Toxicology of nanoparticles

Nanomedicine in Drug Delivery

Volumn , Issue , 2013, Pages 337-354

  Nalabotu, Siva K ^a   Blough, Eric R ^b  

^a MARSHALL UNIVERSITY   (United States)

^b MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COST EFFECTIVENESS;

BENEFICIAL EFFECTS; NANOPARTICLE (NPS); NANOTECHNOLOGY INDUSTRY; NANOTECHNOLOGY RESEARCH; NATIONAL SCIENCE FOUNDATIONS; PHARMACEUTICAL INDUSTRY; PUBLIC AND PRIVATE SECTOR; SCIENTIFIC COMMUNITY;

NANOPARTICLES;

EID: 85020592899     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/b14802     Document Type: Chapter

References (104)

1. NANO technology: Untold promise, unknown risk. Consum Rep, 2007. 72(7): 40-5.
2. Hobson, D.W., Commercialization of nanotechnology. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2009. 1(2): 189-202.
3. Kibble, A., Pharma 2020—An economist conference shaping the future of the pharmaceuticals industry. IDrugs, 2008. 11(5): 331-3.
4. Buzea, C., Pacheco, II, and K. Robbie, Nanomaterials and nanoparticles: Sources and toxicity. Biointerphases, 2007. 2(4): MR17-71.
5. Oberdorster, G., E. Oberdorster, and J. Oberdorster, Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect, 2005. 113(7): 823-39.
6. Simonelli, F., et al., Cyclotron production of radioactive CeO(2) nanoparticles and their application for in vitro uptake studies. IEEE Trans Nanobiosci, 2011. 10(1): 44-50.
7. Environment Directorate, O.F.E.C.-O.A.D., Working party on manufactured nanomaterials: List of manufactured nanomaterials and list of endpoints for phase one of the OECD Testing Programme. ENV/JM/MONO(2008)13/REV, 2008.
8. Singh, S. and H.S. Nalwa, Nanotechnology and health safety—Toxicity and risk assessments of nanostructured materials on human health. J Nanosci Nanotechnol, 2007. 7(9): 3048-70.
9. Kumar, V., et al., Evaluating the toxicity of selected types of nanochemicals. Rev Environ Contam Toxicol, 2012. 215: 39-121.
10. Jennings, T. and G. Strouse, Past, present, and future of gold nanoparticles. Adv Exp Med Biol, 2007. 620: 34-47.
11. Dreaden, E.C., et al., The golden age: Gold nanoparticles for biomedicine. Chem Soc Rev, 2011. 41(7): 2740-79.
12. Islam, T. and M.G. Harisinghani, Overview of nanoparticle use in cancer imaging. Cancer Biomark, 2009. 5(2): 61-7.
13. Fiorino, D.J., Voluntary initiatives, regulation, and nanotechnology oversight charting a path. Woodrow Wilson International Center for Scholars; Project on Emerging Nanotechnologies. 2010.
14. Malsch, D.H.A.I., Hazards and risks of engineered nanoparticles for the environment and human health. Sustainability, 2009. 1(2071-1050): 1161-94.
15. Hofmann-Amtenbrink, M., H. Hofmann, and X. Montet, Superparamagnetic nanoparticles—A tool for early diagnostics. Swiss Med Wkly, 2010. 140: w13081.
16. Islam, T. and L. Josephson, Current state and future applications of active targeting in malignancies using superparamagnetic iron oxide nanoparticles. Cancer Biomark, 2009. 5(2): 99-107.
17. Bhaskar, S., et al., Multifunctional nanocarriers for diagnostics, drug delivery and targeted treatment across blood−brain barrier: Perspectives on tracking and neuroimaging. Part Fibre Toxicol, 2010. 7: 3.
18. Tiede, K., et al., Detection and characterization of engineered nanoparticles in food and the environment. Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 2008. 25(7): 795-821.
19. Morris, V.J., Emerging roles of engineered nanomaterials in the food industry. Trends Biotechnol, 2011. 29(10): 509-16.
20. Gottschalk, F. and B. Nowack, The release of engineered nanomaterials to the environment. J Environ Monit, 2011. 13(5): 1145-55.
21. Bernhardt, E.S., et al., An ecological perspective on nanomaterial impacts in the environment. J Environ Qual, 2010. 39(6): 1954-65.
22. Cassee, F.R., et al., Exposure, health and ecological effects review of engineered nanoscale cerium and cerium oxide associated with its use as a fuel additive. Crit Rev Toxicol, 2011. 41(3): 213-29.
23. Woskie, S., Workplace practices for engineered nanomaterial manufacturers. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2010. 2(6): 685-92.
