Arginase i enhances atherosclerotic plaque stabilization by inhibiting inflammation and promoting smooth muscle cell proliferation

European Heart Journal

Volumn 35, Issue 14, 2014, Pages 911-919

  Wang, Xu Ping ^a   Zhang, Wei ^a   Liu, Xiao Qian ^a   Wang, Wen Ke ^a   Yan, Fei ^a   Dong, Wen Qian ^a   Zhang, Yun ^a   Zhang, Ming Xiang ^a  

^a Qilu Hospital of Shandong University   (China)

Author keywords

Arginase I; Atherosclerotic plaque stability; Inflammation; Proliferation

Indexed keywords

ARGINASE 1; ARGININE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 6; LIPID; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; ARGINASE; ARGINASE I, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL PROLIFERATION; CONTROLLED STUDY; FOAM CELL; HUMAN; HUMAN CELL; INFLAMMATION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; ANIMAL; ANTAGONISTS AND INHIBITORS; ENZYMOLOGY; METABOLISM; PHYSIOLOGY; RABBIT;

ANIMALS; ARGINASE; CELL PROLIFERATION; INTERLEUKIN-6; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NITRIC OXIDE SYNTHASE TYPE II; PLAQUE, ATHEROSCLEROTIC; RABBITS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84898917380     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/eht329     Document Type: Article

References (27)

1. Vancraeynest D, Pasquet A, Roelants V, Gerber BL, Vanoverschelde JL. Imaging the vulnerable plaque. J Am Coll Cardiol 2011;57:1961-1979.
2. Libby P. Inflammation in atherosclerosis. Nature 2002;420:868-874.
3. Rekhter MD, Gordon D. Active proliferation of different cell types, including lymphocytes, in human atherosclerotic plaques. Am J Pathol 1995;147:668-677.
4. Biasucci LM, Liuzzo G, Colizzi C, Maseri A. The role of cytokines in unstable angina. Expert Opin Investig Drugs 1998;7:1667-1672.
5. Geng YJ, Libby P. Evidence for apoptosis in advanced human atheroma. Colocaliza-tion with interleukin-1 beta-converting enzyme. Am J Pathol 1995;147:251-266.
6. Gorenne I, Kavurma M, Scott S, Bennett M.Vascular smooth muscle cell senescence in atherosclerosis. Cardiovasc Res 2006;72:9-17.
7. Burleigh MC, Briggs AD, Lendon CL, Davies MJ, Born GV, Richardson PD. Collagen types I and III, collagen content, GAGs and mechanical strength of human atherosclerotic plaque caps: span-wise variations. Atherosclerosis 1992;96:71-81.
8. Debats IB, Wolfs TG, Gotoh T, Cleutjens JP, Peutz-Kootstra CJ, der Hulst RR. Role of arginine in superficial wound healing in man. Nitric Oxide 2009;21:175-183.
9. Ckless K, Lampert A, Reiss J, Kasahara D, Poynter ME, Irvin CG, Lundblad LK, Norton R, der Vliet A, Janssen-Heininger YM. Inhibitionof arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration. J Immunol 2008;181:4255-4264.
10. Hesse M, Modolell M, LaFlamme AC, Schito M, Fuentes JM, Cheever AW, Pearce EJ, Wynn TA. Differential regulationof nitric oxide synthase-2 and arginase-1by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. J Immunol 2001;167:6533-6544.
11. Iniesta V, Gomez-Nieto LC, Corraliza I. The inhibition of arginase by N(omega)-hydroxy-L-arginine controls the growth of Leishmania inside macro-phages. J Exp Med 2001;193:777-784.
12. Munder M, Mollinedo F, Calafat J, Canchado J, Gil-Lamaignere C, Fuentes JM, Luckner C, Doschko G, Soler G, Eichmann K, Muller FM, Ho AD, Goerner M, Modolell M. Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. Blood 2005;105:2549-2556.
13. Kropf P, Baud D, Marshall SE, Munder M, Mosley A, Fuentes JM, Bangham CR, Taylor GP, Herath S, Choi BS, Soler G, Teoh T, Modolell M, Muller I. Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy. Eur J Immunol 2007;37:935-945.
14. Wang XP, Chen YG, Qin WD, Zhang W, Wei SJ, Wang J, Liu FQ, Gong L, An FS, Zhang Y, Chen ZY, Zhang MX. Arginase I attenuates inflammatory cytokine secretion induced by lipopolysaccharide in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2011;31:1853-1860.
15. Teupser D, Burkhardt R, Wilfert W, Haffner I, Nebendahl K, Thiery J. Identification of macrophage arginase I as a new candidate gene of atherosclerosis resistance. Arter-ioscler Thromb Vasc Biol 2006;26:365-371.
16. Chen WQ, Zhang L, Liu YF, Chen L, Ji XP, Zhang M, Zhao YX, Yao GH, Zhang C, Wang XL, Zhang Y. Prediction of atherosclerotic plaque ruptures with high-frequency ultrasound imaging and serum inflammatory markers. Am J Physiol Heart Circ Physiol 2007;293:H2836-H2844.
17. Gallardo-Soler A, Gomez-Nieto C, Campo ML, Marathe C, Tontonoz P, Castrillo A, Corraliza I. Arginase I induction by modified lipoproteins in macrophages: a peroxi-some proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity. Mol Endocrinol 2008;22:1394-1402.
18. Liu R, Bi K, Jia Y, Wang Q, Yin R, Li Q. Determination of polyamines in human plasma by high-performance liquid chromatography coupled with Q-TOF mass spectrom-etry. J Mass Spectrom 2012;47:1341-1346.
19. Chan ED, Riches DW. IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(mapk) in a mouse macrophage cell line. Am J Physiol Cell Physiol 2001;280:C441-C450.
20. Gobert AP, Cheng Y, Akhtar M, Mersey BD, Blumberg DR, Cross RK, Chaturvedi R, Drachenberg CB, Boucher JL, Hacker A, Casero RA Jr, Wilson KT. Protective role of arginase in a mouse model of colitis. J Immunol 2004;173:2109-2117.
21. Barath P, Fishbein MC, Cao J, Berenson J, Helfant RH, Forrester JS. Detection and localization of tumor necrosis factor in human atheroma. Am J Cardiol 1990;65: 297-302.
22. Fang FC. Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Nat Rev Microbiol 2004;2:820-832.
23. de Boer OJ, der Wal AC, Verhagen CE, Becker AE. Cytokine secretion profiles of cloned T cells from human aortic atherosclerotic plaques. J Pathol 1999;188: 174-179.
24. Pinderski LJ, Fischbein MP, Subbanagounder G, Fishbein MC, Kubo N, Cheroutre H, Curtiss LK, Berliner JA, Boisvert WA. Overexpression of interleukin-10 byactivated T lymphocytes inhibits atherosclerosis in LDL receptor-deficient mice by altering lymphocyte and macrophage phenotypes. Circ Res 2002;90:1064-1071.
25. Weissberg PL, Clesham GJ, Bennett MR.Is vascular smooth muscle cell proliferation beneficial. Lancet 1996;347:305-307.
26. Davies MJ, Thomas AC. Plaque fissuring-the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. Br Heart J 1985;53:363-373.
27. Braganza DM, Bennett MR. New insights into atherosclerotic plaque rupture. Postgrad Med J 2001;77:94-98.