Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway

Oncotarget

Volumn 8, Issue 21, 2017, Pages 34045-34056

  Kinoshita, Daisuke ^a,b   Nagasawa, Ayako ^b   Shimizu, Ippei ^b   Ito, Takashi K ^a   Yoshida, Yohko ^b   Tsuchida, Masanori ^b   Iwama, Atsushi ^a   Hayano, Toshiya ^c   Minamino, Tohru ^b  

^a CHIBA UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^c RITSUMEIKAN UNIVERSITY   (Japan)

Author keywords

Cellular senescence; DNA PK; Gerotarget; HGPS; P53; Vascular smooth muscle cells

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LAMIN A; PROGERIN; PROTEIN P16; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG; LMNA PROTEIN, HUMAN; NUCLEAR PROTEIN; PRKDC PROTEIN, HUMAN; TP53 PROTEIN, HUMAN;

ARTICLE; AUTOPHOSPHORYLATION; CARDIOVASCULAR DISEASE; CELL CYCLE ARREST; CELL GROWTH; CONTROLLED STUDY; DNA DAMAGE RESPONSE; DNA END JOINING REPAIR; GENE ONTOLOGY; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; PATHOGENESIS; PROGERIA; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL; WESTERN BLOTTING; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; DNA DAMAGE; GENETICS; HEK293 CELL LINE; METABOLISM; MUTATION; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

CELL PROLIFERATION; CELLS, CULTURED; DNA DAMAGE; DNA-ACTIVATED PROTEIN KINASE; HEK293 CELLS; HUMANS; LAMIN TYPE A; MUSCLE, SMOOTH, VASCULAR; MUTATION; NUCLEAR PROTEINS; PROGERIA; PROTEIN INTERACTION MAPS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85019849653     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.15973     Document Type: Article

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