메뉴 건너뛰기




Volumn 5, Issue 9, 2017, Pages 747-759

Eosinophils in COPD: just another biomarker?

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CORTICOSTEROID; BRONCHODILATING AGENT;

EID: 85020453624     PISSN: 22132600     EISSN: 22132619     Source Type: Journal    
DOI: 10.1016/S2213-2600(17)30217-5     Document Type: Review
Times cited : (169)

References (114)
  • 2
  • 3
    • 4544304222 scopus 로고    scopus 로고
    • Defining a link with asthma in mice congenitally deficient in eosinophils
    • Lee, JJ, Dimina, D, Macias, MP, et al. Defining a link with asthma in mice congenitally deficient in eosinophils. Science 305 (2004), 1773–1776.
    • (2004) Science , vol.305 , pp. 1773-1776
    • Lee, J.J.1    Dimina, D.2    Macias, M.P.3
  • 4
    • 84987786714 scopus 로고    scopus 로고
    • Lung-resident eosinophils represent a distinct regulatory eosinophil subset
    • Mesnil, C, Raulier, S, Paulissen, G, et al. Lung-resident eosinophils represent a distinct regulatory eosinophil subset. J Clin Invest 126 (2016), 3279–3295.
    • (2016) J Clin Invest , vol.126 , pp. 3279-3295
    • Mesnil, C.1    Raulier, S.2    Paulissen, G.3
  • 5
    • 34249814066 scopus 로고    scopus 로고
    • Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils
    • Wong, CK, Cheung, PF, Ip, WK, Lam, CW, Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am J Respir Cell Mol Biol 37 (2007), 85–96.
    • (2007) Am J Respir Cell Mol Biol , vol.37 , pp. 85-96
    • Wong, C.K.1    Cheung, P.F.2    Ip, W.K.3    Lam, C.W.4
  • 6
    • 80052936263 scopus 로고    scopus 로고
    • Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers
    • Bafadhel, M, McKenna, S, Terry, S, et al. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med 184 (2011), 662–671.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 662-671
    • Bafadhel, M.1    McKenna, S.2    Terry, S.3
  • 7
    • 84863447204 scopus 로고    scopus 로고
    • Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial
    • Bafadhel, M, McKenna, S, Terry, S, et al. Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. Am J Respir Crit Care Med 186 (2012), 48–55.
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 48-55
    • Bafadhel, M.1    McKenna, S.2    Terry, S.3
  • 8
    • 84930866341 scopus 로고    scopus 로고
    • Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials
    • Pascoe, S, Locantore, N, Dransfield, MT, Barnes, NC, Pavord, ID, Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials. Lancet Respir Med 3 (2015), 435–442.
    • (2015) Lancet Respir Med , vol.3 , pp. 435-442
    • Pascoe, S.1    Locantore, N.2    Dransfield, M.T.3    Barnes, N.C.4    Pavord, I.D.5
  • 9
    • 84939433292 scopus 로고    scopus 로고
    • Blood eosinophils: a biomarker of response to extrafine beclomethasone/formoterol in chronic obstructive pulmonary disease
    • Siddiqui, SH, Guasconi, A, Vestbo, J, et al. Blood eosinophils: a biomarker of response to extrafine beclomethasone/formoterol in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 192 (2015), 523–525.
    • (2015) Am J Respir Crit Care Med , vol.192 , pp. 523-525
    • Siddiqui, S.H.1    Guasconi, A.2    Vestbo, J.3
  • 10
    • 84964388893 scopus 로고    scopus 로고
    • Blood eosinophil count and exacerbations in severe chronic obstructive pulmonary disease after withdrawal of inhaled corticosteroids: a post-hoc analysis of the WISDOM trial
    • Watz, H, Tetzlaff, K, Wouters, EFM, et al. Blood eosinophil count and exacerbations in severe chronic obstructive pulmonary disease after withdrawal of inhaled corticosteroids: a post-hoc analysis of the WISDOM trial. Lancet Respir Med 4 (2016), 390–398.
    • (2016) Lancet Respir Med , vol.4 , pp. 390-398
    • Watz, H.1    Tetzlaff, K.2    Wouters, E.F.M.3
  • 11
    • 84958985825 scopus 로고    scopus 로고
    • Blood eosinophils and inhaled corticosteroid/long-acting β-2 agonist efficacy in COPD
    • Pavord, ID, Lettis, S, Locantore, N, et al. Blood eosinophils and inhaled corticosteroid/long-acting β-2 agonist efficacy in COPD. Thorax 71 (2016), 118–125.
    • (2016) Thorax , vol.71 , pp. 118-125
    • Pavord, I.D.1    Lettis, S.2    Locantore, N.3
  • 12
    • 0000291799 scopus 로고
    • Über die specifischen granulationen des blutes
    • Ehrlich, P, Über die specifischen granulationen des blutes. Arch Anat Physiol 3 (1879), 571–579.
    • (1879) Arch Anat Physiol , vol.3 , pp. 571-579
    • Ehrlich, P.1
  • 13
    • 84871482550 scopus 로고    scopus 로고
    • Eosinophils: changing perspectives in health and disease
    • Rosenberg, HF, Dyer, KD, Foster, PS, Eosinophils: changing perspectives in health and disease. Nat Rev Immunol 13 (2013), 9–22.
    • (2013) Nat Rev Immunol , vol.13 , pp. 9-22
    • Rosenberg, H.F.1    Dyer, K.D.2    Foster, P.S.3
  • 14
    • 84905113844 scopus 로고    scopus 로고
    • Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo
    • Chu, DK, Jimenez-Saiz, R, Verschoor, CP, et al. Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo. J Exp Med 211 (2014), 1657–1672.
    • (2014) J Exp Med , vol.211 , pp. 1657-1672
    • Chu, D.K.1    Jimenez-Saiz, R.2    Verschoor, C.P.3
  • 15
    • 0017653531 scopus 로고
    • Localization of eosinophils in the thymus by the peroxidase reaction
    • Müller, E, Localization of eosinophils in the thymus by the peroxidase reaction. Histochemistry 52 (1977), 273–279.
    • (1977) Histochemistry , vol.52 , pp. 273-279
    • Müller, E.1
  • 16
    • 33749143444 scopus 로고    scopus 로고
    • Eosinophil-derived cationic proteins activate the synthesis of remodeling factors by airway epithelial cells
    • Pégorier, S, Wagner, LA, Gleich, GJ, Pretolani, M, Eosinophil-derived cationic proteins activate the synthesis of remodeling factors by airway epithelial cells. J Immunol 177 (2006), 4861–4869.