24. Petosa, A.R., et al., Aggregation and deposition of engineered nanomaterials in aquatic environments: Role of physicochemical interactions. Environ Sci Technol, 2010. 44(17): 6532-49.
25. Ren, H. and X. Huang, Polyacrylate nanoparticles: Toxicity or new nanomedicine? Eur Respir J, 2010. 36(1): 218-21.
26. Warheit, D.B., et al., Health effects related to nanoparticle exposures: Environmental, health and safety considerations for assessing hazards and risks. Pharmacol Ther, 2008. 120(1): 35-42.
27. Yang, H., et al., Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: The role of particle size, shape and composition. J Appl Toxicol, 2009. 29(1): 69-78.
28. Bystrzejewska-Piotrowska, G., J. Golimowski, and P.L. Urban, Nanoparticles: Their potential toxicity, waste and environmental management. Waste Manage, 2009. 29(9): 2587-95.
29. Khlebtsov, N. and L. Dykman, Biodistribution and toxicity of engineered gold nanoparticles: A review of in vitro and in vivo studies. Chem Soc Rev, 2011. 40(3): 1647-71.
30. Trickler, W.J., et al., Silver nanoparticle induced blood−brain barrier inflammation and increased permeability in primary rat brain microvessel endothelial cells. Toxicol Sci, 2010. 118(1): 160-70.
31. Simon-Deckers, A., et al., Size-, composition- and shape-dependent toxicological impact of metal oxide nanoparticles and carbon nanotubes toward bacteria. Environ Sci Technol, 2009. 43(21): 8423-9.
32. Lam, C.W., et al., A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks. Crit Rev Toxicol, 2006. 36(3): 189-217.
33. Jia, G., et al., Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene. Environ Sci Technol, 2005. 39(5): 1378-83.
34. Kreyling, W.G., S. Hirn, and C. Schleh, Nanoparticles in the lung. Nat Biotechnol, 2010. 28(12): 1275-6.
35. Geiser, M. and W.G. Kreyling, Deposition and biokinetics of inhaled nanoparticles. Part Fibre Toxicol, 2010. 7: 2.
36. Sadauskas, E., et al., Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation. Chem Cent J, 2009. 3: 16.
37. Tjalve, H., et al., Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats. Pharmacol Toxicol, 1996. 79(6): 347-56.
38. Elder, A., et al., Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect, 2006. 114(8): 1172-8.
39. Sharma, H.S. and A. Sharma, Nanoparticles aggravate heat stress induced cognitive deficits, blood−brain barrier disruption, edema formation and brain pathology. Prog Brain Res, 2007. 162: 245-73.
40. Oberdorster, G., et al., Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol, 2004. 16(6-7): 437-45.
41. Tallkvist, J., et al., Transport and subcellular distribution of nickel in the olfactory system of pikes and rats. Toxicol Sci, 1998. 43(2): 196-203.
42. Blum, J.L., et al., Cadmium associated with inhaled cadmium oxide nanoparticles impacts fetal and neonatal development and growth. Toxicol Sci, 2012. 126(2): 478-86.
43. Scheuch, G., et al., Deposition, imaging, and clearance: What remains to be done? J Aerosol Med Pulm Drug Deliv, 2010. 23(Suppl 2): S39-57.
44. Henning, A., et al., Influence of particle size and material properties on mucociliary clearance from the airways. J Aerosol Med Pulm Drug Deliv, 2010. 23(4): 233-41.
45. Geiser, M., Update on macrophage clearance of inhaled micro- and nanoparticles. J Aerosol Med Pulm Drug Deliv, 2010. 23(4): 207-17.
46. Gaiser, B.K., et al., Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments. Environ Health, 2009. 8(Suppl 1): S2.
47. Kim, Y.S., et al., Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague−Dawley rats. Inhal Toxicol, 2008. 20(6): 575-83.
48. Nefzger, M., et al., Distribution and elimination of polymethyl methacrylate nanoparticles after peroral administration to rats. J Pharm Sci, 1984. 73(9): 1309-11.
49. Zhao, C.M. and W.X. Wang, Biokinetic uptake and efflux of silver nanoparticles in Daphnia magna. Environ Sci Technol, 2010. 44(19): 7699-704.
50. Smijs, T.G. and J.A. Bouwstra, Focus on skin as a possible port of entry for solid nanoparticles and the toxicological impact. J Biomed Nanotechnol, 2010. 6(5): 469-84.
51. Nohynek, G.J., et al., Safety assessment of personal care products/cosmetics and their ingredients. Toxicol Appl Pharmacol, 2010. 243(2): 239-59.
