메뉴 건너뛰기




Volumn 60, Issue 9, 2017, Pages 1801-1812

The GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant mice by modulating macrophage phenotype

Author keywords

Atherosclerosis; GLP 1; Inflammation; Macrophage; STAT

Indexed keywords

ARGINASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIRAGLUTIDE; LIXISENATIDE; STAT1 PROTEIN; STAT3 PROTEIN; GLUCAGON LIKE PEPTIDE 1; PEPTIDE;

EID: 85020702776     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-017-4330-3     Document Type: Article
Times cited : (93)

References (40)
  • 1
    • 84962364627 scopus 로고    scopus 로고
    • Uncomplicating the macrovascular complications of diabetes: the 2014 Edwin Bierman award lecture
    • COI: 1:CAS:528:DC%2BC2MXhtlGrurjJ, PID: 26207031
    • Bornfeldt KE (2015) Uncomplicating the macrovascular complications of diabetes: the 2014 Edwin Bierman award lecture. Diabetes 64:2689–2697
    • (2015) Diabetes , vol.64 , pp. 2689-2697
    • Bornfeldt, K.E.1
  • 2
    • 84983134120 scopus 로고    scopus 로고
    • Requiem for the ʻvulnerable plaque
    • Libby P, Pasterkamp G (2016) Requiem for the ʻvulnerable plaque. Eur Heart J 36:2984–2987
    • (2016) Eur Heart J , vol.36 , pp. 2984-2987
    • Libby, P.1    Pasterkamp, G.2
  • 3
    • 33645563765 scopus 로고    scopus 로고
    • Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis
    • COI: 1:CAS:528:DC%2BD28XktVKktbc%3D, PID: 16581002
    • Baumgartl J, Baudler S, Scherner M et al (2006) Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab 3:247–256
    • (2006) Cell Metab , vol.3 , pp. 247-256
    • Baumgartl, J.1    Baudler, S.2    Scherner, M.3
  • 4
    • 36048950184 scopus 로고    scopus 로고
    • Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice
    • COI: 1:CAS:528:DC%2BD28Xht1WgsbfI, PID: 17127239
    • Gonzalez-Navarro H, Vila-Caballer M, Pastor MF et al (2007) Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice. Front Biosci 12:2291–2298
    • (2007) Front Biosci , vol.12 , pp. 2291-2298
    • Gonzalez-Navarro, H.1    Vila-Caballer, M.2    Pastor, M.F.3
  • 5
    • 33645567816 scopus 로고    scopus 로고
    • Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions
    • COI: 1:CAS:528:DC%2BD28XktVKkur4%3D, PID: 16581003
    • Han S, Liang CP, DeVries-Seimon T et al (2006) Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell Metab 3:257–266
    • (2006) Cell Metab , vol.3 , pp. 257-266
    • Han, S.1    Liang, C.P.2    DeVries-Seimon, T.3
  • 6
    • 84904365676 scopus 로고    scopus 로고
    • Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis
    • COI: 1:CAS:528:DC%2BC2cXhtFKlsrfI, PID: 24788416
    • Martinez-Hervas S, Vinue A, Nunez L et al (2014) Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis. Cardiovasc Res 103:324–336
    • (2014) Cardiovasc Res , vol.103 , pp. 324-336
    • Martinez-Hervas, S.1    Vinue, A.2    Nunez, L.3
  • 7
    • 85012273600 scopus 로고    scopus 로고
    • A change in inflammatory footprint precedes plaque instability: a systematic evaluation of cellular aspects of the adaptive immune response in human atherosclerosis
    • PID: 25814626
    • van Dijk RA, Duinisveld AJ, Schaapherder AF et al (2015) A change in inflammatory footprint precedes plaque instability: a systematic evaluation of cellular aspects of the adaptive immune response in human atherosclerosis. J Am Heart Assoc 4:e001403
    • (2015) J Am Heart Assoc , vol.4
    • van Dijk, R.A.1    Duinisveld, A.J.2    Schaapherder, A.F.3
