-A self-parameterizing force field Proteins 47, 393-402
-
(2002)
Proteins
, vol.47
, pp. 393-402
-
-
Krieger, E.1
Koraimann, G.2
Vriend, G.3
-
68
-
-
33745631233
-
Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases
-
Greenhagen, B. T., O'Maille, P. E., Noel, J. P., and Chappell, J. (2006) Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases Proc. Natl. Acad. Sci. U.S.A. 103, 9826-9831
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 9826-9831
-
-
Greenhagen, B.T.1
O'Maille, P.E.2
Noel, J.P.3
Chappell, J.4
-
69
-
-
84855919905
-
Second-contact shell mutation diminishes streptavidin-biotin binding affinity through transmitted effects on equilibrium dynamics
-
Baugh, L., Le Trong, I., Cerutti, D. S., Mehta, N., Gülich, S., Stayton, P. S., Stenkamp, R. E., and Lybrand, T. P. (2012) Second-contact shell mutation diminishes streptavidin-biotin binding affinity through transmitted effects on equilibrium dynamics Biochemistry 51, 597-607
-
(2012)
Biochemistry
, vol.51
, pp. 597-607
-
-
Baugh, L.1
Le Trong, I.2
Cerutti, D.S.3
Mehta, N.4
Gülich, S.5
Stayton, P.S.6
Stenkamp, R.E.7
Lybrand, T.P.8
-
70
-
-
84856723541
-
Increased Diels-Alderase activity through backbone remodeling guided by Foldit players
-
Eiben, C. B., Siegel, J. B., Bale, J. B., Cooper, S., Khatib, F., Shen, B. W., Players, F., Stoddard, B. L., Popovic, Z., and Baker, D. (2012) Increased Diels-Alderase activity through backbone remodeling guided by Foldit players Nat. Biotechnol. 30, 190-192
-
(2012)
Nat. Biotechnol.
, vol.30
, pp. 190-192
-
-
Eiben, C.B.1
Siegel, J.B.2
Bale, J.B.3
Cooper, S.4
Khatib, F.5
Shen, B.W.6
Players, F.7
Stoddard, B.L.8
Popovic, Z.9
Baker, D.10
-
71
-
-
44349161622
-
Intense neutral drifts yield robust and evolvable consensus proteins
-
Bershtein, S., Goldin, K., and Tawfik, D. S. (2008) Intense neutral drifts yield robust and evolvable consensus proteins J. Mol. Biol. 379, 1029-1044
-
(2008)
J. Mol. Biol.
, vol.379
, pp. 1029-1044
-
-
Bershtein, S.1
Goldin, K.2
Tawfik, D.S.3
-
72
-
-
0034889536
-
A critical view on conservative mutations
-
Jonson, P. H. and Petersen, S. B. (2001) A critical view on conservative mutations Protein Eng. 14, 397-402
-
(2001)
Protein Eng.
, vol.14
, pp. 397-402
-
-
Jonson, P.H.1
Petersen, S.B.2
-
73
-
-
84856432368
-
The transition of human estrogen sulfotransferase from generalist to specialist using directed enzyme evolution
-
Amar, D., Berger, I., Amara, N., Tafa, G., Meijler, M. M., and Aharoni, A. (2012) The transition of human estrogen sulfotransferase from generalist to specialist using directed enzyme evolution J. Mol. Biol. 416, 21-32
-
(2012)
J. Mol. Biol.
, vol.416
, pp. 21-32
-
-
Amar, D.1
Berger, I.2
Amara, N.3
Tafa, G.4
Meijler, M.M.5
Aharoni, A.6
-
74
-
-
84865306330
-
Directed enzyme evolution: Beyond the low-hanging fruit
-
Goldsmith, M. and Tawfik, D. S. (2012) Directed enzyme evolution: beyond the low-hanging fruit Curr. Opin. Struct. Biol. 22, 406-412
-
(2012)
Curr. Opin. Struct. Biol.
