Inhibition of autophagy blocks cathepsins-tBid-mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytes

Cell Death and Disease

Volumn 8, Issue 2, 2017, Pages

  Zhou, Xian Yong ^a,b   Luo, Yu ^a,b   Zhu, Yong Ming ^a,b   Liu, Zhi He ^c   Kent, Thomas A ^d,e   Rong, Jia Guo ^a,b   Li, Wei ^a,b   Qiao, Shi Gang ^a,b   Li, Min ^a,b   Ni, Yong ^a,b   Ishidoh, Kazumi ^f   Zhang, Hui Ling ^a,b  

^a SOOCHOW UNIVERSITY   (China)

^b MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^c MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; AUTOPHAGY RELATED PROTEIN 5; CASPASE 3; CATHEPSIN B; CATHEPSIN L; CYTOCHROME C; CYTOPLASM PROTEIN; GLUCOSE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 70 1B; OXYGEN; PROTEIN BID; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; ASTROCYTE CULTURE; AUTOPHAGY; BRAIN INFARCTION SIZE; BRAIN MITOCHONDRION; BRAIN PROTECTION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYTOPLASM; EMBRYO; ENZYME ACTIVATION; EXPERIMENTAL CEREBRAL ISCHEMIA; FIBROBLAST; GENE SILENCING; LYSOSOME; LYSOSOME MEMBRANE; MALE; MEMBRANE STABILIZATION; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PRIMARY CULTURE; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; APOPTOSIS; METABOLISM; PATHOLOGY;

ANIMALS; APOPTOSIS; ASTROCYTES; AUTOPHAGY; CATHEPSIN B; LYSOSOMES; MICE; SIGNAL TRANSDUCTION;

EID: 85020015386     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2017.34     Document Type: Article

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