  • 9
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • COI: 1:CAS:528:DC%2BD28Xislyhtr4%3D, PID: 16517403
    • Drucker DJ (2006) The biology of incretin hormones. Cell Metab 3:153–165
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 10
    • 84878808238 scopus 로고    scopus 로고
    • Pharmacology, physiology, and mechanisms of incretin hormone action
    • COI: 1:CAS:528:DC%2BC3sXnvVGktbs%3D, PID: 23684623
    • Campbell JE, Drucker DJ (2013) Pharmacology, physiology, and mechanisms of incretin hormone action. Cell Metab 17:819–837
    • (2013) Cell Metab , vol.17 , pp. 819-837
    • Campbell, J.E.1    Drucker, D.J.2
  • 11
    • 84875299548 scopus 로고    scopus 로고
    • Cardioprotective effects of lixisenatide in rat myocardial ischemia-reperfusion injury studies
    • COI: 1:CAS:528:DC%2BC3sXnvVyjurk%3D, PID: 23537041
    • Wohlfart P, Linz W, Hubschle T et al (2013) Cardioprotective effects of lixisenatide in rat myocardial ischemia-reperfusion injury studies. J Transl Med 11:84
    • (2013) J Transl Med , vol.11 , pp. 84
    • Wohlfart, P.1    Linz, W.2    Hubschle, T.3
  • 12
    • 84893424204 scopus 로고    scopus 로고
    • A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell formation and atherosclerosis
    • COI: 1:CAS:528:DC%2BC2cXmtFant70%3D, PID: 24418070
    • Tashiro Y, Sato K, Watanabe T et al (2014) A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell formation and atherosclerosis. Peptides 54:19–26
    • (2014) Peptides , vol.54 , pp. 19-26
    • Tashiro, Y.1    Sato, K.2    Watanabe, T.3
  • 13
    • 84978839381 scopus 로고    scopus 로고
    • Liraglutide and cardiovascular outcomes in type 2 diabetes
    • COI: 1:CAS:528:DC%2BC28XhvF2ks77O, PID: 27295427
    • Marso SP, Daniels GH, Brown-Frandsen K et al (2016) Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med 375:311–322
    • (2016) N Engl J Med , vol.375 , pp. 311-322
    • Marso, S.P.1    Daniels, G.H.2    Brown-Frandsen, K.3
  • 14
    • 84948740668 scopus 로고    scopus 로고
    • Lixisenatide in patients with type 2 diabetes and acute coronary syndrome
    • COI: 1:CAS:528:DC%2BC28XmvFGgtb4%3D, PID: 26630143
    • Pfeffer MA, Claggett B, Diaz R et al (2015) Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med 373:2247–2257
    • (2015) N Engl J Med , vol.373 , pp. 2247-2257
    • Pfeffer, M.A.1    Claggett, B.2    Diaz, R.3
  • 15
    • 0142179159 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor agonist ZP10A increases insulin mRNA expression and prevents diabetic progression in db/db mice
    • COI: 1:CAS:528:DC%2BD3sXos1SitL4%3D, PID: 12975499
    • Thorkildsen C, Neve S, Larsen BD, Meier E, Petersen JS (2003) Glucagon-like peptide 1 receptor agonist ZP10A increases insulin mRNA expression and prevents diabetic progression in db/db mice. J Pharmacol Exp Ther 307:490–496
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 490-496
    • Thorkildsen, C.1    Neve, S.2    Larsen, B.D.3    Meier, E.4    Petersen, J.S.5
  • 16
    • 77955847376 scopus 로고    scopus 로고
    • Pharmacological profile of lixisenatide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3cXhtVKhtbfE, PID: 20570597
    • Werner U, Haschke G, Herling AW, Kramer W (2010) Pharmacological profile of lixisenatide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes. Regul Pept 164:58–64
    • (2010) Regul Pept , vol.164 , pp. 58-64
    • Werner, U.1    Haschke, G.2    Herling, A.W.3    Kramer, W.4
  • 17
