Phytochemicals approach for Developing cancer immunotherapeutics

Frontiers in Pharmacology

Volumn 8, Issue JUN, 2017, Pages

  Yin, Shu Yi ^a   Yang, Ning Sun ^a   Lin, Tien Jen ^a,b  

^a AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Cancer immunotherapy; Herbal extract; Phytochemicals; Tumor microenvironment

Indexed keywords

ALPHA MANGOSTIN; ARTEMISININ; ARTESUNATE; ASTRAGALUS MEMBRANACEUS EXTRACT; BERBERINE; BIDENS PILOSA EXTRACT; BING DE LING; CAFFEIC ACID; COCHINCHINA MOMORDICA EXTRACT; CODONOPSIS PILOSULAE EXTRACT; CURCUMIN; EMILIA SONCHIFOLIA EXTRACT; GAMBOGIC ACID; HIBISCUS SYRIACUS EXTRACT; HYPERICIN; ISOTHIOCYANIC ACID; JP 1; NOSCAPINE; PACLITAXEL; PIPERINE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; POLYSACCHARIDE; RESVERATROL; SHIKONIN; SILIBININ; SINECATECHINS; SUILLUS COLLINITUS EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZENG SHENG PING;

ANTINEOPLASTIC ACTIVITY; CANCER IMMUNOTHERAPY; CELL DEATH; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOGENIC CELL DEATH; IMMUNOREGULATION; MYELOID-DERIVED SUPPRESSOR CELL; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN SECRETION; SHORT SURVEY; TUMOR IMMUNOGENICITY; TUMOR MICROENVIRONMENT;

EID: 85020845262     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2017.00386     Document Type: Short Survey

References (72)