    • (2006) J Immunol , vol.177 , pp. 4861-4869
    • Pégorier, S.1    Wagner, L.A.2    Gleich, G.J.3    Pretolani, M.4
  • 17
    • 0020419578 scopus 로고
    • The Gordon phenomenon induced by the eosinophil cationic protein and eosinophil protein X
    • Fredens, K, Dahl, R, Venge, P, The Gordon phenomenon induced by the eosinophil cationic protein and eosinophil protein X. J Allergy Clin Immunol 70 (1982), 361–366.
    • (1982) J Allergy Clin Immunol , vol.70 , pp. 361-366
    • Fredens, K.1    Dahl, R.2    Venge, P.3
  • 19
    • 30444436766 scopus 로고    scopus 로고
    • The principal eosinophil peroxidase product, HOSCN, is a uniquely potent phagocyte oxidant inducer of endothelial cell tissue factor activity: a potential mechanism for thrombosis in eosinophilic inflammatory states
    • Wang, JG, Mahmud, SA, Thompson, JA, Geng, JG, Key, NS, Slungaard, A, The principal eosinophil peroxidase product, HOSCN, is a uniquely potent phagocyte oxidant inducer of endothelial cell tissue factor activity: a potential mechanism for thrombosis in eosinophilic inflammatory states. Blood 107 (2006), 558–565.
    • (2006) Blood , vol.107 , pp. 558-565
    • Wang, J.G.1    Mahmud, S.A.2    Thompson, J.A.3    Geng, J.G.4    Key, N.S.5    Slungaard, A.6
  • 20
    • 0032760049 scopus 로고    scopus 로고
    • Molecular basis for selective eosinophil trafficking in asthma: a multistep paradigm
    • Wardlaw, AJ, Molecular basis for selective eosinophil trafficking in asthma: a multistep paradigm. J Allergy Clin Immunol 104 (1999), 917–926.
    • (1999) J Allergy Clin Immunol , vol.104 , pp. 917-926
    • Wardlaw, A.J.1
  • 21
    • 0030942468 scopus 로고    scopus 로고
    • Expression of eotaxin by human lung epithelial cells: induction by cytokines and inhibition by glucocorticoids
    • Lilly, CM, Nakamura, H, Kesselman, H, et al. Expression of eotaxin by human lung epithelial cells: induction by cytokines and inhibition by glucocorticoids. J Clin Invest 99 (1997), 1767–1773.
    • (1997) J Clin Invest , vol.99 , pp. 1767-1773
    • Lilly, C.M.1    Nakamura, H.2    Kesselman, H.3
  • 22
    • 77949872807 scopus 로고    scopus 로고
    • Eosinophils and Th2 immunity: contemporary insights
    • Spencer, LA, Weller, PF, Eosinophils and Th2 immunity: contemporary insights. Immunol Cell Biol 88 (2010), 250–256.
    • (2010) Immunol Cell Biol , vol.88 , pp. 250-256
    • Spencer, L.A.1    Weller, P.F.2
  • 24
    • 84873408369 scopus 로고    scopus 로고
    • Targeting eosinophils in allergy, inflammation and beyond
    • Fulkerson, PC, Rothenberg, ME, Targeting eosinophils in allergy, inflammation and beyond. Nat Rev Drug Discov 12 (2013), 117–129.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 117-129
    • Fulkerson, P.C.1    Rothenberg, M.E.2
  • 25
    • 0018775556 scopus 로고
    • Blood eosinophils and eosinophil cationic protein after acute myocardial infarction or corticosteroid administration
    • Hällgren, R, Venge, P, Cullhed, I, Olsson, I, Blood eosinophils and eosinophil cationic protein after acute myocardial infarction or corticosteroid administration. Br J Haematol 42 (1979), 147–154.
    • (1979) Br J Haematol , vol.42 , pp. 147-154
    • Hällgren, R.1    Venge, P.2    Cullhed, I.3    Olsson, I.4
  • 26
    • 84890456104 scopus 로고    scopus 로고
    • Interleukin-18 expression, CD8(+) T cells, and eosinophils in lungs of nonsmokers with fatal asthma
    • Oda, H, Kawayama, T, Imaoka, H, et al. Interleukin-18 expression, CD8(+) T cells, and eosinophils in lungs of nonsmokers with fatal asthma. Ann Allergy Asthma Immunol 112 (2014), 23–28.
    • (2014) Ann Allergy Asthma Immunol , vol.112 , pp. 23-28
    • Oda, H.1    Kawayama, T.2    Imaoka, H.3
  • 27
    • 0027375511 scopus 로고
    • Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease
    • Lacoste, JY, Bousquet, J, Chanez, P, et al. Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease. J Allergy Clin Immunol 92 (1993), 537–548.
    • (1993) J Allergy Clin Immunol , vol.92 , pp. 537-548
    • Lacoste, J.Y.1    Bousquet, J.2    Chanez, P.3
  • 28
    • 84964297369 scopus 로고    scopus 로고
    • IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs
    • Bal, SM, Bernink, JH, Nagasawa, M, et al. IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs. Nat Immunol 17 (2016), 636–645.
    • (2016) Nat Immunol , vol.17 , pp. 636-645
    • Bal, S.M.1    Bernink, J.H.2    Nagasawa, M.3
  • 29
    • 0242351214 scopus 로고    scopus 로고
    • Nontypeable Haemophilus influenzae activates human eosinophils through beta-glucan receptors
    • Ahren, IL, Eriksson, E, Egesten, A, Riesbeck, K, Nontypeable Haemophilus influenzae activates human eosinophils through beta-glucan receptors. Am J Respir Cell Mol Biol 29 (2003), 598–605.
    • (2003) Am J Respir Cell Mol Biol , vol.29 , pp. 598-605
    • Ahren, I.L.1    Eriksson, E.2    Egesten, A.3    Riesbeck, K.4
  • 30
    • 0033928803 scopus 로고    scopus 로고
    • Induction of proinflammatory cytokines from human respiratory epithelial cells after stimulation by nontypeable Haemophilus influenzae
    • Clemans, DL, Bauer, RJ, Hanson, JA, et al. Induction of proinflammatory cytokines from human respiratory epithelial cells after stimulation by nontypeable Haemophilus influenzae. Infect Immun 68 (2000), 4430–4440.
