메뉴 건너뛰기




Volumn 19, Issue 12, 2017, Pages 2451-2461

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

(38)  Schugar, Rebecca C a   Shih, Diana M h   Warrier, Manya a   Helsley, Robert N a   Burrows, Amy a   Ferguson, Daniel a   Brown, Amanda L a   Gromovsky, Anthony D a   Heine, Markus g   Chatterjee, Arunachal a   Li, Lin a   Li, Xinmin S a   Wang, Zeneng a   Willard, Belinda a   Meng, YongHong h   Kim, Hanjun h   Che, Nam h   Pan, Calvin h   Lee, Richard G c   Crooke, Rosanne M c   more..


Author keywords

adipose; diabetes; flavin containing monooxygenase 3; FMO3; microbiota; nutrition; obesity

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DIMETHYLANILINE MONOOXYGENASE; FLAVIN CONTAINING MONOOXYGENASE 3; MESSENGER RNA; TRIMETHYLAMINE OXIDE; UNCLASSIFIED DRUG; DIMETHYLANILINE MONOOXYGENASE (N-OXIDE FORMING); METHYLAMINE; OXYGENASE; TRIMETHYLOXAMINE;

EID: 85020846804     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.05.077     Document Type: Article
Times cited : (185)

References (45)
  • 2
    • 85027909934 scopus 로고    scopus 로고
    • Adipose tissue browning and metabolic health
    • Bartelt, A., Heeren, J., Adipose tissue browning and metabolic health. Nat. Rev. Endocrinol. 10 (2014), 24–36.
    • (2014) Nat. Rev. Endocrinol. , vol.10 , pp. 24-36
    • Bartelt, A.1    Heeren, J.2
  • 4
    • 78149346457 scopus 로고    scopus 로고
    • CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance
    • Brown, J.M., Betters, J.L., Lord, C., Ma, Y., Han, X., Yang, K., Alger, H.M., Melchior, J., Sawyer, J., Shah, R., et al. CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance. J Lipid Res. 51 (2010), 3306–3315.
    • (2010) J Lipid Res. , vol.51 , pp. 3306-3315
    • Brown, J.M.1    Betters, J.L.2    Lord, C.3    Ma, Y.4    Han, X.5    Yang, K.6    Alger, H.M.7    Melchior, J.8    Sawyer, J.9    Shah, R.10
  • 5
    • 84921417572 scopus 로고    scopus 로고
    • The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases
    • Brown, J.M., Hazen, S.L., The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases. Annu. Rev. Med. 66 (2015), 343–359.
    • (2015) Annu. Rev. Med. , vol.66 , pp. 343-359
    • Brown, J.M.1    Hazen, S.L.2
  • 8
    • 84907563983 scopus 로고    scopus 로고
    • Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences
    • Cox, L.M., Yamanishi, S., Sohn, J., Alekseyenko, A.V., Leung, J.M., Cho, I., Kim, S.G., Li, H., Gao, Z., Mahana, D., et al. Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell 158 (2014), 705–721.
    • (2014) Cell , vol.158 , pp. 705-721
    • Cox, L.M.1    Yamanishi, S.2    Sohn, J.3    Alekseyenko, A.V.4    Leung, J.M.5    Cho, I.6    Kim, S.G.7    Li, H.8    Gao, Z.9    Mahana, D.10
  • 10
    • 84927935370 scopus 로고    scopus 로고
    • Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans
    • Das, S.K., Sharma, N.K., Zhang, B., Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans. BMC Med. Genomics, 8, 2015, 4.
    • (2015) BMC Med. Genomics , vol.8 , pp. 4
    • Das, S.K.1    Sharma, N.K.2    Zhang, B.3
  • 11
    • 84921636319 scopus 로고    scopus 로고
    • Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet
    • Gao, X., Liu, X., Xu, J., Xue, C., Xue, Y., Wang, Y., Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet. J. Biosci. Bioeng. 118 (2014), 476–481.
    • (2014) J. Biosci. Bioeng. , vol.118 , pp. 476-481
    • Gao, X.1    Liu, X.2    Xu, J.3    Xue, C.4    Xue, Y.5    Wang, Y.6
  • 14
  • 16
    • 84918565300 scopus 로고    scopus 로고
    • Betaine and trimethylamine-N-oxide as predictors of cardiovascular outcomes show different patterns in diabetes mellitus: an observational study
    • Lever, M., George, P.M., Slow, S., Bellamy, D., Young, J.M., Ho, M., McEntyre, C.J., Elmslie, J.L., Atkinson, W., Molyneux, S.L., et al. Betaine and trimethylamine-N-oxide as predictors of cardiovascular outcomes show different patterns in diabetes mellitus: an observational study. PLoS ONE, 9, 2014, e114969.
