The dynamics of gastric emptying and self-reported feelings of satiation are better predictors than gastrointestinal hormones of the effects of lipid emulsion structure on fat digestion in healthy adults-A Bayesian inference approach

Journal of Nutrition

Volumn 147, Issue 4, 2017, Pages 706-714

  Steingoetter, Andreas ^a,b,e   Buetikofer, Simon ^a,e   Curcic, Jelena ^a,b   Menne, Dieter ^c   Rehfeld, Jens F ^d   Fried, Michael ^a   Schwizer, Werner ^a   Wooster, Tim J ^e  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c Menne Biomed Consulting   (Germany)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

Acid stability; Cholecystokinin; Droplet size; Fat emulsion; Gastric emptying; Ghrelin; Glucagon like peptide 1; MRI; Peptide YY; Satiation

Indexed keywords

ACID; CHOLECYSTOKININ; FAT DROPLET; GHRELIN; GLUCAGON LIKE PEPTIDE 1; LIPID EMULSION; PEPTIDE YY; HORMONE; LIPID;

ADULT; ARTICLE; BAYES THEOREM; BODY MASS; CONTROLLED STUDY; DIGESTION; FEMALE; HORMONE DETERMINATION; HUMAN; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTIVE VALUE; SATIETY; SELF REPORT; STOMACH EMPTYING; STOMACH FUNCTION; ADOLESCENT; CHEMISTRY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; GASTROINTESTINAL TRACT; METABOLISM; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SATIETY RESPONSE; YOUNG ADULT;

ADOLESCENT; ADULT; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; GASTRIC EMPTYING; GASTROINTESTINAL TRACT; HORMONES; HUMANS; LIPIDS; MALE; SATIETY RESPONSE; YOUNG ADULT;

EID: 85020210092     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.116.237800     Document Type: Article

References (42)

