Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferase

Nucleic Acids Research

Volumn 45, Issue 4, 2017, Pages 1703-1713

  Stepper, Peter ^a   Kungulovski, Goran ^a   Jurkowska, Renata Z ^a,e   Chandra, Tamir ^b,c   Krueger, Felix ^b   Reinhardt, Richard ^d   Reik, Wolf ^b,c   Jeltsch, Albert ^a   Jurkowski, Tomasz P ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d Max Planck Genome Centre Cologne   (Germany)

^e BioMed X Innovation Center   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3L; EPITHELIAL CELL ADHESION MOLECULE; UNCLASSIFIED DRUG; DNA; DNA (CYTOSINE 5) METHYLTRANSFERASE; ENDONUCLEASE; HYBRID PROTEIN;

ARTICLE; BINDING SITE; CHIMERA; CONTROLLED STUDY; CRISPR-CAS9 SYSTEM; CXCR4 GENE; DNA METHYLATION; EPCAM GENE; EPIGENETICS; GENE; GENE REPRESSION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN MULTIMERIZATION; SEQUENCE ANALYSIS; TFRC GENE; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; CLUSTER ANALYSIS; CPG ISLAND; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HIGH THROUGHPUT SEQUENCING; HUMAN; METABOLISM; MOUSE; PROCEDURES; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CLUSTER ANALYSIS; CPG ISLANDS; DNA; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ENDONUCLEASES; EPIGENESIS, GENETIC; EPIGENOMICS; GENE EXPRESSION REGULATION; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MICE; MODELS, BIOLOGICAL; PROMOTER REGIONS, GENETIC; RECOMBINANT FUSION PROTEINS;

EID: 85019832181     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkw1112     Document Type: Article

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