1. Agarwal, R., Agarwal, C., Ichikawa, H., Singh, R. P., and Aggarwal, B. B. (2006). Anticancer potential of silymarin: from bench to bed side. Anticancer. Res. 26, 4457-4498
2. Albini, A., and Sporn, M. B. (2007). The tumour microenvironment as a target for chemoprevention. Nat. Rev. Cancer 7, 139-147. doi: 10.1038/nrc2067
3. Anighoro, A., Bajorath, J., and Rastelli, G. (2014). Polypharmacology: challenges and opportunities in drug discovery. J. Med. Chem. 57, 7874-7887. doi: 10.1021/jm5006463
4. Apaya, M. K., Chang, M. T., and Shyur, L. F. (2016). Phytomedicine polypharmacology: cancer therapy through modulating the tumor microenvironment and oxylipin dynamics. Pharmacol. Ther. 162, 58-68. doi: 10.1016/j.pharmthera.2016.03.001
5. Bannwart, C. F., Peracoli, J. C., Nakaira-Takahagi, E., and Peracoli, M. T. (2010). Inhibitory effect of silibinin on tumour necrosis factor-alpha and hydrogen peroxide production by human monocytes. Nat. Prod. Res. 24, 1747-1757. doi: 10.1080/14786410903314492
6. Bosch-Barrera, J., Sais, E., Canete, N., Marruecos, J., Cuyas, E., Izquierdo, A., et al. (2016). Response of brain metastasis from lung cancer patients to an oral nutraceutical product containing silibinin. Oncotarget 7, 32006-32014. doi: 10.18632/oncotarget.7900
7. Bykov, V. J., Issaeva, N., Shilov, A., Hultcrantz, M., Pugacheva, E., Chumakov, P., et al. (2002). Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat. Med. 8, 282-288. doi: 10.1038/nm0302-282
8. Chang, W. T., Chen, H. M., Yin, S. Y., Chen, Y. H., Wen, C. C., Wei, W. C., et al. (2013). Specific Dioscorea phytoextracts enhance potency of TCL-loaded DC-based cancer vaccines. Evid. Based Complement. Alternat. Med. 2013:932040. doi: 10.1155/2013/932040
9. Chang, W. T., Lai, T. H., Chyan, Y. J., Yin, S. Y., Chen, Y. H., Wei, W. C., et al. (2015). Specific medicinal plant polysaccharides effectively enhance the potency of a DC-based vaccine against mouse mammary tumor metastasis. PLoS ONE 10:e0122374. doi: 10.1371/journal.pone.0122374
10. Chen, H. M., Wang, P. H., Chen, S. S., Wen, C. C., Chen, Y. H., Yang, W. C., et al. (2012). Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine. Cancer Immunol. Immunother. 61, 1989-2002. doi: 10.1007/s00262-012-1258-9
11. Cheng, Y. L., Lee, S. C., Harn, H. J., Huang, H. C., and Chang, W. L. (2008). The extract of Hibiscus syriacus inducing apoptosis by activating p53 and AIF in human lung cancer cells. Am. J. Chin. Med. 36, 171-184. doi: 10.1142/S0192415X08005680
12. Cheng, Y. T., Yang, C. C., and Shyur, L. F. (2016). Phytomedicine-Modulating oxidative stress and the tumor microenvironment for cancer therapy. Pharmacol. Res. 114, 128-143. doi: 10.1016/j.phrs.2016.10.022
13. Chiu, S. C., Tsao, S. W., Hwang, P. I., Vanisree, S., Chen, Y. A., and Yang, N. S. (2010). Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling. BMC Genomics 11:513. doi: 10.1186/1471-2164-11-513
14. Chiu, S. C., and Yang, N. S. (2007). Inhibition of tumor necrosis factor-alpha through selective blockade of Pre-mRNA splicing by shikonin. Mol. Pharmacol. 71, 1640-1645. doi: 10.1124/mol.106.032821
15. Cho, W. C., and Leung, K. N. (2007). In vitro and in vivo anti-tumor effects of Astragalus membranaceus. Cancer Lett. 252, 43-54. doi: 10.1016/j.canlet.2006.12.001
16. Deep, G., and Agarwal, R. (2013). Targeting tumor microenvironment with silibinin: promise and potential for a translational cancer chemopreventive strategy. Curr. Cancer Drug. Targets 13, 486-499. doi: 10.2174/15680096113139990041
17. Dong, J. T., Isaacs, W. B., Barrett, J. C., and Isaacs, J. T. (1997). Genomic organization of the human KAI1 metastasis-suppressor gene. Genomics 41, 25-32. doi: 10.1006/geno.1997.4618
18. Dooley, S., Seib, T., Engel, M., Theisinger, B., Janz, H., Piontek, K., et al. (1994). Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1. Hum. Genet. 93, 63-66. doi: 10.1007/BF00218915
19. Forghani, P., Khorramizadeh, M. R., and Waller, E. K. (2014). Silibinin inhibits accumulation of myeloid-derived suppressor cells and tumor growth of murine breast cancer. Cancer Med. 3, 215-224. doi: 10.1002/cam4.186