    • (2000) Infect Immun , vol.68 , pp. 4430-4440
    • Clemans, D.L.1    Bauer, R.J.2    Hanson, J.A.3
  • 31
    • 40849124076 scopus 로고    scopus 로고
    • Eosinophil cationic protein high-affinity binding to bacteria-wall lipopolysaccharides and peptidoglycans
    • Torrent, M, Navarro, S, Moussaoui, M, Nogues, MV, Boix, E, Eosinophil cationic protein high-affinity binding to bacteria-wall lipopolysaccharides and peptidoglycans. Biochemistry 47 (2008), 3544–3555.
    • (2008) Biochemistry , vol.47 , pp. 3544-3555
    • Torrent, M.1    Navarro, S.2    Moussaoui, M.3    Nogues, M.V.4    Boix, E.5
  • 32
    • 67349125447 scopus 로고    scopus 로고
    • Respiratory viruses and eosinophils: exploring the connections
    • Rosenberg, HF, Dyer, KD, Domachowske, JB, Respiratory viruses and eosinophils: exploring the connections. Antiviral Res 83 (2009), 1–9.
    • (2009) Antiviral Res , vol.83 , pp. 1-9
    • Rosenberg, H.F.1    Dyer, K.D.2    Domachowske, J.B.3
  • 33
    • 0031889924 scopus 로고    scopus 로고
    • Eosinophils bind rhinovirus and activate virus-specific T cells
    • Handzel, ZT, Busse, WW, Sedgwick, JB, et al. Eosinophils bind rhinovirus and activate virus-specific T cells. J Immunol 160 (1998), 1279–1284.
    • (1998) J Immunol , vol.160 , pp. 1279-1284
    • Handzel, Z.T.1    Busse, W.W.2    Sedgwick, J.B.3
  • 34
    • 0025037094 scopus 로고
    • Eosinophilic inflammation in asthma
    • Bousquet, J, Chanez, P, Lacoste, JY, et al. Eosinophilic inflammation in asthma. N Engl J Med 323 (1990), 1033–1039.
    • (1990) N Engl J Med , vol.323 , pp. 1033-1039
    • Bousquet, J.1    Chanez, P.2    Lacoste, J.Y.3
  • 35
    • 0001744937 scopus 로고
    • Causes of death and pathologic findings in 304 cases of bronchial asthma
    • Messer, JW, Peters, GA, Bennett, WA, Causes of death and pathologic findings in 304 cases of bronchial asthma. Dis Chest 38 (1960), 616–624.
    • (1960) Dis Chest , vol.38 , pp. 616-624
    • Messer, J.W.1    Peters, G.A.2    Bennett, W.A.3
  • 36
    • 0037202790 scopus 로고    scopus 로고
    • Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    • Green, RH, Brightling, CE, McKenna, S, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 360 (2002), 1715–1721.
    • (2002) Lancet , vol.360 , pp. 1715-1721
    • Green, R.H.1    Brightling, C.E.2    McKenna, S.3
  • 37
    • 0036795111 scopus 로고    scopus 로고
    • Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
    • Green, RH, Brightling, CE, Woltmann, G, Parker, D, Wardlaw, AJ, Pavord, ID, Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 57 (2002), 875–879.
    • (2002) Thorax , vol.57 , pp. 875-879
    • Green, R.H.1    Brightling, C.E.2    Woltmann, G.3    Parker, D.4    Wardlaw, A.J.5    Pavord, I.D.6
  • 38
    • 61349089164 scopus 로고    scopus 로고
    • Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
    • Gudbjartsson, DF, Bjornsdottir, US, Halapi, E, et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet 41 (2009), 342–347.
    • (2009) Nat Genet , vol.41 , pp. 342-347
    • Gudbjartsson, D.F.1    Bjornsdottir, U.S.2    Halapi, E.3
  • 39
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • Haldar, P, Brightling, CE, Hargadon, B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 360 (2009), 973–984.
    • (2009) N Engl J Med , vol.360 , pp. 973-984
    • Haldar, P.1    Brightling, C.E.2    Hargadon, B.3
  • 40
    • 84919348857 scopus 로고    scopus 로고
    • Glucocorticoids and mepolizumab in eosinophilic asthma
    • Bel, EH, Ortega, HG, Pavord, ID, Glucocorticoids and mepolizumab in eosinophilic asthma. N Engl J Med, 371, 2014, 2434.
    • (2014) N Engl J Med , vol.371 , pp. 2434
    • Bel, E.H.1    Ortega, H.G.2    Pavord, I.D.3
  • 41
    • 84907424177 scopus 로고    scopus 로고
    • Mepolizumab treatment in patients with severe eosinophilic asthma
    • Ortega, HG, Liu, MC, Pavord, ID, et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med 371 (2014), 1198–1207.
    • (2014) N Engl J Med , vol.371 , pp. 1198-1207
    • Ortega, H.G.1    Liu, M.C.2    Pavord, I.D.3
  • 42
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
    • Pavord, ID, Korn, S, Howarth, P, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 380 (2012), 651–659.
    • (2012) Lancet , vol.380 , pp. 651-659
    • Pavord, I.D.1    Korn, S.2    Howarth, P.3
  • 44
    • 84856012857 scopus 로고    scopus 로고
    • Profiling of sputum inflammatory mediators in asthma and chronic obstructive pulmonary disease
    • Bafadhel, M, McCormick, M, Saha, S, et al. Profiling of sputum inflammatory mediators in asthma and chronic obstructive pulmonary disease. Respiration 83 (2012), 36–44.
    • (2012) Respiration , vol.83 , pp. 36-44
    • Bafadhel, M.1    McCormick, M.2    Saha, S.3
  • 45
    • 0033979024 scopus 로고    scopus 로고
    • Comparison of induced sputum with bronchial wash, bronchoalveolar lavage and bronchial biopsies in COPD
    • Rutgers, SR, Timens, W, Kaufmann, HF, van der Mark, TW, Koeter, GH, Postma, DS, Comparison of induced sputum with bronchial wash, bronchoalveolar lavage and bronchial biopsies in COPD. Eur Respir J 15 (2000), 109–115.
    • (2000) Eur Respir J , vol.15 , pp. 109-115
    • Rutgers, S.R.1    Timens, W.2    Kaufmann, H.F.3    van der Mark, T.W.4    Koeter, G.H.5    Postma, D.S.6
  • 46
    • 84864795241 scopus 로고    scopus 로고
    • Cysteinyl leukotriene 1 receptor expression associated with bronchial inflammation in severe exacerbations of COPD
    • Zhu, J, Bandi, V, Qiu, S, et al. Cysteinyl leukotriene 1 receptor expression associated with bronchial inflammation in severe exacerbations of COPD. Chest 142 (2012), 347–357.