1. Carey MC, Small DM, Bliss CM. Lipid digestion and absorption. Annu Rev Physiol 1983;45:651-77
2. Favé G, Coste TC, Armand M. Physicochemical properties of lipids: new strategies to manage fatty acid bioavailability. Cell Mol Biol 2004;50:815-31
3. Little TJ, Feinle-Bisset C. Oral and gastrointestinal sensing of dietary fat and appetite regulation in humans: modification by diet and obesity. Front Neurosci 2010;4:178
4. Mattes RD. The role of macronutrients in appetite regulation. Can J Diet Pract Res 2007;68:3
5. Chapman IM, Goble EA, Wittert GA, Horowitz M. Effects of smallintestinal fat and carbohydrate infusions on appetite and food intake in obese and nonobese men. Am J Clin Nutr 1999;69:6-12
6. Cook CG, Andrews JM, Jones KL, Wittert GA, Chapman IM, Morley JE, Horowitz M. Effects of small intestinal nutrient infusion on appetite and pyloric motility are modified by age. Am J Physiol 1997;273:R755-61
7. Goetze O, Steingoetter A, Menne D, van der Voort IR, Kwiatek MA, Boesiger P, Weishaupt D, Thumshirn M, Fried M, Schwizer W. The effect of macronutrients on gastric volume responses and gastric emptying in humans: a magnetic resonance imaging study. Am J Physiol Gastrointest Liver Physiol 2007;292:G11-7
8. Levine ME, Koch SY, Koch KL. Lipase supplementation before a highfat meal reduces perceptions of fullness in healthy subjects. Gut Liver 2015;9:464-9
9. Feinle C, ODonovan D, Doran S, Andrews JM, Wishart J, Chapman I, Horowitz M. Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans. Am J Physiol Gastrointest Liver Physiol 2003;284:G798-807
10. Marciani L, Faulks R, Wickham MS, Bush D, Pick B, Wright J, Cox EF, Fillery-Travis A, Gowland PA, Spiller RC. Effect of intragastric acid stability of fat emulsions on gastric emptying, plasma lipid profile and postprandial satiety. Br J Nutr 2009;101:919-28
11. Seimon RV, Wooster T, Otto B, Golding M, Day L, Little TJ, Horowitz M, Clifton PM, Feinle-Bisset C. The droplet size of intraduodenal fat emulsions influences antropyloroduodenal motility, hormone release, and appetite in healthy males. Am J Clin Nutr 2009;89:1729-36
12. Maljaars PWJ, van der Wal RJP, Wiersma T, Peters HPF, Haddeman E, Masclee AAM. The effect of lipid droplet size on satiety and peptide secretion is intestinal site-specific. Clin Nutr 2012;31:535-42
13. Steingoetter A, Radovic T, Buetikofer S, Curcic J, Menne D, Fried M, Schwizer W, Wooster TJ. Imaging gastric structuring of lipid emulsions and its effect on gastrointestinal function: a randomized trial in healthy subjects. Am J Clin Nutr 2015;101:714-24
14. Feinle-Bisset C, Patterson M, Ghatei MA, Bloom SR, Horowitz M. Fat digestion is required for suppression of ghrelin and stimulation of peptide YYand pancreatic polypeptide secretion by intraduodenal lipid. Am J Physiol Endocrinol Metab 2005;289:E948-53
15. Heddle R, Dent J, Read NW, Houghton LA, Toouli J, Horowitz M, Maddern GJ, Downton J. Antropyloroduodenal motor responses to intraduodenal lipid infusion in healthy volunteers. Am J Physiol 1988;254:G671-79
16. Schwizer W, Asal K, Kreiss C, Mettraux C, Borovicka J, Remy B, Guzelhan C, Hartmann D, FriedM. Role of lipase in the regulation of upper gastrointestinal function in humans. Am J Physiol 1997;273:G612-20
17. Feltrin KL, Little TJ, Meyer JH, Horowitz M, Smout A, Wishart J, Pilichiewicz AN, Rades T, Chapman IM, Feinle-Bisset C. Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length. Am J Physiol Regul Integr Comp Physiol 2004;287:R524-33
18. Pilichiewicz AN, Papadopoulos P, Brennan IM, Little TJ, Meyer JH, Wishart JM, Horowitz M, Feinle-Bisset C. Load-dependent effects of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men. Am J Physiol Regul Integr Comp Physiol 2007;293:R2170-78
19. Camilleri M. Peripheral mechanisms in appetite regulation. Gastroenterology 2015;148:1219-33
20. Fruehauf H, Goetze O, Steingoetter A, Kwiatek M, Boesiger P, Thumshirn M, Schwizer W, Fried M. Intersubject and intrasubject variability of gastric volumes in response to isocaloric liquid meals in functional dyspepsia and health. Neurogastroenterol Motil 2007;19:553-61
21. Golding M, Wooster TJ. The influence of emulsion structure and stability on lipid digestion. Curr Opin Colloid Interface Sci 2010;15:90-101