, vol.22
, pp. 406-412
-
-
Goldsmith, M.1
Tawfik, D.S.2
-
75
-
-
34548014497
-
Incorporating Synthetic Oligonucleotides via Gene Reassembly (ISOR): A versatile tool for generating targeted libraries
-
Herman, A. and Tawfik, D. S. (2007) Incorporating Synthetic Oligonucleotides via Gene Reassembly (ISOR): a versatile tool for generating targeted libraries Protein Eng., Des. Sel. 20, 219-226
-
(2007)
Protein Eng., Des. Sel.
, vol.20
, pp. 219-226
-
-
Herman, A.1
Tawfik, D.S.2
-
76
-
-
65249152992
-
Advances in generating functional diversity for directed protein evolution
-
Shivange, A. V., Marienhagen, J., Mundhada, H., Schenk, A., and Schwaneberg, U. (2009) Advances in generating functional diversity for directed protein evolution Curr. Opin. Chem. Biol. 13, 19-25
-
(2009)
Curr. Opin. Chem. Biol.
, vol.13
, pp. 19-25
-
-
Shivange, A.V.1
Marienhagen, J.2
Mundhada, H.3
Schenk, A.4
Schwaneberg, U.5
-
77
-
-
77953642931
-
High-throughput metabolic engineering: Advances in small-molecule screening and selection
-
Dietrich, J. A., McKee, A. E., and Keasling, J. D. (2010) High-throughput metabolic engineering: advances in small-molecule screening and selection Annu. Rev. Biochem. 79, 563-590
-
(2010)
Annu. Rev. Biochem.
, vol.79
, pp. 563-590
-
-
Dietrich, J.A.1
McKee, A.E.2
Keasling, J.D.3
-
78
-
-
56649111369
-
Highly L and D enantioselective variants of horseradish peroxidase discovered by an ultrahigh-throughput selection method
-
Antipov, E., Cho, A. E., Wittrup, K. D., and Klibanov, A. M. (2008) Highly L and D enantioselective variants of horseradish peroxidase discovered by an ultrahigh-throughput selection method Proc. Natl. Acad. Sci. U.S.A. 105, 17694-17699
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 17694-17699
-
-
Antipov, E.1
Cho, A.E.2
Wittrup, K.D.3
Klibanov, A.M.4
-
79
-
-
70349110513
-
Directed evolution of enantioselective enzymes: An unconventional approach to asymmetric catalysis in organic chemistry
-
Reetz, M. T. (2009) Directed evolution of enantioselective enzymes: an unconventional approach to asymmetric catalysis in organic chemistry J. Org. Chem. 74, 5767-5778
-
(2009)
J. Org. Chem.
, vol.74
, pp. 5767-5778
-
-
Reetz, M.T.1
-
80
-
-
18744388856
-
Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity
-
Varadarajan, N., Gam, J., Olsen, M. J., Georgiou, G., and Iverson, B. L. (2005) Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity Proc. Natl. Acad. Sci. U.S.A. 102, 6855-6860
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 6855-6860
-
-
Varadarajan, N.1
Gam, J.2
Olsen, M.J.3
Georgiou, G.4
Iverson, B.L.5
-
81
-
-
0034518317
-
Directed evolution of metabolically engineered Escherichia coli for carotenoid production
-
Wang, C., Oh, M. K., and Liao, J. C. (2000) Directed evolution of metabolically engineered Escherichia coli for carotenoid production Biotechnol. Prog. 16, 922-926
-
(2000)
Biotechnol. Prog.