52. Simko, M. and M.O. Mattsson, Risks from accidental exposures to engineered nanoparticles and neurological health effects: A critical review. Part Fibre Toxicol, 2010. 7: 42.
53. Wu, J., et al., Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure. Toxicol Lett, 2009. 191(1): 1-8.
54. Borm, P.J., et al., The potential risks of nanomaterials: A review carried out for ECETOC. Part Fibre Toxicol, 2006. 3: 11.
55. Yang, K., et al., Quantum dot-based visual in vivo imaging for oral squamous cell carcinoma in mice. Oral Oncol, 2010. 46(12): 864-8.
56. Minelli, C., S.B. Lowe, and M.M. Stevens, Engineering nanocomposite materials for cancer therapy. Small, 2010. 6(21): 2336-57.
57. Ting, G., et al., Nanotargeted radionuclides for cancer nuclear imaging and internal radiotherapy. J Biomed Biotechnol, 2010. 9(5): 37-54 58.
58. Colon, J. et al., Protection from radiation-induced pneumonitis using cerium oxide nanoparticles. Nanomedicine, 2009. 5(2): 225-31.
59. Niu, J., et al., Cardioprotective effects of cerium oxide nanoparticles in a transgenic murine model of cardiomyopathy. Cardiovasc Res, 2007. 73(3): 549-59.
60. Stefani, D., D. Wardman, and T. Lambert, The implosion of the Calgary General Hospital: Ambient air quality issues. J Air Waste Manage Assoc, 2005. 55(1): 52-9.
61. Xia, T., et al., Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett, 2006. 6(8): 1794-807.
62. Berton, M., et al., Uptake of oligonucleotide-loaded nanoparticles in prostatic cancer cells and their intracellular localization. Eur J Pharm Biopharm, 1999. 47(2): 119-23.
63. Chawla, J.S. and M.M. Amiji, Cellular uptake and concentrations of tamoxifen upon administration in poly(epsilon-caprolactone) nanoparticles. AAPS PharmSci, 2003. 5(1): E3.
64. Rouse, R.L., et al., Soot nanoparticles promote biotransformation, oxidative stress, and inflammation in murine lungs. Am J Respir Cell Mol Biol, 2008. 39(2): 198-207.
65. Porter, A.E., et al., Uptake of C60 by human monocyte macrophages, its localization and implications for toxicity: Studied by high resolution electron microscopy and electron tomography. Acta Biomater, 2006. 2(4): 409-19.
66. Drescher, D., et al., Toxicity of amorphous silica nanoparticles on eukaryotic cell model is determined by particle agglomeration and serum protein adsorption effects. Anal Bioanal Chem, 2011. 400(5): 1367-73.
67. Stone, V., H. Johnston, and M.J. Clift, Air pollution, ultrafine and nanoparticle toxicology: Cellular and molecular interactions. IEEE Trans Nanobiosci, 2007. 6(4): 331-40.
68. Li, N., T. Xia, and A.E. Nel, The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. Free Radic Biol Med, 2008. 44(9): 1689-99.
69. Ju-Nam, Y. and J.R. Lead, Manufactured nanoparticles: An overview of their chemistry, interactions and potential environmental implications. Sci Total Environ, 2008. 400(1-3): 396-414.
70. Johnston, H.J., et al., A review of the in vivo and in vitro toxicity of silver and gold particulates: Particle attributes and biological mechanisms responsible for the observed toxicity. Crit Rev Toxicol, 2010. 40(4): 328-46.
71. Mocan, T., et al., Implications of oxidative stress mechanisms in toxicity of nanoparticles (review). Acta Physiol Hung, 2010. 97(3): 247-55.
72. Xiong, D., et al., Effects of nano-scale TiO2, ZnO and their bulk counterparts on zebrafish: Acute toxicity, oxidative stress and oxidative damage. Sci Total Environ, 2011. 409(8): 1444-52.
73. Eom, H.J. and J. Choi, Oxidative stress of CeO2 nanoparticles via p38-Nrf-2 signaling pathway in human bronchial epithelial cell, Beas-2B. Toxicol Lett, 2009. 187(2): 77-83.
74. Clichici, S., et al., Blood oxidative stress generation after intraperitoneal administration of functionalized single-walled carbon nanotubes in rats. Acta Physiol Hung, 2011. 98(2): 231-41.
75. Kumar, A., et al., Engineered ZnO and TiO(2) nanoparticles induce oxidative stress and DNA damage leading to reduced viability of Escherichia coli. Free Radic Biol Med, 2011. 51(10): 1872-81.
76. Yamakoshi, Y., et al., Active oxygen species generated from photoexcited fullerene (C60) as potential medicines: O2-* versus 1O2. J Am Chem Soc, 2003. 125(42): 12803-9.
