Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation

Cell Reports

Volumn 19, Issue 11, 2017, Pages 2319-2330

  Błażejewski, Adrian J ^a   Thiemann, Sophie ^a   Schenk, Alexander ^b   Pils, Marina C ^a   Gálvez, Eric J C ^a   Roy, Urmi ^a   Heise, Ulrike ^a   de Zoete, Marcel R ^b,c   Flavell, Richard A ^b,d   Strowig, Till ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UTRECHT UNIVERSITY   (Netherlands)

^d YALE UNIVERSITY   (United States)

Author keywords

caspase 1; caspase 11; colitis; colon; DSS; inflammasome; inflammation induced tumorigenesis; intestine; microbiota

Indexed keywords

CASPASE 11; INFLAMMASOME; INTERLEUKIN 12P70; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 27; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CANCER RISK; CARCINOGENESIS; CELL INFILTRATION; CELL LOSS; COLORECTAL CANCER; CONTROLLED STUDY; CYTOKINE RELEASE; DEXTRAN SODIUM SULFATE-INDUCED COLITIS; DISEASE EXACERBATION; DISEASE SEVERITY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENOTYPE; GOBLET CELL; HOMEOSTASIS; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; MALE; MICROBIAL COMMUNITY; MONOCYTE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; ANIMAL; INFLAMMATION; INTESTINE; METABOLISM; MICROFLORA; MOUSE; PATHOLOGY;

ANIMALS; CASPASE 1; INFLAMMASOMES; INFLAMMATION; INTESTINES; MICE; MICROBIOTA;

EID: 85020704907     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.05.058     Document Type: Article

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