20. Fu, S. L., Hsu, Y. H., Lee, P. Y., Hou, W. C., Hung, L. C., Lin, C. H., et al. (2006). Dioscorin isolated from Dioscorea alata activates TLR4-signaling pathways and induces cytokine expression in macrophages. Biochem. Biophys. Res. Commun. 339, 137-144. doi: 10.1016/j.bbrc.2005.11.005
21. Furuta, S., Jeng, Y. M., Zhou, L., Huang, L., Kuhn, I., Bissell, M. J., et al. (2011). IL-25 causes apoptosis of IL-25R-expressing breast cancer cells without toxicity to nonmalignant cells. Sci. Transl. Med. 3:78ra31. doi: 10.1126/scitranslmed.3001374
22. Gabrilovich, D. I., and Nagaraj, S. (2009). Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9, 162-174. doi: 10.1038/nri2506
23. Gagnier, J. J., Boon, H., Rochon, P., Moher, D., Barnes, J., Bombardier, C., et al. (2006a). Recommendations for reporting randomized controlled trials of herbal interventions: explanation and elaboration. J. Clin. Epidemiol. 59, 1134-1149. doi: 10.1016/j.jclinepi.2005.12.020
24. Gagnier, J. J., Boon, H., Rochon, P., Moher, D., Barnes, J., Bombardier, C., et al. (2006b). Reporting randomized, controlled trials of herbal interventions: an elaborated CONSORT statement. Ann. Intern. Med. 144, 364-367
25. Garg, A. D., Nowis, D., Golab, J., Vandenabeele, P., Krysko, D. V., and Agostinis, P. (2010). Immunogenic cell death, DAMPs and anticancer therapeutics: an emerging amalgamation. Biochim. Biophys. Acta 1805, 53-71. doi: 10.1016/j.bbcan.2009.08.003
26. Garg, A. D., Vandenberk, L., Koks, C., Verschuere, T., Boon, L., Van Gool, S. W., et al. (2016). Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glioma. Sci. Transl. Med. 8, 328ra327. doi: 10.1126/scitranslmed.aae0105
27. Grivennikov, S. I., Greten, F. R., and Karin, M. (2010). Immunity, inflammation, and cancer. Cell 140, 883-899. doi: 10.1016/j.cell.2010.01.025
28. Hargraves, K. G., He, L., and Firestone, G. L. (2016). Phytochemical regulation of the tumor suppressive microRNA, miR-34a, by p53-dependent and independent responses in human breast cancer cells. Mol. Carcinog. 55, 486-498. doi: 10.1002/mc.22296
29. He, L., He, X., Lowe, S. W., and Hannon, G. J. (2007). microRNAs join the p53 network-another piece in the tumour-suppression puzzle. Nat. Rev. Cancer 7, 819-822. doi: 10.1038/nrc2232
30. Hientz, K., Mohr, A., Bhakta-Guha, D., and Efferth, T. (2017). The role of p53 in cancer drug resistance and targeted chemotherapy. Oncotarget 8, 8921-8946. doi: 10.18632/oncotarget.13475
31. Hou, C. C., Chen, Y. P., Wu, J. H., Huang, C. C., Wang, S. Y., Yang, N. S., et al. (2007). A galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma. Cancer Res. 67, 6907-6915. doi: 10.1158/0008-5472.CAN-07-0158
32. Klein, C., and Vassilev, L. T. (2004). Targeting the p53-MDM2 interaction to treat cancer. Br. J. Cancer 91, 1415-1419. doi: 10.1038/sj.bjc.6602164
33. Kroemer, G., Galluzzi, L., Kepp, O., and Zitvogel, L. (2013). Immunogenic cell death in cancer therapy. Annu. Rev. Immunol. 31, 51-72. doi: 10.1146/annurev-immunol-032712-100008
34. Krysko, D. V., Garg, A. D., Kaczmarek, A., Krysko, O., Agostinis, P., and Vandenabeele, P. (2012). Immunogenic cell death and DAMPs in cancer therapy. Nat. Rev. Cancer 12, 860-875. doi: 10.1038/nrc3380
35. Kuan, Y. C., Lee, W. T., Hung, C. L., Yang, C., and Sheu, F. (2012). Investigating the function of a novel protein from Anoectochilus formosanus which induced macrophage differentiation through TLR4-mediated NF-kappaB activation. Int. Immunopharmacol. 14, 114-120. doi: 10.1016/j.intimp.2012.06.014
36. Lan, Y. H., Chiang, J. H., Huang, W. W., Lu, C. C., Chung, J. G., Wu, T. S., et al. (2012). Activations of both extrinsic and intrinsic pathways in HCT 116 human colorectal cancer cells contribute to apoptosis through p53-mediated ATM/Fas signaling by Emilia sonchifolia extract, a folklore medicinal plant. Evid. Based Complement. Alternat. Med. 2012:178178. doi: 10.1155/2012/178178
37. Lin, T. J., Liang, W. M., Hsiao, P. W., M, S. P., Wei, W. C., Lin, H. T., et al. (2015a). Rapamycin promotes mouse 4T1 tumor metastasis that can be reversed by a dendritic cell-based vaccine. PLoS ONE 10:e0138335. doi: 10.1371/journal.pone.0138335