77. Hotze, E.M., et al., Mechanisms of photochemistry and reactive oxygen production by fullerene suspensions in water. Environ Sci Technol, 2008. 42(11): 4175-80.
78. Zhang, Z., et al., On the interactions of free radicals with gold nanoparticles. J Am Chem Soc, 2003. 125(26): 7959-63.
79. Lee, H.M., et al., Nanoparticles up-regulate tumor necrosis factor-alpha and CXCL8 via reactive oxygen species and mitogen-activated protein kinase activation. Toxicol Appl Pharmacol, 2009. 238(2): 160-9.
80. Kennedy, I.M., D. Wilson, and A.I. Barakat, Uptake and inflammatory effects of nanoparticles in a human vascular endothelial cell line. Res Rep Health Eff Inst, 2009. 136: 3-32.
81. Boonstra, J. and J.A. Post, Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene, 2004. 337: 1-13.
82. Hussain, S.M., et al., In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro, 2005. 19(7): 975-83.
83. Turrens, J.F., Mitochondrial formation of reactive oxygen species. J Physiol, 2003. 552(Pt 2): 335-44.
84. Lenaz, G., The mitochondrial production of reactive oxygen species: Mechanisms and implications in human pathology. IUBMB Life, 2001. 52(3-5): 159-64.
85. Kakarla, S.K., et al., Chronic acetaminophen attenuates age-associated increases in cardiac ROS and apoptosis in the Fischer Brown Norway rat. Basic Res Cardiol, 2010. 105(4): 535-44.
86. Asano, S., et al., Aging influences multiple indices of oxidative stress in the heart of the Fischer 344/NNia x Brown Norway/BiNia rat. Redox Rep, 2007. 12(4): 167-80.
87. Morimoto, Y. and I. Tanaka, Effects of nanoparticles on humans. Sangyo Eiseigaku Zasshi, 2008. 50(2): 37-48.
88. Nielsen, G.D., et al., In vivo biology and toxicology of fullerenes and their derivatives. Basic Clin Pharmacol Toxicol, 2008. 103(3): 197-208.
89. Marano, F., et al., Nanoparticles: Molecular targets and cell signalling. Arch Toxicol, 2011. 85(7): 733-41.
90. Park, E.J., et al., Carbon fullerenes (C60s) can induce inflammatory responses in the lung of mice. Toxicol Appl Pharmacol, 2010. 244(2): 226-33.
91. Trouiller, B., et al., Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer Res, 2009. 69(22): 8784-9.
92. Khalil, W.K., et al., Genotoxicity evaluation of nanomaterials: DNA damage, micronuclei, and 8-hydroxy-2-deoxyguanosine induced by magnetic doped CdSe quantum dots in male mice. Chem Res Toxicol, 2011. 24(5): 640-50.
93. Choi, A.O., et al., Quantum dot-induced epigenetic and genotoxic changes in human breast cancer cells. J Mol Med (Berl), 2008. 86(3): 291-302.
94. Folkmann, J.K., et al., Oxidatively damaged DNA in rats exposed by oral gavage to C60 fullerenes and single-walled carbon nanotubes. Environ Health Perspect, 2009. 117(5): 703-8.
95. Mroz, R.M., et al., Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways. Eur Respir J, 2008. 31(2): 241-51.
96. Loden, M., et al., Sunscreen use: Controversies, challenges and regulatory aspects. Br J Dermatol, 2011. 165(2): 255-62.
97. Braydich-Stolle, L., et al., In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci, 2005. 88(2): 412-9.
98. Asare, N., et al., Cytotoxic and genotoxic effects of silver nanoparticles in testicular cells. Toxicology, 2012. 291(1-3): 65-72.
99. Umezawa, M., et al., Maternal exposure to carbon black nanoparticle increases collagen type VIII expression in the kidney of offspring. J Toxicol Sci, 2011. 36(4): 461-8.
100. Yamashita, K., et al., Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. Nat Nanotechnol, 2011. 6(5): 321-8.
101. Norwegian Pollution Control Authority. Environmental fate and ecotoxicity of engineered nanoparticles. Report no. TA 2304/2007. Eds.: E.J. Joner, T. Hartnik and C.E. Amundsen. Bioforsk, Ås. 64 pp. 2008.
102. Henig, R.M., Our silver-coated future. In Onearth, 2007. 29(3): 22-29.
103. Franco, A., et al., Limits and prospects of the “incremental approach” and the European legislation on the management of risks related to nanomaterials. Regul Toxicol Pharmacol, 2007. 48(2), 171-83.
104. Erik, C.D. et al., The golden age: Gold nanoparticles for biomedicine. Chem Soc Rev, 2012, 41(7), 2740-79.