    • (2012) Chest , vol.142 , pp. 347-357
    • Zhu, J.1    Bandi, V.2    Qiu, S.3
  • 47
    • 84891783155 scopus 로고    scopus 로고
    • Effect of a cysteinyl leukotriene receptor antagonist on experimental emphysema and asthma combined with emphysema
    • Ikeda, G, Miyahara, N, Koga, H, et al. Effect of a cysteinyl leukotriene receptor antagonist on experimental emphysema and asthma combined with emphysema. Am J Respir Cell Mol Biol 50 (2014), 18–29.
    • (2014) Am J Respir Cell Mol Biol , vol.50 , pp. 18-29
    • Ikeda, G.1    Miyahara, N.2    Koga, H.3
  • 48
    • 0842323816 scopus 로고    scopus 로고
    • Long-term montelukast therapy in moderate to severe COPD—a preliminary observation
    • Rubinstein, I, Kumar, B, Schriever, C, Long-term montelukast therapy in moderate to severe COPD—a preliminary observation. Respir Med 98 (2004), 134–138.
    • (2004) Respir Med , vol.98 , pp. 134-138
    • Rubinstein, I.1    Kumar, B.2    Schriever, C.3
  • 49
    • 35648937579 scopus 로고    scopus 로고
    • Computed tomographic scan-diagnosed chronic obstructive pulmonary disease-emphysema: eotaxin-1 is associated with bronchodilator response and extent of emphysema
    • Miller, M, Ramsdell, J, Friedman, PJ, Cho, JY, Renvall, M, Broide, DH, Computed tomographic scan-diagnosed chronic obstructive pulmonary disease-emphysema: eotaxin-1 is associated with bronchodilator response and extent of emphysema. J Allergy Clin Immunol 120 (2007), 1118–1125.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 1118-1125
    • Miller, M.1    Ramsdell, J.2    Friedman, P.J.3    Cho, J.Y.4    Renvall, M.5    Broide, D.H.6
  • 50
    • 84938612864 scopus 로고    scopus 로고
    • Host response to the lung microbiome in chronic obstructive pulmonary disease
    • Sze, MA, Dimitriu, PA, Suzuki, M, et al. Host response to the lung microbiome in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 192 (2015), 438–445.
    • (2015) Am J Respir Crit Care Med , vol.192 , pp. 438-445
    • Sze, M.A.1    Dimitriu, P.A.2    Suzuki, M.3
  • 51
    • 84964045832 scopus 로고    scopus 로고
    • Lung microbiome dynamics in COPD exacerbations
    • Wang, Z, Bafadhel, M, Haldar, K, et al. Lung microbiome dynamics in COPD exacerbations. Eur Respir J 47 (2016), 1082–1092.
    • (2016) Eur Respir J , vol.47 , pp. 1082-1092
    • Wang, Z.1    Bafadhel, M.2    Haldar, K.3
  • 52
    • 84964206614 scopus 로고    scopus 로고
    • Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs
    • Silver, JS, Kearley, J, Copenhaver, AM, et al. Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs. Nat Immunol 17 (2016), 626–635.
    • (2016) Nat Immunol , vol.17 , pp. 626-635
    • Silver, J.S.1    Kearley, J.2    Copenhaver, A.M.3
  • 53
    • 78650183459 scopus 로고    scopus 로고
    • Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by toll-like receptor 2
    • Crellin, NK, Trifari, S, Kaplan, CD, Satoh-Takayama, N, Di Santo, JP, Spits, H, Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by toll-like receptor 2. Immunity 33 (2010), 752–764.
    • (2010) Immunity , vol.33 , pp. 752-764
    • Crellin, N.K.1    Trifari, S.2    Kaplan, C.D.3    Satoh-Takayama, N.4    Di Santo, J.P.5    Spits, H.6
  • 54
    • 84894044993 scopus 로고    scopus 로고
    • Activated mouse eosinophils protect against lethal respiratory virus infection
    • Percopo, CM, Dyer, KD, Ochkur, SI, et al. Activated mouse eosinophils protect against lethal respiratory virus infection. Blood, 123, 2014, 743.
    • (2014) Blood , vol.123 , pp. 743
    • Percopo, C.M.1    Dyer, K.D.2    Ochkur, S.I.3
  • 56
    • 84903862707 scopus 로고    scopus 로고
    • COPD exacerbation severity and frequency is associated with impaired macrophage efferocytosis of eosinophils
    • Eltboli, O, Bafadhel, M, Hollins, F, et al. COPD exacerbation severity and frequency is associated with impaired macrophage efferocytosis of eosinophils. BMC Pulm Med, 14, 2014, 112.
    • (2014) BMC Pulm Med , vol.14 , pp. 112
    • Eltboli, O.1    Bafadhel, M.2    Hollins, F.3
  • 57
    • 84918798923 scopus 로고    scopus 로고
    • Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study
    • Brightling, CE, Bleecker, ER, Panettieri, RA Jr, et al. Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study. Lancet Respir Med 2 (2014), 891–901.
    • (2014) Lancet Respir Med , vol.2 , pp. 891-901
    • Brightling, C.E.1    Bleecker, E.R.2    Panettieri, R.A.3
  • 58
    • 84986223146 scopus 로고    scopus 로고
    • What is asthma-COPD overlap syndrome? Towards a consensus definition from a round table discussion
    • Sin, DD, Miravitlles, M, Mannino, DM, et al. What is asthma-COPD overlap syndrome? Towards a consensus definition from a round table discussion. Eur Respir J 48 (2016), 664–673.
    • (2016) Eur Respir J , vol.48 , pp. 664-673
    • Sin, D.D.1    Miravitlles, M.2    Mannino, D.M.3
  • 59
    • 34248206610 scopus 로고    scopus 로고
    • Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial
    • Siva, R, Green, RH, Brightling, CE, et al. Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial. Eur Respir J 29 (2007), 906–913.
    • (2007) Eur Respir J , vol.29 , pp. 906-913
    • Siva, R.1    Green, R.H.2    Brightling, C.E.3
  • 60
    • 66149171754 scopus 로고    scopus 로고
    • Change in inflammation in out-patient COPD patients from stable phase to a subsequent exacerbation
    • Bathoorn, E, Liesker, J, Postma, DS, et al. Change in inflammation in out-patient COPD patients from stable phase to a subsequent exacerbation. Int J Chron Obstruct Pulmon Dis 4 (2009), 101–109.