, vol.16
, pp. 922-926
-
-
Wang, C.1
Oh, M.K.2
Liao, J.C.3
-
82
-
-
33644854595
-
Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis
-
Li, B., Yu, J. P. J., Brunzelle, J. S., Moll, G. N., van der Donk, W. A., and Nair, S. K. (2006) Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis Science 311, 1464-1467
-
(2006)
Science
, vol.311
, pp. 1464-1467
-
-
Li, B.1
Yu, J.P.J.2
Brunzelle, J.S.3
Moll, G.N.4
Van Der Donk, W.A.5
Nair, S.K.6
-
83
-
-
0033543169
-
Mapping the active site topography of the NAD-malic enzyme via alanine-scanning site-directed mutagenesis
-
Karsten, W. E., Chooback, L., Liu, D., Hwang, C. C., Lynch, C., and Cook, P. F. (1999) Mapping the active site topography of the NAD-malic enzyme via alanine-scanning site-directed mutagenesis Biochemistry 38, 10527-10532
-
(1999)
Biochemistry
, vol.38
, pp. 10527-10532
-
-
Karsten, W.E.1
Chooback, L.2
Liu, D.3
Hwang, C.C.4
Lynch, C.5
Cook, P.F.6
-
84
-
-
79958733609
-
Rhamnetin production based on the rational design of the poplar O-methyltransferase enzyme and its biological activities
-
Lee, S., Shin, S. Y., Lee, Y., Park, Y., Kim, B. G., Ahn, J.-H., Chong, Y., Lee, Y. H., and Lim, Y. (2011) Rhamnetin production based on the rational design of the poplar O-methyltransferase enzyme and its biological activities Bioorg. Med. Chem. Lett. 21, 3866-3870
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, pp. 3866-3870
-
-
Lee, S.1
Shin, S.Y.2
Lee, Y.3
Park, Y.4
Kim, B.G.5
Ahn, J.-H.6
Chong, Y.7
Lee, Y.H.8
Lim, Y.9
-
85
-
-
77952240604
-
Engineering cytochrome P450 monooxygenase CYP 116B3 for high dealkylation activity
-
Liu, L., Schmid, R. D., and Urlacher, V. B. (2010) Engineering cytochrome P450 monooxygenase CYP 116B3 for high dealkylation activity Biotechnol. Lett. 32, 841-845
-
(2010)
Biotechnol. Lett.
, vol.32
, pp. 841-845
-
-
Liu, L.1
Schmid, R.D.2
Urlacher, V.B.3
-
86
-
-
79960980943
-
A general strategy for the evolution of bond-forming enzymes using yeast display
-
Chen, I., Dorr, B. M., and Liu, D. R. (2011) A general strategy for the evolution of bond-forming enzymes using yeast display Proc. Natl. Acad. Sci. U.S.A. 108, 11399-11404
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 11399-11404
-
-
Chen, I.1
Dorr, B.M.2
Liu, D.R.3
-
87
-
-
70349694356
-
Directed evolution of the actinomycete cytochrome P450moxA (CYP105) for enhanced activity
-
Kabumoto, H., Miyazaki, K., and Arisawa, A. (2009) Directed evolution of the actinomycete cytochrome P450moxA (CYP105) for enhanced activity Biosci. Biotechnol. Biochem. 73, 1922-1927
-
(2009)
Biosci. Biotechnol. Biochem.
, vol.73
, pp. 1922-1927
-
-
Kabumoto, H.1
Miyazaki, K.2
Arisawa, A.3
-
88
-
-
43449098518
-
Kemp elimination catalysts by computational enzyme design
-
Röthlisberger, D., Khersonsky, O., Wollacott, A. M., Jiang, L., DeChancie, J., Betker, J., Gallaher, J. L., Althoff, E. A., Zanghellini, A., Dym, O., Albeck, S., Houk, K. N., Tawfik, D. S., and Baker, D. (2008) Kemp elimination catalysts by computational enzyme design Nature 453, 190-195
-
(2008)
Nature
, vol.453
, pp. 190-195
-
-
Röthlisberger, D.1
Khersonsky, O.2
Wollacott, A.M.3
Jiang, L.4
Dechancie, J.5
Betker, J.6
Gallaher, J.L.7
Althoff, E.A.8
Zanghellini, A.9
Dym, O.10
Albeck, S.11
Houk, K.N.12
Tawfik, D.S.13
Baker, D.14
-
89
-
-
78650333770
-
Selectivity of fungal sesquiterpene synthases: Role of the active site's H-1 alpha loop in catalysis
-
López-Gallego, F., Wawrzyn, G. T., and Schmidt-Dannert, C. (2010) Selectivity of fungal sesquiterpene synthases: role of the active site's H-1 alpha loop in catalysis Appl. Environ. Microbiol. 76, 7723-7733
-
(2010)
Appl. Environ. Microbiol.
