Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

Nature Communications

Volumn 7, Issue , 2016, Pages

  Grover, Amit ^a,b   Sanjuan Pla, Alejandra ^a,b   Thongjuea, Supat ^a   Carrelha, Joana ^a   Giustacchini, Alice ^a   Gambardella, Adriana ^a,b,c   Macaulay, Iain ^a   Mancini, Elena ^c   Luis, Tiago C ^a   Mead, Adam ^a   Jacobsen, Sten Eirik W ^a   Nerlov, Claus ^a,b,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY EMBL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOG 1; TRANSCRIPTOME; UNCLASSIFIED DRUG; NUCLEAR PROTEIN; ZFPM1 PROTEIN, MOUSE;

CELLS AND CELL COMPONENTS; FUNCTIONAL ROLE; IDENTIFICATION METHOD; IMMUNITY; MOLECULAR ANALYSIS; NUCLEIC ACID;

AGED; ANIMAL CELL; ARTICLE; CELL AGING; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; ERYTHROID PRECURSOR CELL; FEMALE; GENE EXPRESSION PROFILING; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; MALE; MOLECULAR DYNAMICS; MOUSE; MULTIPOTENT STEM CELL; MYELOID PROGENITOR CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPIC VARIATION; RNA SEQUENCE; SINGLE CELL ANALYSIS; STEM CELL EXPANSION; THROMBOCYTE FUNCTION; ANIMAL; BONE MARROW CELL; CELL PROLIFERATION; CYTOLOGY; GENETICS; METABOLISM; PHENOTYPE; PROCEDURES; SEQUENCE ANALYSIS; THROMBOCYTE;

ANIMALS; BLOOD PLATELETS; CELL AGING; CELL LINEAGE; CELL PROLIFERATION; FEMALE; GENE EXPRESSION PROFILING; HEMATOPOIETIC STEM CELLS; MALE; MICE; MYELOID CELLS; NUCLEAR PROTEINS; PHENOTYPE; SEQUENCE ANALYSIS, RNA; SINGLE-CELL ANALYSIS; TRANSCRIPTION FACTORS;

EID: 84962229210     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11075     Document Type: Article

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