22. Golding M, Wooster TJ, Day L, Xu M, Lundin L, Keogh J, Clifton P. Impact of gastric structuring on the lipolysis of emulsified lipids. Soft Matter 2011;7:3513-23
23. Keogh JB, Wooster TJ, Golding M, Day L, Otto B, Clifton PM. Slowly and rapidly digested fat emulsions are equally satiating but their triglycerides are differentially absorbed and metabolized in humans. J Nutr 2011;141:809-15
24. Blatnik M, Soderstrom CI. A practical guide for the stabilization of acylghrelin in human blood collections. Clin Endocrinol (Oxf) 2011;74:325-31
25. Rehfeld JF. Accurate measurement of cholecystokinin in plasma. Clin Chem 1998;44:991-1001
26. Rehfeld JF, Sun G, Christensen T, Hillingso JG. The predominant cholecystokinin in human plasma and intestine is cholecystokinin-33. J Clin Endocrinol Metab 2001;86:251-8
27. Christensen RHB. Ordinal: Regression models for ordinal data. R package version 2015. 6-28 [Internet]. [cited 2015 Jun 28]. Available from: https://cran. r-project. org/web/packages/ordinal/index. html
28. Raftery A, Hoeting J, Volinsky C, Painter I, Yeung KY. BMA: Bayesian model averaging. R package version 3. 18. 4 [Internet]. [cited 2015 Nov 6]. Available from: https://cran. r-project. org/web/packages/BMA/index. html
29. Marciani L, Wickham M, Singh G, Bush D, Pick B, Cox E, Fillery-Travis A, Faulks R, Marsden C, Gowland PA, et al. Enhancement of intragastric acid stability of a fat emulsion meal delays gastric emptying and increases cholecystokinin release and gallbladder contraction. Am J Physiol Gastrointest Liver Physiol 2007;292:G1607-13
30. Hussein MO, Hoad CL, Wright J, Singh G, Stephenson MC, Cox EF, Placidi E, Pritchard SE, Costigan C, Ribeiro H, et al. Fat emulsion intragastric stability and droplet size modulate gastrointestinal responses and subsequent food intake in young adults. J Nutr 2015;145:1170-7
31. Foltz M, Maljaars J, Schuring EA, van der Wal RJ, Boer T, Duchateau GS, Peters HP, Stellaard F, Masclee AA. Intragastric layering of lipids delays lipid absorption and increases plasma CCK but has minor effects on gastric emptying and appetite. Am J Physiol Gastrointest Liver Physiol 2009;296:G982-91
32. Little TJ, Russo A, Meyer JH, Horowitz M, Smyth DR, Bellon M, Wishart JM, Jones KL, Feinle-Bisset C. Free fatty acids have more potent effects on gastric emptying, gut hormones, and appetite than triacylglycerides. Gastroenterology 2007;133:1124-31
33. Feinle-Bisset C, Azpiroz F. Dietary lipids and functional gastrointestinal disorders. Am J Gastroenterol 2013;108:737-47
34. Hoeting JA, Madigan D, Raftery AE, Volinsky CT. Bayesian model averaging: a tutorial. Stat Sci 1999;14:382-417
35. Little TJ, Feinle-Bisset C. Effects of dietary fat on appetite and energy intake in health and obesity-oral and gastrointestinal sensory contributions. Physiol Behav 2011;104:613-20
36. Maljaars PWJ, Peters HPF, Mela DJ, Masclee AAM. Ileal brake: a sensible food target for appetite control. A review. Physiol Behav 2008;95:271-81
37. Matzinger D, Degen L, Drewe J, Meuli J, Duebendorfer R, Ruckstuhl N, DAmato M, Rovati L, Beglinger C. The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans. Gut 2000;46:688-93
38. Seimon RV, Feltrin KL, Meyer JH, Brennan IM, Wishart JM, Horowitz M, Feinle-Bisset C. Effects of varying combinations of intraduodenal lipid and carbohydrate on antropyloroduodenal motility, hormone release, and appetite in healthy males. Am J Physiol Regul Integr Comp Physiol 2009;296:R912-20
39. Ryan AT, Luscombe-Marsh ND, Saies AA, Little TJ, Standfield S, Horowitz M, Feinle-Bisset C. Effects of intraduodenal lipid and protein on gut motility and hormone release, glycemia, appetite, and energy intake in lean men. Am J Clin Nutr 2013;98:300-11
40. Schober G, Lange K, Steinert RE, Hutchison AT, Luscombe-Marsh ND, Landrock MF, Horowitz M, Seimon RV, Feinle-Bisset C. Contributions of upper gut hormones and motility to the energy intake-suppressant effects of intraduodenal nutrients in healthy, lean men-a pooled-data analysis. Physiol Rep 2016;4:e12943
41. Sarkar A, Juan JM, Kolodziejczyk E, Acquistapace S, Donato-Capel L, Wooster TJ. Impact of protein gel porosity on the digestion of lipid emulsions. J Agric Food Chem 2015;63:8829-37
42. Wooster TJ, Day L, Xu M, Golding M, Oiseth S, Keogh J, Clifton P. Impact of different biopolymer networks on the digestion of gastric structured emulsions. Food Hydrocoll 2014;36:102-14