    • 0035516188 scopus 로고    scopus 로고
    • Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats
    • COI: 1:CAS:528:DC%2BD3MXotFGis78%3D, PID: 11679431
    • Larsen PJ, Fledelius C, Knudsen LB, Tang-Christensen M (2001) Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats. Diabetes 50:2530–2539
    • (2001) Diabetes , vol.50 , pp. 2530-2539
    • Larsen, P.J.1    Fledelius, C.2    Knudsen, L.B.3    Tang-Christensen, M.4
  • 18
    • 64649102619 scopus 로고    scopus 로고
    • GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice
    • COI: 1:CAS:528:DC%2BD1MXktleiu7o%3D, PID: 19151200
    • Noyan-Ashraf MH, Momen MA, Ban K et al (2009) GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes 58:975–983
    • (2009) Diabetes , vol.58 , pp. 975-983
    • Noyan-Ashraf, M.H.1    Momen, M.A.2    Ban, K.3
  • 19
    • 84872055241 scopus 로고    scopus 로고
    • A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity
    • COI: 1:CAS:528:DC%2BC3sXjs1yrtQ%3D%3D, PID: 23186644
    • Noyan-Ashraf MH, Shikatani EA, Schuiki I et al (2013) A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity. Circulation 127:74–85
    • (2013) Circulation , vol.127 , pp. 74-85
    • Noyan-Ashraf, M.H.1    Shikatani, E.A.2    Schuiki, I.3
  • 20
    • 84973531905 scopus 로고    scopus 로고
    • Vitamin D receptor activation reduces angiotensin-ii-induced dissecting abdominal aortic aneurysm in apolipoprotein E-knockout mice
    • COI: 1:CAS:528:DC%2BC28Xht1ekt7zE, PID: 27283745
    • Martorell S, Hueso L, Gonzalez-Navarro H, Collado A, Sanz MJ, Piqueras L (2016) Vitamin D receptor activation reduces angiotensin-ii-induced dissecting abdominal aortic aneurysm in apolipoprotein E-knockout mice. Arterioscler Thromb Vasc Biol 36:1587–1597
    • (2016) Arterioscler Thromb Vasc Biol , vol.36 , pp. 1587-1597
    • Martorell, S.1    Hueso, L.2    Gonzalez-Navarro, H.3    Collado, A.4    Sanz, M.J.5    Piqueras, L.6
  • 21
    • 8544272562 scopus 로고    scopus 로고
    • The ligand-binding function of hepatic lipase modulates the development of atherosclerosis in transgenic mice
    • COI: 1:CAS:528:DC%2BD2cXovVCgtbk%3D, PID: 15304509
    • Gonzalez-Navarro H, Nong Z, Amar MJ et al (2004) The ligand-binding function of hepatic lipase modulates the development of atherosclerosis in transgenic mice. J Biol Chem 279:45312–45321
    • (2004) J Biol Chem , vol.279 , pp. 45312-45321
    • Gonzalez-Navarro, H.1    Nong, Z.2    Amar, M.J.3
  • 22
    • 84872609955 scopus 로고    scopus 로고
    • Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging
    • COI: 1:CAS:528:DC%2BC3sXjt1Wns7g%3D, PID: 23107464
    • Gonzalez-Navarro H, Vinue A, Sanz MJ et al (2013) Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging. Aging Cell 12:102–111
    • (2013) Aging Cell , vol.12 , pp. 102-111
    • Gonzalez-Navarro, H.1    Vinue, A.2    Sanz, M.J.3
  • 23
    • 84930680495 scopus 로고    scopus 로고
    • Ink4/Arf locus restores glucose tolerance and insulin sensitivity by reducing hepatic steatosis and inflammation in mice with impaired IRS2-dependent signalling
    • COI: 1:CAS:528:DC%2BC2MXptlOlur0%3D, PID: 26022372
    • Vinue A, Andres-Blasco I, Herrero-Cervera A et al (2015) Ink4/Arf locus restores glucose tolerance and insulin sensitivity by reducing hepatic steatosis and inflammation in mice with impaired IRS2-dependent signalling. Biochim Biophys Acta 1852:1729–1742
    • (2015) Biochim Biophys Acta , vol.1852 , pp. 1729-1742
