JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease

Blood

Volumn 123, Issue 20, 2014, Pages 3139-3151

  Li, Juan ^a,b   Kent, David G ^a,b   Godfrey, Anna L ^a,b,c   Manning, Harriet ^b,d   Nangalia, Jyoti ^a,b,c   Aziz, Athar ^a,b   Chen, Edwin ^a,b   Saeb Parsy, Kourosh ^e   Fink, Juergen ^a,b   Sneade, Rachel ^a,b   Hamilton, Tina L ^a,b   Pask, Dean C ^a,b   Silber, Yvonne ^a,b   Zhao, Xiaodong ^a,b   Ghevaert, Cedric ^b,c,d   Liu, Pentao ^f   Green, Anthony R ^a,b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

^d NHS BLOOD AND TRANSPLANT   (United Kingdom)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CLONE; CELL EXPANSION; CONTROLLED STUDY; DISEASE SEVERITY; ERYTHROBLAST; ERYTHROCYTOSIS; ERYTHROID PRECURSOR CELL; FEMALE; HEMATOPOIETIC STEM CELL; HOMOZYGOSITY; MALE; MOUSE; MYELOPROLIFERATIVE NEOPLASM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; THROMBOCYTE COUNT; THROMBOCYTE LIFESPAN;

ANIMALS; BLOOD PLATELETS; ERYTHROBLASTS; FEMALE; GENE KNOCK-IN TECHNIQUES; HOMOZYGOTE; HUMANS; JANUS KINASE 2; MALE; MEGAKARYOCYTES; MICE; MICE, INBRED C57BL; MUTATION; PHENOTYPE; POLYCYTHEMIA VERA; THROMBOCYTHEMIA, ESSENTIAL; UNIPARENTAL DISOMY;

EID: 84902576384     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-06-510222     Document Type: Article

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