    • (2014) PLoS ONE , vol.9 , pp. e114969
    • Lever, M.1    George, P.M.2    Slow, S.3    Bellamy, D.4    Young, J.M.5    Ho, M.6    McEntyre, C.J.7    Elmslie, J.L.8    Atkinson, W.9    Molyneux, S.L.10
  • 19
    • 84949936110 scopus 로고    scopus 로고
    • Associations among serum trimethylamine-N-oxide (TMAO) levels, kidney function and infarcted coronary artery number in patients undergoing cardiovascular surgery: a cross-sectional study
    • Mafune, A., Iwamoto, T., Tsutsumi, Y., Nakashima, A., Yamamoto, I., Yokoyama, K., Yokoo, T., Urashima, M., Associations among serum trimethylamine-N-oxide (TMAO) levels, kidney function and infarcted coronary artery number in patients undergoing cardiovascular surgery: a cross-sectional study. Clin. Exp. Nephrol. 20 (2016), 731–739.
    • (2016) Clin. Exp. Nephrol. , vol.20 , pp. 731-739
    • Mafune, A.1    Iwamoto, T.2    Tsutsumi, Y.3    Nakashima, A.4    Yamamoto, I.5    Yokoyama, K.6    Yokoo, T.7    Urashima, M.8
  • 20
    • 0032821965 scopus 로고    scopus 로고
    • Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp
    • Matsuda, M., DeFronzo, R.A., Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22 (1999), 1462–1470.
    • (1999) Diabetes Care , vol.22 , pp. 1462-1470
    • Matsuda, M.1    DeFronzo, R.A.2
  • 23
    • 84924310257 scopus 로고    scopus 로고
    • Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock
    • Muoio, D.M., Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock. Cell 159 (2014), 1253–1262.
    • (2014) Cell , vol.159 , pp. 1253-1262
    • Muoio, D.M.1
  • 24
    • 84872156123 scopus 로고    scopus 로고
    • Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice
    • Parks, B.W., Nam, E., Org, E., Kostem, E., Norheim, F., Hui, S.T., Pan, C., Civelek, M., Rau, C.D., Bennett, B.J., et al. Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab. 17 (2013), 141–152.
    • (2013) Cell Metab. , vol.17 , pp. 141-152
    • Parks, B.W.1    Nam, E.2    Org, E.3    Kostem, E.4    Norheim, F.5    Hui, S.T.6    Pan, C.7    Civelek, M.8    Rau, C.D.9    Bennett, B.J.10
  • 25
    • 82355188293 scopus 로고    scopus 로고
    • The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort
    • Poly, C., Massaro, J.M., Seshadri, S., Wolf, P.A., Cho, E., Krall, E., Jacques, P.F., Au, R., The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort. Am. J. Clin. Nutr. 94 (2011), 1584–1591.
    • (2011) Am. J. Clin. Nutr. , vol.94 , pp. 1584-1591
    • Poly, C.1    Massaro, J.M.2    Seshadri, S.3    Wolf, P.A.4    Cho, E.5    Krall, E.6    Jacques, P.F.7    Au, R.8
  • 26
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver, P., Wu, Z., Park, C.W., Graves, R., Wright, M., Spiegelman, B.M., A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92 (1998), 829–839.
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 27
    • 84930004775 scopus 로고    scopus 로고
    • Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite trimethylamine-N-oxide
    • Romano, K.A., Vivas, E.I., Amador-Noguez, D., Rey, F.E., Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite trimethylamine-N-oxide. MBio, 6, 2015, e02481.
    • (2015) MBio , vol.6 , pp. e02481
    • Romano, K.A.1    Vivas, E.I.2    Amador-Noguez, D.3    Rey, F.E.4
  • 30
    • 84920704729 scopus 로고    scopus 로고
    • Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis
    • Shih, D.M., Wang, Z., Lee, R., Meng, Y., Che, N., Charugundla, S., Qi, H., Wu, J., Pan, C., Brown, J.M., et al. Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. J. Lipid Res. 56 (2015), 22–37.
    • (2015) J. Lipid Res. , vol.56 , pp. 22-37
    • Shih, D.M.1    Wang, Z.2    Lee, R.3    Meng, Y.4    Che, N.5    Charugundla, S.6    Qi, H.7    Wu, J.8    Pan, C.9    Brown, J.M.10
  • 31
    • 70349147046 scopus 로고    scopus 로고
    • Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men
    • Stancáková, A., Kuulasmaa, T., Paananen, J., Jackson, A.U., Bonnycastle, L.L., Collins, F.S., Boehnke, M., Kuusisto, J., Laakso, M., Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. Diabetes 58 (2009), 2129–2136.
    • (2009) Diabetes , vol.58 , pp. 2129-2136
    • Stancáková, A.1    Kuulasmaa, T.2    Paananen, J.3    Jackson, A.U.4    Bonnycastle, L.L.5    Collins, F.S.6    Boehnke, M.7    Kuusisto, J.8    Laakso, M.9
  • 32
    • 84959162934 scopus 로고    scopus 로고
    • Trimethylamine N-oxide and prognosis in acute heart failure
    • Suzuki, T., Heaney, L.M., Bhandari, S.S., Jones, D.J., Ng, L.L., Trimethylamine N-oxide and prognosis in acute heart failure. Heart 102 (2016), 841–848.
    • (2016) Heart , vol.102 , pp. 841-848
    • Suzuki, T.1    Heaney, L.M.2    Bhandari, S.S.3    Jones, D.J.4    Ng, L.L.5
  • 34
    • 84908377019 scopus 로고    scopus 로고
    • Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis
    • Tang, W.H., Wang, Z., Fan, Y., Levison, B., Hazen, J.E., Donahue, L.M., Wu, Y., Hazen, S.L., Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis. J. Am. Coll. Cardiol. 64 (2014), 1908–1914.
    • (2014) J. Am. Coll. Cardiol. , vol.64 , pp. 1908-1914
    • Tang, W.H.1    Wang, Z.2    Fan, Y.3    Levison, B.4    Hazen, J.E.5    Donahue, L.M.6    Wu, Y.7    Hazen, S.L.8
  • 35
    • 85008429110 scopus 로고    scopus 로고
    • Increased trimethylamine N-oxide portends high mortality risk independent of glycemic control in patients with type 2 diabetes mellitus
    • Tang, W.H., Wang, Z., Li, X.S., Fan, Y., Li, D.S., Wu, Y., Hazen, S.L., Increased trimethylamine N-oxide portends high mortality risk independent of glycemic control in patients with type 2 diabetes mellitus. Clin. Chem. 63 (2017), 297–306.
    • (2017) Clin. Chem. , vol.63 , pp. 297-306
    • Tang, W.H.1    Wang, Z.2    Li, X.S.3    Fan, Y.4    Li, D.S.5    Wu, Y.6    Hazen, S.L.7
  • 37
    • 84929655318 scopus 로고    scopus 로고
    • Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure
    • Trøseid, M., Ueland, T., Hov, J.R., Svardal, A., Gregersen, I., Dahl, C.P., Aakhus, S., Gude, E., Bjørndal, B., Halvorsen, B., et al. Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure. J. Intern. Med. 277 (2015), 717–726.
    • (2015) J. Intern. Med. , vol.277 , pp. 717-726
    • Trøseid, M.1    Ueland, T.2    Hov, J.R.3    Svardal, A.4    Gregersen, I.5    Dahl, C.P.6    Aakhus, S.7    Gude, E.8    Bjørndal, B.9    Halvorsen, B.10
  • 38
    • 69949111703 scopus 로고    scopus 로고
    • The core gut microbiome, energy balance and obesity
    • Turnbaugh, P.J., Gordon, J.I., The core gut microbiome, energy balance and obesity. J. Physiol. 587 (2009), 4153–4158.
    • (2009) J. Physiol. , vol.587 , pp. 4153-4158
    • Turnbaugh, P.J.1    Gordon, J.I.2
  • 41
    • 84898859680 scopus 로고    scopus 로고
    • Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide
    • Wang, Z., Tang, W.H., Buffa, J.A., Fu, X., Britt, E.B., Koeth, R.A., Levison, B.S., Fan, Y., Wu, Y., Hazen, S.L., Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide. Eur. Heart J. 35 (2014), 904–910.
    • (2014) Eur. Heart J. , vol.35 , pp. 904-910
    • Wang, Z.1    Tang, W.H.2    Buffa, J.A.3    Fu, X.4    Britt, E.B.5    Koeth, R.A.6    Levison, B.S.7    Fan, Y.8    Wu, Y.9    Hazen, S.L.10
  • 45
    • 84959922537 scopus 로고    scopus 로고
    • Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk
    • Zhu, W., Gregory, J.C., Org, E., Buffa, J.A., Gupta, N., Wang, Z., Li, L., Fu, X., Wu, Y., Mehrabian, M., et al. Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk. Cell 165 (2016), 111–124.
    • (2016) Cell , vol.165 , pp. 111-124
    • Zhu, W.1    Gregory, J.C.2    Org, E.3    Buffa, J.A.4    Gupta, N.5    Wang, Z.6    Li, L.7    Fu, X.8    Wu, Y.9    Mehrabian, M.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.