, vol.76
, pp. 7723-7733
-
-
López-Gallego, F.1
Wawrzyn, G.T.2
Schmidt-Dannert, C.3
-
90
-
-
65549113338
-
Rational design of a minimal and highly enriched CYP102A1 mutant library with improved regio-, stereo- and chemoselectivity
-
Seifert, A., Vomund, S., Grohmann, K., Kriening, S., Urlacher, V. B., Laschat, S., and Pleiss, J. (2009) Rational design of a minimal and highly enriched CYP102A1 mutant library with improved regio-, stereo- and chemoselectivity ChemBioChem 10, 853-861
-
(2009)
ChemBioChem
, vol.10
, pp. 853-861
-
-
Seifert, A.1
Vomund, S.2
Grohmann, K.3
Kriening, S.4
Urlacher, V.B.5
Laschat, S.6
Pleiss, J.7
-
91
-
-
79959709452
-
Manipulating the expression rate and enantioselectivity of an epoxide hydrolase by using directed evolution
-
Reetz, M. T. and Zheng, H. (2011) Manipulating the expression rate and enantioselectivity of an epoxide hydrolase by using directed evolution ChembBioChem 12, 1529-1535
-
(2011)
ChembBioChem
, vol.12
, pp. 1529-1535
-
-
Reetz, M.T.1
Zheng, H.2
-
92
-
-
71849104042
-
Enzyme engineering for enantioselectivity: From trial-And-error to rational design?
-
Otten, L. G., Hollmann, F., and Arends, I. W. C. E. (2010) Enzyme engineering for enantioselectivity: from trial-And-error to rational design? Trends Biotechnol. 28, 46-54
-
(2010)
Trends Biotechnol.
, vol.28
, pp. 46-54
-
-
Otten, L.G.1
Hollmann, F.2
Arends, I.W.C.E.3
-
93
-
-
34548354465
-
Correlation between the structural stability and aggregation propensity of proteins
-
Idicula-Thomas, S. and Balaji, P. V. (2007) Correlation between the structural stability and aggregation propensity of proteins In Silico Biol. 7, 225-237
-
(2007)
Silico Biol.
, vol.7
, pp. 225-237
-
-
Idicula-Thomas, S.1
Balaji, P.V.2
-
94
-
-
0028949615
-
Proteins and Temperature
-
Somero, G. N. (1995) Proteins and Temperature Annu. Rev. Physiol. 57, 43-68
-
(1995)
Annu. Rev. Physiol.
, vol.57
, pp. 43-68
-
-
Somero, G.N.1
-
95
-
-
69949162927
-
SOLpro: Accurate sequence-based prediction of protein solubility
-
Magnan, C. N., Randall, A., and Baldi, P. (2009) SOLpro: accurate sequence-based prediction of protein solubility Bioinformatics 25, 2200-2207
-
(2009)
Bioinformatics
, vol.25
, pp. 2200-2207
-
-
Magnan, C.N.1
Randall, A.2
Baldi, P.3
-
96
-
-
35648952843
-
Enhancing the stability and solubility of TEV protease using in silico design
-
Cabrita, L. D., Gilis, D., Robertson, A. L., Dehouck, Y., Rooman, M., and Bottomley, S. P. (2007) Enhancing the stability and solubility of TEV protease using in silico design Protein Sci. 16, 2360-2367
-
(2007)
Protein Sci.