    • (2009) Int J Chron Obstruct Pulmon Dis , vol.4 , pp. 101-109
    • Bathoorn, E.1    Liesker, J.2    Postma, D.S.3
  • 61
    • 85027294834 scopus 로고    scopus 로고
    • Blood eosinophil counts in normal controls with no history of allergic disease
    • (abstr)
    • Anand, A, Ahmed, O, Pavord, ID, McClure, M, Ferry, B, Pavord, SR, Blood eosinophil counts in normal controls with no history of allergic disease. Thorax, 70, 2015, A111 (abstr).
    • (2015) Thorax , vol.70 , pp. A111
    • Anand, A.1    Ahmed, O.2    Pavord, I.D.3    McClure, M.4    Ferry, B.5    Pavord, S.R.6
  • 62
    • 85028400211 scopus 로고    scopus 로고
    • Eosinophilic chronic obstructive pulmonary disease is not associated with helminth infection or exposure
    • Eltboli, O, Bafadhel, M, Pavord, ID, Chiodini, P, Brightling, CE, Eosinophilic chronic obstructive pulmonary disease is not associated with helminth infection or exposure. J Pulm Respir Med, 4, 2014, 179.
    • (2014) J Pulm Respir Med , vol.4 , pp. 179
    • Eltboli, O.1    Bafadhel, M.2    Pavord, I.D.3    Chiodini, P.4    Brightling, C.E.5
  • 63
    • 84916235780 scopus 로고    scopus 로고
    • Eosinophilic inflammation in COPD: prevalence and clinical characteristics
    • Singh, D, Kolsum, U, Brightling, CE, et al. Eosinophilic inflammation in COPD: prevalence and clinical characteristics. Eur Respir J 44 (2014), 1697–1700.
    • (2014) Eur Respir J , vol.44 , pp. 1697-1700
    • Singh, D.1    Kolsum, U.2    Brightling, C.E.3
  • 64
    • 85028408224 scopus 로고    scopus 로고
    • Blood eosinophils poorly correlate with sputum eosinophils, and have few associations with spirometry, clinical and quantitated computed tomography measures compared to sputum eosinophils in the SPIROMICS cohort
    • Hastie, AT, Alexis, NE, Doerschuk, C, et al. Blood eosinophils poorly correlate with sputum eosinophils, and have few associations with spirometry, clinical and quantitated computed tomography measures compared to sputum eosinophils in the SPIROMICS cohort. Am J Respir Crit Care Med, 193, 2016, A6168.
    • (2016) Am J Respir Crit Care Med , vol.193 , pp. A6168
    • Hastie, A.T.1    Alexis, N.E.2    Doerschuk, C.3
  • 65
    • 84859364494 scopus 로고    scopus 로고
    • The sensitivity and specificity of peripheral blood eosinophilia to predict sputum eosinophilia in COPD subjects
    • (abstr)
    • Bafadhel, M, McKenna, S, Pickering, S, et al. The sensitivity and specificity of peripheral blood eosinophilia to predict sputum eosinophilia in COPD subjects. Am J Respir Crit Care Med, 179, 2009, A1479 (abstr).
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. A1479
    • Bafadhel, M.1    McKenna, S.2    Pickering, S.3
  • 66
    • 85028394528 scopus 로고    scopus 로고
    • Can blood eosinophils predict sputum eosinophils in stable COPD?
    • Negewo, N, McDonald, V, Baines, K, et al. Can blood eosinophils predict sputum eosinophils in stable COPD?. Eur Respir J, 46(suppl 59), 2015, PA3967.
    • (2015) Eur Respir J , vol.46 , pp. PA3967
    • Negewo, N.1    McDonald, V.2    Baines, K.3
  • 67
    • 0042750839 scopus 로고    scopus 로고
    • World Health Organization Geneva (accessed March 12, 2017).
    • WHO. Biomarkers in risk assessment: validity and validation, 2001, World Health Organization, Geneva http://www.inchem.org/documents/ehc/ehc/ehc222.htm (accessed March 12, 2017).
    • (2001) Biomarkers in risk assessment: validity and validation
  • 68
    • 0035662268 scopus 로고    scopus 로고
    • Induced sputum and other outcome measures in chronic obstructive pulmonary disease: safety and repeatability
    • Brightling, CE, Monterio, W, Green, RH, et al. Induced sputum and other outcome measures in chronic obstructive pulmonary disease: safety and repeatability. Respir Med 95 (2001), 999–1002.
    • (2001) Respir Med , vol.95 , pp. 999-1002
    • Brightling, C.E.1    Monterio, W.2    Green, R.H.3
  • 69
    • 0037335886 scopus 로고    scopus 로고
    • Long-term repeatability of induced sputum cells and inflammatory markers in stable, moderately severe COPDa
    • Beeh, KM, Beier, J, Kornmann, O, Mander, A, Buhl, R, Long-term repeatability of induced sputum cells and inflammatory markers in stable, moderately severe COPDa. Chest 123 (2003), 778–783.
    • (2003) Chest , vol.123 , pp. 778-783
    • Beeh, K.M.1    Beier, J.2    Kornmann, O.3    Mander, A.4    Buhl, R.5
  • 70
    • 77956689733 scopus 로고    scopus 로고
    • Susceptibility to exacerbation in chronic obstructive pulmonary disease
    • Hurst, JR, Vestbo, J, Anzueto, A, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med 363 (2010), 1128–1138.
    • (2010) N Engl J Med , vol.363 , pp. 1128-1138
    • Hurst, J.R.1    Vestbo, J.2    Anzueto, A.3
  • 71
    • 0028358808 scopus 로고
    • Factors influencing the occurrence of airway hyperreactivity in the general population: the importance of atopy and airway calibre
    • Britton, J, Pavord, I, Richards, K, et al. Factors influencing the occurrence of airway hyperreactivity in the general population: the importance of atopy and airway calibre. Eur Respir J, 7, 1994, 881.
