Autophagy in hypoxia-ischemia induced brain injury: Evidence and speculations

Autophagy

Volumn 5, Issue 2, 2009, Pages 221-223

  Balduini, Walter ^a   Carloni, Silvia ^a   Buonocore, Giuseppe ^b  

^a UNIVERSITY OF URBINO   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

Apoptosis; Autophagy; Development; Hypoxia; Ischemia; Necrosis; Neurodegeneration; Rat

Indexed keywords

RAPAMYCIN; SIMVASTATIN; WORTMANNIN;

APOPTOSIS; ARTICLE; AUTOPHAGY; BRAIN HYPOXIA; BRAIN INJURY; BRAIN ISCHEMIA; NERVE CELL; NONHUMAN;

RATTUS;

EID: 61649124034     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.5.2.7363     Document Type: Article

References (30)

1. Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N. The role of autophagy during the early neonatal starvation period. Nature 2004; 432:1032-6.
2. Zhu C, Wang X, Xu F, Bahr BA, Shibata M, Uchiyama Y, Hagberg H, Blomgren K. The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia. Cell Death Differ 2005; 12:162-76.
3. Wang Y, Han R, Liang ZQ, Wu JC, Zhang XD, Gu ZL, Qin ZH. An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-n-methyl-d-aspartate receptor agonist kainic acid. Autophagy 2008; 4:214-26.
4. Diskin T, Tal-Or P, Erlich S, Mizrachy L, Alexandrovich A, Shohami E, Pinkas-Kramarski R. Closed head injury induces upregulation of beclin 1 at the cortical site of injury. J Neurotrauma 2005; 22:750-62.
5. Rami A, Langhagen A, Steiger S. Focal cerebral ischemia induces upregulation of beclin 1 and autophagy-like cell death. Neurobiol Dis 2008; 29:132-41.
6. Codogno P, Meijer A-J. Autophagy and signaling: Their role in cell survival and cell death. Cell Death Differ 2005; 12:1509-18.
7. Erlich S, Shohami E, Pinkas-Kramarski R. Neurodegeneration induces upregulation of beclin 1. Autophagy 2006; 2:49-51.
8. Carloni S, Buonocore G, Balduini W. Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury. Neurobiol Dis 2008; 32:329-39.
9. Carloni S, Carnevali A, Cimino M, Balduini W. Extended role of necrotic cell death after hypoxia-ischemia-induced neurodegeneration in the neonatal rat. Neurobiol Dis 2007; 27:354-61.
10. Seglen PO, Gordon PB. 3-methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci USA 1982; 79:1889-92.
11. Petiot A, Ogier-Denis E, Blommaart EF, Meijer AJ, Codogno P. Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in ht-29 cells. J Biol Chem 2000; 275:992-8.
12. Ravikumar B, Berger Z, Vacher C, O'Kane CJ, Rubinsztein DC. Rapamycin pre-treatment protects against apoptosis. Hum Mol Genet 2006; 15:1209-16.
13. Liu CL, Siesjo BK, Hu BR. Pathogenesis of hippocampal neuronal death after hypoxia-ischemia changes during brain development. Neuroscience 2004; 127:113-23.
14. Northington FJ, Graham EM, Martin LJ. Apoptosis in perinatal hypoxic-ischemic brain injury: How important is it and should it be inhibited? Brain Res Brain Res Rev 2005; 50:244-57.
15. Benjelloun N, Renolleau S, Represa A, Ben-Ari Y, Charriaut-Marlangue C. Inflammatory responses in the cerebral cortex after ischemia in the p7 neonatal rat. Stroke 1999; 30:1916-23.
16. Yin W, Signore AP, Iwai M, Cao G, Gao Y, Johnnides MJ, Hickey RW, Chen J. Preconditioning suppresses inflammation in neonatal hypoxic ischemia via akt activation. Stroke 2007; 38:1017-24.
17. Balduini W, De Angelis V, Mazzoni E, Cimino M. Simvastatin protects against long-lasting behavioral and morphological consequences of neonatal hypoxic/ischemic brain injury. Stroke 2001; 32:2185-91.
18. Carloni S, Mazzoni E, Cimino M, De Simoni MG, Perego C, Scopa C, Balduini W. Simvastatin reduces caspase-3 activation and inflammatory markers induced by hypoxia-ischemia in the newborn rat. Neurobiol Dis 2006; 21:119-26.
19. Yan L, Vatner DE, Kim SJ, Ge H, Masurekar M, Massover WH, Yang G, Matsui Y, Sadoshima J, Vatner SF. Autophagy in chronically ischemic myocardium. Proc Natl Acad Sci USA 2005; 102:13807-12.
20. Choi S-E, Lee S-M, Lee Y-J, Li L-J, Lee S-J, Lee J-H, Kim Y, Jun H-S, Lee K-W, Kang Y. Protective role of autophagy in palmitate-induced ins-1 beta cell death. Endocrinology 2008; In press.
21. Hay N, Sonenberg N. Upstream and downstream of mtor. Genes Dev 2004; 18:1926-45.
22. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132:27-42.
23. Pan T, Kondo S, Zhu W, Xie W, Jankovic J, Le W. Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement. Neurobiol Dis 2008; 32:16-25.
24. Khan S, Salloum F, Das A, Xi L, Vetrovec G-W, Kukreja RC. Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes. J Mol Cell Cardiol 2006; 41:256-64.
25. Hamacher-Brady A, Brady N-R, Gottlieb R-A. Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem 2006; 281:29776-87.
26. Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J. Rheb binds and regulates the mtor kinase. Curr Biol 2005; 15:702-13.
27. Finlay G-A, Malhowski A-J, Liu Y, Fanburg B-L, Kwiatkowski D-J, Toksoz D. Selective inhibition of growth of tuberous sclerosis complex 2-null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity. Cancer Res 2007; 67:9878-86.
28. Patel P-H, Tamanoi F. Increased rheb-tor signaling enhances sensitivity of the whole organism to oxidative stress. J Cell Sci 2006; 119:4285-92.
29. Buonocore G, Groenendaal F. Anti-oxidant strategies. Semin Fetal Neonatal Med 2007; 12:287-95.
30. Buonocore G, Perrone S. Biomarkers of hypoxic brain injury in the neonate. Clin Perinatol 2004; 31:107-16.