    • Vinue, A.1    Andres-Blasco, I.2    Herrero-Cervera, A.3
  • 24
    • 77951888636 scopus 로고    scopus 로고
    • p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis
    • COI: 1:CAS:528:DC%2BC3cXot1arsrk%3D, PID: 20381282
    • Gonzalez-Navarro H, Abu Nabah YN, Vinue A et al (2010) p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis. J Am Coll Cardiol 55:2258–2268
    • (2010) J Am Coll Cardiol , vol.55 , pp. 2258-2268
    • Gonzalez-Navarro, H.1    Abu Nabah, Y.N.2    Vinue, A.3
  • 25
    • 84982734929 scopus 로고    scopus 로고
    • Hepatic lipase inactivation decreases atherosclerosis in insulin resistance by reducing LIGHT/lymphotoxin β-receptor pathway
    • PID: 27172975
    • Andres-Blasco I, Vinue A, Herrero-Cervera A et al (2016) Hepatic lipase inactivation decreases atherosclerosis in insulin resistance by reducing LIGHT/lymphotoxin β-receptor pathway. Thromb Haemost 116:379–393
    • (2016) Thromb Haemost , vol.116 , pp. 379-393
    • Andres-Blasco, I.1    Vinue, A.2    Herrero-Cervera, A.3
  • 26
    • 84921794871 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase mediates expression of arginase II but not inducible nitric-oxide synthase in lipopolysaccharide-stimulated macrophages
    • COI: 1:CAS:528:DC%2BC2MXhsVCqtbo%3D, PID: 25451938
    • Jin Y, Liu Y, Nelin LD (2015) Extracellular signal-regulated kinase mediates expression of arginase II but not inducible nitric-oxide synthase in lipopolysaccharide-stimulated macrophages. J Biol Chem 290:2099–2111
    • (2015) J Biol Chem , vol.290 , pp. 2099-2111
    • Jin, Y.1    Liu, Y.2    Nelin, L.D.3
  • 27
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: in vivo veritas
    • COI: 1:CAS:528:DC%2BC38XjsV2ms7g%3D, PID: 22378047
    • Sica A, Mantovani A (2012) Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 122:787–795
    • (2012) J Clin Invest , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 28
    • 77951151612 scopus 로고    scopus 로고
    • Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4
    • COI: 1:CAS:528:DC%2BC3cXltFSmtL0%3D, PID: 20068138
    • Arakawa M, Mita T, Azuma K et al (2010) Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Diabetes 59:1030–1037
    • (2010) Diabetes , vol.59 , pp. 1030-1037
    • Arakawa, M.1    Mita, T.2    Azuma, K.3
  • 31
    • 84858707110 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cells
    • COI: 1:CAS:528:DC%2BC38XktlGrsL4%3D, PID: 22284365
    • Shiraki A, Oyama J, Komoda H et al (2012) The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cells. Atherosclerosis 221:375–382
    • (2012) Atherosclerosis , vol.221 , pp. 375-382
    • Shiraki, A.1    Oyama, J.2    Komoda, H.3
  • 32
    • 84899467577 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonist liraglutide inhibits endothelin-1 in endothelial cell by repressing nuclear factor-kappa B activation
    • COI: 1:CAS:528:DC%2BC3sXhsFSktbnJ, PID: 23657563
    • Dai Y, Mehta JL, Chen M (2013) Glucagon-like peptide-1 receptor agonist liraglutide inhibits endothelin-1 in endothelial cell by repressing nuclear factor-kappa B activation. Cardiovasc Drugs Ther 27:371–380
    • (2013) Cardiovasc Drugs Ther , vol.27 , pp. 371-380
    • Dai, Y.1    Mehta, J.L.2    Chen, M.3
  • 33
    • 84901341959 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism
    • PID: 24835252
    • Krasner NM, Ido Y, Ruderman NB, Cacicedo JM (2014) Glucagon-like peptide-1 (GLP-1) analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism. PLoS One 9:e97554
