Imaging gastric structuring of lipid emulsions and its effect on gastrointestinal function: A randomized trial in healthy subjects

American Journal of Clinical Nutrition

Volumn 101, Issue 4, 2015, Pages 714-724

  Steingoetter, Andreas ^a,b   Radovic, Tijana ^a   Buetikofer, Simon ^a   Curcic, Jelena ^a   Menne, Dieter ^c   Fried, Michael ^a   Schwizer, Werner ^a   Wooster, Tim J ^d,e  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c Menne Biomed Consulting   (Germany)

^d CSIRO   (Australia)

^e NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

Acid stability; Fat digestion; Gastrointestinal function; Lipid emulsion; Magnetic resonance imaging

Indexed keywords

FAT; LIPID EMULSION; TRIACYLGLYCEROL; EMULSION; LIPID;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DYNAMICS; FEMALE; GALLBLADDER; GASTROINTESTINAL SECRETION; GASTROINTESTINAL TRACT; GASTROINTESTINAL TRACT FUNCTION; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; RANDOMIZED CONTROLLED TRIAL; SMALL INTESTINE; STOMACH EMPTYING; TRIACYLGLYCEROL BLOOD LEVEL; ADOLESCENT; BLOOD; CHEMISTRY; DIGESTION; EMULSION; NORMAL HUMAN; PHYSIOLOGY; POSTPRANDIAL STATE; STOMACH; YOUNG ADULT;

ADOLESCENT; ADULT; BODY MASS INDEX; CROSS-OVER STUDIES; DIGESTION; DOUBLE-BLIND METHOD; EMULSIONS; FEMALE; GASTRIC EMPTYING; HEALTHY VOLUNTEERS; HUMANS; LIPIDS; MAGNETIC RESONANCE IMAGING; MALE; POSTPRANDIAL PERIOD; STOMACH; TRIGLYCERIDES; YOUNG ADULT;

EID: 84929658252     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.114.100263     Document Type: Article

References (47)