    • (1994) Eur Respir J , vol.7 , pp. 881
    • Britton, J.1    Pavord, I.2    Richards, K.3
  • 72
    • 0033431650 scopus 로고    scopus 로고
    • Asthma attacks with eosinophilia predict mortality from chronic obstructive pulmonary disease in a general population sample
    • Hospers, JJ, Schouten, JP, Weiss, ST, Rijcken, B, Postma, DS, Asthma attacks with eosinophilia predict mortality from chronic obstructive pulmonary disease in a general population sample. Am J Respir Crit Care Med 160 (1999), 1869–1874.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1869-1874
    • Hospers, J.J.1    Schouten, J.P.2    Weiss, S.T.3    Rijcken, B.4    Postma, D.S.5
  • 73
    • 0034649053 scopus 로고    scopus 로고
    • Histamine airway hyper-responsiveness and mortality from chronic obstructive pulmonary disease: a cohort study
    • Hospers, JJ, Postma, DS, Rijcken, B, Weiss, ST, Schouten, JP, Histamine airway hyper-responsiveness and mortality from chronic obstructive pulmonary disease: a cohort study. Lancet 356 (2000), 1313–1317.
    • (2000) Lancet , vol.356 , pp. 1313-1317
    • Hospers, J.J.1    Postma, D.S.2    Rijcken, B.3    Weiss, S.T.4    Schouten, J.P.5
  • 74
    • 0033199934 scopus 로고    scopus 로고
    • Eosinophilia and positive skin tests predict cardiovascular mortality in a general population sample followed for 30 years
    • Hospers, JJ, Rijcken, B, Schouten, JP, Postma, DS, Weiss, ST, Eosinophilia and positive skin tests predict cardiovascular mortality in a general population sample followed for 30 years. Am J Epidemiol 150 (1999), 482–491.
    • (1999) Am J Epidemiol , vol.150 , pp. 482-491
    • Hospers, J.J.1    Rijcken, B.2    Schouten, J.P.3    Postma, D.S.4    Weiss, S.T.5
  • 75
    • 0034007758 scopus 로고    scopus 로고
    • Eosinophilia is associated with increased all-cause mortality after a follow-up of 30 years in a general population sample
    • Hospers, JJ, Schouten, JP, Weiss, ST, Postma, DS, Rijcken, B, Eosinophilia is associated with increased all-cause mortality after a follow-up of 30 years in a general population sample. Epidemiology 11 (2000), 261–268.
    • (2000) Epidemiology , vol.11 , pp. 261-268
    • Hospers, J.J.1    Schouten, J.P.2    Weiss, S.T.3    Postma, D.S.4    Rijcken, B.5
  • 76
    • 84988952068 scopus 로고    scopus 로고
    • Blood eosinophils and exacerbations in chronic obstructive pulmonary disease. The Copenhagen General Population Study
    • Vedel-Krogh, S, Nielsen, SF, Lange, P, Vestbo, J, Nordestgaard, BG, Blood eosinophils and exacerbations in chronic obstructive pulmonary disease. The Copenhagen General Population Study. Am J Respir Crit Care Med 193 (2016), 965–974.
    • (2016) Am J Respir Crit Care Med , vol.193 , pp. 965-974
    • Vedel-Krogh, S.1    Nielsen, S.F.2    Lange, P.3    Vestbo, J.4    Nordestgaard, B.G.5
  • 77
    • 84969750034 scopus 로고    scopus 로고
    • Blood eosinophils as a marker of response to inhaled corticosteroids in COPD
    • Barnes, NC, Sharma, R, Lettis, S, Calverley, PM, Blood eosinophils as a marker of response to inhaled corticosteroids in COPD. Eur Respir J 47 (2016), 1374–1382.
    • (2016) Eur Respir J , vol.47 , pp. 1374-1382
    • Barnes, N.C.1    Sharma, R.2    Lettis, S.3    Calverley, P.M.4
  • 78
    • 84994641724 scopus 로고    scopus 로고
    • The time course of pulmonary function tests in COPD patients with different levels of blood eosinophils
    • Rogliani, P, Puxeddu, E, Ciaprini, C, et al. The time course of pulmonary function tests in COPD patients with different levels of blood eosinophils. Biomed Res Int, 2016, 2016, 4547953.
    • (2016) Biomed Res Int , vol.2016 , pp. 4547953
    • Rogliani, P.1    Puxeddu, E.2    Ciaprini, C.3
  • 79
    • 84955562318 scopus 로고    scopus 로고
    • Prediction of long-term benefits of inhaled steroids by phenotypic markers in moderate-to-severe COPD: a randomized controlled trial
    • Snoeck-Stroband, JB, Lapperre, TS, Sterk, PJ, et al. Prediction of long-term benefits of inhaled steroids by phenotypic markers in moderate-to-severe COPD: a randomized controlled trial. PLoS One, 10, 2015, e0143793.
    • (2015) PLoS One , vol.10 , pp. e0143793
    • Snoeck-Stroband, J.B.1    Lapperre, T.S.2    Sterk, P.J.3
  • 80
  • 82
    • 0031731419 scopus 로고    scopus 로고
    • Sputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitis
    • Pizzichini, E, Pizzichini, MM, Gibson, P, et al. Sputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitis. Am J Respir Crit Care Med 158 (1998), 1511–1517.
    • (1998) Am J Respir Crit Care Med , vol.158 , pp. 1511-1517
    • Pizzichini, E.1    Pizzichini, M.M.2    Gibson, P.3
  • 83
    • 20144382091 scopus 로고    scopus 로고
    • Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease
    • Brightling, CE, McKenna, S, Hargadon, B, et al. Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease. Thorax 60 (2005), 193–198.
    • (2005) Thorax , vol.60 , pp. 193-198
    • Brightling, C.E.1    McKenna, S.2    Hargadon, B.3
  • 84
    • 84906868882 scopus 로고    scopus 로고
    • Management of COPD in the UK primary-care setting: an analysis of real-life prescribing patterns
    • Price, D, West, D, Brusselle, G, et al. Management of COPD in the UK primary-care setting: an analysis of real-life prescribing patterns. Int J Chron Obstruct Pulmon Dis 9 (2014), 889–904.
    • (2014) Int J Chron Obstruct Pulmon Dis , vol.9 , pp. 889-904
    • Price, D.1    West, D.2    Brusselle, G.3
  • 85
    • 84989195861 scopus 로고    scopus 로고
    • 2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY): a double-blind, parallel group, randomised controlled trial
    • 2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY): a double-blind, parallel group, randomised controlled trial. Lancet 388 (2016), 963–973.
    • (2016) Lancet , vol.388 , pp. 963-973
    • Singh, D.1    Papi, A.2    Corradi, M.3
  • 86
    • 0347473812 scopus 로고    scopus 로고
    • Maintenance therapy with budesonide and formoterol in chronic obstructive pulmonary disease
    • Calverley, PM, Boonsawat, W, Cseke, Z, Zhong, N, Peterson, S, Olsson, H, Maintenance therapy with budesonide and formoterol in chronic obstructive pulmonary disease. Eur Respir J 22 (2003), 912–919.
