The droplet size of intraduodenal fat emulsions influences antropyloroduodenal motility, hormone release, and appetite in healthy males

American Journal of Clinical Nutrition

Volumn 89, Issue 6, 2009, Pages 1729-1736

  Seimon, Radhika V ^a,b   Wooster, Timothy ^c   Otto, Bärbel ^d   Golding, Matthew ^c   Day, Li ^c   Little, Tanya J ^a   Horowitz, Michael ^a,b   Clifton, Peter M ^b,c   Feinle Bisset, Christine ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b National Health and Medical Research Council of Australia Centre   (Australia)

^c CSIRO   (Australia)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ; LIPID EMULSION; PEPTIDE YY; TRIACYLGLYCEROL; FAT;

APPETITE; ARTICLE; BLOATING; CALORIC INTAKE; CHOLECYSTOKININ BLOOD LEVEL; CONTROLLED STUDY; DUODENUM; DUODENUM MOTILITY; FOOD INTAKE; FUNCTIONAL FOOD; GASTROINTESTINAL TRACT FUNCTION; HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; LIPOLYSIS; MALE; NAUSEA; NORMAL HUMAN; PYLORUS; TRIACYLGLYCEROL BLOOD LEVEL; AREA UNDER THE CURVE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; EMULSION; FAT INTAKE; GASTROINTESTINAL MOTILITY; HUNGER; MANOMETRY; PARTICLE SIZE; PHYSIOLOGY; PRESSURE; RANDOMIZED CONTROLLED TRIAL; SATIETY; SECRETION; SINGLE BLIND PROCEDURE;

APPETITE; AREA UNDER CURVE; CHOLECYSTOKININ; DIETARY FATS; DUODENUM; EMULSIONS; ENERGY INTAKE; FATS; GASTROINTESTINAL MOTILITY; HUMANS; HUNGER; MALE; MANOMETRY; NAUSEA; PARTICLE SIZE; PEPTIDE YY; PRESSURE; PYLORUS; SATIATION; SINGLE-BLIND METHOD; TRIGLYCERIDES;

EID: 66849099883     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.3945/ajcn.2009.27518     Document Type: Article

References (37)