1. Golding M,Wooster TJ. The influence of emulsion structure and stability on lipid digestion. Curr Opin Colloid Interface Sci 2010;15:90-101.
2. Chan M. Opening address at the 8th Global Conference on Health Promotion. 8th Global Conference on Health Promotion, Helsinki, Finland, 2013 June 10-14.
3. Porter CJH, Trevaskis NL, Charman WN. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov 2007;6:231-48.
4. FavéG, Coste TC, Armand M. Physicochemical properties of lipids: new strategies to manage fatty acid bioavailability. Cell Mol Biol 2004;50:815-31.
5. Carey MC, Small DM, Bliss CM. Lipid digestion and absorption. Annu Rev Physiol 1983;45:651-77.
6. Christensen JØ, Schultz K, Mollgaard B, Kristensen HG, Mullertz A. Solubilization of poorly water-soluble drugs during in vitro lipolysis of medium-and long-chain triacylglycerols. Eur J Pharm Sci 2004;23: 287-96.
7. Borel P, Grolier P, Armand M, Partier A, Lafont H, Lairon D, Azaisbraesco V. Carotenoids in biological emulsions: solubility, surface-to-core distribution, and release from lipid droplets. J Lipid Res 1996;37:250-61.
8. Ostlund RE Jr. Phytosterols in human nutrition. Annu Rev Nutr 2002;22:533-49.
9. McClements DJ, Decker EA, Park Y. Controlling lipid bioavailability through physicochemical and structural approaches. Crit Rev Food Sci Nutr 2009;49:48-67.
10. Maldonado-Valderrama J, Wilde P, Macierzanka A, Mackie A. The role of bile salts in digestion. Adv Colloid Interface Sci 2011;165: 36-46.
11. Golding M, Wooster TJ, Day L, Xu M, Lundin L, Keogh J, Clifton P. Impact of gastric structuring on the lipolysis of emulsified lipids. Soft Matter 2011;7:3513-23.
12. Marciani L, Faulks R, Wickham MSJ, Bush D, Pick B, Wright J, Cox EF, Fillery-Travis A, Gowland PA, Spiller RC. Effect of intragastric acid stability of fat emulsions on gastric emptying, plasma lipid profile and postprandial satiety. Br J Nutr 2009;101:919-28.
13. Day L, Golding M, Xu M, Keogh J, Clifton P, Wooster TJ. Tailoring the digestion of structured emulsions using mixed monoglyceridecaseinate interfaces. Food Hydrocoll 2014;36:151-61.
14. Wooster TJ, Day L, Xu M, Golding M, Oiseth S, Keogh J, Clifton P. Impact of different biopolymer networks on the digestion of gastric structured emulsions. Food Hydrocoll 2014;36:102-14.
15. Wickham M, Wilde P, Fillery-Travis A. A physicochemical investigation of two phosphatidylcholine/bile salt interfaces: implications for lipase activation. Biochim Biophys Acta 2002;1580:110-22.
16. Reis PM, Raab TW, Chuat JY, Leser ME, Miller R, Watzke HJ, Holmberg K. Influence of surfactants on lipase fat digestion in a model gastro-intestinal system. Food Biophys 2008;3:370-81.
17. Sarkar A, Horne DS, Singh H. Interactions of milk protein-stabilized oil-in-water emulsions with bile salts in a simulated upper intestinal model. Food Hydrocoll 2009;24:142-51.
18. Tiss A, Carriere F, Douchet I, Patkar S, Svendsen A, Verger R. Interfacial binding and activity of lipases at the lipid-water interface: effects of gum arabic and surface pressure. Colloids Surf B Biointerfaces 2002;26:135-45.
19. Gargouri Y, Julien R, Bois AG, Verger R, Sarda L. Studies on the detergent inhibition of pancreatic lipase activity. J Lipid Res 1983;24: 1336-42.
20. Tiss A, Carriere F, Verger R. Effects of gum Arabic on lipase interfacial binding and activity. Anal Biochem 2001;294:36-43.
21. Marciani L, Wickham M, Singh G, Bush D, Pick B, Cox E, Fillery-Travis A, Faulks R, Marsden C, Gowland PA, et al. Delaying gastric emptying and enhancing cholecystokinin release and satiety by using acid stable fat emulsions. Gastroenterology 2006;130:A227-A.
22. Marciani L, Wickham M, Singh G, Bush D, Pick B, Cox E, Fillery-Travis A, Faulks R, Marsden C, Gowland PA, et al. Enhancement of intragastric acid stability of a fat emulsion meal delays gastric emptying and increases cholecystokinin release and gallbladder contraction. Am J Physiol Gastrointest Liver Physiol 2007;292:G1607-13.
23. Marciani L, Wickham M, Wright J, Bush D, Faulks R, Fillery-Travis A, Gowland P, Spiller RC. Magnetic resonance imaging (MRI) insights into how fat emulsion stability alters gastric emptying. Gastroenterology 2003;124:A581-A.
24. Marciani L, Wickham MSJ, Bush D, Faulks R, Wright J, Fillery-Travis AJ, Spiller RC, Gowland PA. Magnetic resonance imaging of the behaviour of oil-in-water emulsions in the gastric lumen of man. Br J Nutr 2006;95:331-9.
