TL-2 attenuates β-amyloid induced neuronal apoptosis through the AKT/GSK-3β/β-catenin pathway

International Journal of Neuropsychopharmacology

Volumn 17, Issue 9, 2014, Pages 1511-1519

  Zhu, Xiaolei ^a,b   Wang, Sulei ^b   Yu, Linjie ^a   Yang, Hui ^b   Tan, Renxiang ^c   Yin, Kailin ^a   Jin, Jiali ^a   Zhao, Hui ^a   Guan, Dening ^a   Xu, Yun ^a,b  

^a THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

AKT GSK 3 catenin pathway; apoptosis; Dalesconol B; amyloid

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; BETA CATENIN; CASPASE 3; CASPASE 9; DALESCONOL B; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOSUPPRESSIVE AGENT; NEUROPROTECTIVE AGENT; NOOTROPIC AGENT; PROTEIN KINASE B; UNCLASSIFIED DRUG; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); CHROMONE DERIVATIVE; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; MORPHOLINE DERIVATIVE; ONCOPROTEIN; PEPTIDE FRAGMENT; POLYCYCLIC AROMATIC HYDROCARBON;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; CELL SURVIVAL; CELL VIABILITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DETERMINATION; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMORY DISORDER; MORRIS WATER MAZE TEST; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SHORT COURSE THERAPY; TRANSCRIPTION INITIATION; TREATMENT DURATION; WESTERN BLOTTING; ANIMAL; BRAIN CORTEX; CELL CULTURE; CHEMICALLY INDUCED; COMPLICATION; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; HUMAN; MAZE TEST; MEMORY DISORDERS; METABOLISM; NERVE CELL; PATHOLOGY; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; BETA CATENIN; CASPASE 3; CASPASE 9; CELLS, CULTURED; CEREBRAL CORTEX; CHROMONES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MAZE LEARNING; MEMORY DISORDERS; MICE; MORPHOLINES; NEURONS; NEUROPROTECTIVE AGENTS; ONCOGENE PROTEIN V-AKT; PEPTIDE FRAGMENTS; POLYCYCLIC HYDROCARBONS, AROMATIC; SIGNAL TRANSDUCTION;

EID: 84904878925     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145714000315     Document Type: Article

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