1. Heddle R, Dent J, Read NW, et al. Antropyloroduodenal motor responses to intraduodenal lipid infusion in healthy volunteers. Am J Physiol 1988;254:G671-9.
2. Houghton LA, Read NW, Heddle R, et al. Relationship of the motor activity of the antrum, pylorus, and duodenum to gastric emptying of a solid-liquid mixed meal. Gastroenterology 1988;94:1285-1291 (Pubitemid 18153626)
3. Rehfeld JF. Immunochemical studies on cholecystokinin. II. Distribution and molecular heterogeneity in the central nervous system and small intestine of man and hog. J Biol Chem 1978;253:4022-4030
4. Adrian TE, Ferri GL, Bacarese-Hamilton AJ, Fuessl HS, Polak JM, Bloom SR. Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 1985;89:1070-1077
5. Chapman IM, Goble EA, Wittert GA, Horowitz M. Effects of small-intestinal fat and carbohydrate infusions on appetite and food intake in obese and nonobese men. Am J Clin Nutr 1999;69:6-12. (Pubitemid 29031244)
6. Cook CG, Andrews JM, Jones KL, et al. Effects of small intestinal nutrient infusion on appetite and pyloric motility are modified by age. Am J Physiol 1997;273:R755-61.
7. Schwizer W, Asal K, Kreiss C, et al. Role of lipase in the regulation of upper gastrointestinal function in humans. Am J Physiol 1997;273:G612-20. (Pubitemid 27418780)
8. Pilichiewicz A, O'Donovan D, Feinle C, et al. Effect of lipase inhibition on gastric emptying of, and the glycemic and incretin responses to, an oil/aqueous drink in type 2 diabetes mellitus. J Clin Endocrinol Metab 2003;88:3829-3834 (Pubitemid 37034535)
9. Feinle C, O'Donovan DG, Doran S, et al. Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans. Am J Physiol Gastrointest Liver Physiol 2003;284: G798-807. (Pubitemid 36437980)
10. Hildebrand P, Petrig C, Burckhardt B, et al. Hydrolysis of dietary fat by pancreatic lipase stimulates cholecystokinin release. Gastroenterology 1998;114:123-129 (Pubitemid 28020962)
11. Feinle-Bisset C, Patterson M, Ghatei MA, Bloom SR, Horowitz M. Fat digestion is required for the suppression of ghrelin and stimulation of peptide YYand pancreatic polypeptide secretion by intraduodenal lipid. Am J Physiol Endocrinol Metab 2005;289:E948-53. (Pubitemid 43671042)
12. Drewe J, Mihailovic S, D'Amato M, Beglinger C. Regulation of fat-stimulated neurotensin secretion in healthy subjects. J Clin Endocrinol Metab 2008;93:1964-1970 (Pubitemid 351656545)
13. Matzinger D, Degen L, Drewe J, et al. The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans. Gut 2000;46:688-693 (Pubitemid 30305787)
14. O'Donovan D, Feinle-Bisset C, Wishart J, Horowitz M. Lipase inhibition attenuates the acute inhibitory effects of oral fat on food intake in healthy subjects. Br J Nutr 2003;90:849-852 (Pubitemid 37328059)
15. Armand M, Pasquier B, Andre M, et al. Digestion and absorption of 2 fat emulsions with different droplet sizes in the human digestive tract. Am J Clin Nutr 1999;70:1096-1106
16. Boyd KA, O'Donovan DG, Doran S, et al. High-fat diet effects on gut motility, hormone, and appetite responses to duodenal lipid in healthy men. Am J Physiol Gastrointest Liver Physiol 2003;284:G188-96. (Pubitemid 36120123)
17. Feinle C, Rades T, Otto B, Fried M. Fat digestion modulates gastrointestinal sensations induced by gastric distention and duodenal lipid in humans. Gastroenterology 2001;120:1100-1107 (Pubitemid 32246664)
18. Little TJ, Russo A, Meyer JH, et al. Free fatty acids have more potent effects on gastric emptying, gut hormones, and appetite than triacylglycerides. Gastroenterology 2007;133:1124-1131 (Pubitemid 47494446)
19. Pilichiewicz AN, Chaikomin R, Brennan IM, et al. Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy men. Am J Physiol Endocrinol Metab 2007;293:E743-53. (Pubitemid 47358986)
20. Pilichiewicz AN, Little TJ, Brennan IM, et al. Effects of load, and duration, of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men. Am J Physiol Regul Integr Comp Physiol 2005;290:R668-77.
21. Stunkard AJ, Messick S. The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychosom Res 1985;29:71-83. (Pubitemid 15134378)
22. Parker BA, Sturm K, MacIntosh CG, Feinle C, Horowitz M, Chapman IM. Relation between food intake and visual analogue scale ratings of appetite and other sensations in healthy older and young subjects. Eur J Clin Nutr 2004;58:212-218 (Pubitemid 38256573)
23. Feltrin KL, Little TJ, Meyer JH, et al. Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length. Am J Physiol Regul Integr Comp Physiol 2004;287:R524-33.
24. Samsom M, Roelofs JM, Akkermans LM, van Berge Henegouwen GP, Smout AJ. Proximal gastric motor activity in response to a liquid meal in type I diabetes mellitus with autonomic neuropathy. Dig Dis Sci 1998;43:491-496 (Pubitemid 28155568)
25. Heddle R, Dent J, Toouli J, Read NW. Topography and measurement of pyloric pressure waves and tone in humans. Am J Physiol 1988;255:G490-7. (Pubitemid 18246106)
26. Riepl RL, Fiedler F, Ernstberger M, Teufel J, Lehnert P. Effect of intraduodenal taurodeoxycholate and L-phenylalanine on pancreatic secretion and on gastroenteropancreatic peptide release in man. Eur J Med Res 1996;1:499-505.
27. Little TJ, Feltrin KL, Horowitz M, et al. Dose-related effects of lauric acid on antropyloroduodenal motility, gastrointestinal hormone release, appetite, and energy intake in healthy men. Am J Physiol Regul Integr Comp Physiol 2005;289:R1090-8. (Pubitemid 41397058)
28. Andrews JM, Doran S, Hebbard GS, Rassias G, Sun WM, Horowitz M. Effect of glucose supplementation on appetite and the pyloric motor response to intraduodenal glucose and lipid. Am J Physiol 1998;274:G645-52. (Pubitemid 28217719)
29. Buffa R, Solcia E, Go VL. Immunohistochemical identification of the cholecystokinin cell in the intestinal mucosa. Gastroenterology 1976;70:528-532
30. Little TJ, Doran S, Meyer JH, et al. The release of GLP-1 and ghrelin, but not GIP and CCK, by glucose is dependent upon the length of small intestine exposed. Am J Physiol Endocrinol Metab 2006;291:E647-55. (Pubitemid 44352273)
31. Lin HC, Chey WY, Zhao X. Release of distal gut peptide YY (PYY) by fat in proximal gut depends on CCK. Peptides 2000;21:1561-1563 (Pubitemid 30799345)
32. Brennan IM, Otto B, Feltrin KL, Meyer JH, Horowitz M, Feinle-Bisset C. Intravenous CCK-8, but not GLP-1, suppresses ghrelin and stimulates PYY release in healthy men. Peptides 2007;28:607-611 (Pubitemid 46204995)
33. Xu X, Zhu H, Chen JD. Pyloric electrical stimulation reduces food intake by inhibiting gastric motility in dogs. Gastroenterology 2005;128:43-50. (Pubitemid 40039957)
34. Beglinger C, Degen L, Matzinger D, D'Amato M, Drewe J. Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans. Am J Physiol Regul Integr Comp Physiol 2001;280:R1149-54. (Pubitemid 32521561)
35. Batterham RL, Cowley MA, Small CJ, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 2002;418:650-654
36. Rolls BJ, Kim-Harris S, Fischman MW, Foltin RW, Moran TH, Stoner SA. Satiety after preloads with different amounts of fat and carbohydrate: implications for obesity. Am J Clin Nutr 1994;60:476-487 (Pubitemid 24312992)
37. Feltrin KL, Patterson M, Ghatei MA, et al. Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men. Peptides 2006;27:1638-1643