, vol.16
, pp. 2360-2367
-
-
Cabrita, L.D.1
Gilis, D.2
Robertson, A.L.3
Dehouck, Y.4
Rooman, M.5
Bottomley, S.P.6
-
97
-
-
0030937716
-
Extreme stabilization of a thermolysin-like protease by an engineered disulfide bond
-
Mansfeld, J., Vriend, G., Dijkstra, B. W., Veltman, O. R., Van den Burg, B., Venema, G., Ulbrich-Hofmann, R., and Eijsink, V. G. (1997) Extreme stabilization of a thermolysin-like protease by an engineered disulfide bond J. Biol. Chem. 272, 11152-11156
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11152-11156
-
-
Mansfeld, J.1
Vriend, G.2
Dijkstra, B.W.3
Veltman, O.R.4
Van Den Burg, B.5
Venema, G.6
Ulbrich-Hofmann, R.7
Eijsink, V.G.8
-
98
-
-
0036307678
-
Electrostatics significantly affect the stability of designed homeodomain variants
-
Marshall, S. A., Morgan, C. S., and Mayo, S. L. (2002) Electrostatics significantly affect the stability of designed homeodomain variants J. Mol. Biol. 316, 189-199
-
(2002)
J. Mol. Biol.
, vol.316
, pp. 189-199
-
-
Marshall, S.A.1
Morgan, C.S.2
Mayo, S.L.3
-
99
-
-
4544244867
-
Rational engineering of enzyme stability
-
Eijsink, V. G. H., Bjørk, A., GaÌŠseidnes, S., SirevaÌŠg, R., Synstad, B., van den Burg, B., and Vriend, G. (2004) Rational engineering of enzyme stability J. Biotechnol. 113, 105-120
-
(2004)
J. Biotechnol.
, vol.113
, pp. 105-120
-
-
Eijsink, V.G.H.1
Bjørk, A.2
Gaìšseidnes, S.3
Sirevaìšg, R.4
Synstad, B.5
Van Den Burg, B.6
Vriend, G.7
-
100
-
-
34548218408
-
Development of a screening platform for directed evolution using the reef coral fluorescent protein ZsGreen as a solubility reporter
-
Heddle, C. and Mazaleyrat, S. L. (2007) Development of a screening platform for directed evolution using the reef coral fluorescent protein ZsGreen as a solubility reporter Protein Eng., Des. Sel. 20, 327-337
-
(2007)
Protein Eng., Des. Sel.
, vol.20
, pp. 327-337
-
-
Heddle, C.1
Mazaleyrat, S.L.2
-
101
-
-
78649277331
-
Thermostabilization of an esterase by alignment-guided focussed directed evolution
-
Jochens, H., Aerts, D., and Bornscheuer, U. T. (2010) Thermostabilization of an esterase by alignment-guided focussed directed evolution Protein Eng., Des. Sel. 23, 903-909
-
(2010)
Protein Eng., Des. Sel.
, vol.23
, pp. 903-909
-
-
Jochens, H.1
Aerts, D.2
Bornscheuer, U.T.3
-
102
-
-
79960321967
-
Functional expression of a plant hydroxynitrile lyase in Escherichia coli by directed evolution: Creation and characterization of highly in vivo soluble mutants
-
Asano, Y., Dadashipour, M., Yamazaki, M., Doi, N., and Komeda, H. (2011) Functional expression of a plant hydroxynitrile lyase in Escherichia coli by directed evolution: creation and characterization of highly in vivo soluble mutants Protein Eng., Des. Sel. 24, 607-616
-
(2011)
Protein Eng., Des. Sel.
, vol.24
, pp. 607-616
-
-
Asano, Y.1
Dadashipour, M.2
Yamazaki, M.3
Doi, N.4
Komeda, H.5
-
103
-
-
39149125127
-
Enzyme optimization: Moving from blind evolution to statistical exploration of sequence-function space
-
Fox, R. J. and Huisman, G. W. (2008) Enzyme optimization: moving from blind evolution to statistical exploration of sequence-function space Trends Biotechnol. 26, 132-138
-
(2008)
Trends Biotechnol.