    • (2003) Eur Respir J , vol.22 , pp. 912-919
    • Calverley, P.M.1    Boonsawat, W.2    Cseke, Z.3    Zhong, N.4    Peterson, S.5    Olsson, H.6
  • 87
    • 0037425745 scopus 로고    scopus 로고
    • Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial
    • Calverley, P, Pauwels, R, Vestbo, J, et al. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 361 (2003), 449–456.
    • (2003) Lancet , vol.361 , pp. 449-456
    • Calverley, P.1    Pauwels, R.2    Vestbo, J.3
  • 88
    • 84877126115 scopus 로고    scopus 로고
    • Once-daily inhaled fluticasone furoate and vilanterol versus vilanterol only for prevention of exacerbations of COPD: two replicate double-blind, parallel-group, randomised controlled trials
    • Dransfield, MT, Bourbeau, J, Jones, PW, et al. Once-daily inhaled fluticasone furoate and vilanterol versus vilanterol only for prevention of exacerbations of COPD: two replicate double-blind, parallel-group, randomised controlled trials. Lancet Respir Med 1 (2013), 210–223.
    • (2013) Lancet Respir Med , vol.1 , pp. 210-223
    • Dransfield, M.T.1    Bourbeau, J.2    Jones, P.W.3
  • 89
    • 84906322078 scopus 로고    scopus 로고
    • Extrafine beclomethasone/formoterol in severe COPD patients with history of exacerbations
    • Wedzicha, JA, Singh, D, Vestbo, J, et al. Extrafine beclomethasone/formoterol in severe COPD patients with history of exacerbations. Respir Med 108 (2014), 1153–1162.
    • (2014) Respir Med , vol.108 , pp. 1153-1162
    • Wedzicha, J.A.1    Singh, D.2    Vestbo, J.3
  • 90
    • 0034643610 scopus 로고    scopus 로고
    • Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial
    • Burge, PS, Calverley, PM, Jones, PW, Spencer, S, Anderson, JA, Maslen, TK, Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial. BMJ 320 (2000), 1297–1303.
    • (2000) BMJ , vol.320 , pp. 1297-1303
    • Burge, P.S.1    Calverley, P.M.2    Jones, P.W.3    Spencer, S.4    Anderson, J.A.5    Maslen, T.K.6
  • 91
    • 37849011194 scopus 로고    scopus 로고
    • The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide
    • Wedzicha, JA, Calverley, PM, Seemungal, TA, et al. The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide. Am J Respir Crit Care Med 177 (2008), 19–26.
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 19-26
    • Wedzicha, J.A.1    Calverley, P.M.2    Seemungal, T.A.3
  • 92
    • 33847172367 scopus 로고    scopus 로고
    • Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
    • Calverley, PM, Anderson, JA, Celli, B, et al. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med 356 (2007), 775–789.
    • (2007) N Engl J Med , vol.356 , pp. 775-789
    • Calverley, P.M.1    Anderson, J.A.2    Celli, B.3
  • 93
    • 84968779698 scopus 로고    scopus 로고
    • Fluticasone furoate and vilanterol and survival in chronic obstructive pulmonary disease with heightened cardiovascular risk (SUMMIT): a double-blind randomised controlled trial
    • Vestbo, J, Anderson, JA, Brook, RD, et al., SUMMIT Investigators. Fluticasone furoate and vilanterol and survival in chronic obstructive pulmonary disease with heightened cardiovascular risk (SUMMIT): a double-blind randomised controlled trial. Lancet 387 (2016), 1817–1826.
    • (2016) Lancet , vol.387 , pp. 1817-1826
    • Vestbo, J.1    Anderson, J.A.2    Brook, R.D.3
  • 94
    • 84877599739 scopus 로고    scopus 로고
    • Number needed to treat in COPD: exacerbations versus pneumonias
    • Suissa, S, Number needed to treat in COPD: exacerbations versus pneumonias. Thorax 68 (2013), 540–543.
    • (2013) Thorax , vol.68 , pp. 540-543
    • Suissa, S.1
  • 95
    • 84879713090 scopus 로고    scopus 로고
    • Pneumonia and pneumonia related mortality in patients with COPD treated with fixed combinations of inhaled corticosteroid and long acting β2 agonist: observational matched cohort study (PATHOS)
    • Janson, C, Larsson, K, Lisspers, KH, et al. Pneumonia and pneumonia related mortality in patients with COPD treated with fixed combinations of inhaled corticosteroid and long acting β2 agonist: observational matched cohort study (PATHOS). BMJ, 346, 2013, f3306.
    • (2013) BMJ , vol.346 , pp. f3306
    • Janson, C.1    Larsson, K.2    Lisspers, K.H.3
  • 96
    • 84885766455 scopus 로고    scopus 로고
    • Inhaled corticosteroids in COPD and the risk of serious pneumonia
    • Suissa, S, Patenaude, V, Lapi, F, Ernst, P, Inhaled corticosteroids in COPD and the risk of serious pneumonia. Thorax 68 (2013), 1029–1036.
    • (2013) Thorax , vol.68 , pp. 1029-1036
    • Suissa, S.1    Patenaude, V.2    Lapi, F.3    Ernst, P.4
  • 97
    • 84907779764 scopus 로고    scopus 로고
    • Withdrawal of inhaled glucocorticoids and exacerbations of COPD
    • Magnussen, H, Disse, B, Rodriguez-Roisin, R, et al. Withdrawal of inhaled glucocorticoids and exacerbations of COPD. N Engl J Med 371 (2014), 1285–1294.
    • (2014) N Engl J Med , vol.371 , pp. 1285-1294
    • Magnussen, H.1    Disse, B.2    Rodriguez-Roisin, R.3
  • 98
    • 84933526262 scopus 로고    scopus 로고
    • LANTERN: a randomized study of QVA149 versus salmeterol/fluticasone combination in patients with COPD
    • Zhong, N, Wang, C, Zhou, X, et al. LANTERN: a randomized study of QVA149 versus salmeterol/fluticasone combination in patients with COPD. Int J Chron Obstruct Pulmon Dis 10 (2015), 1015–1026.