25. Marciani L, Gowland PA, Spiller RC, Manoj P, Moore RJ, Young P, Fillery-Travis AJ. Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI. Am J Physiol Gastrointest Liver Physiol 2001;280:G1227-33.
26. Pinheiro J, Bates D, DebRoy S, Sarkar D;R Core Team (2015). nlme: Linear and Nonlinear Mixed Effects Models. R package version 3.1-113, 2015. Available from: http://CRAN.R-project.org/package=nlme.
27. R Core Team. A language and environment for statistical computing. Vienna (Austria): R Foundation for Statistical Computing;2013.
28. Christensen RHB. ordinal-Regression Models for Ordinal Data. R package version 2013.9-30. 2015. Available from: http://www.cran.rproject. org/package=ordinal/.
29. Pasquier B, Armand M, Castelain C, Guillon F, Borel P, Lafont H, Lairon D. Emulsification and lipolysis of triacylglycerols are altered by viscous soluble dietary fibres in acidic gastric medium in vitro. Biochem J 1996;314:269-75.
30. Pasquier B, Armand M, Guillon F, Castelain C, Borel P, Barry JL, Pieroni G, Lairon D. Viscous soluble dietary fibers alter emulsification and lipolysis of triacylglycerols in duodenal medium in vitro. J Nutr Biochem 1996;7:293-302.
31. Schwizer W, Steingoetter A, Fox M. Magnetic resonance imaging for the assessment of gastrointestinal function. Scand J Gastroenterol 2006;41:1245-60.
32. Fruehauf H, Goetze O, Steingoetter A, Kwiatek M, Boesiger P, Thumshirn M, Schwizer W, Fried M. Intersubject and intrasubject variability of gastric volumes in response to isocaloric liquid meals in functional dyspepsia and health. Neurogastroenterol Motil 2007;19: 553-61.
33. Sauter M, Curcic J, Menne D, Goetze O, Fried M, Schwizer W, Steingoetter A. Measuring the interaction of meal and gastric secretion: a combined quantitative magnetic resonance imaging and pharmacokinetic modeling approach. Neurogastroenterol Motil 2012;24:632-8, e272-3.
34. Hoad CL, Marciani L, Foley S, Totman JJ, Wright J, Bush D, Cox EF, Campbell E, Spiller RC, Gowland PA. Non-invasive quantification of small bowel water content by MRI: a validation study. Phys Med Biol 2007;52:6909-22.
35. Stan Development Team. RStan: the R interface to Stan, Version 1.3.0., 2014. Available from: http://mc-stan.org/rstan.html.
36. Revelle W. psych: Procedures for Personality and Psychological Research, Northwestern University, Evanston (IL);2015. Available from: http://CRAN.R-project.org/package=psych Version = 1.5.1.
37. Keogh JB, Wooster TJ, Golding M, Day L, Otto B, Clifton PM. Slowly and rapidly digested fat emulsions are equally satiating but their triglycerides are differentially absorbed and metabolized in humans. J Nutr 2011;141:809-15.
38. Schulze K. Imaging and modelling of digestion in the stomach and the duodenum. Neurogastroenterol Motil 2006;18:172-83.
39. Marciani L, Gowland PA, Fillery-Travis A, Manoj P, Wright J, Smith A, Young P, Moore R, Spiller RC. Assessment of antral grinding of a model solid meal with echo-planar imaging. Am J Physiol Gastrointest Liver Physiol 2001;280:G844-9.
40. Seimon RV, Wooster T, Otto B, Golding M, Day L, Little TJ, Horowitz M, Clifton PM, Feinle-Bisset C. The droplet size of intraduodenal fat emulsions influences antropyloroduodenal motility, hormone release, and appetite in healthy males. Am J Clin Nutr 2009;89:1729-36.
41. Shaffer EA. Review article: Control of gallbladder motor function. Aliment Pharmacol Ther 2000;14(Suppl 2):2-8.
42. Marciani L, Cox EF, Hoad CL, Totman JJ, Costigan C, Singh G, Shepherd V, Chalkley L, Robinson M, Ison R, et al. Effects of various food ingredients on gall bladder emptying. Eur J Clin Nutr 2013;67: 1182-7.
43. Maljaars PWJ, van der Wal RJP, Wiersma T, Peters HPF, Haddeman E, Masclee AAM. The effect of lipid droplet size on satiety and peptide secretion is intestinal site-specific. Clin Nutr 2012;31:535-42.
44. Welch IM, Sepple CP, Read NW. Comparisons of the effects on satiety and eating behavior of infusion of lipid into the different regions of the small intestine. Gut 1988;29:306-11.
45. Maljaars PWJ, Peters HPF, Mela DJ, Masclee AAM. Ileal brake: a sensible food target for appetite control. A review. Physiol Behav 2008;95:271-81.
46. Maljaars PWJ, Symersky T, Kee BC, Haddeman E, Peters HPF, Masclee AAM. Effect of ileal fat perfusion on satiety and hormone release in healthy volunteers. Int J Obes (Lond) 2008;32:1633-9.
47. Jandacek RJ, Heubi JE, Tso P. A novel, noninvasive method for the measurement of intestinal fat absorption. Gastroenterology 2004;127: 139-44.