38. Lin, T. J., Lin, H. T., Chang, W. T., Mitapalli, S. P., Hsiao, P. W., Yin, S. Y., et al. (2015b). Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components. Mol. Cancer 14, 174. doi: 10.1186/s12943-015-0435-9
39. Liu, H. R., Meng, L. Y., Lin, Z. Y., Shen, Y., Yu, Y. Q., and Zhu, Y. Z. (2012). Cochinchina momordica seed extract induces apoptosis and cell cycle arrest in human gastric cancer cells via PARP and p53 signal pathways. Nutr. Cancer 64, 1070-1077. doi: 10.1080/01635581.2012.712737
40. Liu, J. Y., Yang, F. L., Lu, C. P., Yang, Y. L., Wen, C. L., Hua, K. F., et al. (2008). Polysaccharides from Dioscorea batatas induce tumor necrosis factor-alpha secretion via Toll-like receptor 4-mediated protein kinase signaling pathways. J. Agric. Food Chem. 56, 9892-9898. doi: 10.1021/jf8018722
41. Liu, Q., Zhang, Z., Fang, L., Jiang, Y., and Yin, X. (2012). [Application of network pharmacology and high through-put technology on active compounds screening from traditional Chinese medicine]. Zhongguo Zhong Yao Za Zhi 37, 134-137
42. Liu, Z. H., and Sun, X. B. (2012). [Network pharmacology: new opportunity for the modernization of traditional Chinese medicine]. Yao Xue Xue Bao 47, 696-703
43. Mlecnik, B., Bindea, G., Kirilovsky, A., Angell, H. K., Obenauf, A. C., Tosolini, M., et al. (2016). The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis. Sci. Transl. Med. 8:327ra326. doi: 10.1126/scitranslmed.aad6352
44. Okabe, M., Szakacs, G., Reimers, M. A., Suzuki, T., Hall, M. D., Abe, T., et al. (2008). Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters. Mol. Cancer Ther. 7, 3081-3091. doi: 10.1158/1535-7163.MCT-08-0539
45. Parks, D. J., Lafrance, L. V., Calvo, R. R., Milkiewicz, K. L., Gupta, V., Lattanze, J., et al. (2005). 1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2-p53 interaction: discovery and SAR. Bioorg. Med. Chem. Lett. 15, 765-770. doi: 10.1016/j.bmcl.2004.11.009
46. Rajani, D. K., Walch, M., Martinvalet, D., Thomas, M. P., and Lieberman, J. (2012). Alterations in RNA processing during immune-mediated programmed cell death. Proc. Natl. Acad. Sci. U.S.A. 109, 8688-8693. doi: 10.1073/pnas.1201327109
47. Shangary, S., and Wang, S. (2008). Targeting the MDM2-p53 interaction for cancer therapy. Clin. Cancer Res. 14, 5318-5324. doi: 10.1158/1078-0432.CCR-07-5136
48. Shao, B. M., Xu, W., Dai, H., Tu, P., Li, Z., and Gao, X. M. (2004). A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochem. Biophys. Res. Commun. 320, 1103-1111. doi: 10.1016/j.bbrc.2004.06.065
49. Son, Y., Kim, S., Chung, H. T., and Pae, H. O. (2013). Reactive oxygen species in the activation of MAP kinases. Methods Enzymol. 528, 27-48. doi: 10.1016/B978-0-12-405881-1.00002-1
50. Staniforth, V., Wang, S. Y., Shyur, L. F., and Yang, N. S. (2004). Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo. J. Biol. Chem. 279, 5877-5885. doi: 10.1074/jbc.M309185200
51. Su, P. F., Li, C. J., Hsu, C. C., Benson, S., Wang, S. Y., Aravindaram, K., et al. (2011). Dioscorea phytocompounds enhance murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo. Evid. Based Complement. Alternat. Med. 2011:731308. doi: 10.1093/ecam/neq032
52. Su, P. F., Staniforth, V., Li, C. J., Wang, C. Y., Chiao, M. T., Wang, S. Y., et al. (2008). Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissues. J. Biomed. Sci. 15, 813-822. doi: 10.1007/s11373-008-9266-7
53. Sun, L. X., Li, W. D., Lin, Z. B., Duan, X. S., Li, X. F., Yang, N., et al. (2014). Protection against lung cancer patient plasma-induced lymphocyte suppression by Ganoderma lucidum polysaccharides. Cell. Physiol. Biochem. 33, 289-299. doi: 10.1159/000356669
54. Swartz, M. A., and Lund, A. W. (2012). Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity. Nat. Rev. Cancer 12, 210-219. doi: 10.1038/nrc3186
55. Tager, M., Dietzmann, J., Thiel, U., Hinrich Neumann, K., and Ansorge, S. (2001). Restoration of the cellular thiol status of peritoneal macrophages from CAPD patients by the flavonoids silibinin and silymarin. Free Radic. Res. 34, 137-151. doi: 10.1080/10715760100300131