, vol.26
, pp. 132-138
-
-
Fox, R.J.1
Huisman, G.W.2
-
104
-
-
38549117301
-
The MetaCyc Database of metabolic pathways and enzymes and the BioCyc collection of Pathway/Genome Databases
-
Caspi, R., Foerster, H., Fulcher, C. A., Kaipa, P., Krummenacker, M., Latendresse, M., Paley, S., Rhee, S. Y., Shearer, A. G., Tissier, C., Walk, T. C., Zhang, P., and Karp, P. D. (2008) The MetaCyc Database of metabolic pathways and enzymes and the BioCyc collection of Pathway/Genome Databases Nucleic Acids Res. 36, D623-631
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 623-631
-
-
Caspi, R.1
Foerster, H.2
Fulcher, C.A.3
Kaipa, P.4
Krummenacker, M.5
Latendresse, M.6
Paley, S.7
Rhee, S.Y.8
Shearer, A.G.9
Tissier, C.10
Walk, T.C.11
Zhang, P.12
Karp, P.D.13
-
105
-
-
84858983547
-
KEGG for integration and interpretation of large-scale molecular data sets
-
Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., and Tanabe, M. (2011) KEGG for integration and interpretation of large-scale molecular data sets Nucleic Acids Res. 40, D109-D114
-
(2011)
Nucleic Acids Res.
, vol.40
-
-
Kanehisa, M.1
Goto, S.2
Sato, Y.3
Furumichi, M.4
Tanabe, M.5
-
106
-
-
59849106371
-
Protein promiscuity and its implications for biotechnology
-
Nobeli, I., Favia, A. D., and Thornton, J. M. (2009) Protein promiscuity and its implications for biotechnology Nat. Biotechnol. 27, 157-167
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 157-167
-
-
Nobeli, I.1
Favia, A.D.2
Thornton, J.M.3
-
107
-
-
82355183626
-
Substrate promiscuity of secondary metabolite enzymes: Prenylation of hydroxynaphthalenes by fungal indole prenyltransferases
-
Yu, X., Xie, X., and Li, S.-M. (2011) Substrate promiscuity of secondary metabolite enzymes: prenylation of hydroxynaphthalenes by fungal indole prenyltransferases Appl. Microbiol. Biotechnol. 92, 737-748
-
(2011)
Appl. Microbiol. Biotechnol.
, vol.92
, pp. 737-748
-
-
Yu, X.1
Xie, X.2
Li, S.-M.3
-
108
-
-
78649450676
-
Substitution of lysine with glutamic acid at position 193 in bovine CYP11A1 significantly affects protein oligomerization and solubility but not enzymatic activity
-
Janocha, S., Bichet, A., Zöllner, A., and Bernhardt, R. (2011) Substitution of lysine with glutamic acid at position 193 in bovine CYP11A1 significantly affects protein oligomerization and solubility but not enzymatic activity Biochim. Biophys. Acta 1814, 126-131
-
(2011)
Biochim. Biophys. Acta
, vol.1814
, pp. 126-131
-
-
Janocha, S.1
Bichet, A.2
Zöllner, A.3
Bernhardt, R.4
-
109
-
-
0034842869
-
Functional expression and stabilization of horseradish peroxidase by directed evolution in Saccharomyces cerevisiae
-
Morawski, B., Quan, S., and Arnold, F. H. (2001) Functional expression and stabilization of horseradish peroxidase by directed evolution in Saccharomyces cerevisiae Biotechnol. Bioeng. 76, 99-107
-
(2001)
Biotechnol. Bioeng.
, vol.76
, pp. 99-107
-
-
Morawski, B.1
Quan, S.2
Arnold, F.H.3
-
110
-
-
84860389087
-
Computational design and selections for an engineered, thermostable terpene synthase
-
Diaz, J. E., Lin, C.-S., Kunishiro, K., Feld, B. K., Avrantinis, S. K., Bronson, J., Greaves, J., Saven, J. G., and Weiss, G. A. (2011) Computational design and selections for an engineered, thermostable terpene synthase Protein Sci. 20, 1597-1606
-
(2011)
Protein Sci.
, vol.20
, pp. 1597-1606
-
-
Diaz, J.E.1
Lin, C.-S.2
Kunishiro, K.3
Feld, B.K.4
Avrantinis, S.K.5
Bronson, J.6
Greaves, J.7
Saven, J.G.8
Weiss, G.A.9
|