Nanoparticles up-regulate tumor necrosis factor-α and CXCL8 via reactive oxygen species and mitogen-activated protein kinase activation

Toxicology and Applied Pharmacology

Volumn 238, Issue 2, 2009, Pages 160-169

  Lee, Hye Mi ^a   Shin, Dong Min ^a   Song, Hwan Moon ^b   Yuk, Jae Min ^a   Lee, Zee Won ^c   Lee, Sang Hee ^d   Hwang, Song Mei ^a   Kim, Jin Man ^a   Lee, Chang Soo ^b   Jo, Eun Kyeong ^a  

^a Chungnam National University   (South Korea)

^b Chungnam National University   (South Korea)

^c Korea Basic Science Institute (KBSI)   (South Korea)

^d Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

CXCL 8; Inflammation; Mitogen activated protein kinases; Nanoparticles; Reactive oxygen species; Tumor necrosis factor

Indexed keywords

ANTIOXIDANT; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NANOPARTICLE; PROTEIN P47; QUANTUM DOT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM VESICLE; CYTOTOXICITY; ELECTRON MICROSCOPY; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LUNG PARENCHYMA; LYSOSOME; MONOCYTE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANIMALS; CADMIUM COMPOUNDS; CYTOPLASMIC VESICLES; HUMANS; INTERLEUKIN-8; LYSOSOMES; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; NANOPARTICLES; QUANTUM DOTS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SELENIUM COMPOUNDS; STATISTICS, NONPARAMETRIC; TISSUE DISTRIBUTION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 67349215745     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.05.010     Document Type: Article

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