56. Vaz, J. A., Ferreira, I. C., Tavares, C., Almeida, G. M., Martins, A., and Helena Vasconcelos, M. (2012). Suillus collinitus methanolic extract increases p53 expression and causes cell cycle arrest and apoptosis in a breast cancer cell line. Food Chem. 135, 596-602. doi: 10.1016/j.foodchem.2012.04.127
57. von Hagens, C., Walter-Sack, I., Goeckenjan, M., Osburg, J., Storch-Hagenlocher, B., Sertel, S., et al. (2017). Prospective open uncontrolled phase I study to define a well-tolerated dose of oral artesunate as add-on therapy in patients with metastatic breast cancer (ARTIC M33/2). Breast Cancer Res. Treat. doi: 10.1007/s10549-017-4261-1 [Epub ahead of print]
58. Wang, J., Tong, X., Li, P., Cao, H., and Su, W. (2012). Immuno-enhancement effects of Shenqi Fuzheng Injection on cyclophosphamide-induced immunosuppression in Balb/c mice. J. Ethnopharmacol. 139, 788-795. doi: 10.1016/j.jep.2011.12.019
59. Wang, S., Zhao, Y., Aguilar, A., Bernard, D., and Yang, C. Y. (2017). Targeting the MDM2-p53 protein-protein interaction for new cancer therapy: progress and challenges. Cold Spring Harb. Perspect. Med. 7:a026245. doi: 10.1101/cshperspect.a026245
60. Wei, W. C., Lin, S. Y., Lan, C. W., Huang, Y. C., Lin, C. Y., Hsiao, P. W., et al. (2016). Inhibiting MDSC differentiation from bone marrow with phytochemical polyacetylenes drastically impairs tumor metastasis. Sci. Rep. 6:36663. doi: 10.1038/srep36663
61. Wiman, K. G. (2010). Pharmacological reactivation of mutant p53: from protein structure to the cancer patient. Oncogene 29, 4245-4252. doi: 10.1038/onc.2010.188
62. Wurglics, M., Westerhoff, K., Kaunzinger, A., Wilke, A., Baumeister, A., Dressman, J., et al. (2001). Comparison of German St. John's wort products according to hyperforin and total hypericin content. J. Am. Pharm. Assoc. 41, 560-566. doi: 10.1016/S1086-5802(16)31280-3
63. Xu, Q., Brabham, J. G., Zhang, S., Munster, P., Fields, K., Zhao, R. J., et al. (2005). Chinese herbal formula, Bing De Ling, enhances antitumor effects and ameliorates weight loss induced by 5-fluorouracil in the mouse CT26 tumor model. DNA Cell Biol. 24, 470-475. doi: 10.1089/dna.2005.24.470
64. Yao, C. J., Chow, J. M., Lin, P. C., Hu, T. S., Kuo, H. C., Huang, J. S., et al. (2016). Activation of p53/miR-34a tumor suppressor axis by Chinese herbal formula JP-1 in A549 lung adenocarcinoma cells. Evid. Based Complement. Alternat. Med. 2016:5989681. doi: 10.1155/2016/5989681
65. Yin, S. Y., Efferth, T., Jian, F. Y., Chen, Y. H., Liu, C. I, Wang, A. H., et al. (2016a). Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1. Oncotarget 7, 43629-43653. doi: 10.18632/oncotarget.9660
66. Yin, S. Y., Jian, F. Y., Chen, Y. H., Chien, S. C., Hsieh, M. C., Hsiao, P. W., et al. (2016b). Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis. Nat. Commun. 7, 11311. doi: 10.1038/ncomms11311
67. Yin, S. Y., Peng, A. P., Huang, L. T., Wang, Y. T., Lan, C. W., and Yang, N. S. (2013a). The phytochemical shikonin stimulates epithelial-mesenchymal transition (EMT) in skin wound healing. Evid. Based Complement. Alternat. Med. 2013:262796. doi: 10.1155/2013/262796
68. Yin, S. Y., Wei, W. C., Jian, F. Y., and Yang, N. S. (2013b). Therapeutic applications of herbal medicines for cancer patients. Evid. Based Complement. Alternat. Med. 2013:302426. doi: 10.1155/2013/302426
69. Zhang, Y., Dong, H., Li, Z., Xiang, S., Zhu, Y., Zhang, M., et al. (2010). Bing De Ling, a Chinese herbal formula, inhibits cancer cells growth via p53. Front. Biosci. 2, 221-230. doi: 10.2741/e84
70. Zhang, Z., Wang, Y., Yao, R., Li, J., Yan, Y., La Regina, M., et al. (2004). Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models. Oncogene 23, 3841-3850. doi: 10.1038/sj.onc.1207496
71. Zheng, Y., Yin, G., Le, V., Zhang, A., Lu, Y., Yang, M., et al. (2014a). Hypericin-based photodynamic therapy induces a tumor-specific immune response and an effective DC-based cancer immunotherapy. Biochem. Pharmacol. doi: 10.1016/j.bcp.2014.01.036 [Epub ahead of print]
72. Zheng, Y. S., Wu, Z. S., Ni, H. B., Ke, L., Tong, Z. H., Li, W. Q., et al. (2014b). Codonopsis pilosula polysaccharide attenuates cecal ligation and puncture sepsis via circuiting regulatory T cells in mice. Shock 41, 250-255. doi: 10.1097/SHK.0000000000000091