    • (2015) Int J Chron Obstruct Pulmon Dis , vol.10 , pp. 1015-1026
    • Zhong, N.1    Wang, C.2    Zhou, X.3
  • 99
    • 84877676197 scopus 로고    scopus 로고
    • Efficacy and safety of once-daily QVA149 compared with twice-daily salmeterol–fluticasone in patients with chronic obstructive pulmonary disease (ILLUMINATE): a randomised, double-blind, parallel group study
    • Vogelmeier, CF, Bateman, ED, Pallante, J, et al. Efficacy and safety of once-daily QVA149 compared with twice-daily salmeterol–fluticasone in patients with chronic obstructive pulmonary disease (ILLUMINATE): a randomised, double-blind, parallel group study. Lancet Respir Med 1 (2013), 51–60.
    • (2013) Lancet Respir Med , vol.1 , pp. 51-60
    • Vogelmeier, C.F.1    Bateman, E.D.2    Pallante, J.3
  • 100
    • 85028383367 scopus 로고    scopus 로고
    • QVA149 compared with salmeterol/fluticasone (SFC) on exacerbations and its correlation with baseline blood eosinophils: a pooled analysis of LANTERN and ILLUMINATE
    • (abstr)
    • Wedzicha, JA, Price, D, Mezzi, K, Fogel, R, Banerji, D, QVA149 compared with salmeterol/fluticasone (SFC) on exacerbations and its correlation with baseline blood eosinophils: a pooled analysis of LANTERN and ILLUMINATE. Eur Respir J, 46, 2015, PA1005 (abstr).
    • (2015) Eur Respir J , vol.46 , pp. PA1005
    • Wedzicha, J.A.1    Price, D.2    Mezzi, K.3    Fogel, R.4    Banerji, D.5
  • 101
    • 84973882932 scopus 로고    scopus 로고
    • Indacaterol–glycopyrronium versus salmeterol–fluticasone for COPD
    • Wedzicha, JA, Banerji, D, Chapman, KR, et al. Indacaterol–glycopyrronium versus salmeterol–fluticasone for COPD. N Engl J Med 374 (2016), 2222–2234.
    • (2016) N Engl J Med , vol.374 , pp. 2222-2234
    • Wedzicha, J.A.1    Banerji, D.2    Chapman, K.R.3
  • 103
    • 0036794862 scopus 로고    scopus 로고
    • Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
    • Donaldson, GC, Seemungal, TA, Bhowmik, A, Wedzicha, JA, Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax 57 (2002), 847–852.
    • (2002) Thorax , vol.57 , pp. 847-852
    • Donaldson, G.C.1    Seemungal, T.A.2    Bhowmik, A.3    Wedzicha, J.A.4
  • 104
    • 1842671720 scopus 로고    scopus 로고
    • Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments)
    • Connors, AF Jr, Dawson, NV, Thomas, C, et al. Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments). Am J Respir Crit Care Med 154 (1996), 959–967.
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 959-967
    • Connors, A.F.1    Dawson, N.V.2    Thomas, C.3
  • 106
    • 0034064973 scopus 로고    scopus 로고
    • Toward a consensus definition for COPD exacerbations
    • Rodriguez-Roisin, R, Toward a consensus definition for COPD exacerbations. Chest 117:suppl 2 (2000), 398S–401S.
    • (2000) Chest , vol.117 , pp. 398S-401S
    • Rodriguez-Roisin, R.1
  • 108
    • 0028027511 scopus 로고
    • Airway eosinophilia in chronic bronchitis during exacerbations
    • Saetta, M, Di Stefano, A, Maestrelli, P, et al. Airway eosinophilia in chronic bronchitis during exacerbations. Am J Respir Crit Care Med 150 (1994), 1646–1652.
    • (1994) Am J Respir Crit Care Med , vol.150 , pp. 1646-1652
    • Saetta, M.1    Di Stefano, A.2    Maestrelli, P.3
  • 109
    • 66149171754 scopus 로고    scopus 로고
    • Change in inflammation in out-patient COPD patients from stable phase to a subsequent exacerbation
    • Bathoorn, E, Liesker, J, Postma, DS, et al. Change in inflammation in out-patient COPD patients from stable phase to a subsequent exacerbation. Int J Chron Obstruct Pulmon Dis 4 (2009), 101–109.
    • (2009) Int J Chron Obstruct Pulmon Dis , vol.4 , pp. 101-109
    • Bathoorn, E.1    Liesker, J.2    Postma, D.S.3
  • 111
    • 85011600806 scopus 로고    scopus 로고
    • Eosinophils in COPD exacerbations are associated with increased readmissions
    • Couillard, S, Larivee, P, Courteau, J, Vanasse, A, Eosinophils in COPD exacerbations are associated with increased readmissions. Chest 151 (2017), 366–373.
    • (2017) Chest , vol.151 , pp. 366-373
    • Couillard, S.1    Larivee, P.2    Courteau, J.3    Vanasse, A.4
  • 112
    • 84981169484 scopus 로고    scopus 로고
    • Blood eosinophils and outcomes in severe hospitalized exacerbations of COPD
    • Bafadhel, M, Greening, NJ, Harvey-Dunstan, TC, et al. Blood eosinophils and outcomes in severe hospitalized exacerbations of COPD. Chest 150 (2016), 320–328.
    • (2016) Chest , vol.150 , pp. 320-328
    • Bafadhel, M.1    Greening, N.J.2    Harvey-Dunstan, T.C.3
  • 113
    • 74049091219 scopus 로고    scopus 로고
    • Eosinopenia as a marker of mortality and length of stay in patients admitted with exacerbations of chronic obstructive pulmonary disease
    • Holland, M, Alkhalil, M, Chandromouli, S, Janjua, A, Babores, M, Eosinopenia as a marker of mortality and length of stay in patients admitted with exacerbations of chronic obstructive pulmonary disease. Respirology 15 (2010), 165–167.
    • (2010) Respirology , vol.15 , pp. 165-167
    • Holland, M.1    Alkhalil, M.2    Chandromouli, S.3    Janjua, A.4    Babores, M.5
  • 114
    • 84868193054 scopus 로고    scopus 로고
    • The DECAF Score: predicting hospital mortality in exacerbations of chronic obstructive pulmonary disease
    • Steer, J, Gibson, J, Bourke, SC, The DECAF Score: predicting hospital mortality in exacerbations of chronic obstructive pulmonary disease. Thorax 67 (2012), 970–976.
    • (2012) Thorax , vol.67 , pp. 970-976
    • Steer, J.1    Gibson, J.2    Bourke, S.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.