    • (2014) PLoS One , vol.9
    • Krasner, N.M.1    Ido, Y.2    Ruderman, N.B.3    Cacicedo, J.M.4
  • 34
    • 84904543855 scopus 로고    scopus 로고
    • Anti-inflammatory therapies for cardiovascular disease
    • COI: 1:CAS:528:DC%2BC2cXht1SqtrfI, PID: 24864079
    • Ridker PM, Luscher TF (2014) Anti-inflammatory therapies for cardiovascular disease. Eur Heart J 35:1782–1791
    • (2014) Eur Heart J , vol.35 , pp. 1782-1791
    • Ridker, P.M.1    Luscher, T.F.2
  • 35
    • 84901462249 scopus 로고    scopus 로고
    • Cardiovascular actions of incretin-based therapies
    • COI: 1:CAS:528:DC%2BC2cXotlOjsbs%3D, PID: 24855202
    • Ussher JR, Drucker DJ (2014) Cardiovascular actions of incretin-based therapies. Circ Res 114:1788–1803
    • (2014) Circ Res , vol.114 , pp. 1788-1803
    • Ussher, J.R.1    Drucker, D.J.2
  • 36
    • 84869491455 scopus 로고    scopus 로고
    • Distribution of macrophage polarization markers in human atherosclerosis
    • PID: 23078881
    • Stoger JL, Gijbels MJ, van der Velden S et al (2012) Distribution of macrophage polarization markers in human atherosclerosis. Atherosclerosis 225:461–468
    • (2012) Atherosclerosis , vol.225 , pp. 461-468
    • Stoger, J.L.1    Gijbels, M.J.2    van der Velden, S.3
  • 37
    • 84989196169 scopus 로고    scopus 로고
    • Monocytic MKP-1 is a sensor of the metabolic environment and regulates function and phenotypic fate of monocyte-derived macrophages in atherosclerosis
    • COI: 1:CAS:528:DC%2BC28XhsF2qsL%2FE, PID: 27670844
    • Kim HS, Tavakoli S, Piefer LA, Nguyen HN, Asmis R (2016) Monocytic MKP-1 is a sensor of the metabolic environment and regulates function and phenotypic fate of monocyte-derived macrophages in atherosclerosis. Sci Rep 6:34223
    • (2016) Sci Rep , vol.6 , pp. 34223
    • Kim, H.S.1    Tavakoli, S.2    Piefer, L.A.3    Nguyen, H.N.4    Asmis, R.5
  • 38
    • 84865368343 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation
    • COI: 1:CAS:528:DC%2BC38XhtF2rtbjM, PID: 22842565
    • Shiraishi D, Fujiwara Y, Komohara Y, Mizuta H, Takeya M (2012) Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation. Biochem Biophys Res Commun 425:304–308
    • (2012) Biochem Biophys Res Commun , vol.425 , pp. 304-308
    • Shiraishi, D.1    Fujiwara, Y.2    Komohara, Y.3    Mizuta, H.4    Takeya, M.5
  • 39
    • 84989177916 scopus 로고    scopus 로고
    • DPP-4 inhibition by linagliptin attenuates obesity-related inflammation and insulin resistance by regulating M1/M2 macrophage polarization
    • COI: 1:CAS:528:DC%2BC28XhvFOrt7fE, PID: 27445264
    • Zhuge F, Ni Y, Nagashimada M et al (2016) DPP-4 inhibition by linagliptin attenuates obesity-related inflammation and insulin resistance by regulating M1/M2 macrophage polarization. Diabetes 65:2966–2979
    • (2016) Diabetes , vol.65 , pp. 2966-2979
    • Zhuge, F.1    Ni, Y.2    Nagashimada, M.3
  • 40
    • 84898917380 scopus 로고    scopus 로고
    • Arginase I enhances atherosclerotic plaque stabilization by inhibiting inflammation and promoting smooth muscle cell proliferation
    • PID: 23999450
    • Wang XP, Zhang W, Liu XQ et al (2014) Arginase I enhances atherosclerotic plaque stabilization by inhibiting inflammation and promoting smooth muscle cell proliferation. Eur Heart J 35:911–919
    • (2014) Eur Heart J , vol.35 , pp. 911-919
    • Wang, X.P.1    Zhang, W.2    Liu, X.Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.