Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine

Cancer Immunology, Immunotherapy

Volumn 61, Issue 11, 2012, Pages 1989-2002

  Chen, Hui Ming ^a,b   Wang, Pi Hsueh ^b   Chen, Swey Shen ^b,c,d   Wen, Chih Chun ^b   Chen, Yun Hsiang ^b   Yang, Wen Chin ^a,b   Yang, Ning Sun ^b,e,f,g  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

^c Department of Allergy and Vaccinology   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^f NATIONAL CENTRAL UNIVERSITY   (Taiwan)

^g NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Cancer vaccine; Damage associated molecular pattern; Dendritic cells; Immunogenic cell death; Shikonin

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CD86 ANTIGEN; DENDRITIC CELL VACCINE; DOXORUBICIN; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PACLITAXEL; SHIKONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER IMMUNIZATION; CANCER INHIBITION; CANCER SURVIVAL; CELL ACTIVATION; CELL LYSATE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DRUG EFFICACY; DRUG POTENTIATION; FEMALE; FLOW CYTOMETRY; IMMUNOGENICITY; MELANOMA; MELANOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; TH1 CELL; TH17 CELL; TUMOR CELL; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD86; APOPTOSIS; CANCER VACCINES; CELLS, CULTURED; DENDRITIC CELLS; FEMALE; GENES, MHC CLASS II; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NAPHTHOQUINONES; SKIN NEOPLASMS; SPLEEN; TH1 CELLS; TH17 CELLS;

EID: 84871015953     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-012-1258-9     Document Type: Article

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